DE69033082T2 - Verfahren zum In-Vivo-Nachweis von Kollagenabbau - Google Patents

Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Info

Publication number
DE69033082T2
DE69033082T2 DE69033082T DE69033082T DE69033082T2 DE 69033082 T2 DE69033082 T2 DE 69033082T2 DE 69033082 T DE69033082 T DE 69033082T DE 69033082 T DE69033082 T DE 69033082T DE 69033082 T2 DE69033082 T2 DE 69033082T2
Authority
DE
Germany
Prior art keywords
procedure
vivo detection
collagen breakdown
pyridinoline
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033082T
Other languages
English (en)
Other versions
DE69033082D1 (de
Inventor
David R Eyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Washington Research Foundation
Original Assignee
Washington Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27034100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69033082(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/444,881 external-priority patent/US5140103A/en
Application filed by Washington Research Foundation filed Critical Washington Research Foundation
Publication of DE69033082D1 publication Critical patent/DE69033082D1/de
Application granted granted Critical
Publication of DE69033082T2 publication Critical patent/DE69033082T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6881—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/105—Osteoarthritis, e.g. cartilage alteration, hypertrophy of bone
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
DE69033082T 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau Expired - Fee Related DE69033082T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/444,881 US5140103A (en) 1987-11-06 1989-12-01 Peptide fragments containing HP and LP cross-links
US07/614,719 US5300434A (en) 1987-11-06 1990-11-21 Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide

Publications (2)

Publication Number Publication Date
DE69033082D1 DE69033082D1 (de) 1999-06-02
DE69033082T2 true DE69033082T2 (de) 1999-09-30

Family

ID=27034100

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.
DE69025199T Revoked DE69025199T2 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption
DE69033082T Expired - Fee Related DE69033082T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69034170T Expired - Fee Related DE69034170T2 (de) 1989-12-01 1990-11-30 Verfahren zum In-Vivo-Nachweis von Kollagenabbau
DE0502928T Pending DE502928T1 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von kollagenabbau.
DE69025199T Revoked DE69025199T2 (de) 1989-12-01 1990-11-30 Verfahren zum in vivo-nachweis von knochenresorption

Country Status (13)

Country Link
US (5) US5300434A (de)
EP (6) EP0890840A3 (de)
JP (6) JP2782017B2 (de)
AT (3) ATE279730T1 (de)
AU (1) AU645049B2 (de)
DE (4) DE69034170T2 (de)
DK (3) DK0682256T3 (de)
ES (2) ES2061422T3 (de)
GR (3) GR940300047T1 (de)
IE (1) IE65280B1 (de)
NO (1) NO309483B1 (de)
RU (1) RU2139541C1 (de)
WO (1) WO1991008478A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2551939B1 (fr) * 1983-09-14 1985-10-11 Cit Alcatel Dispositif de transfert et de traitement de voies de donnees ou de signalisation d'un ensemble de lignes multiplex
US6027903A (en) * 1987-11-06 2000-02-22 Washington Research Foundation Kit for detecting analyte indicative of type I collagen resorption in vivo
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
US6153732A (en) * 1987-11-06 2000-11-28 Washington Research Foundation Kit for detecting analyte indicative of type II collagen resorption in vivo
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
GB8929366D0 (en) * 1989-12-30 1990-02-28 Rowett Research Inst Method to detect connective tissue disorder in humans and animals
GB9105893D0 (en) * 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation
US5350855A (en) * 1992-09-30 1994-09-27 Metra Biosystems, Inc. Derivatized D-acyl pyridinium reagent
US6132976A (en) * 1992-12-04 2000-10-17 Shriners Hospitals For Children Immunoassays for the measurement of collagen denaturation and cleavage in cartilage
JP3448295B2 (ja) * 1992-12-17 2003-09-22 メトラ バイオシステムズ，インコーポレイテッド 血清ピリジニウム架橋物アッセイ
US5736344A (en) * 1992-12-17 1998-04-07 Metra Biosystems, Inc. Serum pyridinium crosslinks assay
ATE277946T1 (de) * 1992-12-28 2004-10-15 David J Baylink Methode zur messung der knochenresorption
DK104093D0 (da) * 1993-09-17 1993-09-17 Osteometer A S Fremgangsmaade til bestemmelse af collagen-fragmenter i legemsvaesker, test-kit og midler til udoevelse af fremgangsmaaden og anvendelse af fremgangsmaaden til diagnosticering af lidelser associeret til collagen-metabolismen
US6110689A (en) 1994-01-21 2000-08-29 Osteometer A/S Method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
US5516699A (en) * 1994-02-16 1996-05-14 Institute Of Molecular Biology, Inc. Pyridinoline crosslinks as markers of periodontal and peri-implant disease activity
GB9506050D0 (en) 1995-03-24 1995-05-10 Osteometer A S Assaying collagen fragments in body fluids
ES2154739T3 (es) 1994-10-17 2001-04-16 Osteometer Biotech As Estimacion del modelo de fragmentacion del colageno en fluidos corporales y el diagnostico de trastornos asociados con el metabolismo del colageno.
US5661039A (en) * 1995-03-01 1997-08-26 Metra Biosystems, Inc. Perspiration assay for bone resorption
DE19518232A1 (de) * 1995-05-12 1996-11-14 Ruediger Dr Schade Aviäre, vitelline, gegen Stützgewebe gerichtete Antikörper
US5750647A (en) * 1995-05-19 1998-05-12 Washington Research Foundation Synthetic peptide analogs of NTx
US6107047A (en) * 1996-03-21 2000-08-22 Osteometer Biotech A/S Assaying protein fragments in body fluids
DE69734601T2 (de) * 1996-05-16 2006-08-03 The Texas A & M University System, College Station Zusammensetzung von kollagenbindungsprotein und verfahren zu deren verwendungen
GB9617616D0 (en) 1996-08-22 1996-10-02 Osteometer Biotech As Assaying protein fragments in body fluids
JP3913787B2 (ja) 1996-12-09 2007-05-09 オステオメーター・ビオテク・エー／エス Ｉ型コラーゲン断片のサンドウイッチ測定法
US5834610A (en) * 1997-05-06 1998-11-10 Johnson; Gary M. Conversion of pyridinoline to deoxypyridinoline
US5989925A (en) * 1997-06-27 1999-11-23 Serex, Inc. Antibody to and assay for peptide linked-pyridinoline as indicator of bone resorption level
WO1999006840A1 (en) * 1997-07-31 1999-02-11 Metra Biosystems, Inc. Collagen-peptide assay method
US6117646A (en) * 1997-09-22 2000-09-12 Osteometer Biotech A/S Assaying protein fragments in body fluids
US6030792A (en) * 1997-11-13 2000-02-29 Pfizer Inc Assays for measurement of protein fragments in biological media
US6916903B2 (en) * 1998-06-19 2005-07-12 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
US6348320B1 (en) 1998-06-19 2002-02-19 Washington Research Foundation Cartilage resorption assays measuring type II collagen fragments
US6602980B1 (en) 1998-06-19 2003-08-05 Washington Research Foundation Collagen type III synthetic peptides for collagen resorption assays
EP1088228B1 (de) * 1998-06-19 2005-08-24 Washington Research Foundation Knorpelresorptionsassays
EP1149111B1 (de) * 1999-01-06 2009-08-12 University Of Southern California Methode und zubereitung zur hemmung von angiogenese
