DE68926269D1 - Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge - Google Patents

Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge

Info

Publication number
DE68926269D1
DE68926269D1 DE68926269T DE68926269T DE68926269D1 DE 68926269 D1 DE68926269 D1 DE 68926269D1 DE 68926269 T DE68926269 T DE 68926269T DE 68926269 T DE68926269 T DE 68926269T DE 68926269 D1 DE68926269 D1 DE 68926269D1
Authority
DE
Germany
Prior art keywords
analogs
pharmaceutical compositions
manufacturing process
therapeutic treatment
dermorphin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68926269T
Other languages
English (en)
Other versions
DE68926269T2 (de
Inventor
Peter W Schiller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of DE68926269D1 publication Critical patent/DE68926269D1/de
Publication of DE68926269T2 publication Critical patent/DE68926269T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE68926269T 1988-06-30 1989-06-30 Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge Expired - Fee Related DE68926269T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA570874 1988-06-30

Publications (2)

Publication Number Publication Date
DE68926269D1 true DE68926269D1 (de) 1996-05-23
DE68926269T2 DE68926269T2 (de) 1996-08-14

Family

ID=4138301

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926269T Expired - Fee Related DE68926269T2 (de) 1988-06-30 1989-06-30 Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge

Country Status (8)

Country Link
US (1) US5312899A (de)
EP (1) EP0350221B1 (de)
AT (1) ATE136905T1 (de)
DE (1) DE68926269T2 (de)
ES (1) ES2085865T3 (de)
GR (1) GR3020139T3 (de)
HK (1) HK22797A (de)
SG (1) SG64368A1 (de)

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US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
JPH09505555A (ja) * 1993-08-13 1997-06-03 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシーズ ＴＧＦ−βの活性を刺激および阻害する方法および組成物
SE9503924D0 (sv) * 1995-08-18 1995-11-07 Astra Ab Novel opioid peptides
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
AU2001277908A1 (en) * 2000-07-18 2002-01-30 Cornell Research Foundation Inc. Medicinal uses of mu-opioid receptor agonists
US7316819B2 (en) 2001-03-08 2008-01-08 Unigene Laboratories, Inc. Oral peptide pharmaceutical dosage form and method of production
US7401046B2 (en) * 2001-07-25 2008-07-15 Chicago Board Options Exchange System and method for displaying option market information
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
PT2656854E (pt) * 2003-02-04 2015-09-03 Cornell Res Foundation Inc Utilizações de péptido aromático catiónico
CN1767831B (zh) 2003-04-08 2014-12-10 普罗热尼奇制药公司 包含甲基纳曲酮的药物配方
NZ543410A (en) * 2003-05-01 2008-07-31 Cornell Res Foundation Inc Carrier complexes comprising at least one molecule and an aromatic cationic peptide that can cross cell membranes by an energy-independent mechanism and deliver the molecules inside the cell
EP1758927A4 (de) * 2004-01-21 2008-09-17 Unigene Lab Inc Amidierte parathyroidhormonfragmente und verwendungen davon
KR101159254B1 (ko) * 2004-01-23 2012-06-26 코넬 리서치 화운데이션,인크. 산화성 손상을 저감하는 방법
US20050282756A1 (en) * 2004-06-18 2005-12-22 Mehta Nozer M Oral delivery of peptide pharmaceutical compositions
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP3095454A1 (de) 2005-09-16 2016-11-23 Cornell Research Foundation, Inc. Aromatisch-kationisches peptid zur verwendung in einem verfahren zur reduzierung der cd36-expression
US20100279944A1 (en) * 2006-03-30 2010-11-04 Ronald Mathison Suppression and treatment of neuropathic pain
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
JP2010522756A (ja) * 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
TWI553009B (zh) * 2007-03-29 2016-10-11 普吉尼製藥公司 末梢性類鴉片受體拮抗劑及其用途
EP2139890B1 (de) 2007-03-29 2014-06-25 Wyeth LLC Peripherer opioid-rezeptor antagonisten und verwendungen davon
EP2240489A1 (de) * 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. HERSTELLUNG UND VERWENDUNG VON (R), (R)-2,2ýBIS-METHYLNALTREXON
EP2902036A1 (de) 2008-02-07 2015-08-05 Cornell University Verfahren zur Vorbeugung oder Behandlung von Insulinresistenz
WO2009108695A2 (en) 2008-02-26 2009-09-03 Cornell University Methods for prevention and treatment of acute renal injury
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
JP2012521355A (ja) * 2009-03-20 2012-09-13 ザ ジェネラル ホスピタル コーポレイション ディー ビー エイ マサチューセッツ ジェネラル ホスピタル 熱傷及び二次性合併症の予防及び治療方法
JP5909182B2 (ja) * 2009-08-12 2016-04-26 コーネル ユニヴァーシティー 代謝性症候群を予防し又は治療するための方法
EP3708178B1 (de) * 2009-08-24 2023-10-04 Stealth BioTherapeutics Inc. Peptid zur verwendung bei der vorbeugung oder behandlung von makula degenerationugenleiden
EP3120860B1 (de) * 2009-10-05 2019-06-26 Cornell University Verfahren zur prävention und behandlung von herzinsuffizienz
CN107496899A (zh) 2011-09-29 2017-12-22 梅约医学教育与研究基金会 芳族阳离子肽和使用它们的方法
JP7038675B2 (ja) * 2016-03-11 2022-03-18 ステルス バイオセラピューティクス インコーポレイテッド 結晶塩形態
CN110914287A (zh) 2017-04-05 2020-03-24 隐形生物治疗公司 Boc-d-arg-dmt-lys-(boc)-phe-nh2的结晶盐形式
US10278957B2 (en) 2017-09-11 2019-05-07 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
PL439243A1 (pl) * 2021-10-18 2023-04-24 Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk Nowy analog dermorfiny jako lek przeciwbólowy do stosowania w leczeniu bólu przewlekłego

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (nl) * 1979-09-20 1981-03-24 Erba Farmitalia Biologisch actieve peptiden.
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
DE3435727A1 (de) * 1984-09-28 1986-04-10 Victor Dipl.-Chem. Dr.med. 6200 Wiesbaden Brantl Pharmakologisch aktive peptide

Also Published As

Publication number Publication date
ATE136905T1 (de) 1996-05-15
SG64368A1 (en) 1999-04-27
EP0350221B1 (de) 1996-04-17
HK22797A (en) 1997-02-27
EP0350221A2 (de) 1990-01-10
DE68926269T2 (de) 1996-08-14
ES2085865T3 (es) 1996-06-16
GR3020139T3 (en) 1996-08-31
US5312899A (en) 1994-05-17
EP0350221A3 (en) 1990-09-12

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee