DE60304726D1 - Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer - Google Patents

Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Info

Publication number
DE60304726D1
DE60304726D1 DE60304726T DE60304726T DE60304726D1 DE 60304726 D1 DE60304726 D1 DE 60304726D1 DE 60304726 T DE60304726 T DE 60304726T DE 60304726 T DE60304726 T DE 60304726T DE 60304726 D1 DE60304726 D1 DE 60304726D1
Authority
DE
Germany
Prior art keywords
prodrugs
pump inhibitors
protonal
benzimidazole derivatives
bioavailability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60304726T
Other languages
English (en)
Other versions
DE60304726T2 (de
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Winston Pharmaceuticals LLC
US Department of Veterans Affairs VA
Original Assignee
University of California
Winston Pharmaceuticals LLC
US Department of Veterans Affairs VA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Winston Pharmaceuticals LLC, US Department of Veterans Affairs VA filed Critical University of California
Application granted granted Critical
Publication of DE60304726D1 publication Critical patent/DE60304726D1/de
Publication of DE60304726T2 publication Critical patent/DE60304726T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DE60304726T 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer Expired - Lifetime DE60304726T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39745902P 2002-07-19 2002-07-19
US397459P 2002-07-19
PCT/US2003/022419 WO2004009583A2 (en) 2002-07-19 2003-07-15 Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor

Publications (2)

Publication Number Publication Date
DE60304726D1 true DE60304726D1 (de) 2006-05-24
DE60304726T2 DE60304726T2 (de) 2007-08-09

Family

ID=30771064

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60304726T Expired - Lifetime DE60304726T2 (de) 2002-07-19 2003-07-15 Benzimidazolderivative und ihre verwendung als prodrugs für protonenpumpenhemmer

Country Status (23)

Country Link
US (3) US6897227B2 (de)
EP (1) EP1556371B1 (de)
JP (1) JP4463103B2 (de)
KR (2) KR100788778B1 (de)
AT (1) ATE323695T1 (de)
AU (1) AU2003259154B2 (de)
BR (1) BR0312802A (de)
CA (1) CA2492718C (de)
CO (1) CO5690576A2 (de)
DE (1) DE60304726T2 (de)
DK (1) DK1556371T3 (de)
ES (1) ES2263028T3 (de)
HK (1) HK1079207A1 (de)
IL (1) IL166371A0 (de)
MX (1) MXPA05000657A (de)
NO (1) NO20050801L (de)
NZ (1) NZ538221A (de)
PL (1) PL375255A1 (de)
PT (1) PT1556371E (de)
RU (1) RU2292342C2 (de)
TW (1) TW200502231A (de)
WO (1) WO2004009583A2 (de)
ZA (1) ZA200501116B (de)

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US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
EP1534278A4 (de) * 2002-08-01 2006-09-06 Nitromed Inc Nitrosierte protonenpumpen-hemmer, zusammensetzungen und anwendungsverfahren
EP1644352A1 (de) * 2003-07-15 2006-04-12 Allergan, Inc. Verfahren zur herstellung von isomerenreinen prodrugs von protonenpumpeninhibitoren
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
AU2005216862A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
EP1715854A2 (de) * 2004-02-18 2006-11-02 Allergan, Inc. Prodrugs für die intravenöse verabreichung von protonenpumpen-hemmern
BRPI0507796A (pt) * 2004-03-11 2007-07-17 Allergan Inc métodos e composições para o tratamento de condições relacionadas com a secreção de ácido gástrico
US7176319B2 (en) 2004-04-28 2007-02-13 Hetero Drugs Limited Process for substituted sulfoxides
WO2007073301A1 (en) * 2005-12-23 2007-06-28 Astrazeneca Ab Benzoimidazole derivatives as prodrugs of proton pump inhibitors
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation
JP2009536195A (ja) * 2006-05-09 2009-10-08 アストラゼネカ・アクチエボラーグ 最終容器中で電離放射線により滅菌されるプロトンポンプ阻害剤を含む非経口製剤
US20070293543A1 (en) * 2006-06-19 2007-12-20 Edward Lee THRESHOLD BLOOD OMEPRAZOLE CONCENTRATION IS 50 NG/ML FOR THE MAINTENANCE OF INTRAGASTRIC pH OF AT LEAST 4.0 AFTER ORAL DOSING WITH CMA-OMEPRAZOLE, AGN 201904-Z
WO2008036211A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the (1h-pyrrol-1-yl)-1h-benzimidazole moiety
WO2008036201A1 (en) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
KR20090035195A (ko) * 2007-10-05 2009-04-09 엘지전자 주식회사 플라즈마 디스플레이 장치
US20100265240A1 (en) * 2007-10-05 2010-10-21 Lg Electronics Inc. Plasma display device
KR100895333B1 (ko) * 2007-11-01 2009-05-07 엘지전자 주식회사 플라즈마 디스플레이 패널의 구동 방법 및 그를 이용한플라즈마 디스플레이 장치
WO2012051036A1 (en) 2010-10-11 2012-04-19 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
EP2661265B1 (de) 2010-12-23 2017-03-08 Merck Sharp & Dohme Corp. Chinoline und aza-chinolines als crth2-rezeptor-modulatoren
RU2589709C2 (ru) 2010-12-23 2016-07-10 Мерк Шарп Энд Домэ Корп. Хиноксалины и азахиноксалины в качестве модуляторов рецептора crth2
CA2973370A1 (en) * 2015-01-09 2016-07-14 The Regents Of The University Of California Compositions and methods for treating gastrointestinal infections
CN108997177A (zh) * 2018-09-04 2018-12-14 邵阳学院 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法

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Publication number Priority date Publication date Assignee Title
US430042A (en) * 1890-06-10 Valve
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
US4758597A (en) 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
US4965269A (en) 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5045522A (en) 1990-03-27 1991-09-03 Phillips Petroleum Company Absorption composition comprising zinc titanate for removal of hydrogen sulfide from fluid streams
ES2140391T3 (es) 1990-06-20 2000-03-01 Astra Ab Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
SE9301830D0 (sv) 1993-05-28 1993-05-28 Ab Astra New compounds
SK281465B6 (sk) * 1994-06-10 2001-04-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituované arylalkyltioalkyltiopyridínové zlúčeniny, spôsob ich výroby a ich použitie
US5708017A (en) 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
US6093734A (en) 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
BR9912937A (pt) * 1998-08-10 2001-05-08 Partnership Of Michael E Garst Pró-drogas de inibidores de bomba de prótons
CN1141305C (zh) * 1998-08-12 2004-03-10 三角药物公司 生产1,3-氧硫戊环核苷的方法
SE0002476D0 (sv) 2000-06-30 2000-06-30 Astrazeneca Ab New compounds
US6599167B2 (en) 2000-09-27 2003-07-29 Glenn Waltz Game call holder and amplifying device
WO2002030920A1 (fr) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Composes derives de benzimidazole, leur procede de production et leur utilisation

Also Published As

Publication number Publication date
US6897227B2 (en) 2005-05-24
PL375255A1 (en) 2005-11-28
KR100822981B1 (ko) 2008-04-16
ATE323695T1 (de) 2006-05-15
PT1556371E (pt) 2006-09-29
WO2004009583A3 (en) 2004-03-18
DK1556371T3 (da) 2006-08-21
ES2263028T3 (es) 2006-12-01
BR0312802A (pt) 2005-04-19
CA2492718A1 (en) 2004-01-29
TW200502231A (en) 2005-01-16
US20040102484A1 (en) 2004-05-27
NZ538221A (en) 2006-11-30
ZA200501116B (en) 2006-11-29
AU2003259154B2 (en) 2006-12-07
EP1556371B1 (de) 2006-04-19
MXPA05000657A (es) 2005-08-19
CA2492718C (en) 2010-12-21
WO2004009583A2 (en) 2004-01-29
RU2292342C2 (ru) 2007-01-27
CO5690576A2 (es) 2006-10-31
JP4463103B2 (ja) 2010-05-12
JP2005536519A (ja) 2005-12-02
AU2003259154A1 (en) 2004-02-09
EP1556371A2 (de) 2005-07-27
DE60304726T2 (de) 2007-08-09
US20050143423A1 (en) 2005-06-30
HK1079207A1 (en) 2006-03-31
IL166371A0 (en) 2006-01-16
KR100788778B1 (ko) 2007-12-27
US20050182101A1 (en) 2005-08-18
AU2003259154C1 (en) 2004-02-09
KR20070005029A (ko) 2007-01-09
KR20050047078A (ko) 2005-05-19
RU2005105564A (ru) 2005-10-10
NO20050801L (no) 2005-02-15

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