DE60208172D1 - Mehrarmige blockcopolymere und pharmazeutische zusammensetzung - Google Patents
Mehrarmige blockcopolymere und pharmazeutische zusammensetzungInfo
- Publication number
- DE60208172D1 DE60208172D1 DE60208172T DE60208172T DE60208172D1 DE 60208172 D1 DE60208172 D1 DE 60208172D1 DE 60208172 T DE60208172 T DE 60208172T DE 60208172 T DE60208172 T DE 60208172T DE 60208172 D1 DE60208172 D1 DE 60208172D1
- Authority
- DE
- Germany
- Prior art keywords
- block copolymers
- hydrophobic
- polymer segment
- central core
- covalently attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
- C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/22—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the initiator used in polymerisation
- C08G2650/24—Polymeric initiators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26275401P | 2001-01-19 | 2001-01-19 | |
US262754P | 2001-01-19 | ||
PCT/US2002/021872 WO2003000777A2 (en) | 2001-01-19 | 2002-01-22 | Multi-arm block copolymers as drug delivery vehicles |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60208172D1 true DE60208172D1 (de) | 2006-01-26 |
DE60208172T2 DE60208172T2 (de) | 2006-07-13 |
Family
ID=22998880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60208172T Expired - Lifetime DE60208172T2 (de) | 2001-01-19 | 2002-01-22 | Mehrarmige blockcopolymere und pharmazeutische zusammensetzung |
Country Status (12)
Country | Link |
---|---|
US (6) | US6730334B2 (de) |
EP (1) | EP1373366B1 (de) |
JP (1) | JP4078300B2 (de) |
KR (1) | KR100851270B1 (de) |
AT (1) | ATE313586T1 (de) |
AU (1) | AU2002326369B2 (de) |
CA (1) | CA2435301C (de) |
DE (1) | DE60208172T2 (de) |
ES (1) | ES2254717T3 (de) |
MX (1) | MXPA03006449A (de) |
TW (1) | TWI246524B (de) |
WO (1) | WO2003000777A2 (de) |
Families Citing this family (201)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
TWI246524B (en) * | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
US7265186B2 (en) * | 2001-01-19 | 2007-09-04 | Nektar Therapeutics Al, Corporation | Multi-arm block copolymers as drug delivery vehicles |
US20040185101A1 (en) * | 2001-03-27 | 2004-09-23 | Macromed, Incorporated. | Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof |
US7009033B2 (en) * | 2001-07-02 | 2006-03-07 | Polymer Source Inc. | Heterofunctional polyethylene glycol and polyethylene oxide, process for their manufacture |
US7649023B2 (en) * | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
KR20040040782A (ko) * | 2002-11-08 | 2004-05-13 | 선바이오(주) | 신규한 헥사-암 폴리에틸렌글리콜과 유도체 및 그의합성방법 |
EP2405015B1 (de) | 2003-03-05 | 2016-01-06 | Halozyme, Inc. | Lösliches Hyaluronidaseglykoprotein (sHASEGP), Verfahren zu dessen Herstellung, Verwendungen und pharmazeutische Zusammensetzungen, die dieses umfassen |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
JP2005008614A (ja) * | 2003-03-28 | 2005-01-13 | Nano Career Kk | 高分子ミセルを用いた眼科用ドラッグデリバリーシステム |
US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
TWI248947B (en) * | 2003-07-21 | 2006-02-11 | Ind Tech Res Inst | Biodegradable copolymer, and polymeric micelle composition containing the copolymer |
EP1525890A1 (de) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophor Komplex |
EP1670838B1 (de) * | 2003-10-10 | 2015-12-09 | Samyang Biopharmaceuticals Corporation | Amphiphiles blockcopolymer und dieses enthaltende polymerzusammensetzung für die arzneistoffzufuhr |
US20050214250A1 (en) | 2003-11-06 | 2005-09-29 | Harris J M | Method of preparing carboxylic acid functionalized polymers |
NZ586034A (en) | 2004-02-02 | 2011-10-28 | Ambrx Inc | Modified human growth hormone polypeptides and their uses |
US7354980B1 (en) | 2004-03-12 | 2008-04-08 | Key Medical Technologies, Inc. | High refractive index polymers for ophthalmic applications |
US7588745B2 (en) * | 2004-04-13 | 2009-09-15 | Si Options, Llc | Silicon-containing products |
ATE402971T1 (de) * | 2004-05-05 | 2008-08-15 | Firmenich & Cie | Biologisch abbaubare pfropfcopolymere |
WO2005118877A2 (en) * | 2004-06-02 | 2005-12-15 | Vicus Bioscience, Llc | Producing, cataloging and classifying sequence tags |
US7632924B2 (en) | 2004-06-18 | 2009-12-15 | Ambrx, Inc. | Antigen-binding polypeptides and their uses |
EP1773375A1 (de) | 2004-07-14 | 2007-04-18 | University of Utah Research Foundation | Netrin-verwandte zusammensetzungen und anwendungen |
RU2393168C2 (ru) | 2004-07-19 | 2010-06-27 | Биокон Лимитед | Инсулин-олигомерные конъюгаты, их препараты и применения |
MX301374B (es) * | 2004-10-08 | 2012-07-16 | Firmenich & Cie | Copolimeros de bloque en forma de estrella anfifilicos. |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
US7446157B2 (en) | 2004-12-07 | 2008-11-04 | Key Medical Technologies, Inc. | Nanohybrid polymers for ophthalmic applications |
US7736872B2 (en) | 2004-12-22 | 2010-06-15 | Ambrx, Inc. | Compositions of aminoacyl-TRNA synthetase and uses thereof |
KR101224781B1 (ko) | 2004-12-22 | 2013-01-21 | 암브룩스, 인코포레이티드 | 비천연적으로 코딩된 아미노산을 포함하는 인간 성장호르몬의 조제물 |
HUE048419T2 (hu) | 2004-12-22 | 2020-08-28 | Nitto Denko Corp | Gyógyszerhordozó és kit gyógyszerhordozó kit fibrózis gátlására |
JP2008525032A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
EP1871343A2 (de) | 2005-04-12 | 2008-01-02 | Wisconsin Alumni Research Foundation | Mizellenzusammensetzung aus einem polymer und einem weiterleitungsmittel |
US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
KR100664558B1 (ko) | 2005-05-23 | 2007-01-03 | 박기동 | 다관능성 양친매성 고분자 공중합체 및 이의 제조방법 |
JP2008541769A (ja) | 2005-06-03 | 2008-11-27 | アンブレツクス・インコーポレイテツド | 改善されたヒトインターフェロン分子及びそれらの使用 |
CA2653541C (en) | 2005-06-06 | 2014-12-23 | The University Of British Columbia | Polymer-based serum albumin substitute |
EP1898955A2 (de) * | 2005-06-17 | 2008-03-19 | Nektar Therapeutics AL, Corporation | Zusammensetzungen auf polymerbasis und konjugate von nichtsteroidalen antirheumatika |
US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
KR100642220B1 (ko) * | 2005-07-12 | 2006-11-03 | 광주과학기술원 | 사이클로덱스트린과 폴리(옥시에틸렌)의 결합체 및 그제조방법 |
PL1909973T3 (pl) | 2005-07-15 | 2019-01-31 | Micell Technologies, Inc. | Polimerowe powłoki zawierające proszek leku o kontrolowanej morfologii |
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
EP2412744B1 (de) | 2005-07-18 | 2014-01-22 | Nektar Therapeutics | Verfahren zur Herstellung von verzweigten funktionalisierten Polymeren mithilfe von verzweigten Polyol-Kernen |
US20100272769A1 (en) * | 2005-08-03 | 2010-10-28 | Amcol International | Virus-, Bacteria-, and Fungi-Interacting Layered Phyllosilicates and Methods of Use |
US20080184618A1 (en) * | 2005-08-03 | 2008-08-07 | Amcol International | Virus-Interacting Layered Phyllosilicates and Methods of Use |
US20070031512A1 (en) * | 2005-08-03 | 2007-02-08 | Amcol International Corporation | Virus-interacting layered phyllosilicates and methods of inactivating viruses |
ATE477291T1 (de) * | 2005-10-25 | 2010-08-15 | Evonik Degussa Gmbh | Präparate umfassend hyperverzweigte polymere |
DE102005051342A1 (de) * | 2005-10-25 | 2007-04-26 | Goldschmidt Gmbh | Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren |
CN101454461A (zh) | 2005-11-16 | 2009-06-10 | Ambrx公司 | 包括非天然氨基酸的方法和组合物 |
WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
SI1979407T1 (sl) | 2006-01-19 | 2015-01-30 | Allexcel, Inc. | Solubilizacija in ciljano dovajanje zdravil s samozdruĹľljivimi amfifilnimi polimeri |
