DE60333793D1 - Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistung - Google Patents
Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistungInfo
- Publication number
- DE60333793D1 DE60333793D1 DE60333793T DE60333793T DE60333793D1 DE 60333793 D1 DE60333793 D1 DE 60333793D1 DE 60333793 T DE60333793 T DE 60333793T DE 60333793 T DE60333793 T DE 60333793T DE 60333793 D1 DE60333793 D1 DE 60333793D1
- Authority
- DE
- Germany
- Prior art keywords
- solid surface
- high performance
- performance assay
- biomolecular
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007787 solid Substances 0.000 title abstract 2
- 238000003556 assay Methods 0.000 title 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000012096 transfection reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/341,059 US20040138154A1 (en) | 2003-01-13 | 2003-01-13 | Solid surface for biomolecule delivery and high-throughput assay |
| PCT/US2003/038498 WO2004065636A1 (en) | 2003-01-13 | 2003-12-04 | Solid surface for biomolecule delivery and high-throughput assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60333793D1 true DE60333793D1 (de) | 2010-09-23 |
Family
ID=32711435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60333793T Expired - Lifetime DE60333793D1 (de) | 2003-01-13 | 2003-12-04 | Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistung |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20040138154A1 (de) |
| EP (2) | EP2253718B1 (de) |
| JP (1) | JP4580764B2 (de) |
| KR (1) | KR100863774B1 (de) |
| CN (1) | CN1738911B (de) |
| AT (1) | ATE477336T1 (de) |
| AU (1) | AU2003298863B2 (de) |
| CA (1) | CA2512144C (de) |
| DE (1) | DE60333793D1 (de) |
| DK (1) | DK2253718T3 (de) |
| HK (1) | HK1088637A1 (de) |
| WO (1) | WO2004065636A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
| US20070269891A9 (en) * | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
| US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| CN101124316A (zh) * | 2004-12-17 | 2008-02-13 | 日东电工株式会社 | 用于转染真核细胞的固定的可降解阳离子聚合物 |
| US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
| DK1842557T3 (da) | 2004-12-22 | 2013-12-02 | Nitto Denko Corp | Lægemiddelbærer og lægemiddelbærerkit til inhibition af fibrose |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| ES2362376T3 (es) * | 2006-07-07 | 2011-07-04 | Aarhus Universitet | Nanopartículas para la administración de ácido nucleico. |
| TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
| US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| WO2009036368A2 (en) * | 2007-09-14 | 2009-03-19 | Nitto Denko Corporation | Drug carriers |
| KR20110051214A (ko) * | 2008-07-30 | 2011-05-17 | 닛토덴코 가부시키가이샤 | 약물 담체 |
| CN102010508B (zh) * | 2010-10-19 | 2012-10-03 | 北京大学 | 一种阳离子聚合物及其制备方法和应用 |
| US11931740B2 (en) | 2012-02-13 | 2024-03-19 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US9339812B2 (en) | 2012-02-13 | 2016-05-17 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US11485968B2 (en) | 2012-02-13 | 2022-11-01 | Neumodx Molecular, Inc. | Microfluidic cartridge for processing and detecting nucleic acids |
| US9637775B2 (en) | 2012-02-13 | 2017-05-02 | Neumodx Molecular, Inc. | System and method for processing biological samples |
| US9604213B2 (en) | 2012-02-13 | 2017-03-28 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
| US20140120544A1 (en) | 2012-10-25 | 2014-05-01 | Neumodx Molecular, Inc. | Method and materials for isolation of nucleic acid materials |
| US11293021B1 (en) | 2016-06-23 | 2022-04-05 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
| US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
| KR20220104847A (ko) | 2017-06-30 | 2022-07-26 | 인스크립타 인코포레이티드 | 자동 세포 처리 방법, 모듈, 기기 및 시스템 |
| US10526598B2 (en) | 2018-04-24 | 2020-01-07 | Inscripta, Inc. | Methods for identifying T-cell receptor antigens |
| US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
| AU2019292919A1 (en) | 2018-06-30 | 2021-03-11 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
| US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
| US11214781B2 (en) | 2018-10-22 | 2022-01-04 | Inscripta, Inc. | Engineered enzyme |
| US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| US10815467B2 (en) | 2019-03-25 | 2020-10-27 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
| CN113939593A (zh) | 2019-06-06 | 2022-01-14 | 因思科瑞普特公司 | 用于递归的核酸指导的细胞编辑的处治 |
| WO2021102059A1 (en) | 2019-11-19 | 2021-05-27 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
| AU2020407048A1 (en) | 2019-12-18 | 2022-06-09 | Inscripta, Inc. | Cascade/dCas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
| WO2021130215A1 (en) * | 2019-12-23 | 2021-07-01 | Universidad Del País Vasco/Euskal Herriko Unibertsitatea | Golden lipid nanoparticles for gene therapy |
| AU2021213705A1 (en) | 2020-01-27 | 2022-06-16 | Inscripta, Inc. | Electroporation modules and instrumentation |
| US20210332388A1 (en) * | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
| US11299731B1 (en) | 2020-09-15 | 2022-04-12 | Inscripta, Inc. | CRISPR editing to embed nucleic acid landing pads into genomes of live cells |
