DE69111821T2 - In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel. - Google Patents

In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel.

Info

Publication number
DE69111821T2
DE69111821T2 DE69111821T DE69111821T DE69111821T2 DE 69111821 T2 DE69111821 T2 DE 69111821T2 DE 69111821 T DE69111821 T DE 69111821T DE 69111821 T DE69111821 T DE 69111821T DE 69111821 T2 DE69111821 T2 DE 69111821T2
Authority
DE
Germany
Prior art keywords
perfluored
aque
active substance
suspended
delivery vehicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69111821T
Other languages
English (en)
Other versions
DE69111821D1 (de
Inventor
David Louis Meadows
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DE69111821D1 publication Critical patent/DE69111821D1/de
Publication of DE69111821T2 publication Critical patent/DE69111821T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
DE69111821T 1990-09-27 1991-09-10 In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel. Expired - Fee Related DE69111821T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/588,697 US5173298A (en) 1990-09-27 1990-09-27 Nonaqueous fluorinated drug delivery vehicle suspensions
PCT/US1991/006596 WO1992005770A1 (en) 1990-09-27 1991-09-10 Drug delivery vehicles suspended in nonaqueous perfluorinated carrier

Publications (2)

Publication Number Publication Date
DE69111821D1 DE69111821D1 (de) 1995-09-07
DE69111821T2 true DE69111821T2 (de) 1995-12-14

Family

ID=24354930

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69111821T Expired - Fee Related DE69111821T2 (de) 1990-09-27 1991-09-10 In einem nichtwässrigen perfluorierten trägermedium suspendierte wirkstoffabgabevehikel.

Country Status (16)

Country Link
US (1) US5173298A (de)
EP (1) EP0550615B1 (de)
JP (1) JP3253072B2 (de)
KR (1) KR100195760B1 (de)
AT (1) ATE125696T1 (de)
AU (1) AU656919B2 (de)
CA (1) CA2090404C (de)
DE (1) DE69111821T2 (de)
ES (1) ES2075468T3 (de)
IE (1) IE69016B1 (de)
IL (1) IL99290A (de)
NZ (1) NZ239558A (de)
PT (1) PT99108B (de)
TW (1) TW224428B (de)
WO (1) WO1992005770A1 (de)
ZA (1) ZA916770B (de)

