DE69030955T2 - Nukleinsäureverstärkung - Google Patents

Nukleinsäureverstärkung

Info

Publication number
DE69030955T2
DE69030955T2 DE69030955T DE69030955T DE69030955T2 DE 69030955 T2 DE69030955 T2 DE 69030955T2 DE 69030955 T DE69030955 T DE 69030955T DE 69030955 T DE69030955 T DE 69030955T DE 69030955 T2 DE69030955 T2 DE 69030955T2
Authority
DE
Germany
Prior art keywords
nucleic acid
primer
sequence
specific nucleic
template
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69030955T
Other languages
English (en)
Other versions
DE69030955D1 (de
Inventor
Lawrence Malek
Cheryl Davey
Graham Henderson
Roy Sooknanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE69030955D1 publication Critical patent/DE69030955D1/de
Application granted granted Critical
Publication of DE69030955T2 publication Critical patent/DE69030955T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6832Enhancement of hybridisation reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6865Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
DE69030955T 1989-08-23 1990-08-23 Nukleinsäureverstärkung Expired - Lifetime DE69030955T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/397,681 US5130238A (en) 1988-06-24 1989-08-23 Enhanced nucleic acid amplification process
PCT/US1990/004733 WO1991002818A1 (en) 1989-08-23 1990-08-23 Enhanced nucleic acid amplification process

Publications (2)

Publication Number Publication Date
DE69030955D1 DE69030955D1 (de) 1997-07-24
DE69030955T2 true DE69030955T2 (de) 1998-01-29

Family

ID=23572204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69030955T Expired - Lifetime DE69030955T2 (de) 1989-08-23 1990-08-23 Nukleinsäureverstärkung

Country Status (13)

Country Link
US (1) US5130238A (de)
EP (1) EP0487628B1 (de)
JP (1) JP2648802B2 (de)
KR (1) KR960005737B1 (de)
AT (1) ATE154644T1 (de)
AU (1) AU647411B2 (de)
CA (1) CA2065003C (de)
DE (1) DE69030955T2 (de)
DK (1) DK0487628T3 (de)
ES (1) ES2104611T3 (de)
FI (1) FI100192B (de)
NZ (1) NZ235009A (de)
WO (1) WO1991002818A1 (de)

Families Citing this family (851)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090591A (en) * 1987-07-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5622820A (en) * 1988-03-10 1997-04-22 City Of Hope Method for amplification and detection of RNA and DNA sequences
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
GB9024005D0 (en) * 1990-11-05 1990-12-19 British Bio Technology Process for amplifying nucleic acid
WO1992018521A1 (en) * 1991-04-10 1992-10-29 Life Technologies, Inc. Method for amplifying and altering an rna sequence
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
WO1993022461A1 (en) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
US5612200A (en) * 1992-06-24 1997-03-18 Gen-Probe Incorporated Method and kit for destroying ability of nucleic acid to be amplified
AU4681393A (en) * 1992-07-17 1994-02-14 Aprogenex, Inc. Background-reducing compounds for probe-mediated in-situ fluorimetric assays
US5521061A (en) * 1992-07-17 1996-05-28 Aprogenex, Inc. Enhancement of probe signal in nucleic acid-mediated in-situ hybridization studies
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US6890712B1 (en) * 1993-09-22 2005-05-10 Bioveris Corporation Cycling DNA/RNA amplification electrochemiluminescent probe assay
GB2284209A (en) * 1993-11-25 1995-05-31 Ole Buchardt Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template
EP0682121B1 (de) * 1993-12-01 2002-08-28 Toyo Boseki Kabushiki Kaisha Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
FR2714062B1 (fr) * 1993-12-22 1996-02-16 Bio Merieux Promoteur modifié pour ARN polymérase, sa préparation et ses applications.
US20050123926A1 (en) * 1994-01-13 2005-06-09 Enzo Diagnostics, Inc., In vitro process for producing multiple nucleic acid copies
US20110097791A1 (en) * 1999-04-16 2011-04-28 Engelhardt Dean L Novel process, construct and conjugate for producing multiple nucleic acid copies
US6986985B1 (en) 1994-01-13 2006-01-17 Enzo Life Sciences, Inc. Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
CA2140081C (en) 1994-01-13 2008-04-01 Dean L. Engelhardt Process, construct and conjugate for producing multiple nucleic acid copies
AU687535B2 (en) 1994-03-16 1998-02-26 Gen-Probe Incorporated Isothermal strand displacement nucleic acid amplification
ATE209258T1 (de) * 1994-07-15 2001-12-15 Akzo Nobel Nv Verwendung von rna-polymerase zur verbesserung von nukeinsaeure-amplifikationsverfahren
US5500341A (en) 1994-09-19 1996-03-19 Becton, Dickinson And Company Species-specific detection of Mycobacterium kansasii
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
EP0789575B8 (de) 1994-11-02 2009-01-14 Allelix Neuroscience, Inc. Natrium-ionenkanäle spezifisch für das periphäre nervensystem, dna welche diese kodiert, wirkstoff-suche und methoden zu deren herstellung und verwendung
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5606043A (en) 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5665545A (en) * 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
CA2139070C (en) * 1994-12-23 2010-03-30 Burton W. Blais Method for enhancing detection ability of nucleic acid assays employing polymerase chain reaction
US5925518A (en) * 1995-05-19 1999-07-20 Akzo Nobel N.V. Nucleic acid primers for amplification of a mycobacteria RNA template
US5710029A (en) * 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US5705365A (en) * 1995-06-07 1998-01-06 Gen-Probe Incorporated Kits for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
DE69637047T2 (de) * 1995-07-13 2007-12-27 Applera Corp., Foster City Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäuren
AU714486B2 (en) 1995-11-21 2000-01-06 Yale University Unimolecular segment amplification and detection
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US6048688A (en) * 1996-11-12 2000-04-11 Kimberly-Clark Corporation Method for detection of Pseudomonas aeruginosa using polymerase chain reaction
CA2249717A1 (en) * 1996-03-18 1997-09-25 Richard K. Wilkosz Target nucleic acid sequence amplification
US5712127A (en) * 1996-04-29 1998-01-27 Genescape Inc. Subtractive amplification
US5876992A (en) 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US6475724B1 (en) * 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
AU738708B2 (en) * 1997-05-02 2001-09-27 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6221612B1 (en) * 1997-08-01 2001-04-24 Aurora Biosciences Corporation Photon reducing agents for use in fluorescence assays
US6214563B1 (en) 1997-08-01 2001-04-10 Aurora Biosciences Corporation Photon reducing agents for reducing undesired light emission in assays
US6200762B1 (en) 1997-08-01 2001-03-13 Aurora Biosciences Corporation Photon reducing agents and compositions for fluorescence assays
ZA99362B (en) * 1998-01-23 1999-07-19 Akzo Nobel Nv EF-Tu mRNA as a marker for viability of bacteria.
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
CA2319170A1 (en) * 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
JP4438110B2 (ja) * 1998-07-01 2010-03-24 東ソー株式会社 標的核酸の定量方法
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6316229B1 (en) 1998-07-20 2001-11-13 Yale University Single molecule analysis target-mediated ligation of bipartite primers
AU763890B2 (en) 1998-09-15 2003-07-31 Yale University Artificial long terminal repeat vectors
US6287824B1 (en) 1998-09-15 2001-09-11 Yale University Molecular cloning using rolling circle amplification
MXPA01005267A (es) * 1998-11-27 2002-04-24 Synaptics Uk Ltd Sensor de posicion.
US6326173B1 (en) * 1999-04-12 2001-12-04 Nanogen/Becton Dickinson Partnership Electronically mediated nucleic acid amplification in NASBA
US6531302B1 (en) * 1999-04-12 2003-03-11 Nanogen/Becton Dickinson Partnership Anchored strand displacement amplification on an electronically addressable microchip
EP1177423A4 (de) * 1999-04-12 2004-10-27 Nanogen Becton Dickinson Partn Verstärkung und trennung von nukleinsäuresequenzen mittels strangverschiebeverstärkung und bioelektronischer
US6238868B1 (en) * 1999-04-12 2001-05-29 Nanogen/Becton Dickinson Partnership Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
US20030215821A1 (en) * 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
EP1196630B2 (de) 1999-04-20 2018-10-17 Illumina, Inc. Detektion von nukleinsäurereaktionen auf kügelchen-arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6132997A (en) * 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
US7022517B1 (en) 1999-07-16 2006-04-04 Board Of Regents, The University Of Texas System Method and apparatus for the delivery of samples to a chemical sensor array
ATE346287T1 (de) 1999-07-16 2006-12-15 Univ Texas Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
CA2378408C (en) 1999-07-23 2010-07-06 Gen-Probe Incorporated Polynucleotide amplification method
CA2380258C (en) 1999-07-26 2008-07-15 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
CN102586228A (zh) 1999-09-13 2012-07-18 纽亘技术公司 用于多核苷酸序列线性等温扩增的方法及组合物
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
JP2003517858A (ja) * 1999-11-05 2003-06-03 ジェリジーン メディカル コーポレーション 老齢関連の軟組織の欠陥の増強と修復
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6794138B1 (en) * 1999-12-16 2004-09-21 Affymetrix, Inc. Methods of small sample amplification
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
EP2230314A1 (de) * 2000-01-31 2010-09-22 The Board of Regents,The University of Texas System Verfahren zum Nachweis eines Analyten
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7087414B2 (en) * 2000-06-06 2006-08-08 Applera Corporation Methods and devices for multiplexing amplification reactions
EP2351853A1 (de) 2000-06-06 2011-08-03 Life Technologies Corporation Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US20060166227A1 (en) * 2000-06-20 2006-07-27 Stephen Kingsmore Protein expression profiling
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE455186T1 (de) * 2000-06-26 2010-01-15 Nugen Technologies Inc Methoden und zusammensetzungen zur auf transkription basierenden vervielfältigung von nukleinsäuren
US6686157B2 (en) 2000-06-30 2004-02-03 Molecular Staging Inc. Signal amplification with lollipop probes
JP4331476B2 (ja) * 2000-08-03 2009-09-16 エフ.ホフマン−ラ ロシュ アーゲー プリン−2,6−ジアミンのピラゾロ[3,4−d]ピリミジンアナローグを含有する核酸結合性化合物およびそれらの使用
UA81743C2 (uk) 2000-08-07 2008-02-11 Центокор, Инк. МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
US7288390B2 (en) 2000-08-07 2007-10-30 Centocor, Inc. Anti-dual integrin antibodies, compositions, methods and uses
CA2419649C (en) 2000-09-01 2011-03-08 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
US6558929B2 (en) * 2000-09-15 2003-05-06 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forshung E.V. PCR reaction mixture for fluorescence-based gene expression and gene mutation analyses
US6870045B2 (en) 2000-10-23 2005-03-22 Gen-Probe Incorporated Kits for detecting HIV-2
WO2002057491A2 (en) * 2000-10-24 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic dna
US20020192669A1 (en) * 2000-11-10 2002-12-19 Sorge Joseph A. Methods for preparation of nucleic acid for analysis
US6919189B2 (en) 2000-12-11 2005-07-19 Alexion Pharmaceuticals, Inc. Nested oligonucleotides containing a hairpin for nucleic acid amplification
US6858413B2 (en) 2000-12-13 2005-02-22 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US20020197622A1 (en) * 2001-01-31 2002-12-26 Mcdevitt John T. Method and apparatus for the confinement of materials in a micromachined chemical sensor array
JP2005508135A (ja) * 2001-03-09 2005-03-31 ニューゲン テクノロジーズ, インコーポレイテッド Rna配列の増幅のための方法および組成物
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
ATE361996T1 (de) 2001-03-09 2007-06-15 Nugen Technologies Inc Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
AU2003303395A1 (en) * 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US8137911B2 (en) * 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
AU2002305019A1 (en) * 2001-05-25 2002-12-09 University Of British Columbia Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
NZ530343A (en) * 2001-06-22 2007-01-26 Marshfield Clinic Methods and oligonucleotides for the detection of E. coli 0157:H7
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
WO2003006677A2 (en) 2001-07-12 2003-01-23 Illumina, Inc. Multiplex nucleic acid reactions
US20030027196A1 (en) * 2001-08-02 2003-02-06 Barnes Wayne M. Magnesium precipitate methods for magnesium dependent enzymes
TWI335938B (en) * 2001-08-15 2011-01-11 Rna replication and amplification
DE10143106C1 (de) * 2001-09-03 2002-10-10 Artus Ges Fuer Molekularbiolog Vermehrung von Ribonukleinsäuren
US20120077196A9 (en) * 2001-09-03 2012-03-29 Guido Krupp Universal method for selective amplification of mRNAs
JP4439262B2 (ja) * 2001-09-19 2010-03-24 アレクシオン ファーマシューティカルズ, インコーポレイテッド 操作されたテンプレートおよび単一プライマー増幅におけるそれらの使用
US7414111B2 (en) * 2001-09-19 2008-08-19 Alexion Pharmaceuticals, Inc. Engineered templates and their use in single primer amplification
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US7045319B2 (en) 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20030119000A1 (en) * 2001-11-05 2003-06-26 Jon Polansky Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices
MXPA04004671A (es) 2001-11-14 2005-08-25 Johnson & Johnson Anticuerpos anti-interleucina-6, composiciones, metodos y usos.
