DE60311076D1 - Nanostrukturen mit pilin-protein - Google Patents

Nanostrukturen mit pilin-protein

Info

Publication number
DE60311076D1
DE60311076D1 DE60311076T DE60311076T DE60311076D1 DE 60311076 D1 DE60311076 D1 DE 60311076D1 DE 60311076 T DE60311076 T DE 60311076T DE 60311076 T DE60311076 T DE 60311076T DE 60311076 D1 DE60311076 D1 DE 60311076D1
Authority
DE
Germany
Prior art keywords
nanostructures
pilin protein
pilin
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60311076T
Other languages
English (en)
Inventor
Lee Makowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NANOFRAMES Inc
Original Assignee
NANOFRAMES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NANOFRAMES Inc filed Critical NANOFRAMES Inc
Application granted granted Critical
Publication of DE60311076D1 publication Critical patent/DE60311076D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • B82B3/0009—Forming specific nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
DE60311076T 2002-02-21 2003-02-21 Nanostrukturen mit pilin-protein Expired - Fee Related DE60311076D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/080,608 US20030198956A1 (en) 2002-02-21 2002-02-21 Staged assembly of nanostructures
PCT/US2003/005340 WO2003072804A2 (en) 2002-02-21 2003-02-21 Nanostructures containing pilin protein

Publications (1)

Publication Number Publication Date
DE60311076D1 true DE60311076D1 (de) 2007-02-22

Family

ID=27765238

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60311076T Expired - Fee Related DE60311076D1 (de) 2002-02-21 2003-02-21 Nanostrukturen mit pilin-protein

Country Status (8)

Country Link
US (2) US20030198956A1 (de)
EP (3) EP1485129B1 (de)
JP (3) JP2005518456A (de)
KR (3) KR20040102012A (de)
AU (3) AU2003217643A1 (de)
CA (3) CA2477171A1 (de)
DE (1) DE60311076D1 (de)
WO (3) WO2003072803A2 (de)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7534866B2 (en) 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
US7666400B2 (en) * 2005-04-06 2010-02-23 Ibc Pharmaceuticals, Inc. PEGylation by the dock and lock (DNL) technique
US7550143B2 (en) 2005-04-06 2009-06-23 Ibc Pharmaceuticals, Inc. Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
US7527787B2 (en) * 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
US8491896B2 (en) * 2002-06-14 2013-07-23 Immunomedics, Inc. Anti-pancreatic cancer antibodies
US7906118B2 (en) 2005-04-06 2011-03-15 Ibc Pharmaceuticals, Inc. Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology
US9599619B2 (en) 2002-06-14 2017-03-21 Immunomedics, Inc. Anti-pancreatic cancer antibodies
US8821868B2 (en) 2002-06-14 2014-09-02 Immunomedics, Inc. Anti-pancreatic cancer antibodies
WO2004053161A1 (en) * 2002-12-12 2004-06-24 Hapemo Da Method for identification and/or authentication of articles
US20100098877A1 (en) * 2003-03-07 2010-04-22 Cooper Christopher H Large scale manufacturing of nanostructured material
US7419601B2 (en) * 2003-03-07 2008-09-02 Seldon Technologies, Llc Nanomesh article and method of using the same for purifying fluids
CN1867392B (zh) 2003-03-07 2010-06-09 塞尔顿技术公司 使用纳米材料纯化流体
US9005613B2 (en) 2003-06-16 2015-04-14 Immunomedics, Inc. Anti-mucin antibodies for early detection and treatment of pancreatic cancer
US7563500B2 (en) * 2003-08-27 2009-07-21 Northeastern University Functionalized nanosubstrates and methods for three-dimensional nanoelement selection and assembly
US8562988B2 (en) * 2005-10-19 2013-10-22 Ibc Pharmaceuticals, Inc. Strategies for improved cancer vaccines
US8435539B2 (en) * 2004-02-13 2013-05-07 Immunomedics, Inc. Delivery system for cytotoxic drugs by bispecific antibody pretargeting
US8491914B2 (en) 2004-02-13 2013-07-23 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for delivery of interference RNA
US20110064754A1 (en) * 2005-03-03 2011-03-17 Center For Molecular Medicine And Immunology Immunoconjugates Comprising Poxvirus-Derived Peptides and Antibodies Against Antigen-Presenting Cells for Subunit-Based Poxvirus Vaccines
US8003111B2 (en) * 2005-04-06 2011-08-23 Ibc Pharmaceuticals, Inc. Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
US9481878B2 (en) 2004-02-13 2016-11-01 Immunomedics, Inc. Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity
US8034352B2 (en) 2005-04-06 2011-10-11 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
US8652484B2 (en) 2004-02-13 2014-02-18 Immunomedics, Inc. Delivery system for cytotoxic drugs by bispecific antibody pretargeting
US9550838B2 (en) 2004-02-13 2017-01-24 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
US8883160B2 (en) * 2004-02-13 2014-11-11 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
US8551480B2 (en) 2004-02-13 2013-10-08 Immunomedics, Inc. Compositions and methods of use of immunotoxins comprising ranpirnase (Rap) show potent cytotoxic activity
US20110020273A1 (en) * 2005-04-06 2011-01-27 Ibc Pharmaceuticals, Inc. Bispecific Immunocytokine Dock-and-Lock (DNL) Complexes and Therapeutic Use Thereof
US7862624B2 (en) * 2004-04-06 2011-01-04 Bao Tran Nano-particles on fabric or textile
US20050218398A1 (en) * 2004-04-06 2005-10-06 Availableip.Com NANO-electronics
US20050218397A1 (en) * 2004-04-06 2005-10-06 Availableip.Com NANO-electronics for programmable array IC
US7019391B2 (en) 2004-04-06 2006-03-28 Bao Tran NANO IC packaging
US7330369B2 (en) * 2004-04-06 2008-02-12 Bao Tran NANO-electronic memory array
US7671398B2 (en) 2005-02-23 2010-03-02 Tran Bao Q Nano memory, light, energy, antenna and strand-based systems and methods
US8481041B2 (en) 2005-04-06 2013-07-09 Ibc Pharmaceuticals, Inc. Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy
US9623115B2 (en) 2005-04-06 2017-04-18 Ibc Pharmaceuticals, Inc. Dock-and-Lock (DNL) Complexes for Disease Therapy
US8349332B2 (en) 2005-04-06 2013-01-08 Ibc Pharmaceuticals, Inc. Multiple signaling pathways induced by hexavalent, monospecific and bispecific antibodies for enhanced toxicity to B-cell lymphomas and other diseases
US8158129B2 (en) 2005-04-06 2012-04-17 Ibc Pharmaceuticals, Inc. Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo
US8475794B2 (en) 2005-04-06 2013-07-02 Ibc Pharmaceuticals, Inc. Combination therapy with anti-CD74 antibodies provides enhanced toxicity to malignancies, Autoimmune disease and other diseases
AU2006232310B9 (en) * 2005-04-06 2011-07-21 Ibc Pharmaceuticals, Inc. Improved stably tethered structures of defined compositions with multiple functions or binding specificities
JP5011277B2 (ja) * 2005-04-06 2012-08-29 アイビーシー・ファーマシューティカルズ・インコーポレーテッド ホモダイマー、ホモテトラマーまたはダイマーのダイマーのからなる安定に連結された複合体を発生させるための方法および使用
US8067006B2 (en) 2005-04-06 2011-11-29 Immunomedics, Inc. Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites
US9931413B2 (en) 2005-04-06 2018-04-03 Ibc Pharmaceuticals, Inc. Tetrameric cytokines with improved biological activity
US8883162B2 (en) 2005-10-19 2014-11-11 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
US20100226884A1 (en) 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
US9862770B2 (en) 2005-10-19 2018-01-09 Ibc Pharmaceuticals, Inc. Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors
AU2006302848C1 (en) * 2005-10-19 2012-08-02 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
EP2674440B1 (de) * 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
CN103242451B (zh) * 2005-12-16 2017-11-21 Ibc医药公司 基于免疫球蛋白的多价生物活性装配体
US7393699B2 (en) 2006-06-12 2008-07-01 Tran Bao Q NANO-electronics
US7869030B2 (en) * 2007-01-03 2011-01-11 Research Foundation Of State University Of New York Aggregates of plural transition metal nanoparticles and plural cyanine dye molecules
JP2010516675A (ja) * 2007-01-17 2010-05-20 イミューノメディクス、インコーポレイテッド 治療薬剤のポリマー担体および疾病部位の抗体に基づく標的化のための認識部分
US8343627B2 (en) 2007-02-20 2013-01-01 Research Foundation Of State University Of New York Core-shell nanoparticles with multiple cores and a method for fabricating them
WO2009029262A1 (en) * 2007-08-27 2009-03-05 The Regents Of The University Of California Systems and methods for producing multi-component colloidal structures
WO2009066293A1 (en) * 2007-11-20 2009-05-28 Technion Research And Development Foundation Ltd. Chemical sensors based on cubic nanoparticles capped with an organic coating
IL190475A0 (en) * 2008-03-27 2009-02-11 Technion Res & Dev Foundation Chemical sensors based on cubic nanoparticles capped with organic coating for detecting explosives
US9272029B2 (en) 2009-03-26 2016-03-01 Ibc Pharmaceuticals, Inc. Interferon lambada-antibody complexes
CA2726598C (en) * 2008-06-02 2017-05-09 Soo-Kwan Lee Controllable assembly and disassembly of nanoparticle systems via protein and dna agents
WO2011091113A2 (en) 2010-01-22 2011-07-28 Immunomedics, Inc. Detection of early-stage pancreatic adenocarcinoma
US9102520B2 (en) * 2008-08-13 2015-08-11 California Institute Of Technology Nanocomposite structures and related methods and systems
CN102186499B (zh) * 2008-08-20 2015-05-20 Ibc医药公司 用于癌症治疗的对接和锁定(dnl)疫苗
WO2010101355A2 (ko) 2009-03-06 2010-09-10 고려대학교 산학협력단 키메릭 단백질, 그 제조방법 및 그 키메릭 단백질이 고정화된 나노센서 및 그 응용
EP2488546B1 (de) * 2009-10-15 2014-12-31 Kemijski Institut Selbstanordnende strukutren aus einzelpolypeptiden mit mindestens drei coiled-coil-bildenden elementen
US20140086828A1 (en) * 2010-05-28 2014-03-27 Aaron E. Foster Modified gold nanoparticles for therapy
CA2827076A1 (en) 2011-02-15 2012-08-23 Immumomedics, Inc. Anti-mucin antibodies for early detection and treatment of pancreatic cancer
US8601611B2 (en) * 2011-10-05 2013-12-03 Drexel University Methods of preparing nanoprobes and endoscope-like devices
CN104363919A (zh) 2012-06-01 2015-02-18 Ibc药品公司 具有改进的体内稳定性、药物代谢动力学和功效的多聚体复合物
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
WO2014028560A2 (en) 2012-08-14 2014-02-20 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
US20150231241A1 (en) 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
KR101963231B1 (ko) * 2012-09-11 2019-03-28 삼성전자주식회사 이중특이 항체의 제작을 위한 단백질 복합체 및 이를 이용한 이중특이 항체 제조 방법
US9452228B2 (en) 2013-04-01 2016-09-27 Immunomedics, Inc. Antibodies reactive with an epitope located in the N-terminal region of MUC5AC comprising cysteine-rich subdomain 2 (Cys2)
WO2015065987A1 (en) 2013-11-01 2015-05-07 Ibc Pharmaceuticals, Inc. Bispecific antibodies that neutralize both tnf-alpha and il-6: novel therapeutic agent for autoimmune disease
WO2016191481A1 (en) 2015-05-28 2016-12-01 Immunomedics, Inc. T20 constructs for anti-hiv (human immunodeficiency virus) therapy and/or vaccines
US11331019B2 (en) 2017-08-07 2022-05-17 The Research Foundation For The State University Of New York Nanoparticle sensor having a nanofibrous membrane scaffold
WO2020188350A1 (en) 2019-03-18 2020-09-24 Bio-Rad Abd Serotec Gmbh Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation
US20220220156A1 (en) * 2019-03-29 2022-07-14 Carnegie Mellon University Shape-Responsive Nanostructures
CN110550919A (zh) * 2019-09-29 2019-12-10 北京工业大学 一种提高水泥基材料抗氯离子渗透能力的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5708154A (en) * 1989-02-24 1998-01-13 City Of Hope RNA-DNA hybrid molecules of nucleic acid
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
AU690528B2 (en) * 1992-12-04 1998-04-30 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
US5712366A (en) * 1993-05-25 1998-01-27 The United States Of America As Represented By The Secretary Of The Army Fabrication of nanoscale materials using self-assembling proteins
US5561043A (en) * 1994-01-31 1996-10-01 Trustees Of Boston University Self-assembling multimeric nucleic acid constructs
US5877279A (en) * 1994-10-13 1999-03-02 Nanoframes, Llc Materials for the production of nanometer structures and use thereof
WO1996030508A1 (en) * 1995-03-24 1996-10-03 Ely Michael Rabani Assembly of complex molecular and supramolecular objects and devices and uses thereof
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules
US5948897A (en) * 1996-06-14 1999-09-07 Simon Fraser University Method of binding two or more DNA double helices and products formed
AU728480B2 (en) * 1996-08-07 2001-01-11 Hospital For Sick Children, The Self-aligning peptides derived from elastin and other fibrous proteins
EP1080229A4 (de) * 1998-05-20 2005-07-13 Nano-Technologies L Integrated Chemisch zusammengesetzte vorrichtung im nano-masstab
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
DE19917841A1 (de) * 1999-04-13 2000-10-26 Frank Bier Nanostrukturierung an Oberflächen mittels heterogener Polymere
US6756039B1 (en) * 1999-05-10 2004-06-29 The Regents Of The University Of California Self assembling proteins
CA2419156A1 (en) * 2000-07-13 2002-01-24 The Ohio State University Research Foundation Multimeric biopolymers as structural elements, sensors and actuators in microsystems
US6706479B2 (en) * 2000-10-05 2004-03-16 Virginia Tech Intellectual Properties, Inc. Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips
EP1215199A1 (de) * 2000-12-08 2002-06-19 Sony International (Europe) GmbH Linker-moleküle für selektiven Metallisation von Nukleinsäuren und ihre Verwendung
WO2002059156A2 (en) * 2000-12-22 2002-08-01 Medimmune, Inc. Therapeutic compounds structurally-linked to bacterial polypeptides

Also Published As

Publication number Publication date
EP1483408A4 (de) 2005-06-22
US20030198956A1 (en) 2003-10-23
EP1485128A2 (de) 2004-12-15
JP2005518454A (ja) 2005-06-23
AU2003217644A1 (en) 2003-09-09
AU2003215377A1 (en) 2003-09-09
EP1485128A4 (de) 2006-08-30
KR20040102012A (ko) 2004-12-03
KR20040094721A (ko) 2004-11-10
WO2003072803A2 (en) 2003-09-04
WO2003072803A3 (en) 2004-02-19
JP2005518456A (ja) 2005-06-23
CA2477171A1 (en) 2003-09-04
CA2477270A1 (en) 2003-09-04
CA2477271A1 (en) 2003-09-04
EP1485129B1 (de) 2007-01-10
WO2003072804A3 (en) 2004-03-25
JP2005518455A (ja) 2005-06-23
WO2003072804A2 (en) 2003-09-04
KR20040102011A (ko) 2004-12-03
US20030215903A1 (en) 2003-11-20
AU2003217643A1 (en) 2003-09-09
EP1483408A1 (de) 2004-12-08
EP1485129A4 (de) 2005-06-15
WO2003072829A1 (en) 2003-09-04
EP1485129A2 (de) 2004-12-15

Similar Documents

Publication Publication Date Title
DE60311076D1 (de) Nanostrukturen mit pilin-protein
NO2017051I2 (no) Kariprazin, eventuelt i form av et salt
DE60327864D1 (de) Ballondissektor mit kanüle
DE60308332D1 (de) Chinazolinverbindungen mit therapeutischem nutzen
DK1699821T3 (da) Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER
DE50311697D1 (de) Zwischenwirbelimplantat mit kalottenartigen gelenkflächen
DE602004029705D1 (de) 5,7-diaminopyrazoloä4,3-düpyrimidine mit pde-5-hemmender wirkung
BR0307500B1 (pt) sachÊ com trÊs soldas.
DK1563100T3 (da) Fortrængningssandwich-immuno-PCR
DE60326590D1 (de) Tend lamotrigin
DE502004011333D1 (de) Polyalkenamine mit verbesserten anwendungseigenschaften
DE60334181D1 (de) Radsupport mit Lageranordnung
DE602004019159D1 (de) Drosselklappenstutzen
DE60326373D1 (de) Gaspedal
DE60307955D1 (de) Drosselklappe
DE50310143D1 (de) Fahrpedal
FR2837877B1 (fr) Modele de superstatoreacteur
DK1401071T3 (da) Formstoftromle
DE60328921D1 (de) Kondom mit integriertem wulstaufbau
DE60314958D1 (de) Reissverschluss
NO20021944L (no) Slepebåt
DE602004017295D1 (de) Drosselkörper
DE50310181D1 (de) Drosselklappeneinheit
ATA292002A (de) Verdrängungskörper
ATE504278T1 (de) Hosenförmiger artikel mit verbesserter passform

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee