DE60239552D1 - Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser - Google Patents
Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasserInfo
- Publication number
- DE60239552D1 DE60239552D1 DE60239552T DE60239552T DE60239552D1 DE 60239552 D1 DE60239552 D1 DE 60239552D1 DE 60239552 T DE60239552 T DE 60239552T DE 60239552 T DE60239552 T DE 60239552T DE 60239552 D1 DE60239552 D1 DE 60239552D1
- Authority
- DE
- Germany
- Prior art keywords
- humans
- measurement
- protein synthesis
- experimental systems
- marked water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33502901P | 2001-10-24 | 2001-10-24 | |
| PCT/US2002/033996 WO2003061479A1 (en) | 2001-10-24 | 2002-10-23 | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60239552D1 true DE60239552D1 (de) | 2011-05-05 |
Family
ID=27613201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60239552T Expired - Lifetime DE60239552D1 (de) | 2001-10-24 | 2002-10-23 | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7001587B2 (de) |
| EP (1) | EP1437966B1 (de) |
| JP (1) | JP2005515452A (de) |
| AT (1) | ATE502578T1 (de) |
| AU (1) | AU2002365268B2 (de) |
| CA (1) | CA2464474C (de) |
| DE (1) | DE60239552D1 (de) |
| DK (1) | DK1437966T3 (de) |
| IL (1) | IL161498A0 (de) |
| WO (1) | WO2003061479A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5910403A (en) | 1997-05-15 | 1999-06-08 | The Regents Of University Of California | Methods for measuring cellular proliferation and destruction rates in vitro and in vivo |
| US7001587B2 (en) | 2001-10-24 | 2006-02-21 | The Regents Of The University Of California | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
| CA2475924C (en) * | 2002-02-12 | 2016-03-29 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
| AU2003234688A1 (en) * | 2002-04-05 | 2003-10-27 | The Regents Of The University Of California | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| WO2004011426A2 (en) * | 2002-07-30 | 2004-02-05 | The Regents Of The University Of California | Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry |
| DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Hermann Heye I Ins Fa | Pressstempelmechanismus einer Glasformmaschine |
| WO2004021863A2 (en) * | 2002-09-04 | 2004-03-18 | The Regents Of The University Of California | Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism |
| DK1546373T3 (da) | 2002-09-13 | 2009-03-30 | Univ California | Fremgangsmåder til måling af hastigheder af revers cholesteroltransport in vivo som et indeks for antiatherogenese |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| SG152923A1 (en) * | 2002-09-16 | 2009-06-29 | Univ California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| SG152922A1 (en) * | 2002-11-04 | 2009-06-29 | Univ California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7262020B2 (en) | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
| AU2005222430A1 (en) * | 2004-03-11 | 2005-09-22 | The Regents Of University Of California | Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients |
| US20050238577A1 (en) * | 2004-03-29 | 2005-10-27 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| AU2005307808B2 (en) * | 2004-11-15 | 2011-03-10 | University Of North Dakota | A method for single oxygen atom incorporation into digested peptides using peptidases |
| JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
| ES2498973T3 (es) | 2005-04-06 | 2014-09-26 | Washington University In St. Louis | Métodos para medir in vivo biomoléculas procedentes del sistema nervioso |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
| WO2009062152A1 (en) * | 2007-11-09 | 2009-05-14 | Washington University In St. Louis | Methods for measuring the metabolism of cns derived biomolecules in vivo |
| US8574543B2 (en) | 2007-12-14 | 2013-11-05 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Method of isotope labeling and determining protein synthesis, quantitation and protein expression |
| US9110008B2 (en) | 2010-07-26 | 2015-08-18 | Los Gatos Research | Method for isotopic analysis of water in bodily fluids |
| WO2013036885A1 (en) | 2011-09-08 | 2013-03-14 | The Regents Of The University Of California | Metabolic flux measurement, imaging and microscopy |
| CA2848915C (en) | 2011-09-19 | 2021-09-07 | C2N Diagnostics | Methods for the diagnosis and treatment of neurological and neurodegenerative diseases and disorders using labeled alpha syruclein |
| US20140353486A1 (en) | 2011-12-07 | 2014-12-04 | Glaxosmithkline Llc | Methods for determining total body skeletal muscle mass |
| US9149697B2 (en) | 2012-09-14 | 2015-10-06 | Wilson Sporting Goods Co. | Ball bat with optimized barrel wall spacing and improved end cap |
| JP5845236B2 (ja) * | 2012-11-29 | 2016-01-20 | 株式会社ニッピ | コラーゲンの分析方法、および安定同位体標識コラーゲンの製造方法 |
| US20150338419A1 (en) * | 2013-01-04 | 2015-11-26 | The Regents Of The University Of California | Method for the Determination of Biomolecule Turnover Rates |
| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| CN104360002B (zh) * | 2014-09-12 | 2016-08-24 | 江西师范大学 | 一种牛皮明胶的定量检测方法 |
| CA2962969C (en) | 2014-09-30 | 2023-03-21 | Washington University | Tau kinetic measurements |
| US11754478B2 (en) | 2018-08-16 | 2023-09-12 | Abb Schweiz Ag | Rapid equilibrator for water isotope analysis |
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| TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
2002
- 2002-10-23 US US10/279,399 patent/US7001587B2/en not_active Expired - Lifetime
- 2002-10-23 DK DK02806603.3T patent/DK1437966T3/da active
- 2002-10-23 EP EP02806603A patent/EP1437966B1/de not_active Expired - Lifetime
- 2002-10-23 JP JP2003561427A patent/JP2005515452A/ja active Pending
- 2002-10-23 IL IL16149802A patent/IL161498A0/xx not_active IP Right Cessation
- 2002-10-23 WO PCT/US2002/033996 patent/WO2003061479A1/en active Application Filing
- 2002-10-23 CA CA2464474A patent/CA2464474C/en not_active Expired - Lifetime
- 2002-10-23 DE DE60239552T patent/DE60239552D1/de not_active Expired - Lifetime
- 2002-10-23 AU AU2002365268A patent/AU2002365268B2/en not_active Ceased
- 2002-10-23 AT AT02806603T patent/ATE502578T1/de active
-
2004
- 2004-10-12 US US10/963,967 patent/US7307059B2/en not_active Expired - Lifetime
-
2005
- 2005-09-22 US US11/233,549 patent/US7410633B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003061479A1 (en) | 2003-07-31 |
| CA2464474A1 (en) | 2003-07-31 |
| EP1437966A4 (de) | 2006-08-23 |
| DK1437966T3 (da) | 2011-07-04 |
| US7410633B2 (en) | 2008-08-12 |
| US20050147558A1 (en) | 2005-07-07 |
| US20030133871A1 (en) | 2003-07-17 |
| CA2464474C (en) | 2011-12-20 |
| IL161498A0 (en) | 2004-09-27 |
| ATE502578T1 (de) | 2011-04-15 |
| AU2002365268B2 (en) | 2008-02-28 |
| EP1437966A1 (de) | 2004-07-21 |
| US7307059B2 (en) | 2007-12-11 |
| EP1437966B1 (de) | 2011-03-23 |
| JP2005515452A (ja) | 2005-05-26 |
| US7001587B2 (en) | 2006-02-21 |
| US20060029549A1 (en) | 2006-02-09 |
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