DE60216747D1 - Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten - Google Patents

Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten

Info

Publication number
DE60216747D1
DE60216747D1 DE60216747T DE60216747T DE60216747D1 DE 60216747 D1 DE60216747 D1 DE 60216747D1 DE 60216747 T DE60216747 T DE 60216747T DE 60216747 T DE60216747 T DE 60216747T DE 60216747 D1 DE60216747 D1 DE 60216747D1
Authority
DE
Germany
Prior art keywords
melanocortin
agonists
receptor
group
guanidine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60216747T
Other languages
English (en)
Other versions
DE60216747T2 (de
Inventor
Daniel Chu
Rustum S Boyce
David Duhl
Bryan Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Publication of DE60216747D1 publication Critical patent/DE60216747D1/de
Application granted granted Critical
Publication of DE60216747T2 publication Critical patent/DE60216747T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
DE60216747T 2001-04-09 2002-04-08 Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten Expired - Lifetime DE60216747T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28284701P 2001-04-09 2001-04-09
US282847P 2001-04-09
PCT/US2002/010965 WO2002081443A1 (en) 2001-04-09 2002-04-08 Novel guanidino compounds

Publications (2)

Publication Number Publication Date
DE60216747D1 true DE60216747D1 (de) 2007-01-25
DE60216747T2 DE60216747T2 (de) 2007-10-04

Family

ID=23083379

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60216747T Expired - Lifetime DE60216747T2 (de) 2001-04-09 2002-04-08 Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten

Country Status (10)

Country Link
US (4) US7456183B2 (de)
EP (2) EP1767525A1 (de)
JP (1) JP4172541B2 (de)
AT (1) ATE348097T1 (de)
CY (1) CY1107442T1 (de)
DE (1) DE60216747T2 (de)
DK (1) DK1385823T3 (de)
ES (1) ES2278016T3 (de)
PT (1) PT1385823E (de)
WO (1) WO2002081443A1 (de)

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US6716840B2 (en) 2004-04-06
US20040024211A1 (en) 2004-02-05
EP1385823A4 (de) 2005-02-16
US20050038027A1 (en) 2005-02-17
EP1767525A1 (de) 2007-03-28
CY1107442T1 (el) 2012-12-19
EP1385823B1 (de) 2006-12-13
US7456183B2 (en) 2008-11-25
US20040248895A1 (en) 2004-12-09
US6960582B2 (en) 2005-11-01
EP1385823A1 (de) 2004-02-04
PT1385823E (pt) 2007-01-31
WO2002081443A1 (en) 2002-10-17
ES2278016T3 (es) 2007-08-01
DE60216747T2 (de) 2007-10-04
US20020193595A1 (en) 2002-12-19
JP2004535378A (ja) 2004-11-25
JP4172541B2 (ja) 2008-10-29
DK1385823T3 (da) 2007-03-26
ATE348097T1 (de) 2007-01-15

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