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US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US5660851A (en) * 1989-12-26 1997-08-26 Yissum Research Development Company Of The Hebrew Univ. Of Jerusalem Ocular inserts
IL97065A (en) * 1990-02-02 1994-01-25 Fisons Plc Repellent preparations for aerosol
EP0537165B1 (de) * 1990-04-27 1998-07-01 Allergan, Inc. Polymeres arzneimittelabgabesystem
DE4201079C3 (de) * 1992-01-17 1997-09-11 Gramer Eugen Kombinationspräparate zur Augeninnendrucksenkung
WO1993018748A1 (en) * 1992-03-19 1993-09-30 Allergan, Inc. Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid
DE69332105T2 (de) 1992-09-29 2003-03-06 Inhale Therapeutic Systems San Pulmonale abgabe von aktiven fragmenten des parathormons
US5336487A (en) * 1993-03-05 1994-08-09 Refojo Miguel F Method of treating eye disorders with silicon/fluorosilicone copolymer oil
MX9603858A (es) 1994-03-04 1997-12-31 Univ Washington Copolimeros de bloque y de injerto y metodos relacionados con los mismos.
DE4414755C2 (de) * 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
US5661029A (en) * 1994-05-12 1997-08-26 Biomed Biological culture growth and observation device
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5503869A (en) * 1994-10-21 1996-04-02 Glaxo Wellcome Inc. Process for forming medicament carrier for dry powder inhalator
US6294563B1 (en) 1994-10-27 2001-09-25 Allergan Sales, Inc. Combinations of prostaglandins and brimonidine or derivatives thereof
JPH10510198A (ja) * 1995-05-12 1998-10-06 ジェネンテク・インコーポレイテッド 機能生物学的物質の粗いスプレー供給
US5667809A (en) * 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
US5874469A (en) * 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
US5861175A (en) * 1996-03-15 1999-01-19 Alliance Pharmaceutical Corp. Use of fluorocarbons for diagnosis and treatment of articular disorders
ATE302599T1 (de) * 1996-05-24 2005-09-15 Angiotech Pharm Inc Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
GB9816724D0 (en) * 1998-08-01 1998-09-30 Boots Co Plc Therapeutic agents
AU768527B2 (en) * 1999-02-23 2003-12-18 Angiotech International Ag Compositions and methods for improving integrity of compromised body passageways and cavities
AU6124601A (en) 2000-05-10 2001-11-20 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
JPWO2002064114A1 (ja) * 2001-02-15 2004-06-10 株式会社三和化学研究所 新規眼科用組成物
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
SI2949658T1 (sl) 2003-03-03 2018-10-30 Dyax Corp. Peptidi, ki specifično vežejo HGF receptor (cMet) in njihove uporabe
US20050118124A1 (en) * 2003-12-01 2005-06-02 Reinhart Gale M. Compositions for treating keratinous surfaces
EP1763336A1 (de) * 2004-06-08 2007-03-21 Ocularis Pharma, Inc. Wasserabweisende ophthalmische zusammensetzungen und anwendungsverfahren
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US20070219127A1 (en) * 2006-03-20 2007-09-20 Walt John G Cyclosporin a compositions
WO2009036368A2 (en) 2007-09-14 2009-03-19 Nitto Denko Corporation Drug carriers
US9057712B1 (en) 2011-10-27 2015-06-16 Copilot Ventures Fund Iii Llc Methods of delivery of encapsulated perfluorocarbon taggants

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911138B1 (en) * 1973-02-26 1996-10-29 Childrens Hosp Medical Center Artificial blood and method for supporting oxygen transport in animals
US4105798A (en) * 1976-07-19 1978-08-08 Sun Ventures, Inc. Perfluoro polycyclic compounds for use as synthetic blood and perfusion media
US4115544A (en) * 1976-08-18 1978-09-19 Alza Corporation Ocular system made of bioerodible esters having linear ether
DE3049665T1 (de) * 1979-06-25 1982-03-18 Suntech Use of perfluorocarbon as burn treatment
US4452818A (en) * 1982-03-19 1984-06-05 Haidt Sterling J Extraocular method of treating the eye with liquid perfluorocarbons
GR78151B (de) * 1982-04-05 1984-09-26 Alcon Lab Inc
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4879304A (en) * 1987-05-01 1989-11-07 Angelini Pharmaceuticals Ltd. Ophthalmic compositions and process for preparing
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US4882150A (en) * 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
FR2643572A1 (fr) * 1988-12-22 1990-08-31 Rhone Poulenc Chimie Procede d'encapsulation de particules par pelliculage au moyen d'un copolymere silicone thermoplastique

Also Published As

Publication number Publication date
KR100195760B1 (ko) 1999-06-15
IL99290A0 (en) 1992-07-15
AU8644291A (en) 1992-04-28
US5173298A (en) 1992-12-22
JPH06501258A (ja) 1994-02-10
EP0550615B1 (de) 1995-08-02
NZ239558A (en) 1993-10-26
PT99108B (pt) 1999-02-26
WO1992005770A1 (en) 1992-04-16
CA2090404A1 (en) 1992-03-28
TW224428B (de) 1994-06-01
ATE125696T1 (de) 1995-08-15
IE913379A1 (en) 1992-04-08
AU656919B2 (en) 1995-02-23
PT99108A (pt) 1993-11-30
ZA916770B (en) 1992-04-29
IL99290A (en) 1996-09-12
IE69016B1 (en) 1996-07-24
EP0550615A1 (de) 1993-07-14
JP3253072B2 (ja) 2002-02-04
DE69111821D1 (de) 1995-09-07
ES2075468T3 (es) 1995-10-01
CA2090404C (en) 2001-11-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee