DE69033082D1 - Verfahren zum In-Vivo-Nachweis von Kollagenabbau - Google Patents

Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Info

Publication number
DE69033082D1
DE69033082D1 DE69033082T DE69033082T DE69033082D1 DE 69033082 D1 DE69033082 D1 DE 69033082D1 DE 69033082 T DE69033082 T DE 69033082T DE 69033082 T DE69033082 T DE 69033082T DE 69033082 D1 DE69033082 D1 DE 69033082D1
Authority
DE
Germany
Prior art keywords
procedure
vivo detection
collagen breakdown
pyridinoline
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033082T
Other languages
English (en)
Other versions
DE69033082T2 (de
Inventor
David R Eyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington Research Foundation
Original Assignee
Washington Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27034100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69033082(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/444,881 external-priority patent/US5140103A/en
Application filed by Washington Research Foundation filed Critical Washington Research Foundation
Publication of DE69033082D1 publication Critical patent/DE69033082D1/de
Application granted granted Critical
Publication of DE69033082T2 publication Critical patent/DE69033082T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69033082T 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau Expired - Fee Related DE69033082T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/444,881 US5140103A (en) 1987-11-06 1989-12-01 Peptide fragments containing HP and LP cross-links
US07/614,719 US5300434A (en) 1987-11-06 1990-11-21 Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide

Publications (2)

Publication Number Publication Date
DE69033082D1 true DE69033082D1 (de) 1999-06-02
DE69033082T2 DE69033082T2 (de) 1999-09-30

Family

ID=27034100

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau
DE69033082T Expired - Fee Related DE69033082T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau
DE69025199T Revoked DE69025199T2 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69025199T Revoked DE69025199T2 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.

Country Status (13)

Country Link
US (5) US5300434A (de)
EP (6) EP0502928B1 (de)
JP (6) JP2782017B2 (de)
AT (3) ATE279730T1 (de)
AU (1) AU645049B2 (de)
DE (4) DE69034170T2 (de)
DK (3) DK0502928T3 (de)
ES (2) ES2061422T3 (de)
GR (3) GR940300047T1 (de)
IE (1) IE65280B1 (de)
NO (1) NO309483B1 (de)
RU (1) RU2139541C1 (de)
WO (1) WO1991008478A2 (de)

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US6027903A (en) * 1987-11-06 2000-02-22 Washington Research Foundation Kit for detecting analyte indicative of type I collagen resorption in vivo
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US6153732A (en) * 1987-11-06 2000-11-28 Washington Research Foundation Kit for detecting analyte indicative of type II collagen resorption in vivo
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ATE277946T1 (de) * 1992-12-28 2004-10-15 David J Baylink Methode zur messung der knochenresorption
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US5661039A (en) * 1995-03-01 1997-08-26 Metra Biosystems, Inc. Perspiration assay for bone resorption
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US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
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EP0944833B1 (de) 1996-12-09 2001-06-27 Osteometer Biotech AS Sandwichtest zum nachweis von kollagenfragmenten
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Also Published As

Publication number Publication date
GR3030646T3 (en) 1999-10-29
ATE179521T1 (de) 1999-05-15
JP2002139492A (ja) 2002-05-17
DE69025199D1 (de) 1996-03-14
JP2782017B2 (ja) 1998-07-30
JPH09113510A (ja) 1997-05-02
US5677198A (en) 1997-10-14
EP0682257B1 (de) 1999-04-28
US5473052A (en) 1995-12-05
JP2999416B2 (ja) 2000-01-17
DE69034170T2 (de) 2006-03-02
JP2999444B2 (ja) 2000-01-17
DE69034170D1 (de) 2004-11-18
JPH05502223A (ja) 1993-04-22
EP0682257A1 (de) 1995-11-15
JP2000055915A (ja) 2000-02-25
IE904344A1 (en) 1991-06-05
EP0682256B1 (de) 2004-10-13
DK0682257T3 (da) 1999-11-08
DK0682256T3 (da) 2005-02-14
GR3018852T3 (en) 1996-05-31
EP1560026A1 (de) 2005-08-03
EP1632502A1 (de) 2006-03-08
EP0890840A3 (de) 2000-05-17
ES2133656T3 (es) 1999-09-16
GR940300047T1 (en) 1994-07-29
JP2000050865A (ja) 2000-02-22
DK0502928T3 (da) 1996-02-19
IE65280B1 (en) 1995-10-18
WO1991008478A3 (en) 1991-11-28
US5576189A (en) 1996-11-19
AU6889891A (en) 1991-06-26
ATE279730T1 (de) 2004-10-15
NO922149D0 (no) 1992-05-29
NO922149L (no) 1992-07-29
JP3299941B2 (ja) 2002-07-08
US5656439A (en) 1997-08-12
RU2139541C1 (ru) 1999-10-10
DE69025199T2 (de) 1996-05-30
EP0682256A1 (de) 1995-11-15
ES2061422T3 (es) 1996-03-16
US5300434A (en) 1994-04-05
JPH10260183A (ja) 1998-09-29
ES2061422T1 (es) 1994-12-16
AU645049B2 (en) 1994-01-06
NO309483B1 (no) 2001-02-05
DE69033082T2 (de) 1999-09-30
EP0502928A1 (de) 1992-09-16
EP0890840A2 (de) 1999-01-13
EP0502928B1 (de) 1996-01-31
WO1991008478A2 (en) 1991-06-13
ATE133790T1 (de) 1996-02-15
DE502928T1 (de) 1994-08-18

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