US9603941B2 (en) * | 2006-01-24 | 2017-03-28 | Minghui Chai | Method of preparing dendritic drugs |
US8309680B2 (en) * | 2006-02-21 | 2012-11-13 | Nektar Therapeutics | Segmented degradable polymers and conjugates made therefrom |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
CA2652280C (en) * | 2006-05-15 | 2014-01-28 | Massachusetts Institute Of Technology | Polymers for functional particles |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
US20100015068A1 (en) * | 2006-07-06 | 2010-01-21 | Massachusetts Institute Of Technology | Methods and Compositions For Altering Biological Surfaces |
US20100022481A1 (en) * | 2006-08-02 | 2010-01-28 | Dong Wang | Drug Carriers, Their Synthesis, and Methods of Use Thereof |
EP2046391A4 (de) * | 2006-08-02 | 2013-03-20 | Univ Nebraska | Wirkstoffträger, ihre synthese und verfahren zu ihrer anwendung |
DE102006038240A1 (de) * | 2006-08-07 | 2008-02-14 | Biotronik Vi Patent Ag | Verfahren zur Herstellung eines Komposits aus Oligo- oder Polynucleotiden und hydrophoben biodegradierbaren Polymeren sowie nach dem Verfahren erhaltenes Komposit |
DK2061878T3 (da) | 2006-09-08 | 2014-04-07 | Ambrx Inc | Hybridsuppressor-trna for hvirveldyrceller |
MX2009002526A (es) | 2006-09-08 | 2009-04-16 | Ambrx Inc | Transcripcion de tarn supresor en celulas de vertebrados. |
JP5840345B2 (ja) * | 2006-09-08 | 2016-01-06 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾ヒト血漿ポリペプチドまたは修飾ヒトFc足場タンパク質ならびにこれらの利用 |
US8636767B2 (en) | 2006-10-02 | 2014-01-28 | Micell Technologies, Inc. | Surgical sutures having increased strength |
CN102886326A (zh) * | 2006-10-23 | 2013-01-23 | 米歇尔技术公司 | 用于在涂覆过程中为基底充电的保持器 |
US20080153982A1 (en) * | 2006-12-20 | 2008-06-26 | John Ta-Yuan Lai | Vinyl-Thiocarbonate and Polyol Containing Block Copolymers |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
EP2134830A2 (de) | 2007-02-09 | 2009-12-23 | Massachusetts Institute of Technology | Oszillations-zellkultur-bioreaktor |
JP5052919B2 (ja) * | 2007-03-08 | 2012-10-17 | 成均▲館▼大學校 産學協力團 | Ph及び温度敏感性のブロック共重合体ヒドロゲル |
TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
KR101476472B1 (ko) | 2007-03-30 | 2015-01-05 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
WO2008124639A2 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Poly (amino acid) targeting moieties |
JP5443336B2 (ja) * | 2007-04-17 | 2014-03-19 | ミセル テクノロジーズ、インコーポレイテッド | 生分解性層を有するステント |
EP1982698A1 (de) * | 2007-04-18 | 2008-10-22 | Evonik Degussa GmbH | Präparate zur gesteuerten Freisetzung von bioaktiven Naturstoffen |
NZ580686A (en) | 2007-05-02 | 2012-11-30 | Ambrx Inc | Modified interferon beta polypeptides and their uses |
EP2431043A1 (de) | 2007-05-23 | 2012-03-21 | Amcol International Corporation | Mit Cholesterin interagierende Phyllosilikate zur Unterdrückung der gastrointestinalen Cholesterinabsorption |
EP2170418B1 (de) * | 2007-05-25 | 2016-03-16 | Micell Technologies, Inc. | Polymerfilme zur beschichtung von medizinprodukten |
WO2008150845A1 (en) * | 2007-05-31 | 2008-12-11 | Vanderbilt University | Screening for wnt pathway modulators and pyrvinium for the treatment of cance |
US8178617B2 (en) | 2007-07-16 | 2012-05-15 | Allvivo Vascular, Inc. | Antimicrobial constructs |
US20110130822A1 (en) * | 2007-07-20 | 2011-06-02 | Orbusneich Medical, Inc. | Bioabsorbable Polymeric Compositions and Medical Devices |
EP2207570A2 (de) | 2007-09-14 | 2010-07-21 | Nitto Denko Corporation | Arzneimittelträger |
EP2200613B1 (de) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazin-derivate und ihre verwendungen |
ES2627292T3 (es) | 2007-10-12 | 2017-07-27 | Massachusetts Institute Of Technology | Nanotecnología de vacunas |
WO2009051780A1 (en) * | 2007-10-19 | 2009-04-23 | Micell Technologies, Inc. | Drug coated stents |
CN101835496B (zh) * | 2007-10-23 | 2015-11-25 | 尼克塔治疗公司 | 靶向羟基磷灰石的多臂聚合物以及由其制造的偶联物 |
AU2008326324B9 (en) | 2007-11-20 | 2012-11-15 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
US9938333B2 (en) | 2008-02-08 | 2018-04-10 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
KR101647932B1 (ko) | 2008-04-14 | 2016-08-11 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
AU2009251504B2 (en) | 2008-04-17 | 2013-09-05 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
AU2009268528B2 (en) * | 2008-07-09 | 2015-11-05 | Board Of Regents Of The University Of Nebraska | Functional micelles for hard tissue targeted delivery of chemicals |
JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
ES2963062T3 (es) | 2008-07-23 | 2024-03-25 | Ambrx Inc | Polipéptidos G-CSF bovinos modificados y sus usos |
US9991391B2 (en) * | 2008-07-25 | 2018-06-05 | The Board Of Trustees Of The Leland Stanford Junior University | Pristine and functionalized graphene materials |
ES2744975T3 (es) | 2008-09-23 | 2020-02-27 | Nektar Therapeutics | Método de dosificación metronómica con profármacos de camptotecina (p. ej. PEG-Irinotecán) |
BRPI0919403A2 (pt) | 2008-09-26 | 2017-09-26 | Ambrx Inc | polipeptídeos modificados de eritropoetina animal e seus usos |
NZ592249A (en) | 2008-09-26 | 2013-03-28 | Ambrx Inc | Non-natural amino acid replication-dependent microorganisms and vaccines |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
CN101724144A (zh) | 2008-11-03 | 2010-06-09 | 北京键凯科技有限公司 | 新型的多臂聚乙二醇及其制备方法和应用 |
PT3037529T (pt) | 2008-12-09 | 2019-05-31 | Halozyme Inc | Polipéptidos ph20 estendidos solúveis e suas utilizações |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
WO2010111196A2 (en) * | 2009-03-23 | 2010-09-30 | Micell Technologies, Inc. | Peripheral stents having layers |
EP2411083A4 (de) | 2009-03-23 | 2013-11-13 | Micell Technologies Inc | Medizinische wirkstofffreisetzungsvorrichtung |
CA2756388C (en) * | 2009-03-23 | 2015-10-27 | Micell Technologies, Inc. | Biodegradable polymers with low acidic impurity |
CN102481195B (zh) | 2009-04-01 | 2015-03-25 | 米歇尔技术公司 | 涂覆支架 |
EP2419058B1 (de) | 2009-04-17 | 2018-02-28 | Micell Technologies, Inc. | Stents mit gesteuerter elution |
CN101869712B (zh) * | 2009-04-21 | 2016-01-20 | 财团法人工业技术研究院 | 使用包囊抗肿瘤药物的聚合胶束用于治疗肿瘤的药物组合物 |
CN106137479B (zh) | 2009-05-14 | 2017-12-05 | 奥巴斯尼茨医学公司 | 具有多边形过渡区的自膨式支架 |
US8013065B2 (en) * | 2009-06-09 | 2011-09-06 | International Business Machines Corporation | Methods for making multi-branched polymers |
DK2477603T3 (en) | 2009-09-17 | 2016-06-13 | Baxalta Inc | STABLE CO-DEVELOPMENT OF hyaluronidase and Immunoglobulin, AND METHODS OF USE THEREOF |
US20110070320A1 (en) * | 2009-09-23 | 2011-03-24 | Soonkap Hahn | Biodegradable thermoresponsive 3-arm polyethylene glycol poly(lactide-co-glycolide) copolymer for ginseng administration |
CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
CN107674121A (zh) | 2009-12-21 | 2018-02-09 | Ambrx 公司 | 经过修饰的牛促生长素多肽和其用途 |
EP2531140B1 (de) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit |
WO2011106877A1 (en) | 2010-03-01 | 2011-09-09 | The University Of British Columbia | Derivatized hyperbranched polyglycerols |
US8795762B2 (en) * | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8765098B2 (en) | 2010-03-30 | 2014-07-01 | International Business Machines Corporation | Star polymers, methods of preparation thereof, and uses thereof |
WO2011133655A1 (en) | 2010-04-22 | 2011-10-27 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
JP2013533217A (ja) | 2010-05-17 | 2013-08-22 | セビックス・インコーポレイテッド | Peg化c−ペプチド |
EP2585533B1 (de) | 2010-06-25 | 2017-05-17 | E. I. du Pont de Nemours and Company | Polyoxymethylenzusammensetzungen mit verzweigten polymeren |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
ES2661089T3 (es) | 2010-07-20 | 2018-03-27 | Halozyme Inc. | Métodos de tratamiento o prevención de los efectos secundarios adversos asociados con la administración de un agente anti-hialuronano |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
EP2605789B1 (de) | 2010-08-17 | 2019-06-05 | Ambrx, Inc. | Modifizierte relaxinpolypeptide und ihre verwendungen |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
WO2012070030A1 (en) * | 2010-11-26 | 2012-05-31 | University Of The Witwatersrand, Johannesburg | A pharmaceutical composition |
EP2658527B1 (de) | 2010-12-30 | 2022-11-30 | Micell Technologies, Inc. | Nanopartikel und oberflächenmodifizierte partikelbeschichtungen, beschichtete ballons und verfahren dafür |
WO2012109387A1 (en) | 2011-02-08 | 2012-08-16 | Halozyme, Inc. | Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia |
WO2012142319A1 (en) | 2011-04-13 | 2012-10-18 | Micell Technologies, Inc. | Stents having controlled elution |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US20130011378A1 (en) | 2011-06-17 | 2013-01-10 | Tzung-Horng Yang | Stable formulations of a hyaluronan-degrading enzyme |
WO2012174480A2 (en) | 2011-06-17 | 2012-12-20 | Halozyme, Inc. | Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US8445577B2 (en) * | 2011-07-25 | 2013-05-21 | Iowa State University Research Foundation, Inc. | Amphiphilic multi-arm copolymers and nanomaterials derived therefrom |
WO2013040501A1 (en) | 2011-09-16 | 2013-03-21 | Pharmathene, Inc. | Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
BR112014009797A2 (pt) | 2011-10-24 | 2020-10-27 | Halozyme, Inc. | diagnóstico de companhia para terapia de agente anti-hialuronano e métodos de uso do mesmo |
PT3130347T (pt) | 2011-12-30 | 2019-12-10 | Halozyme Inc | Variantes de polipéptidos de ph20, suas formulações e utilizações |
BR112014024291B1 (pt) | 2012-03-30 | 2022-07-05 | The Board Of Regents Of The University Of Oklahoma | Método para a produção de forma recombinante de um polímero de heparosan com alto peso molecular, uso do referido polímero para aumento de tecido, polinucleotídeo isolado e composição de material biológico compreendendo o referido polímero |
CA2986512C (en) | 2012-04-04 | 2022-05-17 | Halozyme, Inc. | Combination therapy with an anti-hyaluronan agent and a tumor-targeted taxane |
WO2013176739A1 (en) * | 2012-05-25 | 2013-11-28 | Regents Of The University Of Minnesota | Biomaterials with a sustainable surface |
US9738724B2 (en) | 2012-06-08 | 2017-08-22 | Sutro Biopharma, Inc. | Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
EP2863955B1 (de) | 2012-06-26 | 2016-11-23 | Sutro Biopharma, Inc. | Modifizierte fc-proteine mit nichtnatürlichen ortsspezifische aminosäureresten, konjugate daraus, verfahren zu deren herstellung und verfahren zu deren verwendung |
SI3584255T1 (sl) | 2012-08-31 | 2022-05-31 | Sutro Biopharma, Inc | Modificirane aminokisline, ki vsebujejo azido skupino |
CN102861610B (zh) * | 2012-09-03 | 2014-05-07 | 宁波长阳科技有限公司 | 一种超支化含胺基吡啶催化剂、其制备方法及其用途 |
US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
CN103910874A (zh) * | 2013-01-06 | 2014-07-09 | 张雅珍 | 一种接枝药物的聚合物的制备和用途 |
CN104193987A (zh) * | 2013-01-21 | 2014-12-10 | 张雅珍 | 一种接枝药物的聚合物的制备和用途 |
JP6330024B2 (ja) | 2013-03-12 | 2018-05-23 | マイセル・テクノロジーズ,インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
WO2014172261A1 (en) * | 2013-04-15 | 2014-10-23 | Kent State University | Biodegradable side chain liquid crystal elastomers: smart responsive scaffolds (srs) for tissue regeneration |
CN105377318A (zh) | 2013-05-15 | 2016-03-02 | 脉胜医疗技术公司 | 可生物吸收的生物医学植入物 |
TW201534726A (zh) | 2013-07-03 | 2015-09-16 | Halozyme Inc | 熱穩定ph20玻尿酸酶變異體及其用途 |
ES2658039T3 (es) | 2013-07-10 | 2018-03-08 | Sutro Biopharma, Inc. | Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso |
CN104910373A (zh) * | 2013-08-25 | 2015-09-16 | 张雅珍 | 一种新聚合物及其制备和用途 |
CN104619246B (zh) | 2013-09-09 | 2016-11-30 | 甘布罗伦迪亚股份公司 | 压力信号中干扰脉冲与生理脉冲的分离 |
WO2015038966A1 (en) * | 2013-09-12 | 2015-03-19 | Regents Of The University Of Minnesota | Semi-solid delivery systems |
US9433638B1 (en) | 2013-10-02 | 2016-09-06 | University Of Kentucky Research Foundation | Polymeric prodrug |
WO2015054658A1 (en) | 2013-10-11 | 2015-04-16 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
CN107148265B (zh) | 2014-07-02 | 2019-04-05 | 纽约州立大学研究基金会 | 具有高的负载物与表面活性剂比率的剥离了表面活性剂的胶束组合物 |
WO2016033555A1 (en) | 2014-08-28 | 2016-03-03 | Halozyme, Inc. | Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor |
JP6625627B2 (ja) | 2014-10-14 | 2019-12-25 | ハロザイム インコーポレイテッド | アデノシンデアミナーゼ−2(ada2)、その変異体の組成物およびそれを使用する方法 |
KR20240024362A (ko) | 2014-10-24 | 2024-02-23 | 브리스톨-마이어스 스큅 컴퍼니 | 변형된 fgf-21 폴리펩티드 및 그의 용도 |
CN105395483B (zh) * | 2015-12-21 | 2018-09-28 | 江南大学 | 一种可还原降解超支化聚合物纳米胶束及其制备方法 |
US10792477B2 (en) | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
CN110201242A (zh) | 2016-02-08 | 2019-09-06 | 祥丰医疗私人有限公司 | 一种医疗装置 |
CN105778021B (zh) | 2016-04-05 | 2018-07-10 | 华南理工大学 | β-环糊精基星形聚合物和制备方法及其单分子胶束诊疗一体化系统 |
EP3512560A4 (de) * | 2016-09-13 | 2020-05-27 | Rasna Research Inc. | Dactinomycinzusammensetzungen und verfahren zur behandlung von myelodysplastischem syndrom und akuter myeloischer leukämie |
US20180085498A1 (en) | 2016-09-23 | 2018-03-29 | Micell Technologies, Inc. | Prolonged drug-eluting products |
US11027040B2 (en) | 2016-12-29 | 2021-06-08 | Industrial Technology Research Institute | Method for manufacturing a porous film, porous film and method for tissue adhesion |
MX2019008449A (es) | 2017-02-08 | 2019-09-09 | Bristol Myers Squibb Co | Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos. |
SG11201912071QA (en) | 2017-06-22 | 2020-01-30 | Catalyst Biosciences Inc | Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use |
US10457759B2 (en) | 2017-07-20 | 2019-10-29 | International Business Machines Corporation | Co-delivery of cholesterol lowering drugs and nutraceuticals |
US11299587B2 (en) | 2017-12-27 | 2022-04-12 | Sanyo Chemical Industries, Ltd. | Starting material, for bulk drug or additives for drug, and bulk drug or drug using same |
CN108707212B (zh) * | 2018-05-02 | 2020-01-07 | 上海交通大学 | 一种水溶性共轭聚合物纳米粒子的可控制备方法 |
US20190351031A1 (en) | 2018-05-16 | 2019-11-21 | Halozyme, Inc. | Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20 |
SG11202102427XA (en) | 2018-09-11 | 2021-04-29 | Ambrx Inc | Interleukin-2 polypeptide conjugates and their uses |
EP3867265A1 (de) | 2018-10-19 | 2021-08-25 | Ambrx, Inc. | Interleukin-10 -polypeptid-konjugate, dimere davon und ihre verwendungen |
CN109608633A (zh) * | 2018-11-09 | 2019-04-12 | 北京诺康达医药科技股份有限公司 | 一种新型的特异性多臂聚乙二醇衍生物及其制备方法 |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
CA3176021A1 (en) | 2018-12-28 | 2020-07-02 | Catalyst Biosciences, Inc. | Modified urokinase-type plasminogen activator polypeptides and methods of use |
EP3680273B1 (de) * | 2019-01-08 | 2022-03-09 | Université de Montpellier | Mit photoreaktiven gruppen funktionalisierter verzweigter blockcopolymer-photovernetzer und dessen verwendung zur formgebung von degradierbaren, für medizinische und gewebetechnische anwendungen geeigneten photovernetzten elastomeren |
