DE68916512T2 - Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung. - Google Patents

Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung.

Info

Publication number
DE68916512T2
DE68916512T2 DE68916512T DE68916512T DE68916512T2 DE 68916512 T2 DE68916512 T2 DE 68916512T2 DE 68916512 T DE68916512 T DE 68916512T DE 68916512 T DE68916512 T DE 68916512T DE 68916512 T2 DE68916512 T2 DE 68916512T2
Authority
DE
Germany
Prior art keywords
composition
reducing post
operative adhesions
adhesions
operative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916512T
Other languages
English (en)
Other versions
DE68916512D1 (de
Inventor
Raymond L Henry
Richard E Leach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MDV Technologies Inc
Original Assignee
Mediventures Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediventures Inc filed Critical Mediventures Inc
Publication of DE68916512D1 publication Critical patent/DE68916512D1/de
Application granted granted Critical
Publication of DE68916512T2 publication Critical patent/DE68916512T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE68916512T 1988-11-16 1989-11-15 Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung. Expired - Fee Related DE68916512T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/272,199 US4911926A (en) 1988-11-16 1988-11-16 Method and composition for reducing postsurgical adhesions

Publications (2)

Publication Number Publication Date
DE68916512D1 DE68916512D1 (de) 1994-08-04
DE68916512T2 true DE68916512T2 (de) 1994-10-27

Family

ID=23038822

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916512T Expired - Fee Related DE68916512T2 (de) 1988-11-16 1989-11-15 Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung.

Country Status (9)

Country Link
US (2) US4911926A (de)
EP (1) EP0369764B1 (de)
JP (1) JPH0647549B2 (de)
KR (1) KR900007425A (de)
AU (1) AU616065B2 (de)
CA (1) CA2003009C (de)
DE (1) DE68916512T2 (de)
DK (1) DK173130B1 (de)
PH (1) PH26319A (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
SE8900586L (sv) * 1989-02-21 1990-08-22 Pharmacia Ab Komposition och foerfarande foer att foerhindra adhesion mellan kroppsvaevnader
US5593683A (en) * 1990-05-01 1997-01-14 Mdv Technologies, Inc. Method of making thermoreversible polyoxyalkylene gels
CA2040460C (en) * 1990-05-01 1997-06-10 Tacey X. Viegas Drug delivery with thermoreversible gels
US5346703A (en) 1990-08-07 1994-09-13 Mediventures, Inc. Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5143731A (en) * 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
CA2114290C (en) * 1993-01-27 2006-01-10 Nagabushanam Totakura Post-surgical anti-adhesion device
US6004547A (en) 1997-09-29 1999-12-21 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
DE69414558T2 (de) * 1993-03-23 1999-07-15 Focal Inc Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe
US5505952A (en) * 1994-04-19 1996-04-09 United States Surgical Corporation Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom
US5498613A (en) * 1994-06-07 1996-03-12 The University Of Southern California Dipyridamole and analogs thereof in preventing adhesion formation
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US5562653A (en) * 1994-11-16 1996-10-08 Hercules Incorporated Medical devices composed of low ceiling temperature polymers
US5607686A (en) * 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
ATE244584T1 (de) * 1995-01-16 2003-07-15 Baxter Int Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US5985383A (en) * 1995-03-15 1999-11-16 Acushnet Company Conforming shoe construction and gel compositions therefor
US5955159A (en) * 1995-03-15 1999-09-21 Acushnet Company Conforming shoe construction using gels and method of making the same
US5939157A (en) * 1995-10-30 1999-08-17 Acushnet Company Conforming shoe construction using gels and method of making the same
JP3145409B2 (ja) * 1995-03-24 2001-03-12 フォーカル， インコーポレイテッド 活性酸素阻害剤の制御送達を用いる癒着の低減
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6551610B2 (en) 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
US6150581A (en) * 1995-06-07 2000-11-21 United States Surgical Corporation Chitosan/alginate anti-adhesion barrier
US5843470A (en) * 1995-10-06 1998-12-01 Mdv Technologies, Inc. Method and composition for inhibiting post-surgical adhesions
AU1526497A (en) * 1995-10-06 1998-07-31 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5766704A (en) * 1995-10-27 1998-06-16 Acushnet Company Conforming shoe construction and gel compositions therefor
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
US6280745B1 (en) * 1997-12-23 2001-08-28 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US5711958A (en) * 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
AU3720097A (en) 1996-07-12 1998-02-09 Baxter International Inc. A fibrin delivery device and method for forming fibrin on a surface
EP0887076A3 (de) * 1997-05-07 1999-03-31 Saturnus A.G. Verhinderung von Gewebeverklebung und ein dafür vorgesehenes endoskopisches System zum Aufblasen einer Körperhöhle
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
CA2316248A1 (en) * 1997-12-23 1999-07-01 Alliance Pharmaceutical Corp. Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
TR200200616T2 (tr) 1999-09-11 2002-06-21 The Procter & Gamble Company Dökülebilir sıvı araçları
US20030202958A1 (en) * 1999-10-15 2003-10-30 Strickland Alan D. Dialysis solution including polyglycol osmotic agent
ES2491866T3 (es) * 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH
AU778318B2 (en) * 2000-02-03 2004-11-25 Tissuemed Limited Device for the closure of a surgical puncture
US6224898B1 (en) * 2000-03-23 2001-05-01 The United States Of America As Represented By The Secretary Of The Army Antimicrobial dendrimer nanocomposites and a method of treating wounds
DK1328300T3 (da) * 2000-10-23 2005-03-21 Tissuemed Ltd Selvklæbende hydratiserbar matrix til topisk terapeutisk anvendelse
CA2429168C (en) * 2000-11-15 2010-06-08 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
US6989373B2 (en) * 2000-11-15 2006-01-24 Bio Syntech Canada Inc. Method for restoring a fat-pad
US20020172712A1 (en) * 2001-03-19 2002-11-21 Alan Drizen Antiemetic, anti-motion sustained release drug delivery system
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7138133B2 (en) * 2001-10-10 2006-11-21 The Procter & Gamble Company Orally administered liquid compositions
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
WO2004039415A2 (en) 2002-10-28 2004-05-13 Northgate Technologies Inc. Dual-capacity insufflator tube
AU2004226578A1 (en) * 2003-04-04 2004-10-14 Tissuemed Limited Tissue-adhesive formulations
US7654975B2 (en) 2003-04-24 2010-02-02 Northgate Technologies, Inc. Mixed-gas insufflation system
WO2005035035A1 (en) 2003-10-07 2005-04-21 Northgate Technologies Inc. System and method for delivering a substance to a body cavity
EP1680173B1 (de) 2003-10-31 2011-01-12 Trudell Medical International System zur manipulierung eines katheters für die ablage einer substanz in einer körperhöhle
US20050171002A1 (en) * 2004-02-03 2005-08-04 Mohanty Dillip K. Polyoxyalkylene compound and method for making
EP1793873B1 (de) * 2004-08-03 2013-08-07 Tissuemed Limited Gewebekleber
US20060045866A1 (en) * 2004-09-01 2006-03-02 Chris Chappelow Novel high purity and high molecular weight mPEG alcohol compositions
US7199193B2 (en) * 2004-09-28 2007-04-03 Dow Global Technologies, Inc. Polyethylene glycol compounds and process of making
JP4975627B2 (ja) 2004-10-07 2012-07-11 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー 医療用途のための多糖ベースのポリマー組織接着剤
US7824919B2 (en) * 2005-03-04 2010-11-02 Dr. Reddy's Laboratories Limited Method for analyzing activated polyethylene glycol compounds
US7850810B2 (en) 2005-07-29 2010-12-14 Gore Enterprise Holdings, Inc. Method of making porous self-cohered web materials
EP1978975B1 (de) * 2006-02-01 2014-12-24 Samyang Biopharmaceuticals Corporation Zusammensetzung zur hemmung von adhäsion
CA2640629A1 (en) 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
US8062282B2 (en) * 2006-02-13 2011-11-22 Fossa Medical, Inc. Methods and apparatus for temporarily occluding body openings
JP2009528430A (ja) * 2006-02-28 2009-08-06 ダウ グローバル テクノロジーズ インコーポレイティド ポリエチレングリコールカーボネートの製造方法
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
US8197499B2 (en) * 2006-06-21 2012-06-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
US8608760B2 (en) * 2006-06-21 2013-12-17 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
CA2656179A1 (en) * 2006-06-21 2007-12-27 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for joining non-conjoined lumens
CA2933737C (en) 2006-08-04 2020-12-29 Northgate Technologies Inc. In-dwelling port for access into a body
US20090035249A1 (en) * 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
EP2224968A2 (de) * 2007-12-20 2010-09-08 Tautona Group, L.P. Zusammensetzungen und verfahren zur verbindung nicht untereinander verbundener lumen
EP2095832A1 (de) * 2008-02-28 2009-09-02 Bayer MaterialScience AG Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile.
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
EP2349357B1 (de) * 2008-11-19 2012-10-03 Actamax Surgical Materials LLC Hydrogel-gewebeklebstoff aus aminiertem polysaccharid und aldehyd-funktionalisiertem mehrarmigen polyether
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
US8563037B2 (en) * 2009-02-06 2013-10-22 Tautona Group, L.P. Compositions and methods for joining non-conjoined lumens
US8409606B2 (en) * 2009-02-12 2013-04-02 Incept, Llc Drug delivery through hydrogel plugs
EP2416811B1 (de) 2009-04-09 2015-09-09 Actamax Surgical Materials LLC Hydrogel-gewebekleber mit verringerter zerfallszeit
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US8778326B2 (en) 2009-07-02 2014-07-15 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2012052527A1 (en) 2010-10-20 2012-04-26 Dsm Ip Assets B.V. Pendant hydrophile bearing biodegradable compositions and related devices
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP2612846A1 (de) 2012-01-09 2013-07-10 Bayer MaterialScience AG Beta-Aminosäureester und deren Verwendung
RU2499613C1 (ru) * 2012-08-14 2013-11-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Северный государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации Способ консервативного лечения спаечной болезни брюшины
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US20160184474A1 (en) 2013-07-29 2016-06-30 Actamax Surgical Materials, Llc Low swell tissue adhesive and sealant formulations
US9572595B1 (en) 2014-03-05 2017-02-21 Northgate Technologies Inc. In-dwelling port for access into a body
US10695351B2 (en) * 2018-07-30 2020-06-30 Harrow Ip, Llc Pharmaceutical formulations for the treatment of dry eye and methods for fabricating and using thereof

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128245C (de) * 1951-05-31
US2674619A (en) * 1953-10-19 1954-04-06 Wyandotte Chemicals Corp Polyoxyalkylene compounds
US2979528A (en) * 1953-10-19 1961-04-11 Wyandotte Chemicals Corp Nitrogen-containing polyoxyalkylene detergent compositions
US3036118A (en) * 1957-09-11 1962-05-22 Wyandotte Chemicals Corp Mixtures of novel conjugated polyoxyethylene-polyoxypropylene compounds
NL130291C (de) * 1964-01-02
US3740421A (en) * 1966-09-19 1973-06-19 Basf Wyandotte Corp Polyoxyethylene-polyoxypropylene aqueous gels
US3639575A (en) * 1968-06-19 1972-02-01 Basf Wyandotte Corp Silver ion gel compositions and method of using the same
US3641240A (en) * 1968-09-27 1972-02-08 Wyandotte Chemicals Corp Method for the treatment of an embolus or thrombus
US3867533A (en) * 1968-12-20 1975-02-18 Basf Wyandotte Corp Preparation of aqueous gel compositions containing a water-insoluble organic ingredient
US3590125A (en) * 1969-10-10 1971-06-29 Wyandotte Chemicals Corp Physiological salt solutions of ethylene oxide-polypropylene glycol condensation products as blood plasma substitutes
US3867521A (en) * 1970-08-26 1975-02-18 Scherer Corp R P Method for absorption of drugs
US3829506A (en) * 1971-06-01 1974-08-13 Basf Wyandotte Corp Biodegradable surface active agents having good foam properties and foam stabilizing characteristics
US3847155A (en) * 1972-01-26 1974-11-12 O Bernaola Methods for the elimination of scars using copolymer films in place of surgical sutures
US4076799A (en) * 1972-12-27 1978-02-28 Cincinnati Milacron, Inc. Method of inhibiting skin irritation
US4188373A (en) * 1976-02-26 1980-02-12 Cooper Laboratories, Inc. Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
US4043344A (en) * 1976-09-20 1977-08-23 American Cyanamid Company Non-absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4047533A (en) * 1976-09-20 1977-09-13 American Cyanamid Company Absorbable surgical sutures coated with polyoxyethylene-polyoxypropylene copolymer lubricant
US4465663A (en) * 1981-07-27 1984-08-14 Basf Wyandotte Corporation Polyoxybutylene-polyoxyethylene aqueous gels
US4360451A (en) * 1981-08-10 1982-11-23 Basf Wyandotte Corporation Amphoteric surfactant gels
US4767619A (en) * 1981-09-14 1988-08-30 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence Of Her Majesty's Canadian Government Burn wound dressing material
US4439196A (en) * 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
DE3234084A1 (de) * 1982-09-14 1984-03-15 B. Braun Melsungen Ag, 3508 Melsungen Pharmazeutische zubereitungen zur behandlung von unerwuenschten verwachsungen sowie deren verwendung
US4474753A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Topical drug delivery system utilizing thermosetting gels
US4474752A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4478822A (en) * 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US4511563A (en) * 1983-07-15 1985-04-16 Basf Wyandotte Corporation Clear analgesic gels with reduced tackiness
US4495169A (en) * 1983-08-22 1985-01-22 Basf Wyandotte Corporation Aerosol gel shaving cream
US4495168A (en) * 1983-08-22 1985-01-22 Basf Wyandotte Corporation Aerosol gel
US4540407A (en) * 1983-11-14 1985-09-10 Dunn Robert N Surgical gloves and surface treatment of surgical gloves for avoiding starch peritonitis and the like
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
US4889722A (en) * 1985-12-16 1989-12-26 Ethicon, Inc. Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
US4651736A (en) * 1986-02-01 1987-03-24 Bruce Sanders Methods for temporomandibular joint small incision surgery
US4879109A (en) * 1986-05-15 1989-11-07 Emory University Method for treating burns
US4810503A (en) * 1987-03-31 1989-03-07 Basf Corporation Polymers which form gels at low concentrations in water
US5068225A (en) * 1987-05-04 1991-11-26 Mdr Group, Inc. Viscoelastic fluid for use in surgery and other therapies and method of using same
US4883660A (en) * 1988-10-17 1989-11-28 Thames Pharmacal Co., Inc. Gel bases for pharmaceutical compositions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5124151A (en) * 1990-08-07 1992-06-23 Mediventures Inc. Drug delivery by injection with thermo-irreversible gels
US5143731A (en) * 1990-08-07 1992-09-01 Mediventures Incorporated Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels
US5071644A (en) * 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels

Also Published As

Publication number Publication date
DE68916512D1 (de) 1994-08-04
US5366735A (en) 1994-11-22
EP0369764A2 (de) 1990-05-23
JPH02200638A (ja) 1990-08-08
PH26319A (en) 1992-04-29
DK173130B1 (da) 2000-01-31
DK571389D0 (da) 1989-11-15
EP0369764B1 (de) 1994-06-29
CA2003009A1 (en) 1990-05-16
KR900007425A (ko) 1990-06-01
AU616065B2 (en) 1991-10-17
CA2003009C (en) 2000-05-02
JPH0647549B2 (ja) 1994-06-22
EP0369764A3 (de) 1991-08-28
US4911926A (en) 1990-03-27
DK571389A (da) 1990-05-17
AU4441689A (en) 1990-05-24

Similar Documents

Publication Publication Date Title
DE68916512T2 (de) Zusammensetzung zur Verminderung von postoperativen Adhäsionen und ihre Verwendung.
ATE107130T1 (de) Zusammensetzung und ihre verwendung.
DE3787590D1 (de) Polytetrafluoraethylenhaltige beschichtungsmasse und ihre verwendung.
DE3578961D1 (de) Vernetzte glykosaminoglykane und ihre verwendung.
DE69115182D1 (de) Polymerzusammensetzung und ihre Verwendung.
DE69106689T2 (de) Umkehrlackierungsverfahrenzusammensetzungen und ihre Verwendung.
DE68903665D1 (de) Balg-pipette und ihre verwendung.
DE69026570T2 (de) Wässrige Polyurethanzusammensetzung und ihre Verwendung
DE267674T1 (de) Zusammensetzungen zur verhinderung von inkrustierungen und deren verwendungen.
DE69100620T2 (de) Schmiermittelzusammensetzung und ihre Verwendung.
DE69432590D1 (de) 1,2,3,4-tetrahydrochinolin-2,3,4-trion-3 oder 4-oxime und ihre verwendung
DE59408857D1 (de) Vorrichtung zur kontinuierlichen Herstellung von Polyacetalen und ihre Verwendung
DE69016606T2 (de) Zusammensetzungen zur kontrollierten Haftverminderung und ihre Verwendung.
DE69009204T2 (de) Hydroxyperoxide und ihre Verwendung.
DE68925335T2 (de) Harzzusammensetzung und ihre Verwendung
DE69416983D1 (de) Zederpollen-Proteine und ihre Verwendung
DE3888608T2 (de) Einbettzusammensetzung und ihre Verwendung.
DE69021162D1 (de) Substituierte Dibenzonfurane und ihre Verwendung.
DE69122469D1 (de) Harzzusammensetzung und ihre Verwendung
DE69007931D1 (de) Akarizide zusammensetzung und ihre verwendung in der befallsbekämpfung.
DE68909694D1 (de) Polymerische Zusammensetzungen und ihre Anwendung für Behälterverschlüsse.
DE68917616T2 (de) Demulgator-Zusammensetzungen und Herstellungsmethode und Verwendung.
DE69427972D1 (de) Polymerzusammensetzungen enthaltende streckmittel und ihre verwendung
DE3583396D1 (de) Einrichtung zur simultanen aktivierung von befehlsfolgen und ihre verwendung in speichern.
DE69007867D1 (de) 1-Phenylcyclohexylperoxyneoalkanoate und ihre Verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MDV TECHNOLOGIES, INC. (N.D. GES. D. STAATES DELAW

8339 Ceased/non-payment of the annual fee