BRPI0214821B8 (pt) * 2001-12-10 2021-07-27 Novartis Ag método para determinar a responsividade de indivíduo com distúrbio psicótico ao tratamento com loperidona
JP4148900B2 (ja) 2002-01-08 2008-09-10 エフ.ホフマン−ラ ロシュ アーゲー 増幅反応におけるシリカ物質の使用
AU2003208959A1 (en) * 2002-01-30 2003-09-02 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
EP1470148B1 (de) 2002-02-01 2012-07-18 Life Technologies Corporation Doppelsträngige oligonukleotide
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
EP1484394A4 (de) 2002-02-20 2005-11-09 Sysmex Corp PRIMER ZUR NUKLEINSÄUREAMPLIFIKATION BEIM NACHWEISEN VON HAUSHALTUNGSGEN-mRNA SOWIE TESTVERFAHREN MIT DIESEN PRIMERN
EP1488001B1 (de) * 2002-03-11 2008-08-20 Nugen Technologies, Inc. Verfahren zur erzeugung doppelsträngiger dna mit einem 3'-einzelstranganteil und verwendungen dieser komplexe zur rekombination
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
US20060246434A1 (en) * 2002-03-15 2006-11-02 Erlander Mark G Nucleic acid amplification
US20040241723A1 (en) * 2002-03-18 2004-12-02 Marquess Foley Leigh Shaw Systems and methods for improving protein and milk production of dairy herds
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003228711C1 (en) 2002-04-26 2010-01-07 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
US20040005614A1 (en) * 2002-05-17 2004-01-08 Nurith Kurn Methods for fragmentation, labeling and immobilization of nucleic acids
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
WO2003106714A1 (en) 2002-06-14 2003-12-24 Gen-Probe Incorporated Compositions and methods for detecting hepatitis b virus
US20040009482A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae surface immunogenic protein genes
US20040009574A1 (en) * 2002-07-09 2004-01-15 Nanibhushan Dattagupta Compositions and methods for detecting streptococcus agalactiae capsular polysaccharide synthesis genes
US20040009483A1 (en) * 2002-07-12 2004-01-15 Ilsley Diane D. Method of linear mRNA amplification using total RNA
US20060073475A1 (en) * 2002-08-09 2006-04-06 Nanibhushan Dattagupta Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins
AU2003236461B2 (en) 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
DE10240868A1 (de) * 2002-09-04 2004-03-18 Artus Gesellschaft für molekularbiologische Diagnostik und Entwicklung mbH Verbesserte Verfahren zur Synthese von Nukleinsäuren
JP2006502747A (ja) 2002-10-16 2006-01-26 ジェン−プロウブ インコーポレイテッド 西ナイルウィルスを検出するための、組成物および方法
US20040101844A1 (en) * 2002-11-21 2004-05-27 Amorese Douglas A. Methods and compositions for producing linearly amplified amounts of (+) strand RNA
WO2004048596A2 (en) 2002-11-21 2004-06-10 Epicentre Technologies Methods for using primers that encode one strand of a double-stranded promoter
AU2003293015A1 (en) * 2002-11-26 2004-06-18 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
US8323897B2 (en) 2002-12-04 2012-12-04 Applied Biosystems, Llc Multiplex amplification of polynucleotides
US7955795B2 (en) * 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US6977153B2 (en) * 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
US6852494B2 (en) * 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
WO2004083806A2 (en) 2003-01-22 2004-09-30 University Of South Florida Autonomous genosensor apparatus and methods for use
ATE373673T1 (de) * 2003-01-29 2007-10-15 Hoffmann La Roche Verbessertes verfahren zur behandlung durch bisulfit
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
EP2390352A1 (de) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren
US20060192960A1 (en) * 2003-03-24 2006-08-31 Rencs Erik V Polarization detection
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
AU2004230494A1 (en) * 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
CA2522753C (en) 2003-04-18 2014-06-10 Becton, Dickinson And Company Immuno-amplification
JP2006524988A (ja) * 2003-05-09 2006-11-09 キャピタルバイオ コーポレーション Sarsウイルスを検出するための方法および組成物
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
FR2855832B1 (fr) 2003-06-03 2007-09-14 Biomerieux Sa Procede de diagnostic et/ou de pronostic d'un syndrome septique
US20040248102A1 (en) * 2003-06-03 2004-12-09 Diane Ilsley-Tyree Methods and compositions for performing template dependent nucleic acid primer extension reactions that produce a reduced complexity product
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
AU2004253882B2 (en) 2003-06-20 2010-06-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
US20060057766A1 (en) * 2003-07-08 2006-03-16 Quanxi Jia Method for preparation of semiconductive films
FR2857375B1 (fr) 2003-07-10 2007-11-09 Biomerieux Sa Procede de detection et/ou d'identification de bacteries de genre staphylococcus
CA2534382C (en) 2003-08-04 2018-12-11 The Hospital For Sick Children Epm2b gene mutations associated with lafora's disease
US20050059035A1 (en) * 2003-09-09 2005-03-17 Quest Diagnostics Incorporated Methods and compositions for the amplification of mutations in the diagnosis of cystic fibrosis
DE602004030271D1 (de) * 2003-09-12 2011-01-05 Univ Cincinnati Verfahren zur risikobeurteilung, überlebensvorhersage und behandlung von herzversagen und anderen leiden auf der grundlage von polymorphismen adrenerger rezeptoren
KR100571817B1 (ko) * 2003-09-19 2006-04-17 삼성전자주식회사 태그 서열에 혼성화하는 검출 프로브를 이용하는 표적핵산의 검출방법
CA2482097C (en) * 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
KR20070012779A (ko) * 2003-10-29 2007-01-29 리보메드 바이오테그놀로지스 인코포레이티드 반복적 올리고뉴클레오티드 합성을 위한 조성물, 방법 및검출 기법
US7385049B2 (en) 2003-11-12 2008-06-10 Bayer Healthcare Llc Oligonucleotides and methods for detection of West Nile virus
EP1692315A1 (de) 2003-12-02 2006-08-23 Roche Diagnostics GmbH Verbessertes verfahren zur bisulfitbehandlung
FR2863275B1 (fr) * 2003-12-09 2007-08-10 Biomerieux Sa Procede pour le diagnostic/pronostic du cancer du sein
DE602004028862D1 (de) 2003-12-19 2010-10-07 Gen Probe Inc Der nukleinsäuren von hiv-1 und hiv-2
US20050136411A1 (en) * 2003-12-22 2005-06-23 Collins Patrick J. Methods and compositions for linear mRNA amplification from small RNA samples
US20050147975A1 (en) * 2003-12-24 2005-07-07 Schembri Carol T. Methods and compositions for amplification of genomic DNA
EP1711591A4 (de) 2003-12-29 2010-04-28 Nugen Technologies Inc Verfahren zur analyse des methylierungsstatus von nukleinsäure und verfahren zur fragmentierung, markierung und immobilisierung von nukleinsäuren
US20050158710A1 (en) * 2004-01-16 2005-07-21 Shirley Tsang Detection of enterovirus nucleic acid
ES2354020T3 (es) * 2004-02-10 2011-03-09 Roche Diagnostics Gmbh Nuevos cebadores y sondas para la detección del parvovirus b19.
AU2005244673B2 (en) 2004-02-19 2009-12-10 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP1721011A1 (de) 2004-03-01 2006-11-15 Applera Corporation Verfahren, zusammensetzungen und kits zur verwendung bei der polynukleotidamplifikation
US8338578B1 (en) * 2004-03-05 2012-12-25 Quest Diagnostics Investments Incorporated Cystic fibrosis gene mutations
EP1574583A1 (de) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Verfahren zur Isolierung von Bakterien aus biologischen Proben
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
FR2868433B1 (fr) 2004-04-06 2008-01-18 Biomerieux Sa Procede pour le pronostic et/ou le diagnostic d'un cancer
US7229800B2 (en) * 2004-04-16 2007-06-12 Becton, Dickinson And Company Neisseria gonorrhoeae assay
US7311794B2 (en) 2004-05-28 2007-12-25 Wafergen, Inc. Methods of sealing micro wells
US8124334B2 (en) * 2004-07-06 2012-02-28 Enzo Biochem, Inc. Selective detection of oncogenic HPV
AU2005262317B2 (en) 2004-07-13 2009-07-16 Gen-Probe Incorporated Compositions and methods for detection of hepatitis A virus nucleic acid
EP2071031B1 (de) * 2004-08-27 2013-10-09 Gen-Probe Incorporated Einfach-Primernukleinsäuren-Erweiterungsverfahren
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
EP1632578A1 (de) 2004-09-03 2006-03-08 Roche Diagnostics GmbH Methode zur Dekontamination der DNA
CA2581086C (en) 2004-09-14 2023-11-07 The Regents Of The University Of Colorado, A Body Corporate Method for treatment with bucindolol based on genetic targeting
US20100063093A1 (en) * 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
EP2975139B1 (de) 2004-09-30 2019-11-06 Gen-Probe Incorporated Verfahren zum nachweis und zur quantifizierung von hiv-1
WO2006039663A2 (en) * 2004-09-30 2006-04-13 Vanda Pharmaceuticals, Inc Methods for the administration of iloperidone
US9132398B2 (en) 2007-10-12 2015-09-15 Rheonix, Inc. Integrated microfluidic device and methods
JP5192238B2 (ja) * 2004-11-09 2013-05-08 ジェン−プローブ・インコーポレーテッド A群連鎖球菌属を検出するための組成物及び方法
CA2588783C (en) * 2004-12-17 2012-03-27 Ventana Medical Systems, Inc. Methods and compositions for a microemulsion-based tissue treatment
EP1841879A4 (de) * 2005-01-25 2009-05-27 Population Genetics Technologi Isothermische dna-amplifikation
FR2881437B1 (fr) 2005-01-31 2010-11-19 Biomerieux Sa Procede pour le diagnostic/pronostic d'un syndrome septique
DE602006018586D1 (de) * 2005-02-07 2011-01-13 Gen Probe Inc Zusammensetzungen und verfahren zum nachweis von streptokokken der gruppe b
US20090124993A1 (en) 2005-02-17 2009-05-14 Burkly Linda C Treating neurological disorders
EP1853706B1 (de) 2005-02-18 2010-12-29 Gen-Probe Incorporated Probenherstellungsverfahren mit einem alkali-stoss
EP1874955A4 (de) * 2005-02-28 2009-05-06 Bioquest Inc Verfahren zur durchführung direkter enzymatischer reaktionen unter beteiligung von nukleinsäuremolekülen
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
WO2006095981A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
JP4398886B2 (ja) * 2005-03-07 2010-01-13 ソニー株式会社 通信端末装置、通信システム、通信方法、およびプログラム
EP1700922B1 (de) 2005-03-10 2016-08-24 Roche Diagnostics GmbH 3-Substituierte 5-Nitroindolderivate und diese enthaltende markierte Oligonukleotidsonden
US7794659B2 (en) 2005-03-10 2010-09-14 Gen-Probe Incorporated Signal measuring system having a movable signal measuring device
US7759469B2 (en) 2005-03-10 2010-07-20 Roche Diagnostics Operations, Inc. Labeling reagent
EP2348320A3 (de) 2005-03-10 2014-06-25 Gen-Probe Incorporated Systeme und Verfahren zur Erkennung mehrerer optischer Signale
JP4658660B2 (ja) * 2005-03-30 2011-03-23 株式会社日立ハイテクノロジーズ 核酸検出法
WO2006105511A1 (en) 2005-03-31 2006-10-05 The General Hospital Corporation Monitoring and modulating hgf/hgfr activity
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
EP1863908B1 (de) 2005-04-01 2010-11-17 Qiagen GmbH Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
US20060240442A1 (en) * 2005-04-20 2006-10-26 Vevea Dirk N Methods and oligonucleotides for the detection of Salmonella SP., E coli 0157:H7, and Listeria monocytogenes
JO3058B1 (ar) 2005-04-29 2017-03-15 Applied Molecular Evolution Inc الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها
EP1877418B1 (de) 2005-05-06 2013-11-20 Gen-Probe Incorporated Zusammensetzungen und testanordnungen zur erkennung von nukleinsäuren des influenza-virus a
NZ564141A (en) 2005-05-09 2011-02-25 Theranos Inc Two way communication system for monitoring an analyte
AU2006246975B2 (en) 2005-05-17 2011-08-11 Ozgene Pty Ltd Sequential cloning system
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US7550264B2 (en) 2005-06-10 2009-06-23 Datascope Investment Corporation Methods and kits for sense RNA synthesis
WO2007002480A2 (en) * 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
AU2006265002B2 (en) 2005-06-30 2012-09-20 Centocor, Inc. Anti-IL-23 antibodies, compositions, methods and uses
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
CA2621146A1 (en) * 2005-09-06 2007-03-15 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
CA2621267A1 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
CA2622295C (en) 2005-09-12 2019-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
EP2377929A1 (de) * 2005-10-06 2011-10-19 Lucigen Corporation Wärmestabile virale Polymerasen und Verwendungsverfahren
EP1937847A2 (de) 2005-10-17 2008-07-02 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von legionella pneumophila-nukleinsäure
WO2007056398A2 (en) 2005-11-07 2007-05-18 Siemens Healthcare Diagnostics Inc. Chlamydia trachomatis specific oligonucleotide sequences
EP2273404B1 (de) 2005-11-14 2013-10-09 Gen-Probe Incorporated Computerlesbares Medium für parametrisches Kalibrationsverfahren
EP1952147A2 (de) 2005-11-16 2008-08-06 Novartis AG Biomarker zur anti-nogo-a-antikörperbehandlung bei rückenmarksverletzung
EP1788389A1 (de) 2005-11-18 2007-05-23 Universitat De Girona Verfahren zum spezifischen Nachweis von Legionella pneumophila
FR2902430B1 (fr) 2005-11-25 2012-11-02 Biomerieux Sa Oligonucleotides, utilisation, methode de detection et kit permettant de diagnostiquer la presence des genes h5 et n1 du virus d'influenza a
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
EA035459B1 (ru) 2005-12-29 2020-06-19 Сентокор, Инк. Антитело против il-23p19
CN103499466B (zh) * 2006-01-18 2017-04-12 阿戈斯治疗公司 用于处理封闭容器中的样品的系统和方法以及相关装置
WO2007087262A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Selective genome amplification
EP2007905B1 (de) 2006-03-15 2012-08-22 Micronics, Inc. Integrierte nukleinsäuretests
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
AU2007235282A1 (en) 2006-04-07 2007-10-18 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae specific oligonucleotide sequences
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
AU2007249286B2 (en) * 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
US7897747B2 (en) * 2006-05-25 2011-03-01 The Board Of Trustees Of The Leland Stanford Junior University Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby
EP2455489A3 (de) 2006-05-25 2012-07-11 Monsanto Technology LLC Verfahren zur Identifizierung von krankheitsresistenten quantitative trait loci in Sojabohnen und Zusammensetzungen damit
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
DK1945821T3 (da) 2006-06-06 2011-03-07 Gen Probe Inc Mærkede oligonukleotider og anvendelse deraf i fremgangsmåder til amplifikation af nukleinsyrer
EP2038429B1 (de) * 2006-06-30 2013-08-21 Nugen Technologies, Inc. Verfahren zur fragmentierung und etikettierung von nukleinsäuren
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
CA2658105C (en) 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US8586006B2 (en) 2006-08-09 2013-11-19 Institute For Systems Biology Organ-specific proteins and methods of their use
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008030605A2 (en) * 2006-09-08 2008-03-13 The Regents Of The University Of Michigan Herv group ii viruses in lymphoma and cancer
FR2906537A1 (fr) 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
EP1932913B1 (de) 2006-12-11 2013-01-16 Roche Diagnostics GmbH Nukleinsäureisolation mithilfe von Polidocanol und Derivaten davon
CN102776173B (zh) 2006-12-11 2014-10-29 霍夫曼-拉罗奇有限公司 使用聚多卡醇和衍生物的核酸分离
US8198027B2 (en) 2006-12-21 2012-06-12 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (de) 2007-04-02 2013-03-27 Gen-Probe Incorporated Zusammensetzungen, Kits und zugehörige Verfahren zur Erkennung und/oder Überwachung von Pseudomonas aeruginosa
CA2629589C (en) 2007-04-20 2016-03-29 F.Hoffmann-La Roche Ag Isolation and purification of nucleic acid molecules with a solid phase
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
AU2008269201B2 (en) 2007-06-21 2011-08-18 Gen-Probe Incorporated Instrument and receptacles for use in performing processes
EP2173872B1 (de) 2007-06-29 2014-04-02 CellScript, Inc. Copy-dna und sense-rna
WO2009009432A2 (en) 2007-07-06 2009-01-15 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
ATE533861T1 (de) 2007-07-06 2011-12-15 Univ Michigan Mipol1-etv1-gen-neuanordnungen
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
EP2183380B1 (de) 2007-08-27 2014-11-26 Life Technologies Corporation Verfahren und zusammensetzungen für pcr
EP3181228B1 (de) 2007-10-02 2020-07-29 Labrador Diagnostics LLC Modulare poc-vorrichtungen und ihre verwendung
WO2009061640A2 (en) * 2007-11-06 2009-05-14 Siemens Healthcare Diagnostics Inc. Hepatitis b virus (hbv) specific oligonucleotide sequences
EP2071034A1 (de) 2007-12-12 2009-06-17 bioMérieux Verfahren zur Behandlung einer Lösung zum Vernichten von Ribonukleinsäure nach der Amplifikation
JP5503552B2 (ja) 2007-12-21 2014-05-28 バイオメリュー・エスエイ メチシリン耐性黄色ブドウ球菌の検出
EP2235214B1 (de) * 2007-12-26 2014-07-09 Gen Probe Inc Zusammensetzungen und verfahren für den nachweis von candida albicans-nukleinsäure
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
CA2719247C (en) * 2008-03-25 2017-03-21 The Regents Of The University Of Michigan Ikki inhibitor therapies and screening methods, and related ikki diagnostics
EP2108699B1 (de) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Vorrichtung zur analytischen Verarbeitung und Detektion
CA2721536A1 (en) 2008-04-21 2009-10-29 Gen-Probe Incorporated Method for detecting chikungunya virus
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
EP2479287B1 (de) 2008-05-13 2014-07-23 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und Fangen von Zielnukleinsäuresequenzen
EP2297346B1 (de) 2008-05-15 2015-04-15 Ribomed Biotechnologies, Inc. VERFAHREN UND REAGENZIEN FÜR DEN NACHWEIS VON CpG-METHYLIERUNG MIT EINEM METHYL-CpG-BINDENDEN PROTEIN (MBP)
US20110136683A1 (en) 2008-05-28 2011-06-09 Genomedx Biosciences, Inc. Systems and Methods for Expression-Based Discrimination of Distinct Clinical Disease States in Prostate Cancer
WO2009158119A2 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
ES2439951T3 (es) 2008-06-06 2014-01-27 F. Hoffmann-La Roche Ag Detección y cuantificación multiplex de ácidos nucleicos microbianos controlada de forma interna
WO2010009060A2 (en) * 2008-07-13 2010-01-21 Ribomed Biotechnologies, Inc. Molecular beacon-based methods for detection of targets using abscription
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
GB0814570D0 (en) 2008-08-08 2008-09-17 Diagnostics For The Real World Isolation of nucleic acid
MX2011001409A (es) 2008-08-14 2011-03-29 Cephalon Australia Pty Ltd Anticuerpos anti-il-12/il-23.
