DE69028370D1 - Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle - Google Patents

Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Info

Publication number
DE69028370D1
DE69028370D1 DE69028370T DE69028370T DE69028370D1 DE 69028370 D1 DE69028370 D1 DE 69028370D1 DE 69028370 T DE69028370 T DE 69028370T DE 69028370 T DE69028370 T DE 69028370T DE 69028370 D1 DE69028370 D1 DE 69028370D1
Authority
DE
Germany
Prior art keywords
fluorescent particles
particles
fluid
burst
highly sensitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69028370T
Other languages
English (en)
Other versions
DE69028370T2 (de
Inventor
Richard Mathies
Konan Peck
Lubert Stryer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of DE69028370D1 publication Critical patent/DE69028370D1/de
Application granted granted Critical
Publication of DE69028370T2 publication Critical patent/DE69028370T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1429—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its signal processing
    • G01N15/1433—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
DE69028370T 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle Expired - Lifetime DE69028370T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/358,782 US4979824A (en) 1989-05-26 1989-05-26 High sensitivity fluorescent single particle and single molecule detection apparatus and method
PCT/US1990/002702 WO1990014589A1 (en) 1989-05-26 1990-05-21 High sensitivity fluorescent single particle and single molecule detection apparatus and method

Publications (2)

Publication Number Publication Date
DE69028370D1 true DE69028370D1 (de) 1996-10-10
DE69028370T2 DE69028370T2 (de) 1997-03-13

Family

ID=23411024

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028370T Expired - Lifetime DE69028370T2 (de) 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Country Status (7)

Country Link
US (1) US4979824A (de)
EP (1) EP0426829B1 (de)
JP (1) JPH04500274A (de)
AT (1) ATE142334T1 (de)
AU (1) AU624047B2 (de)
DE (1) DE69028370T2 (de)
WO (1) WO1990014589A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
JP2575270B2 (ja) * 1992-11-10 1997-01-22 浜松ホトニクス株式会社 核酸の塩基配列決定方法、単一分子検出方法、その装置及び試料の作成方法
FI96638C (fi) * 1992-11-17 1996-07-25 Biohit Oy "Inner-filter"-korjaus fluorometripohjaisella monitoimintoisella laitteella
EP0682671A4 (de) * 1993-02-01 1998-01-14 Seq Ltd Verfahren und geräte zur sequenzierung von dns.
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US6864048B2 (en) * 1993-04-28 2005-03-08 Affymetrix, Inc. Factorial chemical libraries
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
DE69530323T2 (de) * 1994-09-02 2004-02-12 BD Biosciences, Systems and Reagents, Inc., San Jose Verfahren und vorrichtung zur eichung eines optischen abtasters
DE19649048C1 (de) * 1996-11-27 1998-04-09 Evotec Biosystems Gmbh Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion
EP1009802B1 (de) 1997-02-12 2004-08-11 Eugene Y. Chan Verfahren zur analyse von polymeren
AU7831798A (en) * 1997-06-09 1998-12-30 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US6710871B1 (en) * 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US6049380A (en) * 1997-11-12 2000-04-11 Regents Of The University Of California Single molecule identification using selected fluorescence characteristics
SE9800360D0 (sv) * 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US20040106110A1 (en) * 1998-07-30 2004-06-03 Solexa, Ltd. Preparation of polynucleotide arrays
AU770831B2 (en) * 1998-07-30 2004-03-04 Solexa Ltd. Arrayed biomolecules and their use in sequencing
US20100130368A1 (en) * 1998-07-30 2010-05-27 Shankar Balasubramanian Method and system for sequencing polynucleotides
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
DE19844931C1 (de) 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
JP4638043B2 (ja) 1998-12-14 2011-02-23 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6927065B2 (en) * 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US6569685B1 (en) * 1999-10-05 2003-05-27 The Molecular Sciences Institute, Inc. Protein fingerprint system and related methods
US20010038717A1 (en) * 2000-01-27 2001-11-08 Brown Carl S. Flat-field, panel flattening, and panel connecting methods
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
AU2001268291A1 (en) 2000-06-07 2001-12-17 Li-Cor, Inc. Charge-switch nucleotides
US6447995B1 (en) 2000-10-04 2002-09-10 Genvec, Inc. Utilizing intrinsic fluorescence to detect adenovirus
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US20020102596A1 (en) * 2001-01-31 2002-08-01 Davis Lloyd Mervyn Methods for detecting interaction of molecules with surface-bound reagents
WO2002072892A1 (en) 2001-03-12 2002-09-19 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
WO2002086088A2 (en) * 2001-04-24 2002-10-31 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7118907B2 (en) * 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
US7076092B2 (en) * 2001-06-14 2006-07-11 The United States Of America As Represented By The United States Department Of Energy High-throughput, dual probe biological assays based on single molecule detection
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
JP4401172B2 (ja) 2001-07-10 2010-01-20 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 単一細胞内の多数の蛋白質の活性化状態を検出する方法及び組成物
US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
US7381535B2 (en) * 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
EP1546380A4 (de) * 2002-05-28 2007-02-14 Us Genomics Inc Verfahren und vorrichtungen mit einzelpolymeranalyse
KR100473360B1 (ko) * 2002-07-31 2005-03-08 주식회사 디지탈바이오테크놀러지 레이저 반사를 이용한 미세 채널 위치 및 치수의 자동측정방법, 그 측정방법을 이용한 측정장치 및 그측정방법을 이용한 미세 채널 검사장치
WO2005005666A1 (en) * 2002-11-19 2005-01-20 Singulex, Inc. Detection of target molecules through interaction with probes
WO2004092331A2 (en) * 2003-04-08 2004-10-28 Li-Cor, Inc. Composition and method for nucleic acid sequencing
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
US7317521B2 (en) * 2003-09-18 2008-01-08 Micron Technology, Inc. Particle detection method
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP1716254B1 (de) 2004-02-19 2010-04-07 Helicos Biosciences Corporation Verfahren zur analyse von polynukleotidsequenzen
ATE507305T1 (de) 2004-05-25 2011-05-15 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
EP1805500A4 (de) * 2004-09-28 2008-05-07 Singulex Inc System und verfahren zur spektroskopischen analyse einzelner partikel
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
CA2593355A1 (en) * 2005-01-24 2006-07-27 The Board Of Trustees Of The Leland Stanford Junior University Method for modeling cell signaling systems by means of bayesian networks
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
CA2543521C (en) * 2005-04-13 2014-05-27 Frederick David King Particle imaging system with a varying flow rate
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
US20100255518A1 (en) 2006-04-04 2010-10-07 Goix Philippe J Highly sensitive system and methods for analysis of troponin
US8124943B1 (en) * 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
WO2008019448A1 (en) * 2006-08-18 2008-02-21 Macquarie University Time gated fluorescent flow cytometer
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US7804594B2 (en) * 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
EP2479552B1 (de) 2007-04-02 2015-09-02 Acoustic Cytometry Systems, Inc. Verfahren zur verbesserten Analyse von in einem akustischen Feld fokussierten Zellen und Partikeln
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
FR2917842A1 (fr) * 2007-06-19 2008-12-26 Commissariat Energie Atomique Dispositif et methode de comptage de particules elementaires emises par un fluide dans un conduit.
WO2009029550A2 (en) * 2007-08-24 2009-03-05 Singulex, Inc. Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
JP2011508219A (ja) 2007-12-19 2011-03-10 シンギュレックス・インコーポレイテッド 単一分子検出走査分析器およびその使用方法
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
US20090234202A1 (en) * 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
US20090291458A1 (en) * 2008-05-22 2009-11-26 Nodality, Inc. Method for Determining the Status of an Individual
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010006291A1 (en) 2008-07-10 2010-01-14 Nodality, Inc. Methods for diagnosis, prognosis and treatment
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
AU2010259022B2 (en) * 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
JP5250152B2 (ja) * 2010-03-01 2013-07-31 オリンパス株式会社 光分析装置、光分析方法並びに光分析用コンピュータプログラム
EP2566971B1 (de) 2010-05-06 2019-03-27 Singulex, Inc. Verfahren zur diagnose, einstufung und vorhersage des risikos der entwicklung und identifikation von respondern für die behandlung rheumatoider arthritis
US8834847B2 (en) 2010-08-12 2014-09-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
EP2667183A4 (de) 2011-01-20 2017-05-10 Olympus Corporation Lichtanalyseverfahren und lichtanalysevorrichtung mit erkennung von licht aus einzelnen lichtemittierenden teilchen
US9241388B2 (en) * 2011-06-29 2016-01-19 Panasonic Intellectual Property Management Co., Ltd. Method and apparatus for manufacturing a light-emitting device including correction of an application amount of a fluorescent resin based on a fluorescent particle concentration
CN103765196B (zh) 2011-08-26 2016-03-02 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置及光分析方法
WO2013031365A1 (ja) 2011-08-30 2013-03-07 オリンパス株式会社 標的粒子の検出方法
EP2790008B1 (de) * 2011-12-05 2017-11-15 Rion Co., Ltd. Biopartikelzähler, biopartikelzählverfahren, dialysatüberwachungssystem und wasserreinigungsüberwachungssystem
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
JP6360481B2 (ja) 2013-07-31 2018-07-18 オリンパス株式会社 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム
JPWO2017098597A1 (ja) 2015-12-09 2018-10-11 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB696675A (en) * 1950-02-17 1953-09-09 Ici Ltd Improvements in and relating to methods of, and apparatus for, determining the concentration of particulate matter contained in liquid suspensions or colloidal solutionsor of solutes in true solutions
US3536898A (en) * 1967-12-04 1970-10-27 Us Navy Detection device
US4021117A (en) * 1975-08-07 1977-05-03 Hildegard Gohde Process for automatic counting and measurement of particles
US4573798A (en) * 1981-09-16 1986-03-04 Toshiba Kikai Kabushiki Kaisha Method and apparatus for measuring pattern area percentage for engraving films
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4793705A (en) * 1987-10-07 1988-12-27 The United States Of America As Represented By The United States Department Of Energy Single molecule tracking
FR2628530B1 (fr) * 1988-03-08 1994-01-28 Chemunex Sa Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide

Also Published As

Publication number Publication date
DE69028370T2 (de) 1997-03-13
WO1990014589A1 (en) 1990-11-29
AU5677690A (en) 1990-12-18
US4979824A (en) 1990-12-25
AU624047B2 (en) 1992-05-28
EP0426829A1 (de) 1991-05-15
EP0426829A4 (en) 1992-05-06
EP0426829B1 (de) 1996-09-04
ATE142334T1 (de) 1996-09-15
JPH04500274A (ja) 1992-01-16

Similar Documents

Publication Publication Date Title
DE69028370D1 (de) Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle
DE69915481D1 (de) Versuchsanordnung und methode zum screenen eines immuntests
DE69233703D1 (de) Verfahren und Vorrichtung für verbesserte Lumineszenztests
CA2294966A1 (en) Method and apparatus for marking and identifying liquids
ATE542128T1 (de) Verfahren zur erkennung von fehlern in transparentem material
DE3586380D1 (de) Verfahren zur messung von strahlungsschwankungen und anwendung desselben zum nachweis eines analyten.
DE60031988D1 (de) Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
CA2111552A1 (en) Luminometer
ATE16642T1 (de) Untersuchungsverfahren und -vorrichtung.
ATE101739T1 (de) Verfahren zum betrieb eines optischen rauchmelders sowie rauchmelder zur durchfuehrung des verfahrens.
AU560701B2 (en) Photomultiplier testing for defects
DE69930451D1 (de) Spektrophotometrische Vorrichtung mit Nachweis eines Reagenzstreifens
KR970705750A (ko) 다이아몬드 시험 장치 및 방법(examining a diamond)
ATE259503T1 (de) Verfahren zur messung der konzentration eines spezifischen bestandteils
NO973853L (no) Fremgangsmåte for kontroll av en glassbeholder
US5354999A (en) Leak detection achieved by detection of light transmitted through an opaque layer interrupted by a passing bubble
NO983126L (no) Fremgangsmåte og anordning for å måle farge og/eller partikler i et fluid
ATE302406T1 (de) Verfahren und vorrichtung zum analytischen nachweis von spuren
ATE249619T1 (de) Verfahren zur messung der spektralen absorption eines körpers und vorrichtung zur durchführung des verfahrens
ATE17531T1 (de) Vorrichtung zum automatischen erkennen und auswerten der merkmale von druckschriften.
JPS5536733A (en) Method of detecting oil polluted bottle
ATE412887T1 (de) Vorrichtung und verfahren zur durchführung von testmessungen zur elektrochemilumineszenz
KR970053221A (ko) 디벨로프 파티클 검출장치

Legal Events

Date Code Title Description
8364 No opposition during term of opposition