JP2022520792A (ja) | 2019-02-12 | 2022-04-01 | アンブルックス,インコーポレイテッド | 抗体-tlrアゴニストコンジュゲートを含有する組成物、その方法、及び使用 |
CN109929083B (zh) * | 2019-04-10 | 2020-04-28 | 浙江大学 | 一种窄分子量分布的多嵌段共聚物及其制备方法 |
CN110078901A (zh) * | 2019-05-24 | 2019-08-02 | 上海典范医疗科技有限公司 | 一种外消旋聚乳酸制备方法 |
EP3862032A1 (de) | 2020-02-07 | 2021-08-11 | Micell Technologies, Inc. | Stents mit biologisch abbaubaren schichten |
IL296099A (en) | 2020-03-11 | 2022-11-01 | Ambrx Inc | Interleukin-2 polypeptide conjugates and methods of using them |
CN111759552A (zh) | 2020-07-06 | 2020-10-13 | 苏州莱诺医疗器械有限公司 | 一种可吸收支架系统 |
WO2022040596A1 (en) | 2020-08-20 | 2022-02-24 | Ambrx, Inc. | Antibody-tlr agonist conjugates, methods and uses thereof |
IL307282A (en) | 2021-04-03 | 2023-11-01 | Ambrx Inc | Antidote conjugates against HER2 and their applications |
CN113416302B (zh) * | 2021-07-08 | 2022-06-17 | 中国科学院兰州化学物理研究所 | 一种硫醇-丙烯酸酯生物材料及其制备方法和应用 |
CN114713206B (zh) * | 2022-03-15 | 2023-11-14 | 沈阳工业大学 | 咪唑离子液体功能化星型嵌段聚合物固定相的制备及应用 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US673034A (en) * | 1900-08-07 | 1901-04-30 | Russel B Sigafoos | Trussed ladder. |
US3101374A (en) | 1958-08-19 | 1963-08-20 | Wyandotte Chemicals Corp | Polyoxyalkylene surface active agents having heteric polyoxyethylene solubilizing chains |
US4278555A (en) * | 1978-11-15 | 1981-07-14 | Ethyl Corporation | Lubricant composition |
ZA801659B (en) | 1979-03-21 | 1981-10-28 | N Graham | Controlled release compositions |
JPS59155432A (ja) | 1983-02-22 | 1984-09-04 | Rikagaku Kenkyusho | 易動性の大きな分子鎖を有する表面改質ポリマ− |
US5135751A (en) | 1988-11-16 | 1992-08-04 | Mediventures Incorporated | Composition for reducing postsurgical adhesions |
US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
US5681576A (en) | 1988-11-16 | 1997-10-28 | Mdv Technologies, Inc. | Method and composition for post surgical adhesion reduction |
US5306501A (en) | 1990-05-01 | 1994-04-26 | Mediventures, Inc. | Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers |
DE4017688A1 (de) | 1990-06-01 | 1991-12-05 | Bayer Ag | Verbesserte funktionelle fluessigkeiten und neue polyoxyalkylenpolymere |
WO1992000748A1 (en) | 1990-07-06 | 1992-01-23 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
CA2087125A1 (en) * | 1992-01-23 | 1993-07-24 | Mridula Nair | Chemically fixed micelles |
US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5965566A (en) | 1993-10-20 | 1999-10-12 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5618528A (en) | 1994-02-28 | 1997-04-08 | Sterling Winthrop Inc. | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
EP0876165B1 (de) | 1995-12-18 | 2006-06-21 | Angiotech BioMaterials Corp. | Vernetzten polymerisatmassen und verfahren für ihre verwendung |
US5610241A (en) | 1996-05-07 | 1997-03-11 | Cornell Research Foundation, Inc. | Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
US6258351B1 (en) | 1996-11-06 | 2001-07-10 | Shearwater Corporation | Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels |
US6011042A (en) | 1997-10-10 | 2000-01-04 | Enzon, Inc. | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds |
AU740342B2 (en) | 1997-12-12 | 2001-11-01 | Samyang Corporation | Biodegradable mixed polymeric micelles for gene delivery |
ATE255422T1 (de) | 1998-01-07 | 2003-12-15 | Debio Rech Pharma Sa | Abbaubare, heterobifunktionelle polyethylenglykolacrylate, sowie damit herstellbare gele und konjugate |
EP1061954B1 (de) | 1998-03-12 | 2004-06-09 | Nektar Therapeutics Al, Corporation | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
