DE69012138T2 - Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten. - Google Patents
Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.Info
- Publication number
- DE69012138T2 DE69012138T2 DE69012138T DE69012138T DE69012138T2 DE 69012138 T2 DE69012138 T2 DE 69012138T2 DE 69012138 T DE69012138 T DE 69012138T DE 69012138 T DE69012138 T DE 69012138T DE 69012138 T2 DE69012138 T2 DE 69012138T2
- Authority
- DE
- Germany
- Prior art keywords
- spin
- trapping
- administration
- oxide
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/422,651 US5025032A (en) | 1989-10-17 | 1989-10-17 | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
US58917790A | 1990-09-27 | 1990-09-27 | |
PCT/US1990/005952 WO1991005552A1 (en) | 1989-10-17 | 1990-10-17 | Method and compositions for inhibition of disorders associated with oxidative damage |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69012138D1 DE69012138D1 (de) | 1994-10-06 |
DE69012138T2 true DE69012138T2 (de) | 1995-04-06 |
Family
ID=27025701
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69012138T Expired - Fee Related DE69012138T2 (de) | 1989-10-17 | 1990-10-17 | Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten. |
Country Status (12)
Country | Link |
---|---|
US (4) | US5405874A (de) |
EP (1) | EP0496796B1 (de) |
JP (5) | JP2620413B2 (de) |
KR (1) | KR960008230B1 (de) |
AT (1) | ATE110565T1 (de) |
AU (4) | AU653921B2 (de) |
CA (1) | CA2069961C (de) |
DE (1) | DE69012138T2 (de) |
DK (1) | DK0496796T3 (de) |
ES (1) | ES2044829T3 (de) |
HK (1) | HK1007281A1 (de) |
WO (1) | WO1991005552A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0496796B1 (de) * | 1989-10-17 | 1994-08-31 | Oklahoma Medical Research Foundation | Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten |
US5681845A (en) * | 1989-10-17 | 1997-10-28 | Oklahoma Medical Research Foundation | DMPO spin trapping compositions and methods of use thereof |
ATE209908T1 (de) * | 1991-06-18 | 2001-12-15 | Oklahoma Med Res Found | RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN |
US20050107366A1 (en) * | 1991-06-18 | 2005-05-19 | Carney John M. | Spin trapping pharmaceutical compositions and methods for use thereof |
US6002001A (en) * | 1991-06-18 | 1999-12-14 | Oklahoma Medical Research Foundation | Spin trapping pharmaceutical compositions and methods for use thereof |
NZ244268A (en) * | 1991-09-12 | 1994-09-27 | Merrell Pharma Inc | N-oxide quinoline derivatives and pharmaceutical compositions |
US5292746A (en) * | 1991-09-12 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock |
JPH0656669A (ja) * | 1992-06-11 | 1994-03-01 | Asahi Breweries Ltd | 活性酸素消去作用を持つプテリン誘導体製剤 |
EP0675892A1 (de) * | 1993-10-25 | 1995-10-11 | Oklahoma Medical Research Foundation | Neue phosphor-enthaltende radikalfänger-zusammensetzungen |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
FR2731428B1 (fr) * | 1995-03-06 | 1997-06-06 | Centre Nat Rech Scient | Derives phosphoryles de nitrones, leur procede de preparation et compositions les contenant |
CN1250528C (zh) * | 1995-09-11 | 2006-04-12 | 阿温蒂斯药物公司 | 环状硝酮和含有它们的药用组合物 |
ATE349420T1 (de) | 1995-11-17 | 2007-01-15 | Florida Internat University | Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung |
AU725432B2 (en) * | 1996-04-17 | 2000-10-12 | Centaur Pharmaceuticals, Inc. | Nitrone free radical trap treatment of dementia associated with AIDS virus (HIV-1) infection |
NZ332561A (en) * | 1996-04-23 | 2001-01-26 | Centaur Pharmaceuticals Inc | Compositions comprising a nitrone compound for use in treating ocular inflammation |
US5900227A (en) * | 1996-06-17 | 1999-05-04 | Oklahoma Medical Research Foundation | Multicyclic nitrone spin trapping compositions |
AU715226B2 (en) * | 1996-07-19 | 2000-01-20 | Centaur Pharmaceuticals, Inc. | Furan nitrone compounds |
TW429241B (en) | 1996-09-26 | 2001-04-11 | Sumitomo Pharma | Nitrone derivatives |
US6046232A (en) * | 1997-10-17 | 2000-04-04 | Centaur Pharmaceuticals, Inc. | α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same |
US6015831A (en) * | 1998-01-16 | 2000-01-18 | Centaur Pharmaceuticals, Inc. | Thiophene nitrone compounds |
ZA99252B (en) * | 1998-01-16 | 1999-07-14 | Centaur Pharmaceuticals Inc | Thioether furan nitrone compounds. |
EP1098873B1 (de) | 1998-07-17 | 2004-05-26 | Renovis, Inc. | Alpha-(2-hydroxyphenyl)nitrone, diese enthaltenden pharmazeutische zubereitungen sowie deren verwendung zur behandlung von entzündungen |
US6730700B2 (en) | 1998-12-02 | 2004-05-04 | Renovis, Inc. | 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same |
UA66401C2 (en) | 1998-12-02 | 2004-05-17 | Sentor Pharmaceuticals Inc | 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same |
US6339102B1 (en) * | 1999-06-09 | 2002-01-15 | The United States Of America As Represented By The Secretary Of The Army | Method and composition for treating and preventing retinal damage |
CA2404291A1 (en) * | 2000-03-30 | 2001-10-11 | Oklahoma Medical Research Foundation | Butylnitrone containing compositons for inhibition of cancer development |
SE0001916D0 (sv) * | 2000-05-23 | 2000-05-23 | Astrazeneca Ab | Novel formulation |
AU2002253857A1 (en) | 2001-01-08 | 2002-09-04 | Centaur Pharmaceuticals, Inc. | Use of aryl nitrone compounds in methods for treating neuropathic pain |
US20030045461A1 (en) * | 2001-09-06 | 2003-03-06 | Jen-Chang Hsia | Composition and methods of esterified nitroxides gated with carboxylic acids |
FR2846968B1 (fr) * | 2002-11-08 | 2005-02-04 | Salles Jean Pierre | Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone |
US6762322B1 (en) * | 2002-12-20 | 2004-07-13 | Goodyear Tire & Rubber Company | Preparation of nitrone derivatives |
US20050059638A1 (en) * | 2003-08-04 | 2005-03-17 | Kelly Michael G. | Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders |
US20050182060A1 (en) * | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
US20060235370A1 (en) * | 2005-04-04 | 2006-10-19 | Oblong John E | Method of regulating mammalian keratinous tissue |
US7125934B1 (en) * | 2005-06-28 | 2006-10-24 | The Goodyear Tire & Rubber Company | Functionalization of living rubbery polymers with nitrones |
US8420595B2 (en) * | 2006-07-25 | 2013-04-16 | Oklahoma Medical Research Foundation | Methods for treating acute acoustic trauma |
AU2009214727B2 (en) * | 2008-02-12 | 2014-12-11 | Tosk, Incorporated | Doxorubicin adjuvants to reduce toxicity and methods for using the same |
