DE69025199T2 - Verfahren zum in vivo-nachweis von knochenresorption - Google Patents

Verfahren zum in vivo-nachweis von knochenresorption

Info

Publication number
DE69025199T2
DE69025199T2 DE69025199T DE69025199T DE69025199T2 DE 69025199 T2 DE69025199 T2 DE 69025199T2 DE 69025199 T DE69025199 T DE 69025199T DE 69025199 T DE69025199 T DE 69025199T DE 69025199 T2 DE69025199 T2 DE 69025199T2
Authority
DE
Germany
Prior art keywords
bone resorption
vivo detection
pyridinoline
whereinis
kits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69025199T
Other languages
English (en)
Other versions
DE69025199D1 (de
Inventor
David R Eyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington Research Foundation
Original Assignee
Washington Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27034100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69025199(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/444,881 external-priority patent/US5140103A/en
Application filed by Washington Research Foundation filed Critical Washington Research Foundation
Publication of DE69025199D1 publication Critical patent/DE69025199D1/de
Application granted granted Critical
Publication of DE69025199T2 publication Critical patent/DE69025199T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
DE69025199T 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption Revoked DE69025199T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/444,881 US5140103A (en) 1987-11-06 1989-12-01 Peptide fragments containing HP and LP cross-links
US07/614,719 US5300434A (en) 1987-11-06 1990-11-21 Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
PCT/US1990/007015 WO1991008478A2 (en) 1989-12-01 1990-11-30 METHODS OF DETECTING COLLAGEN DEGRADATION $i(IN VIVO)

Publications (2)

Publication Number Publication Date
DE69025199D1 DE69025199D1 (de) 1996-03-14
DE69025199T2 true DE69025199T2 (de) 1996-05-30

Family

ID=27034100

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau
DE69025199T Revoked DE69025199T2 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.
DE69033082T Expired - Fee Related DE69033082T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.
DE69033082T Expired - Fee Related DE69033082T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Country Status (13)

Country Link
US (5) US5300434A (de)
EP (6) EP0502928B1 (de)
JP (6) JP2782017B2 (de)
AT (3) ATE279730T1 (de)
AU (1) AU645049B2 (de)
DE (4) DE69034170T2 (de)
DK (3) DK0682257T3 (de)
ES (2) ES2061422T3 (de)
GR (3) GR940300047T1 (de)
IE (1) IE65280B1 (de)
NO (1) NO309483B1 (de)
RU (1) RU2139541C1 (de)
WO (1) WO1991008478A2 (de)

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US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
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US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US6027903A (en) * 1987-11-06 2000-02-22 Washington Research Foundation Kit for detecting analyte indicative of type I collagen resorption in vivo
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AU5851494A (en) * 1992-12-17 1994-07-04 Metra Biosystems, Inc. Serum pyridinium crosslinks assay
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DE69333641T2 (de) * 1992-12-28 2005-11-03 Baylink, David Jeston, Redlands Methode zur messung der knochenresorption
DK104093D0 (da) † 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
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WO1996012193A1 (en) 1994-10-17 1996-04-25 Osteometer Bio Tech A/S Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
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US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
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ATE258310T1 (de) * 1997-07-31 2004-02-15 Metra Biosystems Inc Testverfahren für collagenpeptid
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
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US6255056B1 (en) 1998-06-19 2001-07-03 Washington Research Foundation Cartilage resorption assays
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US6916903B2 (en) * 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
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Also Published As

Publication number Publication date
JP2999444B2 (ja) 2000-01-17
EP0890840A3 (de) 2000-05-17
EP0682256B1 (de) 2004-10-13
JP2000055915A (ja) 2000-02-25
DE69025199D1 (de) 1996-03-14
NO922149L (no) 1992-07-29
US5656439A (en) 1997-08-12
ES2061422T1 (es) 1994-12-16
JP2000050865A (ja) 2000-02-22
US5677198A (en) 1997-10-14
DE69034170T2 (de) 2006-03-02
JPH10260183A (ja) 1998-09-29
EP1632502A1 (de) 2006-03-08
DE69033082T2 (de) 1999-09-30
ATE179521T1 (de) 1999-05-15
DK0502928T3 (da) 1996-02-19
DE69034170D1 (de) 2004-11-18
EP0682257A1 (de) 1995-11-15
US5473052A (en) 1995-12-05
WO1991008478A2 (en) 1991-06-13
IE65280B1 (en) 1995-10-18
JP2002139492A (ja) 2002-05-17
NO922149D0 (no) 1992-05-29
RU2139541C1 (ru) 1999-10-10
DK0682256T3 (da) 2005-02-14
GR3018852T3 (en) 1996-05-31
US5300434A (en) 1994-04-05
JP2782017B2 (ja) 1998-07-30
JP2999416B2 (ja) 2000-01-17
EP0890840A2 (de) 1999-01-13
ATE279730T1 (de) 2004-10-15
AU6889891A (en) 1991-06-26
GR940300047T1 (en) 1994-07-29
JP3299941B2 (ja) 2002-07-08
IE904344A1 (en) 1991-06-05
EP0502928A1 (de) 1992-09-16
EP1560026A1 (de) 2005-08-03
GR3030646T3 (en) 1999-10-29
DE69033082D1 (de) 1999-06-02
ATE133790T1 (de) 1996-02-15
NO309483B1 (no) 2001-02-05
EP0682256A1 (de) 1995-11-15
JPH09113510A (ja) 1997-05-02
EP0502928B1 (de) 1996-01-31
US5576189A (en) 1996-11-19
DE502928T1 (de) 1994-08-18
AU645049B2 (en) 1994-01-06
DK0682257T3 (da) 1999-11-08
ES2133656T3 (es) 1999-09-16
JPH05502223A (ja) 1993-04-22
EP0682257B1 (de) 1999-04-28
WO1991008478A3 (en) 1991-11-28
ES2061422T3 (es) 1996-03-16

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8363 Opposition against the patent
8331 Complete revocation