DE69033840D1 - [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-heptansäure, ihre Lactonform und Salze davon - Google Patents

[R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-heptansäure, ihre Lactonform und Salze davon

Info

Publication number
DE69033840D1
DE69033840D1 DE69033840T DE69033840T DE69033840D1 DE 69033840 D1 DE69033840 D1 DE 69033840D1 DE 69033840 T DE69033840 T DE 69033840T DE 69033840 T DE69033840 T DE 69033840T DE 69033840 D1 DE69033840 D1 DE 69033840D1
Authority
DE
Germany
Prior art keywords
methylethyl
fluorophenyl
pyrrole
phenylamino
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69033840T
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English (en)
Other versions
DE69033840T2 (de
Inventor
Bruce David Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23516372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69033840(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of DE69033840D1 publication Critical patent/DE69033840D1/de
Application granted granted Critical
Publication of DE69033840T2 publication Critical patent/DE69033840T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69033840T 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-heptansäure, ihre Lactonform und Salze davon Expired - Lifetime DE69033840T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38418789A 1989-07-21 1989-07-21

Publications (2)

Publication Number Publication Date
DE69033840D1 true DE69033840D1 (de) 2001-12-06
DE69033840T2 DE69033840T2 (de) 2002-05-16

Family

ID=23516372

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69034153T Revoked DE69034153T2 (de) 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3 -phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-Heptansäure, ihre Lactonform und Salze davon
DE1061073T Pending DE1061073T1 (de) 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3 -phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-Heptansäure, ihre Lactonform und Salze davon
DE69033840T Expired - Lifetime DE69033840T2 (de) 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-heptansäure, ihre Lactonform und Salze davon

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69034153T Revoked DE69034153T2 (de) 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3 -phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-Heptansäure, ihre Lactonform und Salze davon
DE1061073T Pending DE1061073T1 (de) 1989-07-21 1990-07-20 [R-(R*R*)]-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3 -phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrol-1-Heptansäure, ihre Lactonform und Salze davon

Country Status (20)

Country Link
US (2) US5273995A (de)
EP (2) EP1061073B1 (de)
JP (6) JP3506336B2 (de)
KR (1) KR0167101B1 (de)
AT (2) ATE270274T1 (de)
AU (1) AU628198B2 (de)
CA (1) CA2021546C (de)
CY (1) CY2357B1 (de)
DE (3) DE69034153T2 (de)
DK (2) DK0409281T3 (de)
ES (2) ES2167306T3 (de)
FI (1) FI94339C (de)
GE (1) GEP20043167B (de)
GR (1) GR20010300002T1 (de)
IE (1) IE902659A1 (de)
NO (1) NO174709C (de)
NZ (1) NZ234576A (de)
PT (1) PT94778B (de)
SG (1) SG46495A1 (de)
ZA (1) ZA905742B (de)

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EP0409281B1 (de) 2001-10-31
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IE20040325A1 (en) 2004-06-30
NZ234576A (en) 1992-12-23
DK0409281T3 (da) 2002-02-25
DE69033840T2 (de) 2002-05-16
EP1061073B1 (de) 2004-06-30
PT94778A (pt) 1991-03-20
DE69034153T2 (de) 2005-07-14
USRE40667E1 (en) 2009-03-17
ES2153332T3 (es) 2005-03-01
IE902659A1 (en) 1991-02-27
JP2003201236A (ja) 2003-07-18
AU5972490A (en) 1991-01-24
GR20010300002T1 (en) 2001-02-28
NO174709B (no) 1994-03-14
JP2007137903A (ja) 2007-06-07
ATE270274T1 (de) 2004-07-15
CA2021546A1 (en) 1991-01-22
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ES2153332T1 (es) 2001-03-01
ZA905742B (en) 1992-03-25
US5273995A (en) 1993-12-28
NO903251L (no) 1991-01-22
NO903251D0 (no) 1990-07-20
CY2357B1 (en) 2004-06-04
KR910002794A (ko) 1991-02-26
EP1061073A1 (de) 2000-12-20
JP3506336B2 (ja) 2004-03-15
AU628198B2 (en) 1992-09-10
DE1061073T1 (de) 2001-05-03
NO174709C (no) 1994-06-22
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CA2021546C (en) 1997-04-29
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PT94778B (pt) 1997-04-30
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