DE69029812D1 - Elemente für retinsäureantwortzusammensetzung und nachweisverfahren - Google Patents

Elemente für retinsäureantwortzusammensetzung und nachweisverfahren

Info

Publication number
DE69029812D1
DE69029812D1 DE69029812T DE69029812T DE69029812D1 DE 69029812 D1 DE69029812 D1 DE 69029812D1 DE 69029812 T DE69029812 T DE 69029812T DE 69029812 T DE69029812 T DE 69029812T DE 69029812 D1 DE69029812 D1 DE 69029812D1
Authority
DE
Germany
Prior art keywords
elements
detection method
acid response
retinic acid
response composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029812T
Other languages
English (en)
Other versions
DE69029812T2 (de
Inventor
Henry Sucov
Ronald Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of DE69029812D1 publication Critical patent/DE69029812D1/de
Application granted granted Critical
Publication of DE69029812T2 publication Critical patent/DE69029812T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
DE69029812T 1989-11-16 1990-11-13 Elemente für retinsäureantwortzusammensetzung und nachweisverfahren Expired - Fee Related DE69029812T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/438,757 US5091518A (en) 1989-11-16 1989-11-16 Beta retinoic acid response elements compositions and assays
PCT/US1990/006626 WO1991007488A1 (en) 1989-11-16 1990-11-13 Beta retinoic acid response elements compositions and assays

Publications (2)

Publication Number Publication Date
DE69029812D1 true DE69029812D1 (de) 1997-03-06
DE69029812T2 DE69029812T2 (de) 1997-06-05

Family

ID=23741886

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029812T Expired - Fee Related DE69029812T2 (de) 1989-11-16 1990-11-13 Elemente für retinsäureantwortzusammensetzung und nachweisverfahren

Country Status (11)

Country Link
US (1) US5091518A (de)
EP (1) EP0502979B1 (de)
JP (1) JPH05504474A (de)
AT (1) ATE148166T1 (de)
AU (1) AU637871B2 (de)
CA (1) CA2072644A1 (de)
DE (1) DE69029812T2 (de)
DK (1) DK0502979T3 (de)
ES (1) ES2095931T3 (de)
GR (1) GR3022358T3 (de)
WO (1) WO1991007488A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260432A (en) * 1989-06-22 1993-11-09 Sloan-Kettering Institute For Cancer Research Human gamma retinoic acid receptor DNA
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
US6492137B1 (en) * 1989-11-16 2002-12-10 The Salk Institute For Biological Studies Response element compositions and assays employing same
US5861274A (en) * 1990-03-22 1999-01-19 The Salk Institute For Biological Studies Nucleic acids encoding peroxisome proliferator-activated receptor
US5369028A (en) * 1990-04-03 1994-11-29 The Salk Institute Biotechnology/Industrial Associates, Inc. DNA and mRNA encoding human neuronal nicotinic acetylcholine receptor compositions and cells transformed with same
US6440681B1 (en) 1990-04-03 2002-08-27 Merck & Co., Inc. Methods for identifying agonists and antagonists for human neuronal nicotinic acetylcholine receptors
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
WO1992006715A1 (en) * 1990-10-12 1992-04-30 Seragen, Inc. Mammalian model of a malignant disorder
CA2098838C (en) * 1990-12-21 2002-11-26 Frances M. Sladek Liver enriched transcription factor
CA2100582A1 (en) * 1991-03-18 1992-09-19 David J. Mangelsdorf Response element compositions and assays employing same
SE500453C2 (sv) * 1991-10-07 1994-06-27 Karobio Ab Ett in vitro förfarande för utvärdering av en substans effekter
EP0552612A3 (en) * 1992-01-22 1993-10-20 Hoffmann La Roche Methods for determining and isolating compounds which bind directly to nucleosolic proteins
US6989242B1 (en) 1992-02-26 2006-01-24 The General Hospital Coporation Car receptors and related molecules and methods
US5756448A (en) * 1992-02-26 1998-05-26 The General Hospital Corporation Constitute activator of retinoid (CAR) receptor polypeptides
ES2229216T3 (es) * 1993-03-08 2005-04-16 MERCK & CO., INC. Composiciones de receptores nicotinicos neurales humanos de acetilcolina y procedimientos que emplean las mismas.
GB2287941B (en) * 1993-11-08 1998-01-28 Salk Inst Biotech Ind Human alpha2 neuronal nicotinic acetylcholine receptor compositions and methods employing same
EP0769052A2 (de) * 1994-07-01 1997-04-23 The Salk Institute For Biological Studies Säugertier peroxisompoliferator-aktivierte rezeptoren und verwendungen davon
US5702914A (en) * 1994-12-21 1997-12-30 The Salk Institute For Biological Studies Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
FR2732035B1 (fr) * 1995-03-23 1997-05-30 Agronomique Inst Nat Rech Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
US6485967B1 (en) 1995-06-07 2002-11-26 Merck & Co., Inc. Human neuronal nicotinic acetylcholine receptor α6 and β3 nucleic acid
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6489441B1 (en) 1995-09-01 2002-12-03 The Salk Institute For Biological Studies Transcriptional co-repressor that interacts with nuclear hormone receptors
WO1997034144A1 (de) * 1996-03-14 1997-09-18 Schering Aktiengesellschaft Verfahren zum nachweis der wirkung von testsubstanzen unter verwendung von hühner-urokinase
JP2002505573A (ja) 1997-04-24 2002-02-19 アンスティテュ ナショナル デュ ラ サンテ エ デュ ラ ルシェルシュ メディカル マトリックスメタロプロテイナーゼ遺伝子の発現を調節することにおける使用のための方法および組成物
US6387673B1 (en) 1997-05-01 2002-05-14 The Salk Institute For Biological Studies Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
AU1395999A (en) * 1997-11-10 1999-05-31 Salk Institute For Biological Studies, The Methods for the use of inhibitors of co-repressors for the treatment of neoplastic diseases
CN106480024B (zh) * 2015-08-30 2020-10-20 南通大学附属医院 受维甲酸调控的具有浓度依赖效应的重组启动子及其使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0318500A4 (de) * 1986-08-01 1989-12-22 Genetics Inst Induzierbare expression hohen spiegels für heterologe gene.
US5091518A (en) * 1989-11-16 1992-02-25 The Salk Institute For Biological Studies Beta retinoic acid response elements compositions and assays
DE69132411T2 (de) * 1990-02-09 2001-06-07 Salk Inst For Biolog Studies L Retinoid-rezeptor-zusammensetzungen und verfahren
WO1991014695A1 (en) * 1990-03-22 1991-10-03 The Salk Institute For Biological Studies Insect retinoid receptor compositions and methods

Also Published As

Publication number Publication date
EP0502979A1 (de) 1992-09-16
DE69029812T2 (de) 1997-06-05
JPH05504474A (ja) 1993-07-15
ATE148166T1 (de) 1997-02-15
EP0502979B1 (de) 1997-01-22
AU6956891A (en) 1991-06-13
ES2095931T3 (es) 1997-03-01
WO1991007488A1 (en) 1991-05-30
AU637871B2 (en) 1993-06-10
EP0502979A4 (en) 1993-02-10
CA2072644A1 (en) 1991-05-17
US5091518A (en) 1992-02-25
GR3022358T3 (en) 1997-04-30
DK0502979T3 (da) 1997-04-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee