DE60328496D1 - Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie - Google Patents

Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie

Info

Publication number
DE60328496D1
DE60328496D1 DE60328496T DE60328496T DE60328496D1 DE 60328496 D1 DE60328496 D1 DE 60328496D1 DE 60328496 T DE60328496 T DE 60328496T DE 60328496 T DE60328496 T DE 60328496T DE 60328496 D1 DE60328496 D1 DE 60328496D1
Authority
DE
Germany
Prior art keywords
fotodynamische
fluorinierte
bacteriochlorin
therapie
chlorin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60328496T
Other languages
English (en)
Inventor
Ravindra K Pandey
William R Potter
Thomas J Dougherty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Application granted granted Critical
Publication of DE60328496D1 publication Critical patent/DE60328496D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B47/00—Porphines; Azaporphines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/108—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a phthalocyanine dye
DE60328496T 2002-06-27 2003-06-27 Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie Expired - Lifetime DE60328496D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39247302P 2002-06-27 2002-06-27
PCT/US2003/020427 WO2004002476A2 (en) 2002-06-27 2003-06-27 Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy

Publications (1)

Publication Number Publication Date
DE60328496D1 true DE60328496D1 (en) 2009-09-03

Family

ID=30000878

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60328496T Expired - Lifetime DE60328496D1 (en) 2002-06-27 2003-06-27 Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie

Country Status (6)

Country Link
US (5) US7166719B2 (de)
EP (1) EP1517684B1 (de)
AU (1) AU2003248747A1 (de)
CA (1) CA2490692A1 (de)
DE (1) DE60328496D1 (de)
WO (1) WO2004002476A2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2412800A (en) * 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
CA2358662A1 (en) * 1999-01-15 2000-07-20 James Chen Therapeutic compositions for metabolic bone disorders or bone metastases
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US7097826B2 (en) * 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
JP2003519670A (ja) * 2000-01-12 2003-06-24 ライト サイエンシーズ コーポレイション 眼疾患の新規処置
CA2473924A1 (en) * 2002-01-23 2003-07-31 Light Sciences Corporation Systems and methods for photodynamic therapy
US20050091174A1 (en) * 2003-10-22 2005-04-28 International Business Machines Corporation Searching for services in a UDDI registry
WO2005120573A2 (en) * 2004-06-07 2005-12-22 Yeda Research And Development Co. Ltd. Cationic bacteriochlorophyll derivatives and uses thereof
WO2006089122A2 (en) 2005-02-18 2006-08-24 North Carolina State University De novo synthesis of bacteriochlorins
WO2007047925A2 (en) * 2005-10-20 2007-04-26 North Carolina State University Swallowtail motifs for imparting water solubility to porphyrinic compounds
US8207329B2 (en) * 2005-11-30 2012-06-26 North Carolina State University Synthesis of chlorins and phorbines with enhanced red spectral features
WO2007064841A2 (en) 2005-11-30 2007-06-07 North Carolina State University Porphyrinic compounds for use in flow cytometry
US20070299431A1 (en) * 2006-05-02 2007-12-27 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US7465312B2 (en) 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
KR20090108071A (ko) * 2007-01-09 2009-10-14 헬스 리서치 인코포레이티드 광역학 치료를 이용한 식도의 고 등급 형성이상증의 치료
PT3459955T (pt) 2008-09-18 2022-11-29 Biolitec Unternehmensberatungs Ii Ag Método e aplicação inovadores de porfirinas e cloros não simetricamente meso-substituídos para pdt
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
GB2464958A (en) 2008-10-31 2010-05-05 Univ Muenster Wilhelms A method for the manufacture of a photosensitising nano-material
WO2012166792A1 (en) * 2011-05-31 2012-12-06 North Carolina State University Bacteriochlorin imides
CN103705532B (zh) * 2012-10-08 2016-09-14 浙江海正药业股份有限公司 靶向胸苷激酶光敏剂及其药物组合物与治疗癌症的用途
WO2014110149A2 (en) * 2013-01-08 2014-07-17 Stoneburner Jon F Method of testing or treating the presence of live viruses
CN103961323B (zh) * 2013-02-05 2017-10-17 浙江海正药业股份有限公司 一种注射用hpph冻干粉针制剂及其制备方法
RU2565450C1 (ru) * 2014-07-15 2015-10-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Катионный пурпуринимид, обладающий антибактериальной активностью, и его применение для фотодинамической инактивации бактериальных биопленок
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
WO2016051361A1 (en) 2014-09-30 2016-04-07 Biolitec Unternehmensbeteiligungs Ii Ag Specifically meso-substituted porphyrins and chlorins for photodynamic therapy
CN104459099B (zh) * 2014-12-18 2016-04-13 东南大学 卟啉衍生物在制备检测炎症相关疾病试剂中的应用
EP3210626A1 (de) 2016-02-26 2017-08-30 biolitec Unternehmensbeteiligungs II AG Konjugate von porphyrin-photosensibilisator und glycerol-basierte polymere für photodynamische therapie
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
CN107445967A (zh) * 2016-06-01 2017-12-08 陈志龙 一类n,n‑二羧乙基焦脱镁叶绿酰胺衍生物及其制备方法与应用
JP2019523783A (ja) 2016-06-16 2019-08-29 オンコセレクト セラピューティクス，エルエルシー がんの治療に有用なポルフィリン化合物及び組成物
US10919904B2 (en) 2016-08-17 2021-02-16 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
WO2018102252A1 (en) 2016-11-30 2018-06-07 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
RU2662082C2 (ru) * 2017-10-03 2018-07-23 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр радиологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ радиологии" Минздрава России) Фотостабильная фармацевтическая композиция для терапии очагов бактериального поражения
CN111171030B (zh) * 2018-11-12 2022-11-22 浙江海正药业股份有限公司 细菌叶绿素衍生物及其制备方法
US20220025185A1 (en) 2018-12-10 2022-01-27 Universitat Hamburg Specifically glyco-substituted porphyrins and chlorins for photodynamic therapy
US20220249707A1 (en) 2019-05-20 2022-08-11 Nirvana Sciences Inc. Narrow emission dyes, compositions comprising same, and methods for making and using same