JP5253494B2 (ja) * | 2008-03-07 | 2013-07-31 | 国立大学法人 熊本大学 | 電子スピン共鳴測定用試料溶液及びその乾固物,並びにそれらを用いた測定方法 |
RU2586339C1 (ru) * | 2009-04-20 | 2016-06-10 | Вольво Констракшн Эквипмент Аб | Устройство для перевозки дорожной смеси |
US9034926B2 (en) | 2010-12-30 | 2015-05-19 | Nicholas V. Perricone | Topical nitrone spin trap compositions for psoriasis |
US8986739B2 (en) | 2011-02-28 | 2015-03-24 | Nicholas V. Perricone | Treatment of urinary incontinence using nitrone spin traps |
ES2395803B1 (es) * | 2011-08-01 | 2013-12-19 | Consejo Superior De Investigaciones Científicas (Csic) - 80% | Quinolilnitronas |
DE102011088787A1 (de) | 2011-12-16 | 2013-06-20 | Evonik Industries Ag | Siloxannitrone und deren Anwendung |
WO2022169642A1 (en) * | 2021-02-08 | 2022-08-11 | Oklahoma Medical Research Foundation | Okn-007 as a therapeutic agent for neurodegenerative diseases |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US35112A (en) * | 1862-04-29 | Improvement in head-rests for car-seats | ||
US35213A (en) * | 1862-05-13 | Improved hydrant | ||
DE273702C (de) * | ||||
US3396027A (en) * | 1964-05-13 | 1968-08-06 | Eastman Kodak Co | Method of noodling gelatin dispersions |
US3365296A (en) | 1964-05-18 | 1968-01-23 | Gen Aniline & Film Corp | Light-sensitive ultraviolet absorbing compounds and diazotype materials containing the same |
US3296145A (en) * | 1965-10-21 | 1967-01-03 | Millmaster Onyx Corp | Quaternary ammonium-tertiary amine oxide compositions |
US3775122A (en) * | 1967-07-28 | 1973-11-27 | American Can Co | Image production using photosensitive compositions of nitrone which is heat developed |
US3767818A (en) * | 1971-05-03 | 1973-10-23 | Scm Corp | Phenyl nitrone containing compositions useful as anti microbial agents |
US3834073A (en) * | 1971-05-03 | 1974-09-10 | Scm Corp | Phenyl nitrone derivatives useful as seed protectants |
US3849934A (en) * | 1971-05-03 | 1974-11-26 | Scm Corp | Alpha-aryl-n-lower alkyl nitrone-containing compositions useful as anti-fungal agents |
GB1531278A (en) * | 1975-12-15 | 1978-11-08 | Shionogi & Co | 9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof |
GB1588417A (en) * | 1977-03-15 | 1981-04-23 | Agfa Gevaert | Photoresist materials |
US4197314A (en) * | 1977-10-06 | 1980-04-08 | William H. Rorer, Inc. | Method of treating inflammation |
US4224340A (en) * | 1977-10-06 | 1980-09-23 | William H. Rorer, Inc. | Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds |
US4214003A (en) * | 1977-10-06 | 1980-07-22 | William H. Rorer, Inc. | Method of treatment |
US4153722A (en) * | 1977-10-06 | 1979-05-08 | William H. Rorer, Inc. | Method of treatment |
US4870002A (en) * | 1981-04-07 | 1989-09-26 | The United States Of America As Represented By The Secretary Of The Air Force | Method of prevention of oxidative injury to cells |
AU1107888A (en) * | 1986-12-29 | 1988-07-27 | Pharmacia Ab | Nitroxide compounds for the preparation of a pharmaceutical composition intended for the prophylaxis and treatment of ischemic cell damage |
AU1362488A (en) * | 1987-01-28 | 1988-08-24 | Peter H. Proctor | Topical composition and method for stimulating hair growth with stable free radicals |
EP0496796B1 (de) * | 1989-10-17 | 1994-08-31 | Oklahoma Medical Research Foundation | Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten |
US5025032A (en) * | 1989-10-17 | 1991-06-18 | Oklahoma Medical Research Foundation | Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage |
US5488145A (en) * | 1993-12-23 | 1996-01-30 | Oklahoma Medical Research Foundation | 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps |
-
1990
- 1990-10-17 EP EP90915877A patent/EP0496796B1/de not_active Expired - Lifetime
- 1990-10-17 DK DK90915877.6T patent/DK0496796T3/da active
- 1990-10-17 JP JP2515036A patent/JP2620413B2/ja not_active Expired - Fee Related
- 1990-10-17 ES ES90915877T patent/ES2044829T3/es not_active Expired - Lifetime
- 1990-10-17 AT AT90915877T patent/ATE110565T1/de not_active IP Right Cessation
- 1990-10-17 CA CA002069961A patent/CA2069961C/en not_active Expired - Fee Related
- 1990-10-17 WO PCT/US1990/005952 patent/WO1991005552A1/en active IP Right Grant
- 1990-10-17 DE DE69012138T patent/DE69012138T2/de not_active Expired - Fee Related
- 1990-10-17 AU AU66133/90A patent/AU653921B2/en not_active Ceased
- 1990-10-17 KR KR1019920700900A patent/KR960008230B1/ko not_active IP Right Cessation
-
1993
- 1993-03-05 US US08/027,559 patent/US5405874A/en not_active Expired - Lifetime
-
1994
- 1994-12-28 US US08/365,548 patent/US5578617A/en not_active Expired - Fee Related
-
1995
- 1995-01-20 AU AU11315/95A patent/AU692197B2/en not_active Ceased
- 1995-06-06 US US08/468,563 patent/US6107315A/en not_active Expired - Fee Related
- 1995-06-06 US US08/468,561 patent/US5681965A/en not_active Expired - Fee Related
-
1996
- 1996-07-09 JP JP8179709A patent/JP2816326B2/ja not_active Expired - Fee Related
-
1998
- 1998-03-25 JP JP10077984A patent/JP2975587B2/ja not_active Expired - Fee Related
- 1998-03-25 JP JP10077985A patent/JPH10259128A/ja active Pending
- 1998-06-24 HK HK98106466A patent/HK1007281A1/xx not_active IP Right Cessation
- 1998-09-04 AU AU83101/98A patent/AU710341B2/en not_active Ceased
- 1998-09-04 AU AU83102/98A patent/AU710342B2/en not_active Ceased
-
2001
- 2001-11-08 JP JP2001343709A patent/JP2002179563A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0496796A1 (de) | 1992-08-05 |
DE69012138D1 (de) | 1994-10-06 |
JP2975587B2 (ja) | 1999-11-10 |
HK1007281A1 (en) | 1999-04-09 |
JP2002179563A (ja) | 2002-06-26 |
AU6613390A (en) | 1991-05-16 |
JPH05505792A (ja) | 1993-08-26 |
ES2044829T3 (es) | 1995-01-16 |
JPH0925263A (ja) | 1997-01-28 |
CA2069961A1 (en) | 1991-04-18 |
KR960008230B1 (ko) | 1996-06-21 |
AU8310198A (en) | 1998-12-24 |
AU710342B2 (en) | 1999-09-16 |
ES2044829T1 (es) | 1994-01-16 |
WO1991005552A1 (en) | 1991-05-02 |
AU692197B2 (en) | 1998-06-04 |
JPH10259128A (ja) | 1998-09-29 |
AU8310298A (en) | 1998-10-22 |
JP2816326B2 (ja) | 1998-10-27 |
AU710341B2 (en) | 1999-09-16 |
AU1131595A (en) | 1995-03-23 |
US6107315A (en) | 2000-08-22 |
KR920702220A (ko) | 1992-09-03 |
JP2620413B2 (ja) | 1997-06-11 |
JPH10259178A (ja) | 1998-09-29 |
EP0496796B1 (de) | 1994-08-31 |
ATE110565T1 (de) | 1994-09-15 |
DK0496796T3 (da) | 1994-10-03 |
US5681965A (en) | 1997-10-28 |
CA2069961C (en) | 2000-05-02 |
AU653921B2 (en) | 1994-10-20 |
US5405874A (en) | 1995-04-11 |
US5578617A (en) | 1996-11-26 |
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