US20030059465A1 (en) * | 1998-05-11 | 2003-03-27 | Unger Evan C. | Stabilized nanoparticle formulations of camptotheca derivatives |
US6328988B1 (en) | 1999-04-23 | 2001-12-11 | Rutgers, The State University Of New Jersey | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules |
US6348558B1 (en) | 1999-12-10 | 2002-02-19 | Shearwater Corporation | Hydrolytically degradable polymers and hydrogels made therefrom |
US20020041898A1 (en) * | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
JP2003520210A (ja) | 2000-01-05 | 2003-07-02 | イマレックス セラピューティクス, インコーポレイテッド | 低い水溶性を有する薬物の送達のための薬学的処方物 |
US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
FI109162B (fi) * | 2000-06-30 | 2002-05-31 | Nokia Corp | Menetelmä ja järjestely konvoluutiokoodatun koodisanan dekoodaamiseksi |
TWI246524B (en) * | 2001-01-19 | 2006-01-01 | Shearwater Corp | Multi-arm block copolymers as drug delivery vehicles |
US7265186B2 (en) | 2001-01-19 | 2007-09-04 | Nektar Therapeutics Al, Corporation | Multi-arm block copolymers as drug delivery vehicles |
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2002
- 2002-01-18 TW TW091100825A patent/TWI246524B/zh not_active IP Right Cessation
- 2002-01-22 JP JP2003507177A patent/JP4078300B2/ja not_active Expired - Lifetime
- 2002-01-22 US US10/054,662 patent/US6730334B2/en not_active Expired - Lifetime
- 2002-01-22 AT AT02761075T patent/ATE313586T1/de not_active IP Right Cessation
- 2002-01-22 EP EP02761075A patent/EP1373366B1/de not_active Expired - Lifetime
- 2002-01-22 AU AU2002326369A patent/AU2002326369B2/en not_active Expired
- 2002-01-22 MX MXPA03006449A patent/MXPA03006449A/es active IP Right Grant
- 2002-01-22 WO PCT/US2002/021872 patent/WO2003000777A2/en active IP Right Grant
- 2002-01-22 ES ES02761075T patent/ES2254717T3/es not_active Expired - Lifetime
- 2002-01-22 KR KR1020037009604A patent/KR100851270B1/ko active IP Right Grant
- 2002-01-22 DE DE60208172T patent/DE60208172T2/de not_active Expired - Lifetime
- 2002-01-22 CA CA2435301A patent/CA2435301C/en not_active Expired - Lifetime
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2004
- 2004-03-08 US US10/795,913 patent/US6838528B2/en not_active Expired - Lifetime
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2007
- 2007-08-21 US US11/894,445 patent/US7589157B2/en not_active Expired - Lifetime
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- 2009-08-07 US US12/538,013 patent/US8071692B2/en not_active Expired - Fee Related
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2011
- 2011-11-02 US US13/287,852 patent/US8338545B2/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
KR20040032092A (ko) | 2004-04-14 |
AU2002326369B2 (en) | 2007-03-15 |
US20090299050A1 (en) | 2009-12-03 |
CA2435301C (en) | 2010-04-13 |
US6730334B2 (en) | 2004-05-04 |
WO2003000777A3 (en) | 2003-05-01 |
EP1373366A2 (de) | 2004-01-02 |
US20080234430A1 (en) | 2008-09-25 |
US20120046422A1 (en) | 2012-02-23 |
WO2003000777A2 (en) | 2003-01-03 |
ES2254717T3 (es) | 2006-06-16 |
US20040170595A1 (en) | 2004-09-02 |
US20130144014A1 (en) | 2013-06-06 |
ATE313586T1 (de) | 2006-01-15 |
DE60208172T2 (de) | 2006-07-13 |
US6838528B2 (en) | 2005-01-04 |
US20020156047A1 (en) | 2002-10-24 |
US8071692B2 (en) | 2011-12-06 |
JP2004531627A (ja) | 2004-10-14 |
EP1373366B1 (de) | 2005-12-21 |
JP4078300B2 (ja) | 2008-04-23 |
KR100851270B1 (ko) | 2008-08-08 |
MXPA03006449A (es) | 2004-10-15 |
US8586681B2 (en) | 2013-11-19 |
CA2435301A1 (en) | 2003-01-03 |
US7589157B2 (en) | 2009-09-15 |
TWI246524B (en) | 2006-01-01 |
US8338545B2 (en) | 2012-12-25 |
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Owner name: NEKTAR THERAPEUTICS (N.D.GES.D. STAATES DELAWA, US |