DE69116593T2 - Cephalosporin Acetylhydrolasegen und dadurch kodiertes Protein - Google Patents

Cephalosporin Acetylhydrolasegen und dadurch kodiertes Protein

Info

Publication number
DE69116593T2
DE69116593T2 DE69116593T DE69116593T DE69116593T2 DE 69116593 T2 DE69116593 T2 DE 69116593T2 DE 69116593 T DE69116593 T DE 69116593T DE 69116593 T DE69116593 T DE 69116593T DE 69116593 T2 DE69116593 T2 DE 69116593T2
Authority
DE
Germany
Prior art keywords
cephalosporin
gene
protein
enzyme
protein encoded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69116593T
Other languages
English (en)
Other versions
DE69116593D1 (de
Inventor
Kenji Mitsushima
Akio Takimoto
Shigeo Yagi
Takayasu Sonoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE69116593D1 publication Critical patent/DE69116593D1/de
Publication of DE69116593T2 publication Critical patent/DE69116593T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07Bacillus
    • C12R2001/125Bacillus subtilis ; Hay bacillus; Grass bacillus
DE69116593T 1990-04-27 1991-04-26 Cephalosporin Acetylhydrolasegen und dadurch kodiertes Protein Expired - Lifetime DE69116593T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11348390 1990-04-27

Publications (2)

Publication Number Publication Date
DE69116593D1 DE69116593D1 (de) 1996-03-07
DE69116593T2 true DE69116593T2 (de) 1996-07-04

Family

ID=14613433

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116593T Expired - Lifetime DE69116593T2 (de) 1990-04-27 1991-04-26 Cephalosporin Acetylhydrolasegen und dadurch kodiertes Protein

Country Status (15)

Country Link
US (2) US5281525A (de)
EP (1) EP0454478B1 (de)
JP (1) JP2651288B2 (de)
KR (1) KR960014703B1 (de)
CN (2) CN1047202C (de)
AT (1) ATE133450T1 (de)
AU (1) AU638124B2 (de)
CA (1) CA2040707C (de)
DE (1) DE69116593T2 (de)
DK (1) DK0454478T3 (de)
ES (1) ES2085422T3 (de)
GR (1) GR3018790T3 (de)
IL (1) IL97915A (de)
NZ (1) NZ237878A (de)
RU (1) RU2103364C1 (de)

