DE69034122D1 - Menschlicher c3b/c4b-rezeptor (cr1) - Google Patents

Menschlicher c3b/c4b-rezeptor (cr1)

Info

Publication number
DE69034122D1
DE69034122D1 DE69034122T DE69034122T DE69034122D1 DE 69034122 D1 DE69034122 D1 DE 69034122D1 DE 69034122 T DE69034122 T DE 69034122T DE 69034122 T DE69034122 T DE 69034122T DE 69034122 D1 DE69034122 D1 DE 69034122D1
Authority
DE
Germany
Prior art keywords
fragments
expression
protein
secreted
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69034122T
Other languages
English (en)
Inventor
T Fearon
B Klickstein
W Wong
R Carson
F Concino
H Ip
C Makrides
C Marsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Johns Hopkins University
Celldex Therapeutics Inc
Original Assignee
Brigham and Womens Hospital Inc
Johns Hopkins University
Avant Immunotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc, Johns Hopkins University, Avant Immunotherapeutics Inc filed Critical Brigham and Womens Hospital Inc
Application granted granted Critical
Publication of DE69034122D1 publication Critical patent/DE69034122D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69034122T 1989-09-26 1990-09-25 Menschlicher c3b/c4b-rezeptor (cr1) Expired - Lifetime DE69034122D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41274589A 1989-09-26 1989-09-26
US07/588,128 US5256642A (en) 1988-04-01 1990-09-24 Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
PCT/US1990/005454 WO1991005047A1 (en) 1989-09-26 1990-09-25 THE HUMAN C3b/C4b RECEPTOR (CR1)

Publications (1)

Publication Number Publication Date
DE69034122D1 true DE69034122D1 (de) 2004-01-22

Family

ID=27021901

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69034122T Expired - Lifetime DE69034122D1 (de) 1989-09-26 1990-09-25 Menschlicher c3b/c4b-rezeptor (cr1)

Country Status (15)