DK1210606T3 (da) * 1999-06-17 2005-01-31 Washington Res Found Bruskresorptionsassays
AU2001293964B2 (en) * 2000-10-03 2007-06-14 Rowett Research Institute Method of assaying pyrrole-containing biological compounds
US20020169288A1 (en) * 2001-03-15 2002-11-14 Magnus Hook Collagen-binding adhesin from staphylococcus epidermidis and method of use
US7767652B2 (en) * 2004-07-21 2010-08-03 Medtronic, Inc. Medical devices and methods for reducing localized fibrosis
US20060030538A1 (en) * 2004-07-21 2006-02-09 Medtronic, Inc. Methods for reducing or preventing localized fibrosis using SiRNA
AU2006337105B2 (en) 2005-11-01 2013-05-02 Abbvie Biotechnology Ltd Methods and compositions for diagnosing ankylosing spondylitis using biomarkers
JP2007162988A (ja) * 2005-12-12 2007-06-28 Sanden Corp 蒸気圧縮式冷凍サイクル
CA2690568A1 (en) * 2007-06-20 2008-12-24 Schering Corporation Joint destruction biomarkers for anti-il-17a therapy of inflammatory joint disease
CN108196072A (zh) * 2007-11-05 2018-06-22 北欧生物科技公司 用于进行cvd风险评估的生物化学标志物
WO2009153783A1 (en) * 2008-06-16 2009-12-23 Mor Research Applications Ltd. Monitoring skin metabolism products for evaluating burn injury
EP2479190A4 (de) * 2009-09-16 2013-12-04 Shionogi & Co Collagen-neoepitop-antikörper
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
USRE49477E1 (en) 2012-04-20 2023-03-28 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
WO2017098321A1 (en) 2015-12-11 2017-06-15 Spartan Bioscience Inc. Tube sealing system and methods for nucleic acid amplification
WO2023068248A1 (ja) * 2021-10-20 2023-04-27 積水メディカル株式会社 Ｉ型コラーゲン架橋ｎ－テロペプチドの免疫測定方法及び免疫測定キット、並びに抗体又はその抗体断片
WO2023068249A1 (ja) * 2021-10-20 2023-04-27 積水メディカル株式会社 Ｉ型コラーゲン架橋ｎ－テロペプチドの測定試薬、その調製方法、及びそれを用いた免疫測定方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6716836A (de) * 1967-12-11 1969-06-13
JPS5164788A (ja) * 1974-12-03 1976-06-04 Orion Yakuhin Kogyo Kk Shodokuyomennometsukinhoho
US4094646A (en) * 1977-06-02 1978-06-13 The Baltimore Spice Company Rapid method of assaying collagen in meat and meat products
LU78457A1 (fr) * 1977-11-04 1979-06-13 Prayon Soc Procede de fabrication d'acide phosphorique
DE2816841A1 (de) * 1978-04-18 1979-10-31 Max Planck Gesellschaft Radioimmunologische bestimmung von prokollagen (typ iii) und prokollagen- peptid (typ iii)
US4298593A (en) * 1979-08-21 1981-11-03 Abbott Laboratories Reagents and methods utilizing labeled Fab bound to antigens
US4371374A (en) * 1980-11-17 1983-02-01 The Rockefeller University Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine
DE3209149A1 (de) * 1982-03-13 1983-10-06 Hoechst Ag Verfahren zur gemeinsamen immunologischen bestimmung von prokollagen-peptid (typ iii) und prokollagen-peptid col 1 (typ iii) und verfahren zur herstellung von anti-prokollagen-peptid col 1 (typ iii)-serum
EP0128041A3 (de) * 1983-06-06 1986-12-03 David Jeston Baylink Polypeptide mit einer Skelettwachstumsfaktor-Wirksamkeit
JPS60198156A (ja) * 1984-03-19 1985-10-07 凸版印刷株式会社 プラスチツク製品の殺菌方法
JPS60256457A (ja) * 1984-06-01 1985-12-18 大日本印刷株式会社 包装材料の殺菌方法
US4731326A (en) * 1984-06-04 1988-03-15 Ortho Diagnostic Systems Inc. Disease diagnosis by detection of shed normal tissue antigens
US4774227A (en) * 1986-02-14 1988-09-27 Collagen Corporation Collagen compositions for bone repair containing autogeneic marrow
ATE112684T1 (de) * 1987-04-28 1994-10-15 Boehringer Mannheim Gmbh Verwendung von igf-ii zur behandlung von knochenkrankheiten.
GB2205643B (en) * 1987-05-08 1991-03-13 Farmos Group Limited Type iii collagen degradation assay
US5320970A (en) * 1987-11-06 1994-06-14 Washington Research Foundation Detection of collagen degradation in vivo
US4973666A (en) * 1987-11-06 1990-11-27 Washington Research Foundation Peptide fragments containing HP and LP cross-links
US5300434A (en) * 1987-11-06 1994-04-05 Washington Research Foundation Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
GB8815174D0 (en) * 1988-06-25 1988-08-03 Rowett Research Inst Method of monitoring collagen degradation
WO1990004417A1 (en) * 1988-10-24 1990-05-03 Bruce Caterson Methods of and compositions for diagnosing, monitoring and treating the early stages of osteoarthritis
WO1990008195A1 (en) * 1989-01-13 1990-07-26 President And Fellows Of Harvard College Monoclonal antibody to human type ix collagen
GB9105893D0 (en) * 1991-03-20 1991-05-08 Orion Yhtymae Oy Bone resorption assay based on a peptide liberated during collagen degradation

Also Published As

Publication number Publication date
DE69034170D1 (de) 2004-11-18
US5656439A (en) 1997-08-12
JP2000055915A (ja) 2000-02-25
EP0682256A1 (de) 1995-11-15
JP2000050865A (ja) 2000-02-22
JP2782017B2 (ja) 1998-07-30
DE69025199D1 (de) 1996-03-14
DK0682256T3 (da) 2005-02-14
GR3018852T3 (en) 1996-05-31
NO922149D0 (no) 1992-05-29
JPH05502223A (ja) 1993-04-22
IE904344A1 (en) 1991-06-05
ES2061422T1 (es) 1994-12-16
US5677198A (en) 1997-10-14
ATE133790T1 (de) 1996-02-15
US5473052A (en) 1995-12-05
JP2002139492A (ja) 2002-05-17
DE69034170T2 (de) 2006-03-02
EP0502928A1 (de) 1992-09-16
ES2061422T3 (es) 1996-03-16
JP2999444B2 (ja) 2000-01-17
DE69033082D1 (de) 1999-06-02
AU6889891A (en) 1991-06-26
GR3030646T3 (en) 1999-10-29
JPH10260183A (ja) 1998-09-29
AU645049B2 (en) 1994-01-06
EP0502928B1 (de) 1996-01-31
EP1560026A1 (de) 2005-08-03
ATE279730T1 (de) 2004-10-15
EP0682256B1 (de) 2004-10-13
US5300434A (en) 1994-04-05
EP0890840A2 (de) 1999-01-13
EP0682257B1 (de) 1999-04-28
DK0502928T3 (da) 1996-02-19
JP3299941B2 (ja) 2002-07-08
DE69025199T2 (de) 1996-05-30
ES2133656T3 (es) 1999-09-16
JP2999416B2 (ja) 2000-01-17
ATE179521T1 (de) 1999-05-15
EP0682257A1 (de) 1995-11-15
RU2139541C1 (ru) 1999-10-10
NO922149L (no) 1992-07-29
EP1632502A1 (de) 2006-03-08
DK0682257T3 (da) 1999-11-08
JPH09113510A (ja) 1997-05-02
GR940300047T1 (en) 1994-07-29
DE502928T1 (de) 1994-08-18
WO1991008478A3 (en) 1991-11-28
IE65280B1 (en) 1995-10-18
US5576189A (en) 1996-11-19
NO309483B1 (no) 2001-02-05
WO1991008478A2 (en) 1991-06-13
EP0890840A3 (de) 2000-05-17

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