DE68912923T2 - Penetrationsfördernde oxazolidinonverbindungen. - Google Patents

Penetrationsfördernde oxazolidinonverbindungen.

Info

Publication number
DE68912923T2
DE68912923T2 DE68912923T DE68912923T DE68912923T2 DE 68912923 T2 DE68912923 T2 DE 68912923T2 DE 68912923 T DE68912923 T DE 68912923T DE 68912923 T DE68912923 T DE 68912923T DE 68912923 T2 DE68912923 T2 DE 68912923T2
Authority
DE
Germany
Prior art keywords
penetration
promoting
oxazolidinone compounds
oxazolidinone
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68912923T
Other languages
English (en)
Other versions
DE68912923D1 (de
Inventor
Vithal J Rajadhyaksha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Therapeutic Patch Research N V
Original Assignee
Therapeutic Patch Research N V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therapeutic Patch Research N V filed Critical Therapeutic Patch Research N V
Application granted granted Critical
Publication of DE68912923D1 publication Critical patent/DE68912923D1/de
Publication of DE68912923T2 publication Critical patent/DE68912923T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
    • A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/86—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
DE68912923T 1988-07-12 1989-06-23 Penetrationsfördernde oxazolidinonverbindungen. Expired - Fee Related DE68912923T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/218,316 US4960771A (en) 1988-07-12 1988-07-12 Oxazolidinone penetration enhancing compounds
PCT/US1989/002779 WO1990000407A1 (en) 1988-07-12 1989-06-23 Oxazolidinone penetration enhancing compounds

Publications (2)

Publication Number Publication Date
DE68912923D1 DE68912923D1 (de) 1994-03-17
DE68912923T2 true DE68912923T2 (de) 1994-07-28

Family

ID=22814618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68912923T Expired - Fee Related DE68912923T2 (de) 1988-07-12 1989-06-23 Penetrationsfördernde oxazolidinonverbindungen.

Country Status (5)

Country Link
US (1) US4960771A (de)
EP (1) EP0378657B1 (de)
JP (1) JP2901297B2 (de)
DE (1) DE68912923T2 (de)
WO (1) WO1990000407A1 (de)

Families Citing this family (46)

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US4876249A (en) * 1987-01-12 1989-10-24 Rajadhyaksha Vithal J Compositions and method comprising heterocyclic compounds containing two heteroatoms
US5472946A (en) * 1988-04-08 1995-12-05 Peck; James V. Transdermal penetration enhancers
US5234959A (en) * 1988-04-08 1993-08-10 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
US5156666A (en) * 1989-12-11 1992-10-20 Isp Investments Inc. Delivery system for agricultural chemicals
US6086905A (en) * 1991-03-21 2000-07-11 Peck; James V. Topical compositions useful as skin penetration barriers
US5414014A (en) * 1993-04-08 1995-05-09 Innova Biomed, Inc. Methods for efficacious removal of attached, sucking antropods from human dermis
AU684316B2 (en) * 1993-10-15 1997-12-11 Shionogi & Co., Ltd. Oxazolinone derivative having intracellular phospholipase A2 inhibitor activity
DE4443888A1 (de) * 1994-12-09 1996-06-13 Bayer Ag Dermal applizierbare Formulierungen von Parasitiziden
US5575988A (en) * 1995-04-07 1996-11-19 Littlepoint Corp. Combination sunscreen and insect repellent
EP0842164A4 (de) * 1995-07-07 1998-10-07 Durham Pharmaceuticals Llc Cyclische amide und derivate davon
ZA966885B (en) * 1995-08-22 1998-02-16 Du Pont Merck Pharma Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors.
DE19613334A1 (de) * 1996-04-03 1997-10-09 Bayer Ag Mittel zur Bekämpfung parasitierender Insekten und Milben an Menschen
FR2754449B1 (fr) * 1996-10-14 1998-11-13 Oreal Utilisation de derives d'oxazolidinone comme agents anti-penetrants dans une composition cosmetique et/ou dermatologique
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
MY122454A (en) 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
JP4803511B2 (ja) * 2000-08-25 2011-10-26 株式会社ポーラファルマ 抗真菌医薬組成物
DE60227157D1 (de) 2001-02-13 2008-07-31 Us Gov Sec Army Impstoffe zur transkutanen immunisierung gegen reisediarrhö
JP2003012468A (ja) * 2001-06-28 2003-01-15 Kaminomoto Co Ltd 養毛・発毛促進剤
US6537985B1 (en) 2001-11-30 2003-03-25 Phoenix Scientific, Inc. Antibiotic formulation and a method of making this formulation
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
US20040033255A1 (en) 2002-06-10 2004-02-19 Baker Carl J. Transdermal delivery device disposal system
DE60326354D1 (de) * 2002-08-20 2009-04-09 Euro Celtique Sa Transdermale dosierungsform enthaltend einen wirkstoff und einen antagonisten in freier base und in salz form
FR2847473B1 (fr) * 2002-11-25 2007-06-29 Expanscience Lab Composition comprenant au moins une oxazolidinone, son utilisation cosmetique et comme medicament
US7053085B2 (en) * 2003-03-26 2006-05-30 Merck & Co. Inc. EP4 receptor agonist, compositions and methods thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
WO2007100047A1 (ja) * 2006-03-02 2007-09-07 Ube Industries, Ltd. ２－イミダゾリジノン化合物及び４，５－ジアルコキシ－２－イミダゾリジノン化合物の製造方法
FR2908653B1 (fr) * 2006-11-16 2012-08-03 Lvmh Rech Utilisation d'une alkyloxazolidinone comme agent cosmetique hydratant et procede d'hydratation de la peau
FR2908650B1 (fr) * 2006-11-16 2012-05-25 Lvmh Rech Utilisation d'une alkyloxazolidinone comme agent cosmetique hydratant et procede d'hydratation de la peau.
IL181217A0 (en) * 2007-02-08 2007-07-04 Haim Levy Pharmaceuticalcompositions based on a microemulsion
EP2033957A1 (de) * 2007-09-06 2009-03-11 SOLVAY (Société Anonyme) Verfahren zur Herstellung von Alkylverbindungen
BR112012007090A2 (pt) 2009-09-30 2018-06-05 Shiseido Company, Ltd. inibidor da atividade da heparanase
FR2950807B1 (fr) * 2009-10-06 2012-02-03 Lvmh Rech Composition cosmetique contenant des liposomes encapsules dans un compose oxazolidin-2-one
CA2932628A1 (en) 2013-12-19 2015-06-25 The Procter & Gamble Company Shaping keratin fibres using a reducing composition and a fixing composition
JP6334709B2 (ja) 2013-12-19 2018-05-30 ザ プロクター アンド ギャンブル カンパニー カルボネートエステルを使用したケラチン繊維の真直化方法
JP6385438B2 (ja) 2013-12-19 2018-09-05 ザ プロクター アンド ギャンブル カンパニー 糖類を使用したケラチン繊維の成形
WO2015095685A1 (en) 2013-12-19 2015-06-25 The Procter & Gamble Company Shaping keratin fibres using 2-hydroxypropane-1,2,3-tricarboxylic acid and/or 1,2,3,4-butanetetracarboxylic acid
CN105828787B (zh) 2013-12-19 2019-07-26 宝洁公司 使用氧代乙酸和/或它们的衍生物使角蛋白纤维成形
JP6396473B2 (ja) 2013-12-19 2018-09-26 ザ プロクター アンド ギャンブル カンパニー −ｃ（ｏｈ）−及び−ｃ（＝ｏ）ｏｈから選択される少なくとも２個の官能基を含む活性剤を使用した、ケラチン繊維の成形
MX363629B (es) 2013-12-19 2019-03-28 Procter & Gamble Formar fibras de queratina con el uso de un agente activo que comprende un grupo funcional seleccionado del grupo que consiste en: -c(=o)-, -c(=o)-h y -c(=o)-o-.
CN107106438A (zh) 2014-12-19 2017-08-29 宝洁公司 成形角蛋白纤维的方法
WO2016100257A1 (en) 2014-12-19 2016-06-23 The Procter & Gamble Company Shaping keratin fibres using arabinose and ethylene carbonate
JP6615916B2 (ja) * 2015-06-18 2019-12-04 ザ プロクター アンド ギャンブル カンパニー ２−オキサゾリジノン化合物を使用したケラチン繊維の整形
MX2017016152A (es) 2015-06-18 2018-04-18 Procter & Gamble Modelado de fibras de queratina mediante el uso de compuestos de dialdehido.

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US4405616A (en) * 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
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DE2704904A1 (de) * 1977-02-05 1978-08-10 Henkel Kgaa Kosmetische mittel mit einem gehalt an haut-feuchthaltemitteln
DE2746650A1 (de) * 1977-10-17 1979-04-26 Henkel Kgaa Kosmetische mittel mit einem gehalt an haut-feuchthaltemitteln
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US4677131A (en) * 1985-11-01 1987-06-30 Merck & Co., Inc. Cyclic ureas as dermal penetration enhancers

Also Published As

Publication number Publication date
EP0378657B1 (de) 1994-02-02
DE68912923D1 (de) 1994-03-17
JP2901297B2 (ja) 1999-06-07
EP0378657A1 (de) 1990-07-25
JPH03500298A (ja) 1991-01-24
US4960771A (en) 1990-10-02
WO1990000407A1 (en) 1990-01-25

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Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER INHABER IST ZU AENDERN IN: THERAPEUTIC PATCH RESEARCH N.V., NEW YORK, NEW YORK, US

8381 Inventor (new situation)

Free format text: RAJADHYAKSHA, VITHAL J., ARLINGTON, TEXAS 76017, US

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee