DE60220408D1 - Sequenzielles arzneimittelabgabesystem - Google Patents

Sequenzielles arzneimittelabgabesystem

Info

Publication number
DE60220408D1
DE60220408D1 DE60220408T DE60220408T DE60220408D1 DE 60220408 D1 DE60220408 D1 DE 60220408D1 DE 60220408 T DE60220408 T DE 60220408T DE 60220408 T DE60220408 T DE 60220408T DE 60220408 D1 DE60220408 D1 DE 60220408D1
Authority
DE
Germany
Prior art keywords
active ingredient
sequenced
delivery system
medicament delivery
absorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60220408T
Other languages
English (en)
Other versions
DE60220408T2 (de
Inventor
S Indiran Pather
John Hontz
John M Siebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of DE60220408D1 publication Critical patent/DE60220408D1/de
Application granted granted Critical
Publication of DE60220408T2 publication Critical patent/DE60220408T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A61K9/025—Suppositories; Bougies; Bases therefor; Ovules characterised by shape or structure, e.g. hollow layered, coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
DE60220408T 2001-07-10 2002-07-10 Sequenzielles arzneimittelabgabesystem Expired - Lifetime DE60220408T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/901,983 US20030068356A1 (en) 2001-07-10 2001-07-10 Sequential drug delivery systems
US901983 2001-07-10
PCT/US2002/021796 WO2003005944A1 (en) 2001-07-10 2002-07-10 Sequential drug delivery systems

Publications (2)

Publication Number Publication Date
DE60220408D1 true DE60220408D1 (de) 2007-07-12
DE60220408T2 DE60220408T2 (de) 2008-01-31

Family

ID=25415151

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60220408T Expired - Lifetime DE60220408T2 (de) 2001-07-10 2002-07-10 Sequenzielles arzneimittelabgabesystem

Country Status (11)

Country Link
US (3) US20030068356A1 (de)
EP (2) EP1818029B1 (de)
JP (1) JP4617081B2 (de)
AT (1) ATE363261T1 (de)
AU (2) AU2002320385B2 (de)
CA (1) CA2451106C (de)
DE (1) DE60220408T2 (de)
DK (1) DK1406568T3 (de)
ES (2) ES2286263T3 (de)
HK (1) HK1106126A1 (de)
WO (1) WO2003005944A1 (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
EP1449525A1 (de) * 2003-02-20 2004-08-25 Cross Chem Llc Kaugummi in der Form von Mehrschichttabletten
UA81335C2 (uk) * 2003-07-11 2007-12-25 Ф.Хоффманн-Ля Рош Аг Оральна дозована форма саквінавіру мезилату
BRPI0412523A (pt) * 2003-07-11 2006-09-19 Hoffmann La Roche forma de dosagem oral de mesilato de saquinavir
DE602004031462D1 (de) 2003-12-31 2011-03-31 Cima Labs Inc Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung
US7858121B2 (en) 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
MXPA06007453A (es) * 2003-12-31 2007-01-31 Cima Labs Inc Forma de dosificacion de opiaceo oral efervescente.
KR20140104986A (ko) * 2004-02-17 2014-08-29 트랜스셉트 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
US7615028B2 (en) 2004-12-03 2009-11-10 Chf Solutions Inc. Extracorporeal blood treatment and system having reversible blood pumps
GB0509317D0 (en) * 2005-05-06 2005-06-15 Clarke Anthony Pharmaceutical formulation of apomorphine
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070123562A1 (en) * 2005-05-25 2007-05-31 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the-night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US9066847B2 (en) 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8252328B2 (en) 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
EP1980240A1 (de) * 2007-04-11 2008-10-15 Cephalon France Lyophilisierte pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung und Verwendung
WO2009081411A2 (en) * 2007-12-26 2009-07-02 Rainbow Medical Nitric oxide generation to treat female sexual dysfunction
US20090198271A1 (en) * 2008-01-31 2009-08-06 Rainbow Medical Ltd. Electrode based filter
EA201100313A1 (ru) * 2008-09-09 2011-10-31 Астразенека Аб Способ доставки фармацевтической композиции пациенту, нуждающемуся в этом
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
MX2011010621A (es) * 2009-04-09 2012-01-30 Alkermes Pharma Ireland Ltd Composiciones de clozapina de liberacion controlada.
EA025054B1 (ru) 2009-06-12 2016-11-30 Сайнэпсус Терапьютикс, Инк. Единичная дозированная форма для сублингвального введения, включающая частицы апоморфина, для лечения болезни паркинсона или половой дисфункции
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011025673A1 (en) * 2009-08-26 2011-03-03 Aptapharma, Inc. Multilayer minitablets
US20110202108A1 (en) * 2010-02-18 2011-08-18 Rainbow Medical Ltd. Electrical menorrhagia treatment
US8529914B2 (en) * 2010-06-28 2013-09-10 Richard C. Fuisz Bioactive dose having containing a material for modulating pH of a bodily fluid to help or hinder absorption of a bioactive
PL2651357T3 (pl) 2010-12-16 2020-08-24 Sunovion Pharmaceuticals Inc. Filmy podjęzykowe
CN105963685B (zh) 2010-12-16 2021-01-15 诺和诺德股份有限公司 包含glp-1激动剂和n-(8-(2-羟基苯甲酰)氨基)辛酸盐的固体组合物
CA2832811A1 (en) 2011-04-12 2012-10-18 Novo Nordisk A/S Double-acylated glp-1 derivatives
EP3939569A1 (de) 2011-09-19 2022-01-19 Orexo AB Neue missbrauchssichere pharmazeutische zusammensetzung zur behandlung von opiatsucht
WO2013101897A2 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
DK2827845T3 (en) 2012-03-22 2019-04-01 Novo Nordisk As COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF
WO2013139694A1 (en) 2012-03-22 2013-09-26 Novo Nordisk A/S Compositions of glp-1 peptides and preparation thereof
EP2827845B1 (de) 2012-03-22 2018-12-26 Novo Nordisk A/S Zusammensetzungen mit zuführungsmittel und ihre herstellung
US10588857B2 (en) 2012-03-29 2020-03-17 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
LT2849730T (lt) 2012-05-02 2016-12-27 Orexo Ab Nauja alfentanilo kompozicija, skirta ūmaus skausmo gydymui
JP6517690B2 (ja) 2012-06-20 2019-05-22 ノヴォ ノルディスク アー／エス ペプチド及び送達剤を含む錠剤製剤
CN110075130A (zh) 2013-03-14 2019-08-02 塞拉拜姆有限责任公司 益生生物和/或治疗剂的靶向胃肠道递送
WO2016106329A1 (en) 2014-12-23 2016-06-30 Acelrx Pharmaceuticals, Inc. Systems, devices and methods for dispensing oral transmucosal dosage forms
CA3127926A1 (en) 2015-04-21 2016-10-27 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
CA3087928A1 (en) 2018-02-02 2019-08-08 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131123A (en) * 1959-03-13 1964-04-28 Lab Francais De Therapeutique Enteric tablets and manufacture thereof
US4443428A (en) * 1982-06-21 1984-04-17 Euroceltique, S.A. Extended action controlled release compositions
US4452808A (en) * 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4756710A (en) 1985-04-05 1988-07-12 Merck & Co., Inc. pH-Mediated drug delivery system
US4764375A (en) 1985-09-11 1988-08-16 Kv Pharmaceutical Company Sachet drug delivery system
GB8820327D0 (en) * 1988-08-26 1988-09-28 May & Baker Ltd New compositions of matter
DE3838431A1 (de) * 1988-11-12 1990-05-17 Bayer Ag Ibuprofen-brausezubereitungen
US5178878A (en) * 1989-10-02 1993-01-12 Cima Labs, Inc. Effervescent dosage form with microparticles
EP0737473A1 (de) * 1989-10-02 1996-10-16 Cima Labs, Inc. Brausedosisform
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5102666A (en) * 1990-09-11 1992-04-07 Oramed, Inc. Calcium polycarbophil controlled release composition and method
TW212139B (de) * 1991-04-15 1993-09-01 Yamanouchi Pharma Co Ltd
US5503846A (en) * 1993-03-17 1996-04-02 Cima Labs, Inc. Base coated acid particles and effervescent formulation incorporating same
IT1270831B (it) 1993-09-17 1997-05-13 Romano Deghenghi Composizioni farmaceutiche orali effervescenti contenenti estrone
KR100195873B1 (ko) * 1994-03-07 1999-06-15 챨스 디 에버트 약물을 포함하는 접착성 복합 경피수송 장치
WO1995025504A1 (en) * 1994-03-18 1995-09-28 Pharmavene, Inc. Emulsified drug delivery systems
JP3170139B2 (ja) 1994-04-08 2001-05-28 エスエス製薬株式会社 発泡性錠剤
CA2187023A1 (en) * 1994-04-13 1995-10-26 Steven Andrew Giannos Temporally controlled drug delivery systems
NZ288185A (en) 1994-06-15 1998-02-26 Dumex Alpharma As Particulate pharmaceutical formulation containing coated cores comprising at least 80% of an inert carrier having a friability of <20%; the inert carrier can be calcium carbonate
GB9417524D0 (en) * 1994-08-31 1994-10-19 Cortecs Ltd Pharmaceutical compositions
CA2160423A1 (en) * 1994-11-02 1996-05-03 Hemant N. Joshi Salts of nefazodone having improved dissolution rates
FR2732217B1 (fr) * 1995-03-29 1997-06-06 Hesnard Xavier Forme d'administration solide a usage oral
GB9510830D0 (en) * 1995-05-27 1995-07-19 Zeneca Ltd Proteins
US5607697A (en) * 1995-06-07 1997-03-04 Cima Labs, Incorporated Taste masking microparticles for oral dosage forms
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
CN1207675A (zh) 1995-11-06 1999-02-10 萨默塞特药品有限公司 丙炔苯丙胺的经颊和舌下给药法
EP1062952B1 (de) 1998-03-11 2003-08-06 Grelan Pharmaceutical Co., Ltd. Darmlösliche sprudelnde zusammensetzungen
US6200604B1 (en) * 1998-03-27 2001-03-13 Cima Labs Inc. Sublingual buccal effervescent
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6350470B1 (en) * 1998-04-29 2002-02-26 Cima Labs Inc. Effervescent drug delivery system for oral administration
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
DE19814257A1 (de) 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
US6312728B1 (en) * 1998-07-07 2001-11-06 Cascade Development, Inc. Sustained release pharmaceutical preparation
WO2000009093A1 (en) 1998-08-13 2000-02-24 Cima Labs Inc. Microemulsions as solid dosage forms for oral administration
AU2367900A (en) * 1998-12-18 2000-07-03 Bayer Corporation Chewable drug delivery system
US6210699B1 (en) 1999-04-01 2001-04-03 Watson Pharmaceuticals, Inc. Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity
US6326384B1 (en) * 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
US7858121B2 (en) * 2003-12-31 2010-12-28 Cima Labs, Inc. Effervescent oral fentanyl dosage form and methods of administering fentanyl
MXPA06007453A (es) * 2003-12-31 2007-01-31 Cima Labs Inc Forma de dosificacion de opiaceo oral efervescente.
DE602004031462D1 (de) * 2003-12-31 2011-03-31 Cima Labs Inc Allgemein lineare brauseform von fentanyl zur oralen anwendung und verfahren zur verabreichung
US20070036853A1 (en) * 2003-12-31 2007-02-15 Cima Labs Inc. Generally linear effervescent oral fentanyl dosage form and methods of administering