Country Link
US (3) US5256642A (de)
EP (1) EP0502892B1 (de)
JP (1) JP3097753B2 (de)
CN (1) CN1060112A (de)
AT (1) ATE256181T1 (de)
AU (1) AU656312B2 (de)
CA (1) CA2067744C (de)
DE (1) DE69034122D1 (de)
FI (1) FI921291A (de)
GR (1) GR900100716A (de)
IE (1) IE903447A1 (de)
IL (1) IL95806A (de)
NZ (1) NZ235445A (de)
PT (1) PT95437B (de)
WO (1) WO1991005047A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
US6395888B1 (en) * 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
WO1992010205A1 (en) * 1990-12-06 1992-06-25 T Cell Sciences, Inc. Synergistic compositions of soluble complement receptors and compounds that inhibit complement and/or suppress immune activity
EP0512733A2 (de) * 1991-05-03 1992-11-11 Washington University Modifizierter Komplementsystemregler
US6756211B1 (en) * 1992-05-11 2004-06-29 Corvas International, Inc. Neutropohil inhibitors
US5456909A (en) * 1992-08-07 1995-10-10 T Cell Sciences, Inc. Glycoform fractions of recombinant soluble complement receptor 1 (sCR1) having extended half-lives in vivo
TW262386B (de) * 1992-09-30 1995-11-11 Senju Pharma Co
GB9301289D0 (en) * 1993-01-22 1993-03-17 Smithkline Beecham Plc Novel composition
CA2155933C (en) 1993-02-12 2000-04-04 James L. Levin Pulmonary administration of scr1 and other complement inhibitory proteins
US5520912A (en) * 1993-07-02 1996-05-28 Immuno Aktiengesellschaft Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen
EP0812200B1 (de) * 1993-07-09 2002-02-27 Avant Immunotherapeutics, Inc. Proteinreinigung
US5861272A (en) * 1995-06-02 1999-01-19 Human Genome Sciences, Inc. C5A receptor
FI951778A (fi) * 1995-04-12 1996-10-13 Aboatech Ab Oy Menetelmä allergian toteamiseksi
GB9604518D0 (en) * 1996-03-02 1996-05-01 Smithkline Beecham Plc Novel compounds
AU2203197A (en) 1996-03-13 1997-10-01 Trustees Of The University Of Pennsylvania, The Novel peptides which inhibit complement activation
JP2000516911A (ja) 1996-03-28 2000-12-19 ホワイトヘッド インスティテュート フォー バイオメディカル リサーチ オプソニン強化細胞、および抗原に対する免疫応答を調節する方法
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
US6319890B1 (en) * 1996-12-30 2001-11-20 Manfred P. Dierich Inhibition of binding of complement Factor H
US6221621B1 (en) 1997-03-06 2001-04-24 Bard Diagnostic Sciences, Inc. Methods of screening for colorectal cancers in which a complement Factor I or related protein is associated
WO1998039659A1 (en) * 1997-03-06 1998-09-11 Bion Diagnostic Sciences, Inc. Screening and treatment using complement regulator or receptor proteins
WO1998040743A1 (en) * 1997-03-10 1998-09-17 Beth Israel Deaconess Medical Center Immune complexes and methods of detection and treatment thereof
US8088386B2 (en) * 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
WO1999037149A1 (en) 1998-01-27 1999-07-29 Brigham & Women's Hospital Methods of treating cytotoxic damage
EP1054693B8 (de) * 1998-02-20 2009-03-04 Genentech, Inc. Inhibitoren der komplement-aktivierung
US6956107B2 (en) * 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
US20020102581A1 (en) * 1999-02-19 2002-08-01 Hageman Gregory S. Diagnostics and therapeutics for ocular disorders
GB9905503D0 (en) 1999-03-10 1999-05-05 Adprotech Plc Novel compound formulations and methods of delivery
US7011952B2 (en) * 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
US20030118983A1 (en) * 2000-03-09 2003-06-26 Cassidy Richard A. Rapid screening procedure for inflammation mediators
CA2407715C (en) * 2000-04-29 2009-03-24 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
GB0016811D0 (en) * 2000-07-07 2000-08-30 Adprotech Ltd Lipid rafts
US20030050692A1 (en) * 2000-12-22 2003-03-13 Avantec Vascular Corporation Delivery of therapeutic capable agents
US20020082679A1 (en) * 2000-12-22 2002-06-27 Avantec Vascular Corporation Delivery or therapeutic capable agents
US6820011B2 (en) 2001-04-11 2004-11-16 The Regents Of The University Of Colorado Three-dimensional structure of complement receptor type 2 and uses thereof
PL372246A1 (en) * 2002-05-28 2005-07-11 3-Dimensional Pharmaceuticals, Inc. Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
EP2311480B1 (de) * 2002-09-20 2013-06-26 The Trustees of The University of Pennsylvania Compstatin-Analoga mit verbesserter Aktivität
JP4915980B2 (ja) * 2002-11-15 2012-04-11 エムユーエスシー ファウンデーション フォー リサーチ デベロップメント 補体レセプター２標的化補体調節因子
WO2005069726A2 (en) * 2004-01-21 2005-08-04 Case Western Reserve University Hybrid and chimeric polypeptides that regulate activation of complement
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
EP1814576A2 (de) * 2004-07-20 2007-08-08 Critical Therapeutics, Inc. Kombinationstherapien von hmgb- und komplementinhibitoren gegen entzündungen
EP1738763A1 (de) 2005-06-30 2007-01-03 AVANT Immunotherapeutics, Inc. Verwendung eines Komplement-inhibierenden Proteins zur Behandlung von Rückenmarksverletzungen
CN1314811C (zh) * 2005-07-25 2007-05-09 中国人民解放军第四军医大学 重组嵌合分子Cb1－Grb7(SH2）－RING真核表达质粒及抗肿瘤基因药物用途
CN101355956A (zh) * 2005-11-04 2009-01-28 健泰科生物技术公司 利用补体途径抑制剂治疗眼部疾病
CN106188239B (zh) * 2005-11-28 2020-01-07 宾夕法尼亚州大学理事会 有效的坎普他汀类似物
US20070196367A1 (en) * 2006-02-22 2007-08-23 Valentin Dinu Methods of preventing and treating Alzheimer's disease, age related macular degeneration and other diseases involving extra-cellular debris through the inhibition of the complement system
HUE026496T2 (en) 2006-03-08 2016-06-28 Archemix Llc Complement-binding aptamers and anti-C5 agents for treating eye diseases
DE102006019296A1 (de) 2006-04-26 2007-10-31 Robert Bosch Gmbh Zündspule, insbesondere für eine Brennkraftmaschine eines Kraftfahrzeugs
SI2044111T1 (sl) 2006-06-21 2015-02-27 Musc Foundation For Research Development Ciljanje komplementa faktorja H za zdravljenje bolezni
SI3028716T1 (sl) 2006-10-10 2021-01-29 Regenesance B.V. Komplementarna inhibicija za izboljšano regeneracijo živcev
CN106188299A (zh) * 2006-11-02 2016-12-07 健泰科生物技术公司 人源化的抗‑d因子抗体
MX2009006812A (es) * 2006-12-22 2009-07-02 Encysive Pharmaceuticals Inc Moduladores del receptor c3a y metodos de uso de los mismos.
CR20170001A (es) 2008-04-28 2017-08-10 Genentech Inc Anticuerpos anti factor d humanizados
EP2350274B1 (de) 2008-10-21 2019-01-23 The General Hospital Corporation Zelltransplantation
GB0904427D0 (en) 2009-03-13 2009-04-29 Lachmann Peter Treatment of diseases related to hyperactivity of the complement system
US9066925B2 (en) 2009-07-02 2015-06-30 Musc Foundation For Research Development Methods of stimulating liver regeneration
AU2010314931A1 (en) 2009-11-05 2012-06-21 Taligen Therapeutics, Inc. Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis
EP2569332B1 (de) 2010-05-14 2019-01-09 The Regents of the University of Colorado, A Body Corporate Verbesserte komplement-rezeptor-2-anzielungsgruppen
MX2012014975A (es) 2010-06-22 2013-03-12 Univ Colorado Regents Anticuerpos al fragmento c3d de componente 3 de complemento.
EP2601299B1 (de) 2010-08-06 2019-04-24 The General Hospital Corporation D/B/A Massachusetts General Hospital System und vorrichtung zur behandlung von zellen
CN102702339B (zh) * 2011-05-24 2013-10-30 华南师范大学 斜带石斑鱼补体c3基因、载体、重组菌株和蛋白及其应用
WO2013036778A2 (en) 2011-09-07 2013-03-14 The Trustees Of The University Of Pennsylvania Compstatin analogs with improved pharmacokinetic properties
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
WO2014028865A1 (en) 2012-08-17 2014-02-20 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for detecting complement activation
US10413620B2 (en) 2012-08-17 2019-09-17 The Regents Of The University Of Colorado, A Body Corporate Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging
US10093978B2 (en) 2013-08-12 2018-10-09 Genentech, Inc. Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
US10179821B2 (en) 2014-05-01 2019-01-15 Genentech, Inc. Anti-factor D antibodies
JP2018536650A (ja) 2015-10-30 2018-12-13 ジェネンテック， インコーポレイテッド 抗ｄ因子抗体変異体コンジュゲート及びその使用
TW201730211A (zh) 2015-10-30 2017-09-01 建南德克公司 抗因子d抗體及結合物
AU2019247467B2 (en) 2018-04-06 2023-01-19 The Trustees Of The University Of Pennsylvania Compstatin analogs with increased solubility and improved pharmacokinetic properties
US20210238238A1 (en) * 2018-05-16 2021-08-05 Csl Limited Soluble complement receptor type i variants and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212071A (en) * 1988-04-01 1993-05-18 The Johns Hopkins University Nucleic acids encoding a human C3b/C4b receptor (CR1)
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
DE3065190D1 (en) * 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation
US4642284A (en) * 1983-06-13 1987-02-10 Scripps Clinic And Research Foundation Method and system for detection of complement pathway activation
US4713332A (en) * 1984-01-13 1987-12-15 The Ontario Cancer Institute T cell specific CDNA clone
US4672044A (en) * 1984-08-24 1987-06-09 Scripps Clinic & Research Foundation Murine monoclonal antibody combining site to human C3b receptor (CR1)
US4761371A (en) * 1985-02-12 1988-08-02 Genentech, Inc. Insulin receptor
US4886743A (en) * 1985-04-24 1989-12-12 California Institute Of Technology Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof
JPH0742235B2 (ja) * 1985-11-08 1995-05-10 三共株式会社 自己免疫性疾病の予防・治療剤
IL89790A (en) * 1988-04-01 2002-05-23 Johns Hopking University Sequences of nucleic acids encoding and cells producing CR1 protein and methods for its production and purification
AT402153B (de) * 1989-06-26 1997-02-25 Immuno Ag Protein-s-hältige pharmazeutische präparation
IL94522A (en) * 1990-05-28 1994-02-27 Joseph Eldor Device for combined spinal and epidural anesthesia