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
WO2010030461A2 (en) * 2008-09-12 2010-03-18 Promega Corporation Assessing expression of endogenous and exogenous genes
EP2172563A1 (de) 2008-09-24 2010-04-07 bioMérieux S.A. Verfahren zur Verringerung der Abhängigkeit von Sequenzvariationen eines Nukleinsäuretargets in einem diagnostischen Hybridisierungs-Assay
US9090948B2 (en) * 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
EP2177271B8 (de) 2008-10-15 2019-12-18 F. Hoffmann-La Roche AG Magnetisches Trennsystem mit flexiblen magnetischen Stiften und zugehöriges Verfahren
US20100144781A1 (en) * 2008-10-29 2010-06-10 Dong-Jing Fu Methods of treating psychosis and schizophrenia based on polymorphisms in the erbb4 gene
LT2356269T (lt) 2008-10-31 2016-09-12 Janssen Biotech, Inc. Karkaso kompozicijos iii tipo fibronektino domeno pagrindu, būdai ir panaudojimas
EP2189218A1 (de) 2008-11-12 2010-05-26 F. Hoffmann-Roche AG Trennung in einer Mikrowell platte unter Zuhilfenahme des Deckels
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
FR2940805B1 (fr) 2009-01-05 2015-10-16 Biomerieux Sa Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede
EP2382328A2 (de) 2009-01-09 2011-11-02 The Regents of the University of Michigan Rezidivierende genfusionen bei krebs
AU2010208085B2 (en) 2009-01-30 2014-02-06 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
EP2396011B1 (de) 2009-02-12 2016-04-13 Janssen Biotech, Inc. Auf fibronectin-typ-iii-domain basierende gerüstzusammensetzungen, verfahren und anwendung
CA2756659A1 (en) 2009-02-26 2010-09-02 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
AU2010225937B2 (en) 2009-03-15 2014-09-18 Ribomed Biotechnologies, Inc. Abscription based molecular detection
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
EP3360978A3 (de) 2009-05-07 2018-09-26 Veracyte, Inc. Verfahren zur diagnose von schilddrüsenerkrankungen
EP3450573B1 (de) 2009-06-23 2022-01-26 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von nukleinsäure aus mollicutes
CA2766391C (en) 2009-07-01 2021-04-20 Gen-Probe Incorporated Methods and compositions for multiplex nucleic acid amplification
AU2010276236B2 (en) 2009-07-21 2014-03-20 Gen-Probe Incorporated Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range
US8614062B1 (en) 2009-07-24 2013-12-24 University Of South Florida RNA-based system and method to differentiate seafood
US20110059453A1 (en) * 2009-08-23 2011-03-10 Affymetrix, Inc. Poly(A) Tail Length Measurement by PCR
CA2770888C (en) 2009-08-31 2020-04-14 Gen-Probe Incorporated Dengue virus assay
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
AU2010295689B2 (en) * 2009-09-17 2014-02-13 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
FR2950358B1 (fr) 2009-09-18 2015-09-11 Biomerieux Sa Dispositif d'amplification d'acides nucleiques simplifie et son procede de mise en oeuvre
MX2012004620A (es) 2009-10-19 2012-06-25 Theranos Inc Sistema integrado de captura y analisis de datos de salud.
CA2780678A1 (en) 2009-11-19 2011-05-26 Ou Solis Biodyne Compositions for increasing polypeptide stability and activity, and related methods
EP2510126B1 (de) 2009-12-07 2017-08-09 Illumina, Inc. Indexierung mehrerer proben für multiplex-genotypisierung
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
ES2587191T3 (es) 2009-12-23 2016-10-21 Arca Biopharma, Inc. Métodos y composiciones para enfermedades y afecciones cardiovasculares
WO2011082325A2 (en) 2009-12-31 2011-07-07 Life Technologies Corporation Sequences of e.coli 055:h7 genome
CN102725424B (zh) 2010-01-25 2014-07-09 Rd生物科技公司 靶核酸的自折叠扩增
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
US9181593B2 (en) 2010-02-17 2015-11-10 Gen-Probe Incorporated Compositions and methods to detect Atopobium vaginae nucleic acid
MY163133A (en) 2010-03-30 2017-08-15 Janssen Biotech Inc Humanized il-25 antibodies
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
RS54482B1 (en) 2010-04-05 2016-06-30 Prognosys Biosciences, Inc. SPATIAL CODING BIOLOGICAL TESTING
WO2011133811A2 (en) 2010-04-21 2011-10-27 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acid
EP2563380B1 (de) 2010-04-26 2018-05-30 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten der cysteinyl-trna-synthetase
WO2011139799A2 (en) 2010-04-27 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
US9068177B2 (en) 2010-04-29 2015-06-30 Atyr Pharma, Inc Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases
US8986680B2 (en) 2010-04-29 2015-03-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
US8981045B2 (en) 2010-05-03 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
EP2566515B1 (de) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen
JP6008840B2 (ja) 2010-05-03 2016-10-19 エータイアー ファーマ, インコーポレイテッド フェニルアラニルαtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
EP2568996B1 (de) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-beta-trna-synthetasen
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 HIF?2α 형질전환 마우스 및 이의 용도
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 HIF-2α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
JP5916718B2 (ja) 2010-06-04 2016-05-11 ビオメリューBiomerieux 結腸直腸癌の予後判定のための方法及びキット
ES2569220T3 (es) 2010-06-22 2016-05-09 F. Hoffmann-La Roche Ag Envase de suspensión para partículas de unión para el aislamiento de material biológico
EP2588629B1 (de) 2010-06-30 2017-05-17 Gen-Probe Incorporated Methode und apparatur zur identifizierung von analyt-beinhaltenden proben unter verwendung von single-read determination des analyten und prozesskontrollsignalen
BR112013000433A2 (pt) 2010-07-07 2016-05-17 Univ Michigan diagnóstico e tratamento de câncer de mama
JP6116479B2 (ja) 2010-07-12 2017-04-19 エータイアー ファーマ, インコーポレイテッド グリシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2593569B1 (de) 2010-07-12 2018-01-03 Gen-Probe Incorporated Zusammensetzungen und tests für den nachweis von nukleinsäuren des saisonalen h1 influenza a virus
US9663834B2 (en) 2010-07-16 2017-05-30 Tocagen Inc. Retrovirus detection
CN107058617A (zh) 2010-07-29 2017-08-18 霍夫曼-拉罗奇有限公司 通用样品制备
ES2640522T3 (es) 2010-07-29 2017-11-03 F. Hoffmann-La Roche Ag Ácidos nucleicos de control para múltiples parámetros
CA2802548C (en) 2010-07-29 2017-01-03 F. Hoffmann-La Roche Ag Qualitative and quantitative detection of microbial nucleic acids
ES2644797T3 (es) 2010-07-29 2017-11-30 F. Hoffmann-La Roche Ag PCR genérica
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2608801B1 (de) 2010-08-25 2019-08-21 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von tyrosyl-trna-synthetasen
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
EP2426222A1 (de) 2010-09-07 2012-03-07 F. Hoffmann-La Roche AG Generischer Puffer zur Amplifikation
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
PL3590949T3 (pl) 2010-10-01 2022-08-29 Modernatx, Inc. Kwasy rybonukleinowe zawierające n1-metylo-pseudouracyle i ich zastosowania
EP2625297B1 (de) 2010-10-04 2018-10-10 Gen-Probe Prodesse, Inc. Zusammensetzungen, verfahren und kits für den nachweis von adenovirus-nukleinsäuren
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (de) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Verfahren zum nachweis eines bakteriums in einer vollblutprobe
CN103282511A (zh) 2010-11-01 2013-09-04 贝克顿·迪金森公司 阴道加特纳菌测定
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
CA3012765A1 (en) 2010-11-19 2012-05-24 The Regents Of The University Of Michigan Ncrna and uses thereof
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
EP2465945A1 (de) 2010-12-17 2012-06-20 F. Hoffmann-La Roche AG Allgemeine Matrix zur Steuerung von Nukleinsäuren
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
CA2997473C (en) 2010-12-31 2023-10-03 Bioatla, Llc Comprehensive monoclonal antibody generation
CN103620032B (zh) 2010-12-31 2016-02-24 生物蛋白有限公司 抗体的快速人源化
BR112013018656B1 (pt) 2011-01-21 2021-03-02 Labrador Diagnostics Llc método para detectar a presença ou concentração de um analito numa amostra de fluido contido num recipiente, e, método de medição da concentração de analito numa amostra de fluido
WO2012106546A2 (en) 2011-02-02 2012-08-09 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
WO2012112558A1 (en) 2011-02-14 2012-08-23 The Regents Of The University Of Michigan Compositions and methods for the treatment of obesity and related disorders
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
AU2012236099A1 (en) 2011-03-31 2013-10-03 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
EP2694677A2 (de) 2011-04-04 2014-02-12 Netherland Cancer Institute Verfahren und zusammensetzungen zur vorhersage der resistenz gegenüber einer antikrebsbehandlung mit proteinkinasehemmern
WO2012138789A2 (en) 2011-04-04 2012-10-11 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CA2833262C (en) 2011-04-15 2020-08-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
EP3272886B1 (de) 2011-04-25 2019-09-25 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von bv-assoziierter bakterieller nukleinsäure
WO2012149038A1 (en) 2011-04-25 2012-11-01 Advanced Bioscience Laboratories, Inc. Truncated hiv envelope proteins (env), methods and compositions related thereto
EP2535712A1 (de) 2011-06-15 2012-12-19 F. Hoffmann-La Roche AG Analytisches System zur Herstellung eines biologischen Materials
WO2012174119A2 (en) 2011-06-17 2012-12-20 Life Technologies Corporation Compositions and methods for detection of cronobacter spp. and cronobacter species and strains
ES2945966T3 (es) 2011-07-15 2023-07-11 Gen Probe Inc Composiciones y procedimiento para detectar ácido nucleico del parvovirus humano y ácido nucleico del virus de la hepatitis A
US8778843B1 (en) 2011-08-03 2014-07-15 Fry Laboratories, L.L.C. Semi-pan-protozoal by quantitative PCR
ES2680143T3 (es) 2011-08-24 2018-09-04 Oxoid Limited Composiciones y métodos para la detección de múltiples microorganismos
EP2753714B1 (de) 2011-09-06 2017-04-12 Gen-Probe Incorporated Zirkularisierte schablonen zur sequenzierung
US10767208B2 (en) 2011-09-06 2020-09-08 Gen-Probe Incorporated Closed nucleic acid structures
AU2012304327B2 (en) 2011-09-08 2015-07-09 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
EP2758547B1 (de) 2011-09-21 2015-09-16 Gen-Probe Incorporated Verfahren zur amplifikation von nukleinsäuren unter verwendung von tag-vermittelter verschiebung
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
CA2849104A1 (en) 2011-09-25 2013-04-11 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
RS62993B1 (sr) 2011-10-03 2022-03-31 Modernatx Inc Modifikovani nukleozidi, nukleotidi, i nukleinske kiseline, i njihove upotrebe
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
SG10201510189WA (en) 2011-10-19 2016-01-28 Nugen Technologies Inc Compositions And Methods For Directional Nucleic Acid Amplification And Sequencing
WO2013064908A1 (en) 2011-11-04 2013-05-10 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
EP2773757B1 (de) 2011-11-04 2019-01-09 Gen-Probe Incorporated Molekulartestreagenzien und verfahren
AU2012340015B2 (en) 2011-11-14 2017-09-21 Alfasigma S.P.A. Assays for selecting a treatment regimen for a subject with depression and methods for treatment
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
AU2012352153B2 (en) 2011-12-13 2018-07-26 Veracyte, Inc. Cancer diagnostics using non-coding transcripts
EP4144378A1 (de) 2011-12-16 2023-03-08 ModernaTX, Inc. Modifizierte nukleosid-, nukleotid- und nukleinsäurezusammensetzungen
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
WO2013096460A1 (en) 2011-12-20 2013-06-27 The Regents Of The University Of Michigan Pseudogenes and uses thereof
WO2013096838A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
AU2012356749B2 (en) 2011-12-23 2018-08-02 Biomerieux Detection of mecA variant strains of methicillin-resistant Staphylococcus aureus
WO2013101935A1 (en) 2011-12-27 2013-07-04 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
WO2013104990A1 (en) 2012-01-09 2013-07-18 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
SG10201504490QA (en) 2012-01-26 2015-07-30 Nugen Technologies Inc Compositions And Methods For Targeted Nucleic Acid Sequence Enrichment And High Efficiency Library Generation
EP3311847A1 (de) 2012-02-16 2018-04-25 Atyr Pharma, Inc. Histidyl-trna-synthetasen zur behandlung von autoimmun- und entzündungserkrankungen
WO2013124738A2 (en) 2012-02-21 2013-08-29 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
CA2865281C (en) 2012-02-24 2021-11-23 Gen-Probe Prodesse, Inc. Detection of shiga toxin genes in bacteria
AU2013229151A1 (en) 2012-03-06 2014-09-25 Aarhus University Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
AR090544A1 (es) 2012-03-29 2014-11-19 Novarits Ag Metodo para tratar selectivamente a un sujeto que tenga cancer
EP2831260B1 (de) 2012-03-29 2018-10-17 Becton, Dickinson and Company Nucleinsäuren zur nucleinsäureamplifikation
EP2834369B1 (de) 2012-04-02 2018-05-30 Life Technologies Corporation Zusammensetzungen und verfahren zur detektion von vogelmykobakterium-paratuberkulose
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
JP2015513914A (ja) 2012-04-02 2015-05-18 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 分泌タンパク質の産生のための修飾ポリヌクレオチド
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
RU2627383C2 (ru) 2012-04-13 2017-08-08 Бектон, Дикинсон Энд Компани Дополнительное исследование проб с применением остаточных материалов от предыдущего теста
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
SG11201408478QA (en) 2012-06-18 2015-02-27 Nugen Technologies Inc Compositions and methods for negative selection of non-desired nucleic acid sequences
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
US20140005061A1 (en) 2012-06-29 2014-01-02 Life Technologies Corporation Compositions and methods for detection of multiple microorganisms
WO2014008312A2 (en) 2012-07-02 2014-01-09 Price Lance B Primers, assays and methods for detecting an e. coli subtype
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
WO2014015217A1 (en) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients
EP3428290B1 (de) 2012-07-26 2022-04-06 Illumina, Inc. Zusammensetzungen und verfahren zur amplifikation von nukleinsäuren
EP2877952B1 (de) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual-referenzkalibrierverfahren und system zum quantifizieren von polynukleotiden
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
CA2881627A1 (en) 2012-08-16 2014-02-20 Genomedx Biosciences Inc. Cancer diagnostics using biomarkers
ES2761920T3 (es) 2012-08-30 2020-05-21 Gen Probe Inc Amplificación de ácido nucleico multifásica
JP2015535173A (ja) 2012-09-11 2015-12-10 セラノス, インコーポレイテッド 生物学的シグネチャーを用いる情報管理のシステムおよび方法
SG11201502618PA (en) 2012-10-04 2015-05-28 Univ Leland Stanford Junior Methods and reagents for detection, quantitation, and serotyping of dengue viruses
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
EP2909341A2 (de) 2012-10-18 2015-08-26 Oslo Universitetssykehus HF Biomarker für gebärmutterhalskrebs
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
SI2922554T1 (sl) 2012-11-26 2022-06-30 Modernatx, Inc. Terminalno modificirana RNA
AU2013352339B2 (en) 2012-11-27 2019-07-04 Pontificia Universidad Catolica De Chile Compositions and methods for diagnosing thyroid tumors
CN105026573A (zh) 2012-11-28 2015-11-04 艾布维兹生物公司 用于单引物扩增的基因特异模板的制备
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
JP2016509206A (ja) 2012-12-21 2016-03-24 マイクロニクス, インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
JP2016509480A (ja) 2013-01-24 2016-03-31 カリフォルニア インスティチュート オブ テクノロジー 発色団に基づく特徴づけおよび検出方法
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
SG11201506421PA (en) 2013-02-18 2015-09-29 Theranos Inc Systems and methods for collecting and transmitting assay results
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
US20140249037A1 (en) 2013-03-04 2014-09-04 Fry Laboratories, LLC Method and kit for characterizing microorganisms
AU2013382098B2 (en) 2013-03-13 2019-02-07 Illumina, Inc. Methods and compositions for nucleic acid sequencing
EP2971169A4 (de) 2013-03-13 2016-10-26 Abbott Molecular Inc Systeme und verfahren zur isolierung von nukleinsäuren
PL2969479T3 (pl) 2013-03-13 2021-12-27 Illumina, Inc. Wielowarstwowe urządzenia płynowe i sposoby ich wytwarzania
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
EP2971175B1 (de) 2013-03-14 2019-04-17 Abbott Molecular Inc. Fehlerminimierung mittels uracil-dna-n-glycosylase
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
JP6615744B2 (ja) 2013-03-15 2019-12-04 ベクトン・ディキンソン・アンド・カンパニー ナイセリア・ゴノレアの検出
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
EP2971140B1 (de) 2013-03-15 2019-01-16 Ibis Biosciences, Inc. Verfahren zur beurteilung von kontamination in der dna-sequenzierung
AU2014228343B2 (en) 2013-03-15 2019-11-07 Gen-Probe Incorporated Calibration method, apparatus and computer program product
WO2014144092A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
GB2525568B (en) 2013-03-15 2020-10-14 Abvitro Llc Single cell barcoding for antibody discovery
US9890425B2 (en) 2013-03-15 2018-02-13 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
WO2014160818A2 (en) 2013-03-27 2014-10-02 Sample Technologies, Inc. Recombinant phage and bacterial detection methods
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
US10501802B2 (en) 2013-04-30 2019-12-10 Universite De Montreal Biomarkers for acute myeloid leukemia
US8946424B2 (en) 2013-05-02 2015-02-03 The Regents Of The University Of Michigan Deuterated amlexanox
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス, インコーポレイテッド 核酸の調製および分析のためのデバイス
US10190153B2 (en) 2013-05-07 2019-01-29 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US20160186263A1 (en) 2013-05-09 2016-06-30 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
WO2014187308A2 (zh) 2013-05-21 2014-11-27 生物梅里埃股份公司 一种大肠癌预后试剂盒
CA2947840A1 (en) 2013-05-30 2014-12-04 The Regents Of The University Of California Substantially unbiased amplification of genomes
