DE68925067D1 - Metalloporphyrinderivate, ihre Herstellung, ihre therapeutische Anwendung und ihre Anwendung zur Herstellung von hybridischen Molekülen - Google Patents

Metalloporphyrinderivate, ihre Herstellung, ihre therapeutische Anwendung und ihre Anwendung zur Herstellung von hybridischen Molekülen

Info

Publication number
DE68925067D1
DE68925067D1 DE68925067T DE68925067T DE68925067D1 DE 68925067 D1 DE68925067 D1 DE 68925067D1 DE 68925067 T DE68925067 T DE 68925067T DE 68925067 T DE68925067 T DE 68925067T DE 68925067 D1 DE68925067 D1 DE 68925067D1
Authority
DE
Germany
Prior art keywords
production
application
pct
linear
hybrid molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68925067T
Other languages
English (en)
Inventor
Bernard Meunier
Guita Etemad-Moghadam
Li Ding
Suzy Cros
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of DE68925067D1 publication Critical patent/DE68925067D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/04—Nickel compounds
    • C07F15/045—Nickel compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C07F19/005—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00 without metal-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/06—Zinc compounds
DE68925067T 1988-06-02 1989-06-02 Metalloporphyrinderivate, ihre Herstellung, ihre therapeutische Anwendung und ihre Anwendung zur Herstellung von hybridischen Molekülen Expired - Lifetime DE68925067D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8807372A FR2632187B1 (fr) 1988-06-02 1988-06-02 Derives de metalloporphyrines, leur preparation, leur application en therapeutique et leur utilisation pour la preparation de molecules hybrides

Publications (1)

Publication Number Publication Date
DE68925067D1 true DE68925067D1 (de) 1996-01-25

Family

ID=9366884

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68925067T Expired - Lifetime DE68925067D1 (de) 1988-06-02 1989-06-02 Metalloporphyrinderivate, ihre Herstellung, ihre therapeutische Anwendung und ihre Anwendung zur Herstellung von hybridischen Molekülen

Country Status (10)

Country Link
US (1) US5236914A (de)
EP (1) EP0345171B1 (de)
JP (1) JPH03504725A (de)
AT (1) ATE131481T1 (de)
AU (1) AU3832789A (de)
CA (1) CA1333602C (de)
DE (1) DE68925067D1 (de)
FR (1) FR2632187B1 (de)
WO (1) WO1989012049A1 (de)
ZA (1) ZA894185B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2656866B1 (fr) * 1990-01-10 1992-05-15 Cis Bio Int Derives de porphyrine et metalloporphyrines eventuellement couples a une molecule biologiquement active, et composition pharmaceutique les contenant.
FR2697254A1 (fr) * 1992-10-22 1994-04-29 Genset Sa Conjugués constitués par un oligonucléotide lié à des dérivés de métalloporphyrine cationique, leur préparation et leur utilisation.
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
AU3758695A (en) * 1994-09-20 1996-04-09 Duke University Oxidoreductase activity of manganic porphyrins
DE69635304T2 (de) * 1995-06-07 2006-07-20 Duke University Faenger fuer oxidantien
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US6620805B1 (en) * 1996-03-14 2003-09-16 Yale University Delivery of nucleic acids by porphyrins
CA2283057A1 (en) * 1997-02-05 1998-08-06 Board Of Regents, The University Of Texas System Porphyrin compounds as telomerase inhibitors
DE19743903A1 (de) * 1997-07-16 1999-04-15 Deutsch Zentr Luft & Raumfahrt Verwendung von metallierten und/oder unmetallierten polymergebundenen Porphyrinen
ES2198767T3 (es) 1997-11-03 2004-02-01 Duke University Porfirinas sustituidas.
JP4648542B2 (ja) 1998-04-24 2011-03-09 デューク ユニバーシティ 置換ポルフィリン
DE19840608A1 (de) * 1998-09-05 2000-03-09 Dlr Ev Metallierte oder unmetallierte Phthalocyanine
IL126953A0 (en) 1998-11-08 1999-09-22 Yeda Res & Dev Pharmaceutical compositions comprising porphyrins and some novel porphyrin derivatives
MXPA01007451A (es) 1999-01-25 2004-03-10 Nat Jewish Med & Res Center Porfirinas sustituidas.
US6403788B1 (en) * 2000-07-11 2002-06-11 Eukarion, Inc. Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species
DK1392328T3 (da) * 2001-01-19 2009-11-09 Nat Jewish Health Medikament til beskyttelse i radioterapi
EP1439842A4 (de) 2001-06-01 2009-09-02 Nat Jewish Med & Res Center Oxidantienfänger zur behandlung von diabetes oder zur verwendung bei der transplantation oder induktion von immuntoleranz
EP1513537A4 (de) * 2002-06-07 2006-09-06 Univ Duke Substituierte porphyrine
ITFI20020200A1 (it) * 2002-10-21 2004-04-22 Molteni & C Dei Flii Alitti S P A Societa L Porfirine meso-sostituite.
GB2397067B (en) * 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
GB0602125D0 (en) * 2006-02-03 2006-03-15 Univ Belfast Sensitizer-incorporated biomaterials
ES2600469T3 (es) 2008-05-23 2017-02-09 National Jewish Health Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro
FR2935974B1 (fr) * 2008-09-15 2010-10-08 Centre Nat Rech Scient Derives de metalloporphyrines, nanoparticules les comprenant
FR2988721B1 (fr) 2012-03-27 2014-04-04 Centre Nat Rech Scient Nanoparticules de silicium poreux fonctionnalisees et leurs utilisations en therapie photodynamique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2740794A (en) * 1954-07-26 1956-04-03 Exxon Research Engineering Co Synthesis of novel vanadium porphyrin
US4386087A (en) * 1981-07-01 1983-05-31 Research Foundation Of The City University Of New York N-Substituted metalloporphyrins as anti-tumor agents against PS-P-388(P388) leukemia in animals
JPS60126291A (ja) * 1983-03-14 1985-07-05 Koichi Shiyudo ポルフイリン誘導体
DE3464252D1 (en) * 1983-06-03 1987-07-23 Hoffmann La Roche Labelled molecules for fluorescence immunoassays and processes and intermediates for their preparation
GB8429845D0 (en) * 1984-11-26 1985-01-03 Efamol Ltd Porphyrins & cancer treatment

Also Published As

Publication number Publication date
FR2632187B1 (fr) 1990-09-14
EP0345171A1 (de) 1989-12-06
WO1989012049A1 (fr) 1989-12-14
JPH03504725A (ja) 1991-10-17
AU3832789A (en) 1990-01-05
EP0345171B1 (de) 1995-12-13
CA1333602C (fr) 1994-12-20
ATE131481T1 (de) 1995-12-15
FR2632187A1 (fr) 1989-12-08
ZA894185B (en) 1990-02-28
US5236914A (en) 1993-08-17

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