Also Published As

Publication number Publication date
CN1060112A (zh) 1992-04-08
EP0502892A1 (de) 1992-09-16
PT95437A (pt) 1991-08-14
PT95437B (pt) 1998-12-31
NZ235445A (en) 1993-02-25
CA2067744A1 (en) 1991-03-27
FI921291A0 (fi) 1992-03-25
EP0502892A4 (en) 1992-11-19
IL95806A (en) 1998-04-05
EP0502892B1 (de) 2003-12-10
IL95806A0 (en) 1991-06-30
US5856297A (en) 1999-01-05
JPH05504053A (ja) 1993-07-01
US5472939A (en) 1995-12-05
CA2067744C (en) 2001-02-06
FI921291A (fi) 1992-03-25
AU656312B2 (en) 1995-02-02
JP3097753B2 (ja) 2000-10-10
IE903447A1 (en) 1991-04-10
ATE256181T1 (de) 2003-12-15
US5256642A (en) 1993-10-26
GR900100716A (el) 1992-01-20
WO1991005047A1 (en) 1991-04-18
AU6755090A (en) 1991-04-28

Similar Documents

Publication Publication Date Title
ATE256181T1 (de) Menschlicher c3b/c4b-rezeptor (cr1)
DE68929466D1 (de) Menschlicher rezeptor c3b/c4b (cr1)
US5401651A (en) DNA encoding ENA-78, a neutrophil activating factor
HUT77578A (hu) A 10-es számú fibroblaszt növekedési faktor (FGF-10)
DK1000146T3 (da) 5' EST'er for non-vævsspecifikke secernerede proteiner
KR970705405A (ko) 사람 케모킨 폴리펩타이드(Human Chemokine Polypeptides)
NZ503235A (en) Amino-terminally truncated RANTES as chemokine antagonists
MX9203654A (es) Purificacion, clonacion y caracterizacion del gen para la interleucina i.
JPH05503512A (ja) 白血球接着阻害因子としての［ａｌａ　ｉｌ―８］↓７↓７
JP2829405B2 (ja) 機能性ポリペプチド
ES2243942T3 (es) Isoforma intracelular del antagonista del receptor de la interleuquina.
PT98695A (pt) Gene codificador do factor neurotrofico de ligacao a heparina
Sherry et al. Characterization of high molecular weight glycosylated forms of murine tumor necrosis factor
EP0913470A3 (de) Menschlicher C3b/C4b Rezeptor (CR1)
JP2002519016A (ja) 疎水性ドメインを有するヒト蛋白質とそれをコードするｄｎａ
KR930701475A (ko) 사람의 거핵구-집락 촉진 인자(hMeg-CSF) 및 그것의 생산방법
EP0308424A1 (de) Ein neues protein, neuroleukin
KR20010030984A (ko) 폴리펩티드, 그 폴리펩티드를 암호화하는 ｃＤＮＡ 및이들의 용도
Schwaeble et al. Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase
Sakaguchi et al. Extracellular secretion of human granulocyte-macrophage colony-stimulating factor in Escherichia coli
JP2002518053A (ja) ヒトグリコプロテアーゼ様蛋白質およびそれをコードするｄｎａ
JPH07309778A (ja) 創傷治療剤

Legal Events

Date Code Title Description
8332 No legal effect for de