DE60235646D1 - Reiterative oligonukleotidsynthese nutzende molekulare nachweissysteme - Google Patents

Reiterative oligonukleotidsynthese nutzende molekulare nachweissysteme

Info

Publication number
DE60235646D1
DE60235646D1 DE60235646T DE60235646T DE60235646D1 DE 60235646 D1 DE60235646 D1 DE 60235646D1 DE 60235646 T DE60235646 T DE 60235646T DE 60235646 T DE60235646 T DE 60235646T DE 60235646 D1 DE60235646 D1 DE 60235646D1
Authority
DE
Germany
Prior art keywords
oligonucleotide
detecting
molecular
oligonucleotide synthesis
refrigeration systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235646T
Other languages
English (en)
Inventor
Michelle M Hanna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribomed Biotechnologies Inc
Original Assignee
Ribomed Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribomed Biotechnologies Inc filed Critical Ribomed Biotechnologies Inc
Application granted granted Critical
Publication of DE60235646D1 publication Critical patent/DE60235646D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
DE60235646T 2001-10-30 2002-10-29 Reiterative oligonukleotidsynthese nutzende molekulare nachweissysteme Expired - Lifetime DE60235646D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/984,664 US7045319B2 (en) 2001-10-30 2001-10-30 Molecular detection systems utilizing reiterative oligonucleotide synthesis
PCT/US2002/034419 WO2003038042A2 (en) 2001-10-30 2002-10-29 Molecular detection systems utilizing reiterative oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
DE60235646D1 true DE60235646D1 (de) 2010-04-22

Family

ID=25530752

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235646T Expired - Lifetime DE60235646D1 (de) 2001-10-30 2002-10-29 Reiterative oligonukleotidsynthese nutzende molekulare nachweissysteme

Country Status (8)

Country Link
US (7) US7045319B2 (de)
EP (1) EP1451366B1 (de)
JP (1) JP2006507792A (de)
AT (1) ATE460499T1 (de)
AU (1) AU2002360306A1 (de)
CA (1) CA2465158C (de)
DE (1) DE60235646D1 (de)
WO (1) WO2003038042A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US7045319B2 (en) * 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
ES2253461T3 (es) * 2002-03-05 2006-06-01 Epigenomics Ag Procedimiento y dispositivo para la determinacion de la especificidad del tejido y del adn que flota libre en tejidos corporales.
AU2003903430A0 (en) * 2003-07-04 2003-07-17 Johnson & Johnson Research Pty Limited Method for detection of alkylated cytosine in dna
JP5590757B2 (ja) * 2003-09-17 2014-09-17 キヤノン株式会社 安定なハイブリッド体
US7964344B2 (en) 2003-09-17 2011-06-21 Canon Kabushiki Kaisha Stable hybrid
AU2004286265A1 (en) * 2003-10-29 2005-05-12 Ribomed Biotechnologies, Inc. Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
WO2006036943A2 (en) 2004-09-27 2006-04-06 The University Of North Carolina At Chapel Hill Determination of molecular age by detection of ink4a/arf expression
US20070111216A1 (en) * 2004-09-27 2007-05-17 Epicentre Technologies Methods for identifying polymerase inhibitors
JP2006094814A (ja) * 2004-09-30 2006-04-13 Nissan Motor Co Ltd 情報化核酸及びこれを用いた情報化核酸組成物
JP2006094807A (ja) * 2004-09-30 2006-04-13 Nissan Motor Co Ltd 情報化核酸担持微粒子及びその製造方法
JP2006169332A (ja) * 2004-12-15 2006-06-29 Nissan Motor Co Ltd 着色上塗り塗料組成物及び着色上塗り塗膜
JP4674794B2 (ja) * 2004-12-15 2011-04-20 日産自動車株式会社 クリヤー塗料組成物及びクリヤー塗膜
US9505846B2 (en) 2005-01-28 2016-11-29 Life Technologies Corporation Multi-component inhibitors of nucleic acid polymerases
AU2006339538A1 (en) * 2005-11-08 2007-09-13 Euclid Diagnostics Llc Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer
US7772390B1 (en) 2006-07-18 2010-08-10 The Regents Of The University Of California Lipid mediated nucleic acid synthesis
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
US20080160638A1 (en) * 2006-12-27 2008-07-03 David Lederman Functionalized Microcantilever Sensor and Associated Method For Detection of Targeted Analytes
US8906354B2 (en) 2007-02-28 2014-12-09 Bruker Biospin Corporation Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes
US8017104B2 (en) * 2007-02-28 2011-09-13 Carestream Health, Inc. Large stoke shift dye used for optical imaging
US7906316B2 (en) * 2007-07-05 2011-03-15 The Johns Hopkins University Apparatus for detecting molecules
US20090137024A1 (en) * 2007-11-28 2009-05-28 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
US20090162845A1 (en) * 2007-12-20 2009-06-25 Elazar Rabbani Affinity tag nucleic acid and protein compositions, and processes for using same
WO2009140666A2 (en) 2008-05-15 2009-11-19 Ribomed Biotechnologies, Inc. METHODS AND REAGENTS FOR DETECTING CpG METHYLATION WITH A METHYL CpG BINDING PROTEIN (MBP)
EP2235177B1 (de) * 2008-06-13 2012-07-18 RiboxX GmbH Verfahren zur enzymatischen synthese chemisch modifizierter rna
US8211644B2 (en) * 2008-07-13 2012-07-03 Ribomed Biotechnologies, Inc. Molecular beacon-based methods for detection of targets using abscription
US8815778B2 (en) 2008-12-18 2014-08-26 The Texas A&M University System PH modulation method to detect ligand-receptor binding
US8394584B2 (en) 2008-12-19 2013-03-12 The Board Of Trustees Of The University Of Illinois Detecting and sorting methylated DNA using a synthetic nanopore
CN102325901A (zh) 2008-12-22 2012-01-18 赛卢拉有限公司 检测等位基因、基因组和转录物组的方法和基因型分析谱
KR20120007002A (ko) * 2009-03-15 2012-01-19 리보메드 바이오테크놀로지스, 인코퍼레이티드 압스크립션 기반 분자 검출
EP2280080A1 (de) * 2009-07-31 2011-02-02 Qiagen GmbH Verfahren zur standardisierten Quantifizierung von Nukleinsäuren unter Verwendung von Anker-Oligonukleotiden und Adapter-Oligonukleotiden
WO2011063416A2 (en) * 2009-11-23 2011-05-26 The General Hospital Corporation Microfluidic devices for the capture of biological sample components
US8748091B2 (en) * 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
CN103079598B (zh) 2010-04-02 2015-12-16 药物影像股份有限公司 罗丹明(rhodamine)染料的单一同分异构结合物
WO2011142719A1 (en) 2010-05-14 2011-11-17 Staalhandske Per Kit and method
WO2012075313A2 (en) 2010-12-01 2012-06-07 The Texas A&M University System Ph modulation methods and systems for detecting binding events
WO2012109668A1 (en) 2011-02-11 2012-08-16 The Trustees Of The University Of Pennsylvania Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same
GB201112622D0 (en) * 2011-07-22 2011-09-07 Ucl Business Plc Pathogen screening
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20140127698A1 (en) * 2012-11-02 2014-05-08 Life Technologies Corporation Reiterative oligonucleotide synthesis
US20160153973A1 (en) * 2013-07-09 2016-06-02 Lucas David Smith Device and method of rapid linker mediated label-based immunoassays
CN111373042A (zh) * 2017-10-20 2020-07-03 纽亘技术公司 用于选择性扩增核酸的寡核苷酸
EP4077344A1 (de) * 2019-12-18 2022-10-26 F. Hoffmann-La Roche AG Verfahren zur sequenzierung durch synthese unter verwendung eines fortlaufenden markierungsschemas