Family Cites Families (249)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US3927193A (en) 1973-05-18 1975-12-16 Hoffmann La Roche Localization of tumors by radiolabelled antibodies
US4374925A (en) 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4361544A (en) 1980-03-03 1982-11-30 Goldenberg Milton David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4444744A (en) 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4348376A (en) 1980-03-03 1982-09-07 Goldenberg Milton David Tumor localization and therapy with labeled anti-CEA antibody
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4468457A (en) 1981-06-01 1984-08-28 David M. Goldenberg Method for producing a CSAp tryptic peptide and anti-CSAp antibodies
US4474893A (en) 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4521762A (en) 1981-08-27 1985-06-04 Gte Automatic Electric Laboratories, Incorporated Integratable D/A converter
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
US4479895A (en) 1982-05-05 1984-10-30 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS60500132A (ja) 1982-09-27 1985-01-31 ヘルス・リサーチ・インコーポレーテッド 腫瘍の診断および治療のための精製されたヘマトポルフイリン誘導体ならびにその方法
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4577636A (en) 1982-11-23 1986-03-25 The Beth Israel Hospital Association Method for diagnosis of atherosclerosis
US4818709A (en) 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
US4624846A (en) 1983-07-29 1986-11-25 Immunomedics, Inc. Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
US4675338A (en) 1984-07-18 1987-06-23 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4693885A (en) 1984-07-18 1987-09-15 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US4753958A (en) 1985-02-07 1988-06-28 University Of Cal Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins
US4656186A (en) 1985-04-30 1987-04-07 Nippon Petrochemicals Co., Ltd. Tetrapyrrole therapeutic agents
US5066274A (en) 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
US5216012A (en) 1986-01-02 1993-06-01 University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5051415A (en) 1986-01-02 1991-09-24 The University Of Toledo Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions
US5534506A (en) 1986-01-02 1996-07-09 University Of Toledo Use of purpurins, chlorins and purpurin- and chlorin-containing compositions
GB8610551D0 (en) 1986-04-30 1986-06-04 Hoffmann La Roche Polypeptide & protein derivatives
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US5095030A (en) 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
US4878891A (en) 1987-06-25 1989-11-07 Baylor Research Foundation Method for eradicating infectious biological contaminants in body tissues
US5503637A (en) 1987-06-26 1996-04-02 Light Sciences, Inc. Apparatus for producing and delivering high-intensity light to a subject
US4957481A (en) 1987-10-01 1990-09-18 U.S. Bioscience Photodynamic therapeutic technique
JP2668369B2 (ja) 1987-11-09 1997-10-27 株式会社 佐藤薬学研究所 含フツ素プロトポルフイリン誘導体及びその塩
US5033252A (en) 1987-12-23 1991-07-23 Entravision, Inc. Method of packaging and sterilizing a pharmaceutical product
US5052558A (en) 1987-12-23 1991-10-01 Entravision, Inc. Packaged pharmaceutical product
US5004811A (en) 1987-12-24 1991-04-02 Nippon Petrochemicals Company, Ltd. Tetrapyrrole aminocarboxylic acids
US5053006A (en) 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
EP0430968B1 (de) 1988-05-02 1996-11-20 PHANOS TECHNOLOGIES, Inc. Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen
US4968715A (en) 1988-07-06 1990-11-06 Health Research, Inc. Use of purified hematoporphyrin trimers in photodynamic therapy
US5190966A (en) 1988-07-06 1993-03-02 Health Research, Inc. Purified hematoporphyrin dimers and trimers useful in photodynamic therapy
US4925736A (en) 1988-07-06 1990-05-15 Long Island Jewish Medical Center Topical hematoporphyrin
US5093349A (en) 1988-07-20 1992-03-03 Health Research Inc. Photosensitizing agents
USRE38994E1 (en) 1988-07-20 2006-02-28 Health Research, Inc. Pyropheophorbides conjugates and their use in photodynamic therapy
US5002962A (en) 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
USRE39094E1 (en) 1988-07-20 2006-05-09 Health Research, Inc. Pyropheophorbides and their use in photodynamic therapy
US5198460A (en) 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
US5111821A (en) 1988-11-08 1992-05-12 Health Research, Inc. Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation
US5205291A (en) 1988-11-08 1993-04-27 Health Research, Inc. In vivo fluorescence photometer
US5028594A (en) 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5059415A (en) 1989-02-21 1991-10-22 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health Method for diagnostically imaging lesions in the brain inside a blood-brain barrier
US4935498A (en) 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5041078A (en) 1989-03-06 1991-08-20 Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas Photodynamic viral deactivation with sapphyrins
US5599923A (en) 1989-03-06 1997-02-04 Board Of Regents, University Of Tx Texaphyrin metal complexes having improved functionalization
US5171741A (en) 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
US5173504A (en) 1989-04-21 1992-12-22 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
US5631281A (en) 1989-06-29 1997-05-20 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives
US5580896A (en) 1989-06-29 1996-12-03 Warner-Lambert Company Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives
US4997639A (en) 1989-11-27 1991-03-05 Nippon Petrochemicals Company, Limited Method for detecting cholesterol deposited in bodies of mammals
US5594136A (en) 1989-12-21 1997-01-14 Pharmacyclics, Inc. Texaphyrin solid supports and devices
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
DE69033449T2 (de) 1990-01-08 2000-10-12 Health Research Inc Tauchanordnung mit Linse und optischer Faser
US5074632A (en) 1990-03-07 1991-12-24 Health Research, Inc. Fiber optic diffusers and methods for manufacture of the same
US5219345A (en) 1990-03-30 1993-06-15 Health Research, Inc. Backscatter monitoring system
JPH03291033A (ja) 1990-04-06 1991-12-20 Mitsubishi Electric Corp 和分復号回路
US5418130A (en) 1990-04-16 1995-05-23 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US6162213A (en) 1990-04-25 2000-12-19 Cincinnati Sub-Zero Products, Inc. Multiple wavelength metal vapor laser system for medical applications
US5066291A (en) 1990-04-25 1991-11-19 Cincinnati Sub-Zero Products, Inc. Solid-state laser frequency conversion system
US5219878A (en) * 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5549660A (en) 1990-11-15 1996-08-27 Amron, Ltd. Method of treating acne
US5500009A (en) 1990-11-15 1996-03-19 Amron, Ltd. Method of treating herpes
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
JP3154742B2 (ja) 1991-04-30 2001-04-09 日本石油化学株式会社 哺乳類の動脈硬化症治療剤
GB9114290D0 (en) * 1991-07-02 1991-08-21 Courtaulds Plc Polymer compositions
US5263925A (en) 1991-07-22 1993-11-23 Gilmore Jr Thomas F Photopheresis blood treatment
US5222795A (en) 1991-12-26 1993-06-29 Light Sciences, Inc. Controlled light extraction from light guides and fibers
GB9203037D0 (en) 1992-02-11 1992-03-25 Salutar Inc Contrast agents
US5330741A (en) 1992-02-24 1994-07-19 The Regents Of The University Of California Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors
US6010715A (en) 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
US6024975A (en) 1992-04-08 2000-02-15 Americare International Diagnostics, Inc. Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
US5257970A (en) 1992-04-09 1993-11-02 Health Research, Inc. In situ photodynamic therapy
US6096289A (en) 1992-05-06 2000-08-01 Immunomedics, Inc. Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy
WO1993021940A1 (en) 1992-05-06 1993-11-11 Immunomedics, Inc. Intraoperative, intravascular and endoscopic tumor and lesion detection and therapy
