DE60212651D1 - Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz - Google Patents

Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz

Info

Publication number
DE60212651D1
DE60212651D1 DE60212651T DE60212651T DE60212651D1 DE 60212651 D1 DE60212651 D1 DE 60212651D1 DE 60212651 T DE60212651 T DE 60212651T DE 60212651 T DE60212651 T DE 60212651T DE 60212651 D1 DE60212651 D1 DE 60212651D1
Authority
DE
Germany
Prior art keywords
aliphatic
composition
ester
mixture
prostagland
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60212651T
Other languages
English (en)
Inventor
L Yeager
Nadir Bueyuektimkin
Servet Bueyuektimkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexmed Holdings Inc
Original Assignee
Nexmed Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc filed Critical Nexmed Holdings Inc
Application granted granted Critical
Publication of DE60212651D1 publication Critical patent/DE60212651D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
DE60212651T 2001-09-06 2002-09-06 Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz Expired - Lifetime DE60212651D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/947,617 US6693135B2 (en) 2000-01-10 2001-09-06 Prostaglandin compositions and methods of treatment for male erectile dysfunction
PCT/US2002/028507 WO2003022310A1 (en) 2001-09-06 2002-09-06 Prostaglandin compositions and methods of treatment for male erectile dysfunction

Publications (1)

Publication Number Publication Date
DE60212651D1 true DE60212651D1 (de) 2006-08-03

Family

ID=25486427

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60212651T Expired - Lifetime DE60212651D1 (de) 2001-09-06 2002-09-06 Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz

Country Status (19)

Country Link
US (1) US6693135B2 (de)
EP (1) EP1423147B1 (de)
JP (1) JP4544859B2 (de)
KR (1) KR20040033024A (de)
CN (1) CN1551784A (de)
AT (1) ATE330635T1 (de)
AU (1) AU2002323650B2 (de)
BR (1) BR0212352A (de)
CA (1) CA2457895A1 (de)
DE (1) DE60212651D1 (de)
EA (1) EA009384B1 (de)
GE (1) GEP20063982B (de)
HU (1) HU229602B1 (de)
IL (1) IL160404A0 (de)
MX (1) MXPA04002133A (de)
NZ (1) NZ531806A (de)
UA (1) UA79759C2 (de)
WO (1) WO2003022310A1 (de)
ZA (1) ZA200401437B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA008720B1 (ru) * 1998-12-10 2007-06-29 Нексмед (Холдингс), Инк. Применение композиции на основе простагландина для лечения расстройства сексуального возбуждения у женщин
US20050004226A1 (en) * 1998-12-10 2005-01-06 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6825234B2 (en) 1998-12-10 2004-11-30 Nexmed (Holdings) , Inc. Compositions and methods for amelioration of human female sexual dysfunction
US7105571B2 (en) * 2000-01-10 2006-09-12 Nexmed Holdings, Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
CN1761461B (zh) 2003-03-21 2010-05-05 奈克斯麦德控股有限公司 前列腺素组合物在制备治疗早泄的药物中的应用
EP1605913A2 (de) * 2003-03-21 2005-12-21 Nexmed (Holdings), Inc. Förderung der angiogenese durch prostaglandin-zusammensetzungen und verfahren
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US20060127483A1 (en) * 2004-12-10 2006-06-15 Alan Drizen Topical drug delivery system
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
ES2466346T3 (es) 2006-10-02 2014-06-10 Techfields Biochem Co. Ltd Profármacos de prostaglandinas solubles en agua con carga positiva y compuestos relacionados con índices de penetración en la piel muy altos
US7560489B2 (en) * 2006-10-11 2009-07-14 Nexmed Holdings, Inc. Stabilized prostaglandin E composition
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
CN101541743A (zh) * 2006-11-08 2009-09-23 于崇曦 多肽及相关化合物的透皮给药系统
CN107652212B (zh) 2007-01-15 2019-11-15 于崇曦 维生素a酸类和类维生素a酸化合物的前药
PL2170826T3 (pl) 2007-06-04 2022-09-05 Techfields Inc Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze
CN108191846B (zh) 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
RU2767051C2 (ru) 2009-05-08 2022-03-16 Текфилдз Байокем Ко., Лтд. Пролекарственные композиции с высокой степенью проникновения на основе пептидов и родственных пептидам соединений
CA2745320A1 (en) 2011-07-06 2013-01-06 Duoject Medical Systems Inc. Reconstitution device
CN104161720A (zh) * 2014-07-07 2014-11-26 中山尼克美制药有限公司 一种治疗勃起功能障碍的外用前列腺素e1乳膏及制备方法
JP6856532B2 (ja) 2015-01-20 2021-04-07 エックスオーシー ファーマシューティカルズ インコーポレイテッドＸｏｃ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ エルゴリン化合物およびその使用
US9676776B2 (en) 2015-01-20 2017-06-13 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CA3138100A1 (en) 2019-04-17 2020-10-22 Compass Pathfinder Limited Treatment of depression and other various disorders with psilocybin
WO2022265537A1 (ru) * 2021-06-18 2022-12-22 Общество с ограниченной ответственностью "ИнертГаз Медикал" Способ лечения эректильной дисфункции

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2818855A (en) 1954-02-11 1958-01-07 Anthony P Miller Surgical device
BE790840A (fr) 1971-11-01 1973-04-30 Upjohn Co Solutions de medicaments instables et leur preparation
US4127118B1 (en) 1977-03-16 1995-12-19 Alvaro Latorre Method of effecting and enhancing an erection
US4254145A (en) 1978-08-16 1981-03-03 American Cyanamid Company Topical application of prostaglandin hypotensive agents
US4311707A (en) 1979-02-12 1982-01-19 American Cyanamid Company Process for topically producing cutaneous vasodilation for the treatment of vasospastic or ischemic conditions
US4801587A (en) 1987-03-02 1989-01-31 Gene Voss Impotence ointment
US5256652A (en) 1987-11-12 1993-10-26 Pharmedic Co. Topical compositions and methods for treatment of male impotence
US4980378A (en) 1988-06-01 1990-12-25 Odontex, Inc. Biodegradable absorption enhancers
SE463851B (sv) 1988-09-02 1991-02-04 Amsu Ltd Komposition foer behandling av erektil dysfunktion via uretra
CA2352552C (en) 1990-04-25 2008-12-02 Virgil A. Place Treatment of erectile dysfunction
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
JP3202777B2 (ja) 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
US5380760A (en) 1993-11-19 1995-01-10 Minnesota Mining And Manufacturing Company Transdermal prostaglandin composition
JPH10505611A (ja) 1995-03-14 1998-06-02 ヴィヴァス・インコーポレーテッド 勃起機能不全を予防するための方法およびキット
US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
US6046244A (en) 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
US6486207B2 (en) 1998-12-10 2002-11-26 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
US6224573B1 (en) * 1999-01-15 2001-05-01 Nexmed Holdings, Inc. Medicament dispenser
US6102849A (en) 1999-04-03 2000-08-15 Hakac; John R. Non-surgical penile prosthesis
WO2001035998A1 (en) 1999-11-12 2001-05-25 Pharmaderm Laboratories, Ltd. Compositions for transdermal and transmucosal administration of therapeutic agents
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction

Also Published As

Publication number Publication date
HUP0401816A2 (hu) 2004-12-28
KR20040033024A (ko) 2004-04-17
MXPA04002133A (es) 2004-06-29
EA009384B1 (ru) 2007-12-28
GEP20063982B (en) 2006-12-11
NZ531806A (en) 2006-05-26
EP1423147A1 (de) 2004-06-02
HUP0401816A3 (en) 2012-09-28
EA200400398A1 (ru) 2004-08-26
IL160404A0 (en) 2004-07-25
JP4544859B2 (ja) 2010-09-15
US20020045665A1 (en) 2002-04-18
ATE330635T1 (de) 2006-07-15
US6693135B2 (en) 2004-02-17
BR0212352A (pt) 2004-07-27
AU2002323650B2 (en) 2007-12-13
EP1423147B1 (de) 2006-06-21
CN1551784A (zh) 2004-12-01
JP2005504073A (ja) 2005-02-10
HU229602B1 (en) 2014-02-28
UA79759C2 (en) 2007-07-25
CA2457895A1 (en) 2003-03-20
WO2003022310A1 (en) 2003-03-20
ZA200401437B (en) 2005-05-25

Similar Documents

Publication Publication Date Title
DE60212651D1 (de) Prostaglandinenthaltende zusammensetzungen und verfahren zur behandlung vom impotenz
DE60109274D1 (de) Prostaglandinenthaltende zusammensetzungen zur behandlung von männlicher impotenz
ATE273714T1 (de) Topische zusammensetzungen zur prostaglandin e1 abgabe
MXPA05009816A (es) Composiciones y metodos para el tratamiento de la eyaculacion precoz.
ATE209856T1 (de) Zusammensetzung und verfahren zur behandlung der erektilen disfunktion des penis
DE68910520D1 (de) Verfahren zur Verminderung von Hautirritationen bei Anwendung von durchdringungsverstärkenden Arzneimittelzusammensetzungen.
ATE471159T1 (de) Zusammensetzungen und verfahren zur behandlung eines hinteren augensegments
BR0109863A (pt) Composições tópicas contendo prostaglandina e1
DE60005952T8 (de) Lösliche hla-g enthaltende zusammensetzungen zur behandlung entzündlicher hautkrankheiten
DE69925158D1 (de) Zusammensetzung zur behandlung von verbrennungen
CA2442479A1 (en) Topical compositions for prostaglandin e1 delivery
TH8733A (th) ตัวปลุกฤทธิ์โปรตีนไคเนสเป็นตัวกระตุ้นการผลิตเมลานิน

Legal Events

Date Code Title Description
8332 No legal effect for de