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2345412C2 (de) * 1973-09-08 1983-11-03 Bomag-Menck GmbH, 5407 Boppard Zweiachsige Straßenwalze
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) * 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4582788A (en) * 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
US5503979A (en) * 1984-05-25 1996-04-02 The Trustees Of Columbia University In The City Of New York Method of using replicatable hybridzable recombinant RNA probes
US4786600A (en) * 1984-05-25 1988-11-22 The Trustees Of Columbia University In The City Of New York Autocatalytic replication of recombinant RNA
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
CA1340843C (en) 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
US5246866A (en) * 1987-12-23 1993-09-21 Hitachi Software Engineering Co., Ltd. Method for transcription of a DNA sequence
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
CA2001110A1 (en) 1988-11-18 1990-05-18 Zvi G. Loewy Compositions and process for amplifying and detecting nucleic acid sequences
US5508178A (en) * 1989-01-19 1996-04-16 Rose; Samuel Nucleic acid amplification using single primer
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US5595891A (en) * 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5888819A (en) * 1991-03-05 1999-03-30 Molecular Tool, Inc. Method for determining nucleotide identity through primer extension
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
CA2135073C (en) * 1992-05-06 2002-11-19 Daniel L. Kacian Nucleic acid sequence amplification method, composition and kit
US5554669A (en) * 1992-05-27 1996-09-10 Mitsui Petrochemical Industries, Ltd. Emulsion of polymer having (meth)acrylate unit and adhesive compositions containing the emulsion
DE69310179T2 (de) * 1992-07-31 1997-07-31 Behringwerke Ag Verfahren zur einführung von definierten sequenzen am 3' ende von polynukleotiden
ZA936016B (en) * 1992-08-24 1994-03-10 Akzo Nv Method for nucleic acid amplification
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5571669A (en) * 1993-01-14 1996-11-05 The University Of Pennsylvania Transcription and nucleic acid sequence determination with short primer DNA/RNA molecules and RNA polymerase
US5597694A (en) * 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
GB2284209A (en) * 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
US5648211A (en) * 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
KR100188085B1 (ko) * 1995-06-15 1999-06-01 김광호 초고속 쌍극성 트랜지스터의 제조방법
FR2737223B1 (fr) * 1995-07-24 1997-09-12 Bio Merieux Procede d'amplification de sequences d'acide nucleique par deplacement, a l'aide d'amorces chimeres
US5912340A (en) 1995-10-04 1999-06-15 Epoch Pharmaceuticals, Inc. Selective binding complementary oligonucleotides
US6072043A (en) 1996-06-04 2000-06-06 Polyprobe, Inc. Optimally fluorescent oligonucleotides
US5914229A (en) * 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
US6008334A (en) * 1996-07-24 1999-12-28 The Board Of Regents Of The University Of Oklahoma Base-protected nucleotide analogs with protected thiol groups
US5849546A (en) * 1996-09-13 1998-12-15 Epicentre Technologies Corporation Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
US5858801A (en) * 1997-03-13 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Patterning antibodies on a surface
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6114519A (en) * 1997-10-15 2000-09-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized oligonucleotides
US6268131B1 (en) * 1997-12-15 2001-07-31 Sequenom, Inc. Mass spectrometric methods for sequencing nucleic acids
WO2001025485A2 (en) * 1999-10-06 2001-04-12 Amersham Biosciences Corp Method for detecting mutations using arrayed primer extension
ATE423221T1 (de) 2000-06-13 2009-03-15 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung
US20020168641A1 (en) * 2001-03-09 2002-11-14 Bruce Mortensen Fluorescein-cyanine 5 as a fluorescence resonance energy transfer pair
US6605529B2 (en) * 2001-05-11 2003-08-12 Agere Systems Inc. Method of creating hydrogen isotope reservoirs in a semiconductor device
US7045319B2 (en) 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
AU2004286265A1 (en) * 2003-10-29 2005-05-12 Ribomed Biotechnologies, Inc. Compositions, methods and detection technologies for reiterative oligonucleotide synthesis

Also Published As

Publication number Publication date
AU2002360306A1 (en) 2003-05-12
WO2003038042A2 (en) 2003-05-08
ATE460499T1 (de) 2010-03-15
US20040137461A1 (en) 2004-07-15
CA2465158A1 (en) 2003-05-08
US20050064414A1 (en) 2005-03-24
US20030099950A1 (en) 2003-05-29
WO2003038042A3 (en) 2004-03-25
US7226738B2 (en) 2007-06-05
EP1451366B1 (de) 2010-03-10
US20040157257A1 (en) 2004-08-12
CA2465158C (en) 2013-01-22
US7473775B2 (en) 2009-01-06
US20040234996A1 (en) 2004-11-25
US7468261B2 (en) 2008-12-23
US7541165B2 (en) 2009-06-02
US20050026150A1 (en) 2005-02-03
JP2006507792A (ja) 2006-03-09
US7470511B2 (en) 2008-12-30
US20040175724A1 (en) 2004-09-09
EP1451366A2 (de) 2004-09-01
US7045319B2 (en) 2006-05-16
EP1451366A4 (de) 2006-09-13

Similar Documents

Publication Publication Date Title
DE60235646D1 (de) Reiterative oligonukleotidsynthese nutzende molekulare nachweissysteme
WO2004096997A3 (en) Molecular detection systems utilizing reiterative oligonucleotide synthesis
Sengle et al. Novel RNA catalysts for the Michael reaction
US20180201968A1 (en) Azidomethyl Ether Deprotection Method
JP3143475B2 (ja) 二本鎖ｄｎａの核酸類似体による誘導転写
WO2006026388A3 (en) Single-primer nucleic acid amplification methods
WO2003078587A3 (en) Nucleic acid detection method
WO2001094630A3 (en) Compositions and methods for array-based nucleic acid hybridization
WO2003051901A3 (en) Pseudonucleotide comprising an intercalator
UA49843C2 (uk) Олігонуклеотид для ампліфікації послідовностей нуклеїнових кислот, спосіб ампліфікації цільової послідовності нуклеїнової кислоти, набір для здійснення реакції ампліфікації нуклеїнової кислоти
IS6705A (is) Aðferð til að ákvarða stig metýleringar afmarkaðra sýtósína í genamengi DNA í raðasamhenginu 5'-CPG-3'
WO2002048402A3 (en) Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
CN112423885B (zh) 多核苷酸合成方法、试剂盒和系统
JP2013509871A5 (de)
WO2018152323A1 (en) Compositions and methods for template-free enzymatic nucleic acid synthesis
WO2008108843A3 (en) Methods and kits for amplifying dna
WO2005042709A3 (en) Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
PT1171634E (pt) Pares de iniciadores de amplificacao e de sequenciacao e sua utilizacao
CA2917686A1 (en) Compositions and methods for bisulfite converted sequence capture
Fairbanks et al. Towards high-efficiency synthesis of Xenonucleic acids
ATE223499T1 (de) Von kreisförmiger matrize abhängige kettenreaktion
Dennis et al. RNA polymerase: a model for rotational translocation
DE60236659D1 (de) Auf NASBA basiertes Detektionsverfahren zur Detektion des Tuberkelbazillus
Wahl et al. PEG-tethered guanosine acetal conjugates for the enzymatic synthesis of modified RNA
Buck Modified RNA with a phosphate-methylated backbone. A serious omission in our (retracted) study at HIV-1 RNA loops and integrated DNA. Specific properties of the (modified) RNA and DNA dimers

Legal Events

Date Code Title Description
8364 No opposition during term of opposition