US6217869B1 (en) 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
US5976535A (en) 1992-06-09 1999-11-02 Neorx Corporation Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US5292320A (en) 1992-07-06 1994-03-08 Ceramoptec, Inc. Radial medical laser delivery device
US5298018A (en) 1992-08-14 1994-03-29 Pdt Cardiovascular, Inc. Method for treating cardiovascular disease through adjunctive photodynamic therapy
ATE201596T1 (de) 1992-09-21 2001-06-15 Quadra Logic Tech Inc Transkutane in-vivo aktivierung von photoempfindlichen mitteln im blut
DE69334009T2 (de) 1992-11-20 2006-11-23 The University Of British Columbia, Vancouver Verfahren zur Aktivierung von photoempfindlichen Mitteln
JP3247001B2 (ja) 1992-12-21 2002-01-15 キヤノン株式会社 ピリリウム化合物を用いた２本鎖核酸の検出方法、ピリリウム化合物を含有するプローブ及びそれを用いた標的核酸の検出方法、新規ピリリウム化合物
US5368841A (en) 1993-02-11 1994-11-29 The General Hospital Corporation Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
JP3565442B2 (ja) 1993-04-22 2004-09-15 新日本石油化学株式会社 哺乳類の関節炎の診断剤および／または治療剤
US5482698A (en) 1993-04-22 1996-01-09 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin polymer conjugates
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5445608A (en) 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
US5514669A (en) 1993-09-29 1996-05-07 Medical College Of Ohio Use of photodynamic therapy to treat prostatic tissue
US5441531A (en) 1993-10-18 1995-08-15 Dusa Pharmaceuticals Inc. Illuminator and methods for photodynamic therapy
US6015897A (en) 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
JPH07233065A (ja) 1993-12-27 1995-09-05 Canon Inc ピリリウム塩又はピリリウム類似塩を含む光化学治療薬
US5556612A (en) 1994-03-15 1996-09-17 The General Hospital Corporation Methods for phototherapeutic treatment of proliferative skin diseases
US5851225A (en) 1994-03-18 1998-12-22 Spectra Science Corporation Photoemitting catheters and other structures suitable for use in photo-dynamic therapy and other applications
DE69514262T2 (de) 1994-03-23 2001-10-11 Yasuo Hashimoto Katheter mit Lichtleitfaser
US5498710A (en) * 1994-04-22 1996-03-12 Health Research, Inc. Alkyl ether analogues of benzoporphyrin derivatives
US5591847A (en) 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages
EP0684239B1 (de) 1994-05-26 2003-12-10 Canon Kabushiki Kaisha Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US5759542A (en) 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US6232295B1 (en) 1994-10-12 2001-05-15 Jon Faiz Kayyem Cell-specific contrast agent and gene delivery vehicles
US5648485A (en) 1994-10-26 1997-07-15 University Of British Columbia β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US5703230A (en) 1994-12-02 1997-12-30 University Of British Columbia Meso-monoiodo-substituted tetramacrocyclic compounds and methods for making and using the same
US6176842B1 (en) 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US5983134A (en) 1995-04-23 1999-11-09 Electromagnetic Bracing Systems Inc. Electrophoretic cuff apparatus drug delivery system
US5571152A (en) 1995-05-26 1996-11-05 Light Sciences Limited Partnership Microminiature illuminator for administering photodynamic therapy
US6316652B1 (en) 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
IT1275571B (it) 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
JP2961074B2 (ja) 1995-09-06 1999-10-12 明治製菓株式会社 光化学療法用の新生血管閉塞剤
US5824080A (en) 1995-09-28 1998-10-20 The General Hospital Corporation Photochemistry for the preparation of biologic grafts--allografts and xenografts
DE19539409C2 (de) 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US6039975A (en) 1995-10-17 2000-03-21 Hoffman-La Roche Inc. Colon targeted delivery system
JP3718887B2 (ja) * 1995-10-30 2005-11-24 株式会社光ケミカル研究所 ポルフィリン誘導体とその用途
US5885557A (en) 1996-02-08 1999-03-23 Estee Lauder Inc. Compositions useful in the phototherapeutic treatment of proliferative skin disorders
US5800478A (en) 1996-03-07 1998-09-01 Light Sciences Limited Partnership Flexible microcircuits for internal light therapy
US5952366A (en) * 1996-03-08 1999-09-14 Health Research, Inc. Alkyl ether analogs of chlorins having an N-substituted imide ring
US5770730A (en) * 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
US5773977A (en) 1996-04-18 1998-06-30 Johnson Controls Technology Company Method of testing an electric storage battery by determining a bounce-back voltage after a load has been removed
TW345603B (en) 1996-05-29 1998-11-21 Gmundner Fertigteile Gmbh A noise control device for tracks
US5671317A (en) 1996-07-16 1997-09-23 Health Research, Inc. Fiber optic positioner
US5944748A (en) 1996-07-25 1999-08-31 Light Medicine, Inc. Photodynamic therapy apparatus and methods
US5814008A (en) 1996-07-29 1998-09-29 Light Sciences Limited Partnership Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy
AU3578497A (en) 1996-08-08 1998-03-06 Light Sciences Limited Partnership Method and apparatus to treat gingival and periodontal disease
US5715837A (en) 1996-08-29 1998-02-10 Light Sciences Limited Partnership Transcutaneous electromagnetic energy transfer
US5849027A (en) 1996-09-04 1998-12-15 Mbg Technologies, Inc. Photodynamic therapy method and apparatus
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US5913884A (en) 1996-09-19 1999-06-22 The General Hospital Corporation Inhibition of fibrosis by photodynamic therapy
AU722289B2 (en) 1996-10-01 2000-07-27 Aptalis Pharmatech, Inc. Taste-masked microcapsule compositions and methods of manufacture
US6063777A (en) 1996-10-01 2000-05-16 Wyeth Lederle Japan, Ltd. Iminochlorinaspartic acid derivatives
US5702432A (en) 1996-10-03 1997-12-30 Light Sciences Limited Partnership Intracorporeal light treatment of blood
WO1998015273A1 (en) 1996-10-10 1998-04-16 The General Hospital Corporation Photodynamic therapy for the treatment of osteoarthritis
ATE314097T1 (de) 1996-10-28 2006-01-15 Amersham Health As Kontrastmittel
EP0946202B1 (de) 1996-10-28 2003-09-10 Amersham Health AS Kontrastmittel
US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US5832931A (en) 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US5741316A (en) 1996-12-02 1998-04-21 Light Sciences Limited Partnership Electromagnetic coil configurations for power transmission through tissue
US6080160A (en) 1996-12-04 2000-06-27 Light Sciences Limited Partnership Use of shape memory alloy for internally fixing light emitting device at treatment site
US6063108A (en) 1997-01-06 2000-05-16 Salansky; Norman Method and apparatus for localized low energy photon therapy (LEPT)
US5876427A (en) 1997-01-29 1999-03-02 Light Sciences Limited Partnership Compact flexible circuit configuration
US5782896A (en) 1997-01-29 1998-07-21 Light Sciences Limited Partnership Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe
US5997569A (en) 1997-01-29 1999-12-07 Light Sciences Limited Partnership Flexible and adjustable grid for medical therapy
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US5827186A (en) 1997-04-11 1998-10-27 Light Sciences Limited Partnership Method and PDT probe for minimizing CT and MRI image artifacts
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
WO1998048838A1 (en) 1997-04-29 1998-11-05 Nycomed Imaging As Compounds
US5957960A (en) 1997-05-05 1999-09-28 Light Sciences Limited Partnership Internal two photon excitation device for delivery of PDT to diffuse abnormal cells
US6051702A (en) 1997-05-08 2000-04-18 Rutgers, The University Of New Jersey Organic dyes for photovoltaic cells and for photoconductive electrophotography systems
GB9710049D0 (en) 1997-05-19 1997-07-09 Nycomed Imaging As Method
US6100893A (en) 1997-05-23 2000-08-08 Light Sciences Limited Partnership Constructing solid models using implicit functions defining connectivity relationships among layers of an object to be modeled
US5921244A (en) 1997-06-11 1999-07-13 Light Sciences Limited Partnership Internal magnetic device to enhance drug therapy
WO1999004628A1 (en) 1997-07-28 1999-02-04 Dermatolazer Technologies Ltd. Phototherapy based method for treating pathogens and composition for effecting same
US5886173A (en) 1997-07-30 1999-03-23 Pharmacyclics, Inc. Metallation of macrocycles with 2,4-dicarbonyl-metal complexes
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
US6048359A (en) 1997-08-25 2000-04-11 Advanced Photodynamic Technologies, Inc. Spatial orientation and light sources and method of using same for medical diagnosis and photodynamic therapy
IL129848A (en) 1997-09-09 2003-04-10 Select Release L C Coated particles and methods of making and using same
WO1999018679A1 (en) 1997-10-06 1999-04-15 Dsc Communications A/S An optical network with protection path for failure recovery
US6138681A (en) 1997-10-13 2000-10-31 Light Sciences Limited Partnership Alignment of external medical device relative to implanted medical device
US5865840A (en) 1997-10-22 1999-02-02 Light Sciences Limited Partnership Enhancement of light activation effect by immune augmentation
EP0968711B9 (de) 1997-10-28 2008-05-28 Bando Chemical Industries, Ltd. Dermatologisches pflaster und verfahren zur herstellung seiner basisschicht
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20030030342A1 (en) 1998-02-10 2003-02-13 Chen James C. Contactless energy transfer apparatus
US5945762A (en) 1998-02-10 1999-08-31 Light Sciences Limited Partnership Movable magnet transmitter for inducing electrical current in an implanted coil
US6331744B1 (en) 1998-02-10 2001-12-18 Light Sciences Corporation Contactless energy transfer apparatus
US6281611B1 (en) 1998-02-10 2001-08-28 Light Sciences Corporation Use of moving element to produce heat
US6028099A (en) 1998-03-13 2000-02-22 John Hopkins University, School Of Medicine Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization
WO1999051586A1 (fr) 1998-03-31 1999-10-14 Tetsuo Nagano Reactif de determination d'oxygene singulet
US5997842A (en) 1998-04-13 1999-12-07 Light Sciences Limited Partnership Radionuclide excited phosphorescent material for administering PDT
US5957912A (en) 1998-04-16 1999-09-28 Camino Neurocare, Inc. Catheter having distal stylet opening and connector
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
WO1999058149A1 (en) 1998-05-13 1999-11-18 Light Sciences Limited Partnership Controlled activation of targeted radionuclides
US6103751A (en) * 1998-06-22 2000-08-15 Health Research, Inc. Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents
US6416531B2 (en) 1998-06-24 2002-07-09 Light Sciences Corporation Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy
US6096066A (en) 1998-09-11 2000-08-01 Light Sciences Limited Partnership Conformal patch for administering light therapy to subcutaneous tumors
KR20010075107A (ko) 1998-09-17 2001-08-09 다께다 가즈히꼬 광화학 요법 치료제
US6117862A (en) 1998-10-09 2000-09-12 Qlt, Inc. Model and method for angiogenesis inhibition
AU6427299A (en) 1998-10-13 2000-05-01 Brown University Research Foundation Substituted perhalogenated phthalocyanines
US6569846B1 (en) 1998-12-09 2003-05-27 Yeda Research And Development Co. Ltd. Palladium-substituted bacteriochlorophyll derivatives and use thereof
US6344050B1 (en) 1998-12-21 2002-02-05 Light Sciences Corporation Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue
CA2358662A1 (en) 1999-01-15 2000-07-20 James Chen Therapeutic compositions for metabolic bone disorders or bone metastases
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
AU2412800A (en) 1999-01-15 2000-08-01 Light Sciences Corporation Noninvasive vascular therapy
US6162242A (en) 1999-01-21 2000-12-19 Peyman; Gholam A. Selective photodynamic treatment
US6515113B2 (en) 1999-02-18 2003-02-04 The Regents Of The University Of California Phthalamide lanthanide complexes for use as luminescent markers
EP1154991B1 (de) 1999-02-18 2004-07-28 The Regents of the University of California Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker
US6273904B1 (en) 1999-03-02 2001-08-14 Light Sciences Corporation Polymer battery for internal light device
JP2002541124A (ja) 1999-04-02 2002-12-03 センター・フォー・モレキュラー・メディシン・アンド・イムノロジー 子宮内膜症を検出する方法
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
WO2000061585A2 (en) * 1999-04-14 2000-10-19 The University Of British Columbia (Ubc) 1,3-dipolar cycloadditions to polypyrrolic macrocycles
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6210425B1 (en) 1999-07-08 2001-04-03 Light Sciences Corporation Combined imaging and PDT delivery system
US6238426B1 (en) 1999-07-19 2001-05-29 Light Sciences Corporation Real-time monitoring of photodynamic therapy over an extended time
US6084717A (en) 1999-08-03 2000-07-04 Health Research, Inc. Laser beam splitter
US20030114434A1 (en) 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US6268120B1 (en) 1999-10-19 2001-07-31 Gambro, Inc. Isoalloxazine derivatives to neutralize biological contaminants
DE19958836A1 (de) 1999-11-29 2001-05-31 Deutsche Telekom Ag Verfahren und Anordnung zur Verbesserung der Kommunikation in einem Fahrzeug
US6319273B1 (en) 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
JP2003519670A (ja) 2000-01-12 2003-06-24 ライト サイエンシーズ コーポレイション 眼疾患の新規処置
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
JP3565758B2 (ja) 2000-03-09 2004-09-15 株式会社日立製作所 腫瘍治療用増感剤
CA2376001A1 (en) * 2000-03-30 2001-10-11 Martinus Bernardus Vrouenraets Photodynamic therapy compounds
EP1233651A1 (de) 2000-04-07 2002-08-21 Ibiden Co., Ltd. Keramisches heizelement
US6489314B1 (en) 2001-04-03 2002-12-03 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
US6520669B1 (en) 2000-06-19 2003-02-18 Light Sciences Corporation Flexible substrate mounted solid-state light sources for exterior vehicular lighting
US6765092B2 (en) * 2000-07-21 2004-07-20 North Carolina State University Regioisomerically pure oxochlorins and methods of synthesis
US6559374B2 (en) * 2000-07-21 2003-05-06 North Carolina State University Trans beta substituted chlorins and methods of making and using the same
US6580228B1 (en) 2000-08-22 2003-06-17 Light Sciences Corporation Flexible substrate mounted solid-state light sources for use in line current lamp sockets
US6514995B1 (en) 2000-09-25 2003-02-04 Advanced Research And Technology Institute, Inc. Enediyne compounds and methods related thereto
FR2820549B1 (fr) 2001-02-08 2003-03-21 Inst Francais Du Petrole Procede et dispositif de production d'electricite dans une pile a combustible par oxydation d'hydrocarbures suivie d'une filtration des particules
US20020127224A1 (en) 2001-03-02 2002-09-12 James Chen Use of photoluminescent nanoparticles for photodynamic therapy
US6495585B2 (en) 2001-03-07 2002-12-17 Health Research, Inc. Method for treating hyperproliferative tissue in a mammal
US6849607B2 (en) 2001-05-09 2005-02-01 Health Research, Inc. Galectin recognized photosensitizers for photodynamic therapy
DE60213996T2 (de) * 2001-06-01 2007-09-06 Ceramoptec Gmbh Wasserlösliche porphyrinderivate für die photodynamische therapie, ihre verwendung und herstellung
US6566517B2 (en) 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
WO2003029494A1 (en) 2001-10-03 2003-04-10 Micrologix Biotech Inc. Attachment of thiophosphate tethered oligonucleotides to a solid surface
ITMI20012147A1 (it) 2001-10-17 2003-04-17 De Longhi Spa Dispositivo e procedimento per la cottura di un prodotto alimentare con microonde
US7093007B2 (en) 2001-12-21 2006-08-15 Hewlett-Packard Development Company, L.P. Identifying a physical device's avatar using a unique, substantially non-removable communication identifier
CA2473924A1 (en) 2002-01-23 2003-07-31 Light Sciences Corporation Systems and methods for photodynamic therapy
AU2003249742A1 (en) 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
CA2491472C (en) 2002-07-09 2011-09-27 Lonza Ag Process for the preparation of n-monosubstituted .beta.-amino alcohols

Also Published As

Publication number Publication date
WO2004002476A9 (en) 2004-04-01
CA2490692A1 (en) 2004-01-08
US7820143B2 (en) 2010-10-26
US20090162289A1 (en) 2009-06-25
US7166719B2 (en) 2007-01-23
US20040044197A1 (en) 2004-03-04
AU2003248747A8 (en) 2004-01-19
US7501509B2 (en) 2009-03-10
EP1517684B1 (de) 2009-07-22
AU2003248747A1 (en) 2004-01-19
USRE43274E1 (en) 2012-03-27
US20070149497A1 (en) 2007-06-28
US20110091390A1 (en) 2011-04-21
WO2004002476B1 (en) 2004-07-08
WO2004002476A2 (en) 2004-01-08
EP1517684A2 (de) 2005-03-30
WO2004002476A3 (en) 2004-05-13

Similar Documents

Publication Publication Date Title
DE60328496D1 (en) Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie
IL157640A0 (en) Pyrazolopyrimidines as therapeutic agents
EP1385524A4 (de) Pyrazolpyrimidine als therapeutische mittel
GB0206876D0 (en) Therapeutic agents
GB0229931D0 (en) Therapeutic agents
GB0201850D0 (en) Therapeutic treatment
GB0216321D0 (en) Therapeutic treatment
GB0209991D0 (en) Therapeutic agents
GB0209995D0 (en) Therapeutic agents
GB0209997D0 (en) Therapeutic agents
GB0230087D0 (en) Therapeutic agents
GB0210127D0 (en) Therapeutic agents
GB0210124D0 (en) Therapeutic agents
GB0230088D0 (en) Therapeutic agents
GB0223349D0 (en) Therapeutic agents
HK1078784A1 (en) Therapeutic treatment
GB0223367D0 (en) Therapeutic treatment
AU2003272317A8 (en) Treatment of periodontal disease with photosensitizers
GB0218876D0 (en) Therapeutic agents
GB0210464D0 (en) Therapeutic treatment
GB0226462D0 (en) Therapeutic agents
GB0217068D0 (en) Therapeutic agents
GB0225501D0 (en) Therapeutic agents
GB0208394D0 (en) Therapeutic agents
HK1058324A1 (en) Chemical bed design

Legal Events

Date Code Title Description
8364 No opposition during term of opposition