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IT1250698B (it) * 1991-07-24 1995-04-21 Mini Ricerca Scient Tecnolog Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici.
DE69432645T2 (de) * 1993-08-06 2004-04-08 Brigham Young University Technology Transfer Office, Provo Monoklonale antikörper gegen isozyme der thymidinkinase
AT408660B (de) 1998-01-28 2002-02-25 Biochemie Gmbh Nukleinsäure-molekül, das für cephalosporin-acetylesterase kodiert
KR100270508B1 (ko) * 1998-04-24 2001-02-01 고두모 신규세파로스포린디아세틸라아제유전자및이를이용한단백질제조방법
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
ES2156812B1 (es) 1999-04-09 2002-02-01 Antibioticos Sau Una proteasa extracelular de acremonium chrysogenum con actividad cpc-acetilhidrolasa y su utilizacion para la sintesis de derivados desacetilados de cefalosporina c e inactivacion del gen para aumentar la produccion de cefalosporina.
RU2209244C2 (ru) * 2001-04-28 2003-07-27 Закрытое акционерное общество "АСГЛ-Фармацевтические Инновации" Нуклеиновая кислота, кодирующая лидерную последовательность (варианты), вектор на основе плазмиды р6803-platform (варианты), лидерный пептид (варианты) и способ получения белков
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
ES2272115B1 (es) * 2004-02-13 2008-03-16 Universidad De Murcia Produccion de formas quimericas de cefalosporina c acetilasa.
US7311906B2 (en) 2004-04-30 2007-12-25 Brigham Young University Anti-viral activity of an anti-thymidine kinase monoclonal antibody
US8551486B2 (en) 2004-05-21 2013-10-08 Savoy Pharmaceuticals, Inc. Monoclonal antibodies to human thymidine kinase to treat cancer
US7837998B2 (en) 2004-05-21 2010-11-23 Nathaniel Lallatin Anti-cancer activity of an anti-thymidine kinase monoclonal antibody
US8518675B2 (en) 2005-12-13 2013-08-27 E. I. Du Pont De Nemours And Company Production of peracids using an enzyme having perhydrolysis activity
US7964378B2 (en) * 2005-12-13 2011-06-21 E.I. Du Pont De Nemours And Company Production of peracids using an enzyme having perhydrolysis activity
US7951566B2 (en) * 2005-12-13 2011-05-31 E.I. Du Pont De Nemours And Company Production of peracids using an enzyme having perhydrolysis activity
US8288136B2 (en) 2005-12-13 2012-10-16 E. I. Du Pont De Nemours And Company Production of peracids using an enzyme having perhydrolysis activity
EP1960529B1 (de) * 2005-12-13 2010-02-24 E.I. Du Pont De Nemours And Company Herstellung von peraciden unter verwendung eines enzyms mit perhydrolyse-aktivität
US7723083B2 (en) * 2005-12-13 2010-05-25 E.I. Du Pont De Nemours And Company Production of peracids using an enzyme having perhydrolysis activity
US7473658B2 (en) * 2006-11-13 2009-01-06 E. I. Du Pont Nemours And Company Partially fluorinated amino acid derivatives as gelling and surface active agents
WO2009013611A2 (en) * 2007-07-26 2009-01-29 Orchid Chemicals & Pharmaceuticals Limited Modified esterase and its applications
WO2010019544A1 (en) 2008-08-13 2010-02-18 E.I. Du Pont De Nemours And Company Control of enzymatic peracid generation
JP5665747B2 (ja) 2008-10-03 2015-02-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 酵素的過酸生成用の改善されたペルヒドロラーゼ
US8293101B2 (en) 2009-03-13 2012-10-23 Terrasep, Llc Methods and apparatus for centrifugal liquid chromatography
AU2010281409B2 (en) 2009-07-27 2014-08-14 The Chemours Company Fc, Llc Enzymatic in situ preparation of peracid-based removable antimicrobial coating compositions and methods of use
US20110177148A1 (en) * 2009-07-27 2011-07-21 E. I. Du Pont De Nemours And Company Enzymatic in situ preparation of peracid-based removable antimicrobial coating compositions and methods of use
US8222012B2 (en) * 2009-10-01 2012-07-17 E. I. Du Pont De Nemours And Company Perhydrolase for enzymatic peracid production
US7910347B1 (en) * 2009-12-07 2011-03-22 E. I. Du Pont De Nemours And Company Perhydrolase providing improved peracid stability
US7960528B1 (en) * 2009-12-07 2011-06-14 E. I. Du Pont De Nemours And Company Perhydrolase providing improved peracid stability
US7927854B1 (en) 2009-12-07 2011-04-19 E. I. Du Pont De Nemours And Company Perhydrolase providing improved peracid stability
US7932072B1 (en) 2009-12-07 2011-04-26 E. I. Du Pont De Nemours And Company Perhydrolase providing improved peracid stability
US7923233B1 (en) * 2009-12-07 2011-04-12 E. I. Du Pont De Nemours And Company Perhydrolase providing improved peracid stability
WO2011082345A2 (en) 2009-12-30 2011-07-07 Brigham Young University Compositions and methods for cancer management using antibodies binding to nucleotide salvage pathway enzymes and complexes thereof
WO2011119710A1 (en) 2010-03-26 2011-09-29 E.I. Dupont De Nemours And Company Perhydrolase providing improved specific activity
CA2792930A1 (en) 2010-03-26 2011-09-29 E. I. Du Pont De Nemours And Company Polyarylene sulfide-containing polymer melt
US8445242B2 (en) 2010-03-26 2013-05-21 E. I. Du Pont De Nemours And Company Perhydrolase providing improved specific activity
US8389254B2 (en) * 2010-03-26 2013-03-05 E.I. Du Pont De Nemours And Company Perhydrolase providing improved specific activity
CN102906256B (zh) 2010-03-26 2014-08-06 纳幕尔杜邦公司 用于纯化蛋白质的方法
WO2011119712A1 (en) 2010-03-26 2011-09-29 E.I. Dupont De Nemours And Company Perhydrolase providing improved specific activity
AU2011349447A1 (en) * 2010-12-20 2013-05-30 E. I. Du Pont De Nemours And Company Targeted perhydrolases
US8389259B2 (en) 2010-12-21 2013-03-05 E.I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2012087790A1 (en) 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
US8394617B2 (en) 2010-12-21 2013-03-12 E.I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8389257B2 (en) 2010-12-21 2013-03-05 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8389256B2 (en) 2010-12-21 2013-03-05 E.I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2012087788A1 (en) 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
US8389260B2 (en) 2010-12-21 2013-03-05 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2012087789A1 (en) 2010-12-21 2012-06-28 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
US8546120B2 (en) 2011-10-25 2013-10-01 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8956843B2 (en) 2011-10-25 2015-02-17 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8809030B2 (en) 2011-10-25 2014-08-19 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8962294B2 (en) 2011-10-25 2015-02-24 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8546119B2 (en) 2011-10-25 2013-10-01 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8557556B2 (en) 2011-10-25 2013-10-15 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
US8735125B2 (en) 2011-10-25 2014-05-27 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2013062885A1 (en) 2011-10-25 2013-05-02 E.I. Dupont De Nemours And Company Perhydrolase variant providing improved specific activity
US8486679B2 (en) 2011-10-25 2013-07-16 E. I. Du Pont De Nemours And Company Perhydrolase variant providing improved specific activity
WO2013096045A1 (en) 2011-12-19 2013-06-27 E. I. Du Pont De Nemours And Company Perhydrolase variants providing improved specific activity in the presence of surfactant
JP6574376B2 (ja) 2012-03-30 2019-09-11 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーE.I.Du Pont De Nemours And Company 過酸生成に有用な酵素
MX2014011651A (es) 2012-03-30 2015-02-13 Du Pont Enzimas utiles para la produccion de peracidos.
US8865435B2 (en) 2012-03-30 2014-10-21 E. I. Du Pont De Nemours And Company Enzymes useful for peracid production
MX2014011654A (es) 2012-03-30 2014-10-24 Du Pont Enzimas utiles para la produccion de peracidos.
RU2644333C2 (ru) 2012-03-30 2018-02-08 Е.И.Дюпон Де Немур Энд Компани Ферменты, пригодные для получения перкислот
CN111517481A (zh) * 2020-06-18 2020-08-11 山东海景天环保科技股份公司 一种皮革废水深度脱氮用复合碳源及其制备方法

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Also Published As

Publication number Publication date
CA2040707C (en) 2002-07-09
NZ237878A (en) 1993-02-25
US5338676A (en) 1994-08-16
CN1155712C (zh) 2004-06-30
AU7535491A (en) 1991-11-07
RU2103364C1 (ru) 1998-01-27
CN1047202C (zh) 1999-12-08
CA2040707A1 (en) 1991-10-28
DK0454478T3 (da) 1996-02-12
GR3018790T3 (en) 1996-04-30
EP0454478A1 (de) 1991-10-30
ES2085422T3 (es) 1996-06-01
JPH04228079A (ja) 1992-08-18
JP2651288B2 (ja) 1997-09-10
CN1227872A (zh) 1999-09-08
US5281525A (en) 1994-01-25
DE69116593D1 (de) 1996-03-07
IL97915A0 (en) 1992-06-21
ATE133450T1 (de) 1996-02-15
AU638124B2 (en) 1993-06-17
CN1058045A (zh) 1992-01-22
EP0454478B1 (de) 1996-01-24
KR910018549A (ko) 1991-11-30
IL97915A (en) 2000-08-31
KR960014703B1 (ko) 1996-10-19

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