DE68917336T2 - Verfahren zur Herstellung von Trans-6-[2-(substituierte pyrol-1-yl)alkyl]pyran-2-on als Cholesterolsynthesehemmer. - Google Patents

Verfahren zur Herstellung von Trans-6-[2-(substituierte pyrol-1-yl)alkyl]pyran-2-on als Cholesterolsynthesehemmer.

Info

Publication number
DE68917336T2
DE68917336T2 DE68917336T DE68917336T DE68917336T2 DE 68917336 T2 DE68917336 T2 DE 68917336T2 DE 68917336 T DE68917336 T DE 68917336T DE 68917336 T DE68917336 T DE 68917336T DE 68917336 T2 DE68917336 T2 DE 68917336T2
Authority
DE
Germany
Prior art keywords
trans
pyran
preparation
oxo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68917336T
Other languages
English (en)
Other versions
DE68917336D1 (de
Inventor
Donald Eugene Butler
Carl Francis Deering
Alan Millar
Thomas Norman Nanninga
Bruce David Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26855024&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68917336(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE68917336D1 publication Critical patent/DE68917336D1/de
Application granted granted Critical
Publication of DE68917336T2 publication Critical patent/DE68917336T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DE68917336T 1988-02-22 1989-02-22 Verfahren zur Herstellung von Trans-6-[2-(substituierte pyrol-1-yl)alkyl]pyran-2-on als Cholesterolsynthesehemmer. Expired - Lifetime DE68917336T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15843988A 1988-02-22 1988-02-22
US07/303,733 US5003080A (en) 1988-02-22 1989-02-01 Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis

Publications (2)

Publication Number Publication Date
DE68917336D1 DE68917336D1 (de) 1994-09-15
DE68917336T2 true DE68917336T2 (de) 1994-12-01

Family

ID=26855024

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68917336T Expired - Lifetime DE68917336T2 (de) 1988-02-22 1989-02-22 Verfahren zur Herstellung von Trans-6-[2-(substituierte pyrol-1-yl)alkyl]pyran-2-on als Cholesterolsynthesehemmer.

Country Status (16)

Country Link
US (1) US5003080A (de)
EP (2) EP0448552A1 (de)
JP (2) JP2843627B2 (de)
KR (1) KR970011578B1 (de)
AT (1) ATE109777T1 (de)
AU (2) AU634689B2 (de)
CA (1) CA1330441C (de)
DE (1) DE68917336T2 (de)
DK (1) DK175135B1 (de)
ES (1) ES2058356T3 (de)
FI (2) FI94958C (de)
HK (1) HK1000732A1 (de)
IE (1) IE63994B1 (de)
NZ (1) NZ228050A (de)
PT (1) PT89774B (de)
WO (1) WO1989007598A2 (de)

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FI941550A (fi) 1994-04-05
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WO1989007598A3 (en) 1989-11-02
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ES2058356T3 (es) 1994-11-01
DE68917336D1 (de) 1994-09-15
PT89774A (pt) 1989-10-04
AU1601892A (en) 1992-07-09
FI94958B (fi) 1995-08-15
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ATE109777T1 (de) 1994-08-15
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CA1330441C (en) 1994-06-28
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DK175135B1 (da) 2004-06-14
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JPH03502798A (ja) 1991-06-27
PT89774B (pt) 1994-03-31
KR900700478A (ko) 1990-08-13
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US5003080A (en) 1991-03-26
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