DE60319128D1 - Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere - Google Patents

Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Info

Publication number
DE60319128D1
DE60319128D1 DE60319128T DE60319128T DE60319128D1 DE 60319128 D1 DE60319128 D1 DE 60319128D1 DE 60319128 T DE60319128 T DE 60319128T DE 60319128 T DE60319128 T DE 60319128T DE 60319128 D1 DE60319128 D1 DE 60319128D1
Authority
DE
Germany
Prior art keywords
block copolymers
ortho esters
ketenacetales
dioxide
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60319128T
Other languages
English (en)
Other versions
DE60319128T2 (de
Inventor
Jorge Heller
Steven Y Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heron Therapeutics LLC
Original Assignee
AP Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AP Pharma Inc filed Critical AP Pharma Inc
Publication of DE60319128D1 publication Critical patent/DE60319128D1/de
Application granted granted Critical
Publication of DE60319128T2 publication Critical patent/DE60319128T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
    • C08G2/18—Copolymerisation of aldehydes or ketones
    • C08G2/24—Copolymerisation of aldehydes or ketones with acetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups
DE60319128T 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere Expired - Fee Related DE60319128T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US298151 2002-11-15
US10/298,151 US7045589B2 (en) 2002-11-15 2002-11-15 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
PCT/US2003/036616 WO2004046328A2 (en) 2002-11-15 2003-11-13 Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them

Publications (2)

Publication Number Publication Date
DE60319128D1 true DE60319128D1 (de) 2008-03-27
DE60319128T2 DE60319128T2 (de) 2009-02-05

Family

ID=32297370

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60319128T Expired - Fee Related DE60319128T2 (de) 2002-11-15 2003-11-13 Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere

Country Status (11)

Country Link
US (2) US7045589B2 (de)
EP (1) EP1569664B1 (de)
JP (1) JP2006506514A (de)
KR (1) KR20050075414A (de)
CN (1) CN1726043A (de)
AT (1) ATE385801T1 (de)
AU (1) AU2003295563B2 (de)
CA (1) CA2506241A1 (de)
DE (1) DE60319128T2 (de)
ES (1) ES2299746T3 (de)
WO (1) WO2004046328A2 (de)

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KR102063027B1 (ko) 2013-10-31 2020-01-07 (주)아모레퍼시픽 캡슐화된 향기를 포함하는 조성물
JP6232280B2 (ja) * 2013-12-25 2017-11-15 株式会社ダイセル 含酸素飽和ヘテロ環を有する重合体及びその製造方法
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN114886840B (zh) * 2020-07-10 2023-08-25 南京海鲸药业股份有限公司 一种具有酸敏感降解、温敏性质的系列聚合物及其载药组合物

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Also Published As

Publication number Publication date
CA2506241A1 (en) 2004-06-03
ES2299746T3 (es) 2008-06-01
JP2006506514A (ja) 2006-02-23
US20060155101A1 (en) 2006-07-13
AU2003295563A1 (en) 2004-06-15
US20040096506A1 (en) 2004-05-20
ATE385801T1 (de) 2008-03-15
EP1569664A4 (de) 2006-11-02
CN1726043A (zh) 2006-01-25
WO2004046328A2 (en) 2004-06-03
KR20050075414A (ko) 2005-07-20
US7045589B2 (en) 2006-05-16
AU2003295563B2 (en) 2009-01-08
WO2004046328A3 (en) 2004-08-26
EP1569664B1 (de) 2008-02-13
DE60319128T2 (de) 2009-02-05
EP1569664A2 (de) 2005-09-07
US7163694B2 (en) 2007-01-16

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