AU2014281406A1 (en) 2013-06-19 2016-01-21 Sample6 Technologies, Inc. Phage-based bacterial detection assay
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
WO2015002813A1 (en) 2013-07-01 2015-01-08 Illumina, Inc. Catalyst-free surface functionalization and polymer grafting
CN105473737B (zh) 2013-07-25 2019-10-25 德诚分子诊断 用于检测细菌污染的方法和组合物
EP3156797B1 (de) 2013-08-08 2019-06-12 Institut Pasteur Korrelation von erkrankungsaktivitäten mit klonalen expansionen menschlicher papillomavirus 16-spezifischer cd8+-t-zellen bei patienten mit schwerem erosivem oralem lichen planus
AU2014306512C1 (en) 2013-08-14 2021-07-08 Gen-Probe Incorporated Compositions and methods for detecting HEV nucleic acid
WO2015031691A1 (en) 2013-08-28 2015-03-05 Cellular Research, Inc. Massively parallel single cell analysis
US11545241B1 (en) 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
EP3052521A1 (de) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynukleotide zur codierung von low-density-lipoprotein-rezeptor
WO2015073711A1 (en) 2013-11-13 2015-05-21 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
EP3068903B1 (de) 2013-11-15 2019-02-13 Institut Pasteur Molekularer marker der resistenz von artemisinin gegen plasmodium falciparum
WO2015088913A1 (en) 2013-12-09 2015-06-18 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
SG11201604737VA (en) 2013-12-11 2016-07-28 Accuragen Inc Compositions and methods for detecting rare sequence variants
WO2015089438A1 (en) 2013-12-13 2015-06-18 Northwestern University Biomarkers for post-traumatic stress states
DK3083994T3 (da) 2013-12-20 2021-09-13 Illumina Inc Bevarelse af genomisk konnektivitetsinformation i fragmenterede genomiske DNA-prøver
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
EP3094742A1 (de) 2014-01-16 2016-11-23 Illumina, Inc. Ampliconherstellung und -sequenzierung auf festen trägern
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
US10760109B2 (en) 2014-06-06 2020-09-01 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
EP3155125A1 (de) 2014-06-13 2017-04-19 Illumina Cambridge Limited Verfahren und zusammensetzungen zur herstellung von sequenzierungsbibliotheken
DK3161152T3 (en) 2014-06-30 2019-03-25 Illumina Inc Methods and compositions using one-sided transposition
CN106661600B (zh) 2014-07-16 2021-04-06 唐恩生物科技股份有限公司 用于扩增核酸样品的等温方法
WO2016026924A1 (en) 2014-08-21 2016-02-25 Illumina Cambridge Limited Reversible surface functionalization
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
EP3536786B1 (de) 2014-09-15 2021-06-30 AbVitro LLC Nukleotidbibliotheksequenzierung mit hohem durchsatz
KR102472027B1 (ko) 2014-10-17 2022-11-30 일루미나 케임브리지 리미티드 근접 보존 전위
EP3632944B1 (de) 2014-10-31 2021-12-01 Illumina Cambridge Limited Polymere und dna-copolymerbeschichtungen
WO2016073353A1 (en) 2014-11-03 2016-05-12 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
CN114606309A (zh) 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断系统和方法
EP3218482A4 (de) 2014-11-11 2018-05-09 Abbott Molecular Inc. Hybridisierungssonden und verfahren
EP3736346B1 (de) 2015-01-09 2023-12-20 Gen-Probe Incorporated Verfahren und zusammensetzungen zur diagnose von bakterieller vaginose
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 siRNA의 공동―운반용 나노복합체 및 이의 용도
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
CN107429297A (zh) 2015-03-16 2017-12-01 简·探针公司 用于检测细菌核酸和诊断细菌性阴道病的方法和组合物
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
WO2016156845A1 (en) 2015-03-31 2016-10-06 Illumina Cambridge Limited Surface concatamerization of templates
CN107532207B (zh) 2015-04-10 2021-05-07 空间转录公司 生物样本的空间区别、多重核酸分析
US11035849B2 (en) 2015-04-13 2021-06-15 The Translational Genomics Research Institute Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
BR112017022379A2 (pt) 2015-04-24 2018-07-17 Becton, Dickinson And Company detecção multiplex da candidíase vulvovaginal, tricomoníase e vaginose bacteriana
CA3160383A1 (en) 2015-05-11 2016-11-17 Illumina, Inc. Platform for discovery and analysis of therapeutic agents
CA2985015C (en) 2015-05-29 2021-10-05 F. Hoffmann-La Roche Ag A method of inactivating microbes by citraconic anhydride
CN208562324U (zh) 2015-06-05 2019-03-01 米罗库鲁斯公司 空气基质数字微流控(dmf)装置
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
KR20180029046A (ko) 2015-06-19 2018-03-19 세라 프로그노스틱스 인코포레이티드 조산 예측용 바이오마커 쌍
WO2017006108A1 (en) 2015-07-06 2017-01-12 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
WO2017007753A1 (en) 2015-07-07 2017-01-12 Illumina, Inc. Selective surface patterning via nanoimrinting
CN107835857A (zh) 2015-07-17 2018-03-23 亿明达股份有限公司 用于测序应用的聚合物片层
EP3124619B1 (de) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagenzien, verfahren und kit zur glaukomdiagnose über hunderassen hinweg und innerhalb von hunderassen
US9789087B2 (en) 2015-08-03 2017-10-17 Thomas Jefferson University PAR4 inhibitor therapy for patients with PAR4 polymorphism
EP3344389B1 (de) 2015-09-02 2020-06-10 Illumina Cambridge Limited Verfahren zur reparatur von defekten in einer hydrophobischen oberfläche eines tröpfchen-aktuators
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
KR20180055905A (ko) 2015-10-09 2018-05-25 아큐라젠 홀딩스 리미티드 증폭 산물의 농축을 위한 방법 및 조성물
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
CN115927547A (zh) 2015-12-03 2023-04-07 安可济控股有限公司 用于形成连接产物的方法和组合物
CA3010232A1 (en) 2016-01-04 2017-07-13 Gen-Probe Incorporated Methods and compositions for detecting candida species
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
US10214536B2 (en) 2016-01-29 2019-02-26 The Regents Of The University Of Michigan Amlexanox analogs
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017172798A1 (en) 2016-03-28 2017-10-05 Illumina, Inc. Multi-plane microarrays
KR20240034883A (ko) 2016-03-29 2024-03-14 얀센 바이오테크 인코포레이티드 항-il12 및/또는 항-il23 항체의 증가된 투여 간격을 사용한 건선의 치료
WO2017180745A1 (en) 2016-04-14 2017-10-19 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
EP3458586B1 (de) 2016-05-16 2022-12-28 Accuragen Holdings Limited Verfahren zur verbesserten sequenzierung durch strangidentifizierung
SG11201809376WA (en) 2016-05-18 2018-12-28 Illumina Inc Self assembled patterning using patterned hydrophobic surfaces
JP6803930B2 (ja) 2016-06-10 2021-01-06 ジェン−プローブ・インコーポレーテッド Zikaウイルス核酸を検出するための組成物および方法
US20200182884A1 (en) 2016-06-27 2020-06-11 Juno Therapeutics, Inc. Method of identifying peptide epitopes, molecules that bind such epitopes and related uses
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
AU2017296237A1 (en) 2016-07-15 2019-01-03 Poseida Therapeutics, Inc. Chimeric antigen receptors (CARS) specific for MUC1 and methods for their use
WO2018014038A1 (en) 2016-07-15 2018-01-18 Poseida Therapeutics, Inc. Chimeric antigen receptors and methods for use
WO2018017892A1 (en) 2016-07-21 2018-01-25 Takara Bio Usa, Inc. Multi-z imaging and dispensing with multi-well devices
AU2017299803B2 (en) 2016-07-22 2023-06-29 Illumina, Inc. Single cell whole genome libraries and combinatorial indexing methods of making thereof
CA3033016A1 (en) 2016-08-10 2018-02-15 Institut Pasteur Methods and reagents for detecting piperaquine-resistant plasmodium falciparum malaria
SG11201901296TA (en) 2016-08-15 2019-03-28 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
EP3500660A4 (de) 2016-08-22 2020-03-04 Miroculus Inc. Rückkopplungssystem für parallele tröpfchensteuerung in einer digitalen mikrofluidischen vorrichtung
CN110506127B (zh) 2016-08-24 2024-01-12 维拉科特Sd公司 基因组标签预测前列腺癌患者对术后放射疗法应答性的用途
MA46366A (fr) 2016-09-30 2019-08-07 Janssen Biotech Inc Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique contre l'il-23
CA3038178A1 (en) 2016-09-30 2018-04-05 The Governing Council Of The University Of Toronto System for identifying and targeting individual cells within a heterogeneous population for selective extraction of cellular content
CN110267980A (zh) 2016-10-06 2019-09-20 波赛达治疗公司 诱导型胱天蛋白酶及使用方法
US10422012B2 (en) 2016-10-10 2019-09-24 Roche Molecular Systems, Inc. Devices comprising bacteriophage PHI6 internal control compositions
EP3529381B1 (de) 2016-10-19 2022-07-06 Gen-Probe Incorporated Mischungen und verfahren zur detektion und quantifizierung von hepatitis c viren
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
WO2018093841A1 (en) 2016-11-16 2018-05-24 Janssen Biotech, Inc. Method of treating psoriasis with anti-il-23 specific antibody
JP7125395B2 (ja) 2016-11-21 2022-08-24 ジェン-プローブ・インコーポレーテッド B型肝炎ウイルスを検出または定量化するための組成物および方法
US10793901B2 (en) 2016-12-28 2020-10-06 Roche Molecular Systems, Inc. Reversibly protected nucleotide reagents with high thermal stability
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
EP3571322B9 (de) 2017-01-20 2023-10-04 VERACYTE SD, Inc. Molekulare untertypisierung, prognose und behandlung von blasenkrebs
CN110234351A (zh) 2017-01-30 2019-09-13 詹森生物科技公司 用于治疗活动性银屑病关节炎的抗tnf抗体、组合物和方法
MX2019009377A (es) 2017-02-07 2019-12-11 Janssen Biotech Inc Anticuerpos anti-tnf, composiciones y metodos para el tratamiento de la espondilitis anquilosante activa.
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
JP7206227B2 (ja) 2017-03-13 2023-01-17 ポセイダ セラピューティクス,インコーポレイティド 造血幹細胞の選択的除去と置換のための組成物と方法
CA3057154A1 (en) 2017-03-24 2018-09-27 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
CA3176517C (en) 2017-03-24 2024-03-05 Gen-Probe Incorporated Compositions and methods for detection of viral pathogens in samples
AU2018240553B2 (en) 2017-03-24 2023-03-02 Gen-Probe Incorporated Cover assembly and related methods of use
WO2018187013A1 (en) 2017-04-04 2018-10-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
ES2929837T3 (es) 2017-04-23 2022-12-02 Illumina Cambridge Ltd Composiciones y métodos para mejorar la identificación de muestras en bibliotecas de ácidos nucleicos indexados
DK3615671T3 (da) 2017-04-23 2021-10-18 Illumina Cambridge Ltd Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
EP3615691B1 (de) 2017-04-23 2021-05-26 Illumina, Inc. Zusammensetzungen und verfahren zur verbesserung der probenidentifikation in indizierten nukleinsäurebibliotheken
EP4124862A1 (de) 2017-05-05 2023-02-01 bioMérieux Verfahren zum nachweis einer zellulären immunantwort
CA3062716A1 (en) 2017-05-12 2018-11-15 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
KR102550778B1 (ko) 2017-05-26 2023-07-03 에이비비트로 엘엘씨 고-처리량 폴리뉴클레오타이드 라이브러리 시퀀싱 및 전사체 분석
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
AU2018281196B2 (en) 2017-06-07 2022-04-28 Gen-Probe Incorporated Detecting Babesia species nucleic acid in a sample
NZ759895A (en) 2017-06-07 2023-05-26 Illumina Inc Single cell whole genome libraries for methylation sequencing
US20180363044A1 (en) 2017-06-14 2018-12-20 Roche Molecular Systems, Inc. Compositions and methods for improving the thermal stability of nucleic acid amplification reagents
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
US20210155978A1 (en) 2017-07-10 2021-05-27 Gen-Probe Incorporated Analytical systems and methods for nucleic acid amplification using sample assigning parameters
CN110892258A (zh) 2017-07-24 2020-03-17 米罗库鲁斯公司 具有集成的血浆收集设备的数字微流控系统和方法
CN110785813A (zh) 2017-07-31 2020-02-11 伊鲁米那股份有限公司 具有多路生物样本聚合的测序系统
WO2019028047A1 (en) 2017-08-01 2019-02-07 Illumina, Inc SPATIAL INDEXING OF GENETIC MATERIAL AND PREPARATION OF PHARMACOTOQUE USING HYDROGEL BALLS AND FLOW CELLS
SG11201911871TA (en) 2017-08-01 2020-01-30 Illumina Inc Hydrogel beads for nucleotide sequencing
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
US10858701B2 (en) 2017-08-15 2020-12-08 Omniome, Inc. Scanning apparatus and method useful for detection of chemical and biological analytes
EP3668996A4 (de) 2017-08-18 2021-04-21 Sera Prognostics, Inc. Clock-schwangerschaftsprotein zur vorhersage des entbindungstermins und der zeit bis zur entbindung
CA3073058A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. Digital microfluidics devices and methods of using them
WO2019051335A1 (en) 2017-09-07 2019-03-14 Juno Therapeutics, Inc. METHODS OF IDENTIFYING CELLULAR CHARACTERISTICS RELATED TO RESPONSES ASSOCIATED WITH CELL THERAPY
WO2019051424A2 (en) 2017-09-08 2019-03-14 Poseida Therapeutics, Inc. COMPOSITIONS AND METHODS FOR CONDITIONAL GENE EXPRESSION MEDIATED BY A CHIMERIC LIGAND RECEPTOR (CLR)
TW201922780A (zh) 2017-09-25 2019-06-16 美商健生生物科技公司 以抗il12/il23抗體治療狼瘡之安全且有效之方法
AU2018353136B2 (en) 2017-10-19 2022-05-19 Pacific Biosciences Of California, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
EP3704723B1 (de) 2017-10-31 2023-10-11 F. Hoffmann-La Roche AG Verbesserte magnetische partikel und verwendungen davon
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
CA3082909C (en) 2017-11-17 2023-07-25 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
US11078534B2 (en) 2017-11-27 2021-08-03 Roche Molecular Systems, Inc. Photocleavable nucleotide reagents with high stability
JP2021506274A (ja) 2017-12-15 2021-02-22 ジェン−プローブ・インコーポレーテッド 毒素産生Clostridium difficileを検出するための組成物および方法
RU2020123705A (ru) 2017-12-20 2022-01-20 Посейда Терапьютикс, Инк. Композиции vcar и способы применения
WO2019148169A1 (en) 2018-01-29 2019-08-01 Gen-Probe Incorporated Analytical systems and methods
CA3067140C (en) 2018-02-13 2023-03-21 Illumina, Inc. Dna sequencing using hydrogel beads
KR20200129125A (ko) 2018-03-05 2020-11-17 얀센 바이오테크 인코포레이티드 항-il23 특이적 항체로 크론병을 치료하는 방법
CN112601583A (zh) 2018-03-07 2021-04-02 波赛达治疗公司 CARTyrin组合物和使用方法
US20190292596A1 (en) 2018-03-21 2019-09-26 Roche Molecular Systems, Inc. Modified nucleoside phosphates with high thermal stability
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
US20190367909A1 (en) 2018-04-02 2019-12-05 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
AU2019255987A1 (en) 2018-04-19 2020-12-10 Pacific Biosciences Of California, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
CA3067181A1 (en) 2018-04-20 2019-10-24 Illumina, Inc. Methods of encapsulating single cells, the encapsulated cells and uses thereof
BR112020024083A2 (pt) 2018-05-25 2021-05-04 Arca Biopharma Inc. métodos e composições envolvendo bucindolol para o tratamento de fibrilação atrial
US11384376B2 (en) 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
CN111247248A (zh) 2018-06-04 2020-06-05 伊鲁米纳公司 高通量单细胞转录组文库及制备和使用方法
US11453919B2 (en) 2018-06-13 2022-09-27 Gen-Probe Incorporated Compositions and methods for detecting group B Streptococcus nucleic acid
US20210317515A1 (en) 2018-07-10 2021-10-14 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
EP3824295A4 (de) 2018-07-18 2022-04-27 Janssen Biotech, Inc. Prädiktoren mit verzögerter wirkung nach behandlung mit anti-il23-spezifischem antikörper
WO2020028631A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
AU2019319203A1 (en) 2018-08-08 2021-03-11 Gen-Probe Incorporated Compositions, methods and kits for detecting
EP3841224A1 (de) 2018-08-21 2021-06-30 Gen-Probe Incorporated Zusammensetzungen und verfahren zur amplifikation, detektion oder quantifizierung von menschlichem cytomegalovirus
CA3108906A1 (en) 2018-08-24 2020-02-27 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
US20220389077A1 (en) 2018-09-05 2022-12-08 Poseida Therapeutics, Inc. Allogeneic cell compositions and methods of use
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
CN113195743A (zh) 2018-10-22 2021-07-30 简·探针公司 扩增,检测或定量人类多瘤病毒bk病毒的组合物和方法
CA3113271A1 (en) 2018-10-26 2020-04-30 Illumina, Inc. Modulating polymer beads for dna processing
US20240011086A1 (en) 2018-11-15 2024-01-11 Omniome, Inc. Electronic detection of nucleic acid structure
MA55149A (fr) 2018-11-20 2021-09-29 Janssen Biotech Inc Procédé sûr et efficace de traitement du psoriasis avec un anticorps spécifique anti-il-23
EP4293126A3 (de) 2018-11-30 2024-01-17 Illumina, Inc. Analyse von mehreren analyten unter verwendung eines einzigen tests
GB2578528B (en) 2018-12-04 2021-02-24 Omniome Inc Mixed-phase fluids for nucleic acid sequencing and other analytical assays
JP2022514561A (ja) 2018-12-18 2022-02-14 ヤンセン バイオテツク,インコーポレーテツド 抗il12/il23抗体でループスを治療する安全かつ有効な方法
DK3899037T3 (da) 2018-12-19 2023-11-06 Illumina Inc Fremgangsmåder til forbedring af polynukleotidklyngeklonalitetsprioritet
CN113227348A (zh) 2018-12-20 2021-08-06 欧姆尼欧美公司 用于分析核酸和其他分析物的温度控制
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
JP2022513507A (ja) 2018-12-20 2022-02-08 ポセイダ セラピューティクス,インコーポレイティド ナノトランスポゾン組成物および使用方法
US20220080425A1 (en) 2018-12-31 2022-03-17 Gen-Probe Incorporated Tray for transfering solid reagents to a multi-well cartridge
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
EP3911676A1 (de) 2019-01-15 2021-11-24 Janssen Biotech, Inc. Anti-tnf-antikörperzusammensetzungen und verfahren zur behandlung von juveniler idiopathischer arthritis
KR20210118878A (ko) 2019-01-23 2021-10-01 얀센 바이오테크 인코포레이티드 건선성 관절염의 치료 방법에 사용하기 위한 항-tnf 항체 조성물
US11680950B2 (en) 2019-02-20 2023-06-20 Pacific Biosciences Of California, Inc. Scanning apparatus and methods for detecting chemical and biological analytes
SG11202102530QA (en) 2019-03-01 2021-04-29 Illumina Inc High-throughput single-nuclei and single-cell libraries and methods of making and of using
CA3133395A1 (en) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ, インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
CA3133383A1 (en) 2019-03-14 2020-09-17 Janssen Biotech, Inc. Methods for producing anti-tnf antibody compositions
CN113840838A (zh) 2019-03-14 2021-12-24 詹森生物科技公司 用于产生抗tnf抗体组合物的制造方法
KR20210141998A (ko) 2019-03-14 2021-11-23 얀센 바이오테크 인코포레이티드 항-tnf 항체 조성물의 제조 방법
US20220098647A1 (en) 2019-03-22 2022-03-31 Gen-Probe Incorporated Compositions and Methods for Detecting Group A Streptococcus
CN113646007A (zh) 2019-03-29 2021-11-12 希森美康株式会社 新人工核酸、其制造方法及用途
US11738345B2 (en) 2019-04-08 2023-08-29 Miroculus Inc. Multi-cartridge digital microfluidics apparatuses and methods of use
JP2022530832A (ja) 2019-05-03 2022-07-01 ジェン-プローブ・インコーポレーテッド 分析システム用レセプタクル輸送システム
KR20220012883A (ko) 2019-05-23 2022-02-04 얀센 바이오테크 인코포레이티드 Il-23 및 tnf 알파에 대한 항체의 병용요법으로 염증성 장질환을 치료하는 방법
CA3142580A1 (en) 2019-06-03 2020-12-10 Janssen Biotech, Inc. Anti-tnf antibodies, compositions, and methods for the treatment of active ankylosing spondylitis
MX2021014885A (es) 2019-06-03 2022-04-06 Janssen Biotech Inc Composiciones de anticuerpos anti-tnf, y métodos para el tratamiento de la artritis psoriásica.
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
CA3144452A1 (en) 2019-07-03 2021-01-07 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
KR20220034716A (ko) 2019-07-12 2022-03-18 일루미나 케임브리지 리미티드 고체 지지물 상에 고정된 crispr/cas9를 사용하여 핵산 서열분석 라이브러리를 제조하기 위한 조성물 및 방법
MX2021007774A (es) 2019-07-12 2021-08-05 Illumina Cambridge Ltd Preparacion de genoteca de acido nucleico usando electroforesis.
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
WO2021028752A1 (en) 2019-08-15 2021-02-18 Janssen Biotech, Inc. Anti-tfn antibodies for treating type i diabetes
WO2021041056A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
CA3149892A1 (en) 2019-09-05 2021-03-11 Eric M. Ostertag Allogeneic cell compositions and methods of use
JP2022553489A (ja) 2019-09-05 2022-12-23 ジェン-プローブ・インコーポレーテッド Chlamydia trachomatis変異体の核酸の検出
EP4265628A3 (de) 2019-09-10 2024-01-03 Pacific Biosciences of California, Inc. Reversible nukleotide änderung
EP4025711A2 (de) 2019-11-08 2022-07-13 10X Genomics, Inc. Erhöhung der spezifität einer analytbindung
WO2021091611A1 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
EP4073268B1 (de) 2019-12-09 2024-04-10 Gen-Probe Incorporated Quantifizierung von polynukleotidanalyten aus getrockneten proben
CN114787286A (zh) 2019-12-09 2022-07-22 豪夫迈·罗氏有限公司 双阳离子荧光染料
WO2021127436A2 (en) 2019-12-19 2021-06-24 Illumina, Inc. High-throughput single-cell libraries and methods of making and of using
CA3162246A1 (en) 2019-12-20 2021-06-24 Poseida Therapeutics, Inc. Anti-muc1 compositions and methods of use
ES2946357T3 (es) 2019-12-23 2023-07-17 10X Genomics Inc Métodos para el análisis espacial usando ligación con molde de ARN
US20230227924A1 (en) 2019-12-23 2023-07-20 Abbott Laboratories Compositions and methods for detecting picobirnavirus
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
EP4342999A2 (de) 2020-01-16 2024-03-27 DNAe Diagnostics Limited Zusammensetzungen, kits und verfahren zur isolierung von zielpolynukleotiden
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US20230054204A1 (en) 2020-02-04 2023-02-23 Pacific Biosciences Of California, Inc. Flow cells and methods for their manufacture and use
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
WO2021178644A1 (en) 2020-03-04 2021-09-10 Gen-Probe Incorporated Compositions and methods for detecting sars-cov-2 nucleic acid
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
AU2021230361A1 (en) 2020-03-04 2022-09-08 Poseida Therapeutics, Inc. Compositions and methods for the treatment of Metabolic Liver Disorders
EP4118107A1 (de) 2020-03-11 2023-01-18 Poseida Therapeutics, Inc. Chimäre stimulationsrezeptoren und verfahren zur verwendung bei der t-zell-aktivierung und -differenzierung
US20230105642A1 (en) 2020-03-30 2023-04-06 Illumina, Inc. Method and compositions for preparing nucleic acid libraries
EP4135758A1 (de) 2020-04-14 2023-02-22 Poseida Therapeutics, Inc. Zusammensetzungen und verfahren zur verwendung bei der behandlung von krebs
EP4242325A3 (de) 2020-04-22 2023-10-04 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
US20230220499A1 (en) 2020-05-07 2023-07-13 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
AU2021271637A1 (en) 2020-05-12 2022-12-08 Illumina Singapore Pte. Ltd. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2021237087A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Spatial analysis to detect sequence variants
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
WO2021247543A2 (en) 2020-06-02 2021-12-09 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
EP4163397A1 (de) 2020-06-05 2023-04-12 Seegene, Inc. Probentransportkit zum nachweis von atemwegspathogenen und verfahren zum nachweis von atemwegspathogenen damit
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
EP4165207A1 (de) 2020-06-10 2023-04-19 10X Genomics, Inc. Verfahren zur bestimmung einer position eines analyten in einer biologischen probe
WO2021252574A1 (en) 2020-06-10 2021-12-16 Sera Prognostics, Inc. Nucleic acid biomarkers for placental dysfunction
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
US20210403993A1 (en) 2020-06-30 2021-12-30 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US20230243001A1 (en) 2020-07-17 2023-08-03 Gen-Probe Incorporated Detection of Macrolide-Resistant Mycoplasma Genitalium
CN116171330A (zh) 2020-08-06 2023-05-26 Illumina公司 使用小珠连接的转座体制备rna和dna测序文库
EP4200416A1 (de) 2020-08-18 2023-06-28 Illumina, Inc. Sequenzspezifische gezielte transposition und selektion und sortierung von nukleinsäuren
MX2023001400A (es) 2020-09-11 2023-04-25 Illumina Cambridge Ltd Metodos para enriquecer una secuencia diana a partir de una genoteca de secuenciación usando adaptadores de horquilla.
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
EP4219517A1 (de) 2020-09-25 2023-08-02 Riken Genesis Co., Ltd. Neuartige künstliche nukleinsäure, verfahren zur herstellung davon und verwendung davon
US20230393163A1 (en) 2020-10-21 2023-12-07 Gen-Probe Incorporated Fluid container management system
EP4231999A1 (de) 2020-10-21 2023-08-30 Poseida Therapeutics, Inc. Zusammensetzungen und verfahren zur abgabe von nukleinsäuren
EP4240876A1 (de) 2020-11-05 2023-09-13 Becton, Dickinson and Company Multiplex-nachweis und typisierung von vibrio cholerae
CN116438320A (zh) 2020-11-05 2023-07-14 贝克顿迪金森公司 细菌性呼吸道病原体的多重检测
US20240060145A1 (en) 2020-11-05 2024-02-22 Becton, Dickinson And Company Rapid identification and typing of vibrio parahaemolyticus
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
CA3208854A1 (en) 2021-02-04 2022-08-11 Illumina, Inc. Long indexed-linked read generation on transposome bound beads
WO2022182797A1 (en) 2021-02-23 2022-09-01 Poseida Therapeutics, Inc. Genetically modified induced pluripotent stem cells and methods of use thereof
KR20230148824A (ko) 2021-02-23 2023-10-25 포세이다 테라퓨틱스, 인크. 핵산을 전달하기 위한 조성물 및 방법
WO2022187671A1 (en) 2021-03-04 2022-09-09 Poseida Therapeutics, Inc. Compositions and methods for the treatment of hemophilia
US20220298236A1 (en) 2021-03-12 2022-09-22 Janssen Biotech, Inc. Safe and Effective Method of Treating Psoriatic Arthritis with Anti-IL23 Specific Antibody
WO2022190034A1 (en) 2021-03-12 2022-09-15 Janssen Biotech, Inc. Method of treating psoriatic arthritis patients with inadequate response to tnf therapy with anti-il23 specific antibody
EP4301870A1 (de) 2021-03-18 2024-01-10 10X Genomics, Inc. Multiplex-erfassung von gen- und proteinexpression aus einer biologischen probe
CA3210451A1 (en) 2021-03-22 2022-09-29 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
WO2022212280A1 (en) 2021-03-29 2022-10-06 Illumina, Inc. Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias
IL307195A (en) 2021-03-29 2023-11-01 Illumina Inc Improved methods of library preparation
KR20230161955A (ko) 2021-03-30 2023-11-28 일루미나, 인코포레이티드 등온 상보적 dna 및 라이브러리 제조의 개선된 방법
BR112023019945A2 (pt) 2021-03-31 2023-11-14 Illumina Cambridge Ltd Métodos para a preparação de bibliotecas de sequenciamento por tagmentação direcional com o uso de tecnologia baseada em transposon com identificadores moleculares exclusivos para correção de erros
EP4337797A1 (de) 2021-05-14 2024-03-20 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von humaner adenovirus-nukleinsäure
US20230016633A1 (en) 2021-06-15 2023-01-19 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
CA3220932A1 (en) 2021-07-01 2023-01-05 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
KR20240032991A (ko) 2021-07-09 2024-03-12 얀센 바이오테크 인코포레이티드 항-tnf 항체 조성물의 생성을 위한 제조 방법
AU2022306144A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-tnf antibody compositions
AU2022306973A1 (en) 2021-07-09 2024-02-22 Janssen Biotech, Inc. Manufacturing methods for producing anti-il12/il23 antibody compositions
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
US20230116852A1 (en) 2021-07-23 2023-04-13 Illumina, Inc. Methods for preparing substrate surface for dna sequencing
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
EP4196605A1 (de) 2021-09-01 2023-06-21 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur blockierung einer erfassungssonde auf einer räumlichen anordnung
WO2023060089A2 (en) 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
CA3233506A1 (en) 2021-10-04 2023-04-13 Joseph S. LUCAS Transposon compositions and methods of use thereof
WO2023069927A1 (en) 2021-10-20 2023-04-27 Illumina, Inc. Methods for capturing library dna for sequencing
WO2023073615A1 (en) 2021-10-29 2023-05-04 Janssen Biotech, Inc. Methods of treating crohn's disease with anti-il23 specific antibody
US20230151087A1 (en) 2021-11-15 2023-05-18 Janssen Biotech, Inc. Methods of Treating Crohn's Disease with Anti-IL23 Specific Antibody
WO2023095000A1 (en) 2021-11-23 2023-06-01 Janssen Biotech, Inc. Method of treating ulcerative colitis with anti-il23 specific antibody
CN113981041A (zh) * 2021-11-25 2022-01-28 首都医科大学附属北京安贞医院 靶向富集测序试剂及靶向富集方法
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression
CA3223362A1 (en) 2022-01-20 2023-07-27 Xiaolin Wu Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
WO2023141576A1 (en) 2022-01-21 2023-07-27 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
WO2023164573A1 (en) 2022-02-23 2023-08-31 Poseida Therapeutics, Inc. Genetically modified cells and methods of use thereof
WO2023175434A1 (en) 2022-03-15 2023-09-21 Diagenode S.A. Detection of methylation status of a dna sample
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
WO2023223265A1 (en) 2022-05-18 2023-11-23 Janssen Biotech, Inc. Method for evaluating and treating psoriatic arthritis with il23 antibody
EP4282980A1 (de) 2022-05-23 2023-11-29 Mobidiag Oy Methoden zum verstärken einer nukleinsäure
WO2024020360A1 (en) 2022-07-18 2024-01-25 Pairwise Plants Services, Inc. Mustard green plants named 'pwrg-1', 'pwrg-2,' and 'pwsgc'
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0055742A4 (de) * 1980-07-08 1983-06-15 Salk Inst For Biological Studi System zur amplifikation eukaryotischer zellen.
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
SE8601784L (sv) * 1986-04-18 1987-10-19 Flensburg Carl G A Sett for ileggning av signaturer samt ileggare for utovning av settet
EP0272098A3 (de) * 1986-12-15 1990-06-06 City Of Hope National Medical Center Verfahren zur Vergrösserung und zum Nachweis von RNS-Sequenzen
IL86724A (en) * 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
WO1989001050A1 (en) * 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
DE3726934A1 (de) * 1987-08-13 1989-02-23 Merck Patent Gmbh Verfahren zum nachweis von nukleinsaeure-sequenzen
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
AU4829690A (en) * 1988-12-16 1990-07-10 Siska Diagnostics, Inc. Self-sustained, sequence replication system
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)

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ES2104611T3 (es) 1997-10-16
US5130238A (en) 1992-07-14
JP2648802B2 (ja) 1997-09-03
DE69030955D1 (de) 1997-07-24
FI920766A0 (fi) 1992-02-21
EP0487628A1 (de) 1992-06-03
DK0487628T3 (da) 1998-01-26
KR960005737B1 (ko) 1996-05-01
WO1991002818A1 (en) 1991-03-07
ATE154644T1 (de) 1997-07-15
NZ235009A (en) 1992-06-25
FI100192B (fi) 1997-10-15
JPH04507197A (ja) 1992-12-17
CA2065003A1 (en) 1991-02-24
AU6336590A (en) 1991-04-03
CA2065003C (en) 1998-09-01
AU647411B2 (en) 1994-03-24
EP0487628B1 (de) 1997-06-18

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