DE69017324T2 - Lebendes Gewebeäquivalent. - Google Patents

Lebendes Gewebeäquivalent.

Info

Publication number
DE69017324T2
DE69017324T2 DE69017324T DE69017324T DE69017324T2 DE 69017324 T2 DE69017324 T2 DE 69017324T2 DE 69017324 T DE69017324 T DE 69017324T DE 69017324 T DE69017324 T DE 69017324T DE 69017324 T2 DE69017324 T2 DE 69017324T2
Authority
DE
Germany
Prior art keywords
living tissue
tissue equivalent
tissue equivalents
present
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69017324T
Other languages
English (en)
Other versions
DE69017324D1 (de
Inventor
Paul Kemp
Eugene Bell
David T Kagan
Valerie Mason
John Cavallaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organogenesis Inc
Original Assignee
Organogenesis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organogenesis Inc filed Critical Organogenesis Inc
Publication of DE69017324D1 publication Critical patent/DE69017324D1/de
Application granted granted Critical
Publication of DE69017324T2 publication Critical patent/DE69017324T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
DE69017324T 1989-09-15 1990-09-11 Lebendes Gewebeäquivalent. Expired - Lifetime DE69017324T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40805289A 1989-09-15 1989-09-15

Publications (2)

Publication Number Publication Date
DE69017324D1 DE69017324D1 (de) 1995-04-06
DE69017324T2 true DE69017324T2 (de) 1995-08-03

Family

ID=23614662

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69017324T Expired - Lifetime DE69017324T2 (de) 1989-09-15 1990-09-11 Lebendes Gewebeäquivalent.

Country Status (12)

Country Link
US (1) US5536656A (de)
EP (1) EP0418035B1 (de)
JP (1) JPH03151977A (de)
KR (1) KR940001379B1 (de)
AT (1) ATE119194T1 (de)
AU (1) AU6215690A (de)
CA (2) CA2023968C (de)
DE (1) DE69017324T2 (de)
DK (1) DK0418035T3 (de)
ES (1) ES2071778T3 (de)
IE (1) IE903340A1 (de)
IL (1) IL95429A (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
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US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
GB9306449D0 (en) * 1993-03-29 1993-05-19 Nat Heart Research Fund Tissue equivalents
DE69527141T2 (de) * 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent mit kollagen
US5665114A (en) * 1994-08-12 1997-09-09 Meadox Medicals, Inc. Tubular expanded polytetrafluoroethylene implantable prostheses
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
US20020086423A1 (en) * 1997-09-09 2002-07-04 Toshiaki Takezawa Hydrogel thin film containing extracellular matrix components
US6498138B1 (en) 1998-03-11 2002-12-24 University Of Southern California Method of promoting production of living tissue equivalents
US6129757A (en) * 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
ES2249928T3 (es) * 1998-11-19 2006-04-01 Organogenesis Inc. Constructos de tejido manipulado mediante bioingenieria y metodos para producirlos y utilizarlos.
US7001746B1 (en) 1999-01-29 2006-02-21 Artecel Sciences, Inc. Methods and compositions for the differentiation of human preadipocytes into adipocytes
WO2000047129A2 (en) * 1999-02-11 2000-08-17 The General Hospital Corporation Microfabricated membranes and matrices
US6197061B1 (en) * 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
MXPA01013423A (es) 1999-06-21 2002-12-05 Gen Hospital Corp Sistemas de cultivo celular y metodos para dispositivos auxiliares del organo.
CA2383398C (en) * 1999-08-23 2013-06-11 Organogenesis, Inc. Skin care compositions and treatments
EP1918366A1 (de) 2000-02-26 2008-05-07 Artecel, Inc. Pluripotente Stammzellen aus Bindegewebszellen aus dem Fettgewebe und Verwendungen dafür
PT1261694E (pt) 2000-02-26 2008-04-03 Artecel Inc Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações.
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
DK1290145T3 (da) 2000-05-31 2006-03-13 Fraunhofer Ges Forschung Tredimensional hudmodel
AU6904101A (en) * 2000-05-31 2001-12-11 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Infection model
US7144729B2 (en) 2000-09-01 2006-12-05 Dfb Pharmaceuticals, Inc. Methods and compositions for tissue regeneration
US7597712B2 (en) 2000-09-18 2009-10-06 Organogenesis, Inc. Method for treating a patient using a cultured connective tissue construct
EP1832300A3 (de) * 2000-09-18 2008-02-27 Organogenesis Inc. Verfahren zur Behandlung eines Patienten unter Verwendung eines kultivierten Bindegewebekonstrukts
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
CA2439899C (en) * 2001-03-02 2015-09-29 Stratatech Corporation Improved skin substitutes and uses thereof
US6974697B2 (en) * 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
US20030211793A1 (en) * 2001-03-05 2003-11-13 Eugene Bell Injectable bio-compatible material and methods of use
JP3960969B2 (ja) 2001-06-14 2007-08-15 ミリポア・コーポレイション 突出部を備えるトレイ
US7476257B2 (en) * 2001-09-15 2009-01-13 Rush University Medical Center Methods to engineer stratified cartilage tissue
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
WO2003072128A2 (en) * 2002-02-22 2003-09-04 Ebi, L.P. Methods and compositions for treating bone or cartilage defects
US7741116B2 (en) 2002-03-06 2010-06-22 University Of Cincinnati Surgical device for skin therapy or testing
NZ536205A (en) * 2002-04-30 2008-04-30 Stratatech Corp Keratinocytes expressing exogenous angiogenic growth factors
US7229820B2 (en) * 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
AU2003254298A1 (en) * 2002-08-02 2004-02-23 Stratatech Corporation Species specific dna detection
EP2481287B1 (de) * 2003-08-01 2016-07-20 Stratatech Corporation Exogene Polypeptide exprimierende Äquivalente menschlicher Haut
FR2881434B1 (fr) * 2005-02-02 2007-05-11 Coletica Sa Dispositif de support de culture de cellules
AU2006218610B2 (en) 2005-03-01 2011-01-20 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
WO2006101834A1 (en) 2005-03-17 2006-09-28 Stratatech Corporation Skin substitutes with improved purity
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
RU2498808C9 (ru) * 2006-03-03 2014-01-20 Огенодженесис, Инк. Способ лечения состояния ротовой полости больного (варианты)
FR2903702B1 (fr) * 2006-07-13 2012-10-19 Oreal Equivalent d'epiderme capable de se pigmenter obtenu a partir de cellules de la matrice, procede de preparation et utilisation
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
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US20100278798A1 (en) * 2007-09-27 2010-11-04 The Trustees Of Columbia University In The City Of New York Methods and systems for forming biocompatible materials
DK2215212T3 (da) 2007-11-14 2017-11-27 Stratatech Corp Kold opbevaring af organotypisk dyrkede hudækvivalenter til kliniske anvendelser
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US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
WO2010048441A2 (en) * 2008-10-22 2010-04-29 Regenemed, Inc. Culture systems
DK2352472T3 (en) 2008-11-04 2017-04-10 Stratatech Corp Dried and irradiated skin equivalents ready to use
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US20100330046A1 (en) * 2009-05-21 2010-12-30 Stratatech Corporation Human skin substitutes expressing il-12
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FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
US8765254B2 (en) 2010-04-05 2014-07-01 Emd Millipore Corporation Polymeric membranes with human skin-like permeability properties and uses thereof
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FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
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FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
PL226837B1 (pl) 2012-08-24 2017-09-29 Celther Polska Spółka Z Ograniczoną Odpowiedzialnością Aktywna warstwa polimerowa utworzona zpochodnych chityny zwłaszcza doopatrunku oraz jejzastosowanie
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
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US10159555B2 (en) 2012-09-28 2018-12-25 Sofradim Production Packaging for a hernia repair device
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EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
EP3106185B1 (de) 2015-06-19 2018-04-25 Sofradim Production Synthetische prothese mit einem gewirk und einem nichtporösen film und verfahren zur formung davon
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
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EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
EP3398554A1 (de) 2017-05-02 2018-11-07 Sofradim Production Prothese zur leistenbruch-reparatur
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Also Published As

Publication number Publication date
CA2298856C (en) 2004-11-16
CA2298856A1 (en) 1991-03-16
IL95429A0 (en) 1991-06-30
CA2023968A1 (en) 1991-03-16
JPH03151977A (ja) 1991-06-28
DE69017324D1 (de) 1995-04-06
EP0418035A1 (de) 1991-03-20
ATE119194T1 (de) 1995-03-15
US5536656A (en) 1996-07-16
CA2023968C (en) 2000-05-02
IL95429A (en) 1997-09-30
AU6215690A (en) 1991-08-01
KR940001379B1 (ko) 1994-02-21
DK0418035T3 (da) 1995-07-10
EP0418035B1 (de) 1995-03-01
ES2071778T3 (es) 1995-07-01
JPH0553505B2 (de) 1993-08-10
KR910005893A (ko) 1991-04-27
IE903340A1 (en) 1991-04-10

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