| US11512297B2 (en) | 2020-11-09 | 2022-11-29 | Inscripta, Inc. | Affinity tag for recombination protein recruitment |
| CA3204158A1 (en) | 2021-01-04 | 2022-07-07 | Juhan Kim | Mad nucleases |
| US11332742B1 (en) | 2021-01-07 | 2022-05-17 | Inscripta, Inc. | Mad nucleases |
| US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US6509032B1 (en) * | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| WO1996000295A1 (en) * | 1994-06-27 | 1996-01-04 | The Johns Hopkins University | Targeted gene delivery system |
| US5767168A (en) * | 1995-03-30 | 1998-06-16 | The Proctor & Gamble Company | Biodegradable and/or compostable polymers made from conjugated dienes such as isoprene and 2,3-dimethyl-1, 3-butadiene |
| US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| JP3851369B2 (ja) * | 1995-08-24 | 2006-11-29 | ミレニウム・バイオロジクス・インコーポレイテッド | マルチウェル骨細胞培養装置 |
| CA2256900A1 (en) | 1996-05-29 | 1997-12-04 | Xiao-Ying Meng | Cationic polymer/lipid nucleic acid delivery vehicles |
| JP2000514440A (ja) * | 1996-07-09 | 2000-10-31 | ザ ジョーンズ ホプキンス ユニバーシティー | 遺伝子輸送システム |
| DE19743135A1 (de) | 1997-09-30 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Biologisch verträgliche niedermolekular Polyethylenimine |
| US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
| US6475994B2 (en) * | 1998-01-07 | 2002-11-05 | Donald A. Tomalia | Method and articles for transfection of genetic material |
| US6544790B1 (en) * | 1999-09-17 | 2003-04-08 | Whitehead Institute For Biomedical Research | Reverse transfection method |
| US20020006664A1 (en) * | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
| US8143195B2 (en) * | 2000-01-24 | 2012-03-27 | Yingjian Wang | Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays |
| US6319715B1 (en) | 2000-04-21 | 2001-11-20 | Cornell Research Foundation, Inc. | Method of enhancing the delivery of nucleic acids using silica nanoparticles |
| CA2408351A1 (en) | 2000-05-18 | 2001-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Lipid bilayer array methods and devices |
| US20040120979A1 (en) * | 2000-06-02 | 2004-06-24 | Roessler Blake J. | Delivery systems comprising biocompatible and bioerodable membranes |
| US6696038B1 (en) | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
| US6897067B2 (en) * | 2000-11-03 | 2005-05-24 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
| JP2005505231A (ja) * | 2000-11-03 | 2005-02-24 | リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 表面トランスフェクションおよび発現法 |
| EP1399189A1 (de) * | 2001-06-11 | 2004-03-24 | Universite De Montreal | Mittel und verfahren zur erhöhung des nukleinsäuretransfers in zellen |
| US6586524B2 (en) * | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
| US20040048260A1 (en) * | 2002-09-10 | 2004-03-11 | Fu-Hsiung Chang | Transfection of nucleic acid |
| US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
| US7125709B2 (en) * | 2004-02-10 | 2006-10-24 | Nitto Denko Corporation | Culture device and method for eukaryotic cell transfection |
-
2003
- 2003-01-13 US US10/341,059 patent/US20040138154A1/en not_active Abandoned
- 2003-12-04 AT AT03796622T patent/ATE477336T1/de not_active IP Right Cessation
- 2003-12-04 CN CN2003801086781A patent/CN1738911B/zh not_active Expired - Fee Related
- 2003-12-04 EP EP10075260A patent/EP2253718B1/de not_active Expired - Lifetime
- 2003-12-04 AU AU2003298863A patent/AU2003298863B2/en not_active Ceased
- 2003-12-04 CA CA2512144A patent/CA2512144C/en not_active Expired - Fee Related
- 2003-12-04 DE DE60333793T patent/DE60333793D1/de not_active Expired - Lifetime
- 2003-12-04 DK DK10075260.9T patent/DK2253718T3/da active
- 2003-12-04 EP EP03796622A patent/EP1587954B1/de not_active Expired - Lifetime
- 2003-12-04 WO PCT/US2003/038498 patent/WO2004065636A1/en active Application Filing
- 2003-12-04 JP JP2004566927A patent/JP4580764B2/ja not_active Expired - Fee Related
- 2003-12-04 KR KR1020057012842A patent/KR100863774B1/ko not_active IP Right Cessation
-
2006
- 2006-08-15 HK HK06109068.2A patent/HK1088637A1/xx not_active IP Right Cessation
- 2006-09-26 US US11/527,134 patent/US8192989B2/en not_active Expired - Fee Related
- 2006-09-26 US US11/526,927 patent/US20070020761A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2512144A1 (en) | 2004-08-05 |
| JP2006513703A (ja) | 2006-04-27 |
| US8192989B2 (en) | 2012-06-05 |
| JP4580764B2 (ja) | 2010-11-17 |
| DK2253718T3 (da) | 2012-10-08 |
| EP2253718A2 (de) | 2010-11-24 |
| KR100863774B1 (ko) | 2008-10-16 |
| EP1587954B1 (de) | 2010-08-11 |
| EP2253718B1 (de) | 2012-07-04 |
| ATE477336T1 (de) | 2010-08-15 |
| KR20050096130A (ko) | 2005-10-05 |
| US20070020761A1 (en) | 2007-01-25 |
| CA2512144C (en) | 2013-07-02 |
| CN1738911A (zh) | 2006-02-22 |
| CN1738911B (zh) | 2012-09-05 |
| EP2253718A3 (de) | 2010-12-15 |
| EP1587954A4 (de) | 2006-04-12 |
| EP1587954A1 (de) | 2005-10-26 |
| AU2003298863B2 (en) | 2008-04-24 |
| US20040138154A1 (en) | 2004-07-15 |
| HK1088637A1 (en) | 2006-11-10 |
| US20070072171A1 (en) | 2007-03-29 |
| AU2003298863A1 (en) | 2004-08-13 |
| WO2004065636A1 (en) | 2004-08-05 |
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