Also Published As

Publication number Publication date
DK1406568T3 (da) 2007-10-01
AU2002320385B2 (en) 2008-05-01
JP4617081B2 (ja) 2011-01-19
EP1406568A4 (de) 2004-12-15
EP1818029A2 (de) 2007-08-15
EP1406568B1 (de) 2007-05-30
EP1406568A1 (de) 2004-04-14
AU2008203464A1 (en) 2008-08-21
EP1818029B1 (de) 2016-09-07
US20050031677A1 (en) 2005-02-10
AU2008203464B2 (en) 2010-07-01
CA2451106C (en) 2009-12-22
US20030232080A1 (en) 2003-12-18
CA2451106A1 (en) 2003-01-23
JP2004534839A (ja) 2004-11-18
ES2604780T3 (es) 2017-03-09
US7670617B2 (en) 2010-03-02
EP1818029A3 (de) 2008-06-11
ES2286263T3 (es) 2007-12-01
WO2003005944A1 (en) 2003-01-23
ATE363261T1 (de) 2007-06-15
US20030068356A1 (en) 2003-04-10
DE60220408T2 (de) 2008-01-31
HK1106126A1 (zh) 2008-03-07

Similar Documents

Publication Publication Date Title
DE60220408D1 (de) Sequenzielles arzneimittelabgabesystem
DE60027921D1 (de) Vorrichtung zur gleichzeitigen verabreichung von gasen und medikamenten
ATE450252T1 (de) Arzneimittel-mikroteilchen
IS6557A (is) Blandaðar sjúkdómsmeðferðir úr blóðþrýstingslækkandi efnum og efnum sem hamla æðamyndun
ATE468845T2 (de) Bukkale transmukosale arzneidarreichung unter verwendung einer festen lösung
NO20062504L (no) Sammensetninger og doseringsformer for forbedret absorpsjon
HUP9902076A2 (hu) Szexuális rendellenességek kezelésére alkalmas intranazális készítmény
ATE387430T1 (de) Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
ATE309798T1 (de) Pharmazeutische zusammensetzungen enthaltend cannabidiol-derivate
CY1109861T1 (el) Διαδερμικο θεραπευτικο συστημα για την ασθενεια του παρκινσον που προκαλει υψηλα επιπεδα πλασματος της ροτιγοτινης
DE69919713D1 (de) Pharmazeutische zubereitung mit verzögerter wirkstofffreisetzung von phenytoin natrium
SE0102276D0 (sv) Device and method for the administration of a medicament
WO2002013801A3 (en) Method of treating the syndrome of coronary heart disease risk factors in humans
HUP0002490A2 (hu) Csersav-polimer kompozíciók gyógyászati anyagok szabályozott leadására, különösen a szájüregben
EA200600817A1 (ru) Антагонисты в1 рецептора брадикинина (варианты), фармацевтическая композиция, лекарственное средство, способ лечения заболеваний (варианты)
NO20023464D0 (no) Sammensetning for intestinal avlevering
BR9812553A (pt) Formulação medicamentosa com liberação de substância ativa controlada
BRPI0406858A (pt) Liberação controlada de agentes altamente solúveis
DK1343472T3 (da) Thixotropisk næsespray
ATE374600T1 (de) Pharmazeutische formulierung enthaltend olanzapin
ATE395064T1 (de) Kombinationspräparate von 3-n- formylhydroxylaminopropylphosphonsäurederivaten oder 3-n- acetylhydroxylaminopropylphosphonsäurederivaten mit speziellen pharmazeutischen wirkstoffen
ATE340576T1 (de) Wirkstoff-kombination zur medikamentösen therapie der nikotinabhängigkeit
BR0317292A (pt) Derivados de amida de ácido antranìlico e seu uso farmacêutico
WO2002072016A3 (en) Method of preventing adhesions with ifn-¿y?
ATE462411T1 (de) Darreichungssysteme von wirkstoffen und methoden zum schutz und zur verabreichung von wirkstoffen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition