DE69006236T2 - Stabilisierung von Polyprenylverbindungen. - Google Patents

Stabilisierung von Polyprenylverbindungen.

Info

Publication number
DE69006236T2
DE69006236T2 DE69006236T DE69006236T DE69006236T2 DE 69006236 T2 DE69006236 T2 DE 69006236T2 DE 69006236 T DE69006236 T DE 69006236T DE 69006236 T DE69006236 T DE 69006236T DE 69006236 T2 DE69006236 T2 DE 69006236T2
Authority
DE
Germany
Prior art keywords
stabilization
polyprenyl compounds
polyprenyl
amino acid
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69006236T
Other languages
English (en)
Other versions
DE69006236D1 (de
Inventor
Keizo Uesugi
Nobutaka Noda
Michiru Tanaka
Masanori Kayano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1065384A external-priority patent/JP2928261B2/ja
Priority claimed from JP6538589A external-priority patent/JP2812977B2/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE69006236D1 publication Critical patent/DE69006236D1/de
Application granted granted Critical
Publication of DE69006236T2 publication Critical patent/DE69006236T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
DE69006236T 1989-03-17 1990-03-05 Stabilisierung von Polyprenylverbindungen. Expired - Fee Related DE69006236T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1065384A JP2928261B2 (ja) 1989-03-17 1989-03-17 安定なポリプレニル系化合物含有組成物の製法
JP6538589A JP2812977B2 (ja) 1989-03-17 1989-03-17 ポリプレニル系化合物含有硬カプセル剤の製造方法

Publications (2)

Publication Number Publication Date
DE69006236D1 DE69006236D1 (de) 1994-03-10
DE69006236T2 true DE69006236T2 (de) 1994-07-07

Family

ID=26406534

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69006236T Expired - Fee Related DE69006236T2 (de) 1989-03-17 1990-03-05 Stabilisierung von Polyprenylverbindungen.

Country Status (10)

Country Link
US (1) US5304381A (de)
EP (1) EP0387655B1 (de)
KR (1) KR920005812B1 (de)
AT (1) ATE100709T1 (de)
DE (1) DE69006236T2 (de)
DK (1) DK0387655T3 (de)
ES (1) ES2062133T3 (de)
FI (1) FI901046A0 (de)
NO (1) NO178137C (de)
PH (1) PH26952A (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW523816B (en) 2000-06-16 2003-03-11 Gen Semiconductor Inc Semiconductor trench device with enhanced gate oxide integrity structure
CN111971036A (zh) * 2018-07-30 2020-11-20 第一三共株式会社 含有稳定剂的固体药物制剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH433944A (de) * 1962-12-17 1967-04-15 Hoffmann La Roche Präparat zur Vitaminierung von Lebens- und Futtermitteln und Verfahren zu dessen Herstellung
JPS5115094B2 (de) * 1972-11-01 1976-05-14
JPS5815940A (ja) * 1981-07-23 1983-01-29 Eisai Co Ltd ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
JPS5832873A (ja) * 1981-08-20 1983-02-25 Eisai Co Ltd ポリプレニルアミド系化合物含有組成物
DE3201511A1 (de) * 1982-01-20 1983-07-28 Henkel Kgaa Sebosuppressive kosmetische mittel, welche laengerkettige alkanole und antioxidantien enthalten
DE3486029T2 (de) * 1983-10-14 1993-05-13 Sumitomo Pharma Ifn-praeparat mit verzoegerter abgabe fuer parentale verabreichung.
US4711894A (en) * 1986-01-16 1987-12-08 Henkel Corporation Stabilized tocopherol in dry, particulate, free-flowing form
FI96169C (fi) * 1989-07-10 1996-05-27 Eisai Co Ltd Menetelmä polyprenyyliyhdistettä sisältävän farmaseuttisen koostumuksen valmistamiseksi

Also Published As

Publication number Publication date
EP0387655A3 (de) 1991-06-05
ATE100709T1 (de) 1994-02-15
ES2062133T3 (es) 1994-12-16
NO901209D0 (no) 1990-03-15
DE69006236D1 (de) 1994-03-10
KR920005812B1 (ko) 1992-07-20
FI901046A0 (fi) 1990-03-01
EP0387655B1 (de) 1994-01-26
US5304381A (en) 1994-04-19
KR900013957A (ko) 1990-10-22
NO178137C (no) 1996-01-31
DK0387655T3 (da) 1994-02-28
NO901209L (no) 1990-09-18
NO178137B (no) 1995-10-23
EP0387655A2 (de) 1990-09-19
PH26952A (en) 1992-12-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee