DE69123247D1 - Verfahren zur behandlung von alkoholsucht mit nalmefen - Google Patents

Verfahren zur behandlung von alkoholsucht mit nalmefen

Info

Publication number
DE69123247D1
DE69123247D1 DE69123247T DE69123247T DE69123247D1 DE 69123247 D1 DE69123247 D1 DE 69123247D1 DE 69123247 T DE69123247 T DE 69123247T DE 69123247 T DE69123247 T DE 69123247T DE 69123247 D1 DE69123247 D1 DE 69123247D1
Authority
DE
Germany
Prior art keywords
nalmefen
alcohol addiction
treating alcohol
treating
alcoholics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69123247T
Other languages
English (en)
Other versions
DE69123247T2 (de
Inventor
John Sinclair
Harry Scheinin
Risto Lammintausta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Contral Clinics Oy
Original Assignee
Alko Oy AB
Orion Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alko Oy AB, Orion Yhtyma Oy filed Critical Alko Oy AB
Application granted granted Critical
Publication of DE69123247D1 publication Critical patent/DE69123247D1/de
Publication of DE69123247T2 publication Critical patent/DE69123247T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
DE69123247T 1990-06-04 1991-05-10 Verfahren zur behandlung von alkoholsucht mit nalmefen Expired - Lifetime DE69123247T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/532,424 US5086058A (en) 1990-06-04 1990-06-04 Method for treating alcoholism with nalmefene
PCT/US1991/003241 WO1991018605A1 (en) 1990-06-04 1991-05-10 Method for treating alcoholism with nalmefene

Publications (2)

Publication Number Publication Date
DE69123247D1 true DE69123247D1 (de) 1997-01-02
DE69123247T2 DE69123247T2 (de) 1998-01-15

Family

ID=24121726

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123247T Expired - Lifetime DE69123247T2 (de) 1990-06-04 1991-05-10 Verfahren zur behandlung von alkoholsucht mit nalmefen

Country Status (19)

Country Link
US (1) US5086058A (de)
EP (1) EP0531415B1 (de)
JP (1) JP3059213B2 (de)
AT (1) ATE145329T1 (de)
AU (1) AU642748B2 (de)
CA (1) CA2084519C (de)
DE (1) DE69123247T2 (de)
DK (1) DK0531415T3 (de)
ES (1) ES2097209T3 (de)
FI (1) FI925513A (de)
GR (1) GR3022289T3 (de)
HU (1) HU210637B (de)
IE (1) IE77333B1 (de)
LT (1) LT3893B (de)
LV (1) LV10190B (de)
NZ (1) NZ238391A (de)
RU (1) RU2090190C1 (de)
WO (1) WO1991018605A1 (de)
ZA (1) ZA914185B (de)

Families Citing this family (57)

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US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
US6271239B1 (en) * 1992-04-13 2001-08-07 Regents Of The University Of Minnesota Delta opioid receptor-selective benzylidene-substituted morphinans
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
USRE36547E (en) * 1992-09-21 2000-02-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists
US6096756A (en) * 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5580876A (en) * 1992-09-21 1996-12-03 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5298622A (en) * 1993-05-12 1994-03-29 Regents Of The University Of Minnesota Spiroindane opiate analogs
US5457208A (en) 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
US5587381A (en) * 1995-03-27 1996-12-24 Sinclair; John D. Method for terminating methadone maintenance through extinction of the opiate-taking responses
WO1997018781A1 (en) * 1995-11-20 1997-05-29 University Of Miami Method of treating nicotine dependence
US5878750A (en) * 1996-11-14 1999-03-09 Clemens; Anton H. Method of treating the syndrome of coronary heart disease risk factors in humans
US5780479A (en) * 1997-04-04 1998-07-14 Regents Of The University Of Minnesota Use of opioid antagonists to treat impulse-control disorders
DK1041987T3 (da) 1997-12-22 2006-08-21 Euro Celtique Sa Oral farmaceutisk doseringsform omfattende en kombination af en opioid-agonist og naltrexon
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
HUP0100310A3 (en) * 1997-12-22 2002-11-28 Euro Celtique Sa A method of preventing abuse of opioid dosage forms
EP1248800A2 (de) * 1999-11-30 2002-10-16 Corixa Corporation Kompositionen und methoden zur therapie und diagnose von brustkrebs
RS50407B (sr) 2000-02-08 2009-12-31 Euro-Celtique S.A., Oralne formulacije opijatnog agonista otporne na mehaničke,termičke i/ili hemijske promene fizičkih osobina doznog oblika
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
US20040024004A1 (en) * 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
US6528520B2 (en) * 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6262062B1 (en) * 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
ATE540613T1 (de) * 2001-07-13 2012-01-15 Arkray Inc Analysevorrichtung und durchstechelement- integrierte verbindung für eine konzentrationsanalysevorrichtung
CA2454328C (en) * 2001-07-18 2008-03-18 Christopher D. Breder Pharmaceutical combinations of oxycodone and naloxone
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
MXPA04001210A (es) 2001-08-06 2004-07-08 Euro Celtique Sa Formulaciones de agonista opioide con antagonista liberable y aislado.
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030153590A1 (en) * 2001-08-14 2003-08-14 Oy Contral Pharma Ltd Method of treating alcoholism or alcohol abuse
CN102813654A (zh) 2002-04-05 2012-12-12 欧洲凯尔蒂克公司 含有羟氢可待酮和烯丙羟吗啡酮的药物制剂
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
JP4668611B2 (ja) * 2002-05-31 2011-04-13 タイタン ファーマシューティカルズ インコーポレイテッド ブプレノルフィンの持続放出のための埋め込み型ポリマー製装置
PT1551372T (pt) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Subunidade de sequestração e composições e métodos relacionados
CN1777426A (zh) 2003-03-31 2006-05-24 泰坦医药品公司 用于持续释放多巴胺受体激动剂的可植入聚合物装置
US20040202717A1 (en) * 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
WO2004091593A2 (en) * 2003-04-14 2004-10-28 Pain Therapeutics, Inc. Methods for the treatment of pain comprising opioid antagonists
MY135852A (en) * 2003-04-21 2008-07-31 Euro Celtique Sa Pharmaceutical products
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US20060009478A1 (en) * 2003-10-15 2006-01-12 Nadav Friedmann Methods for the treatment of back pain
EP1604666A1 (de) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioide zur Behandlung der chronischen obstruktiven Lungenkrankheit
EP1702558A1 (de) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Verfahren und Vorrichtung zur Darmtätigkeitserfassung
EP2526932B1 (de) 2006-06-19 2017-06-07 Alpharma Pharmaceuticals LLC Pharmazeutische Zusammensetzung
BRPI0718420A2 (pt) 2006-10-20 2013-11-12 Cpd Llc Método de restabelecimento do efeito da incretina
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
US8623418B2 (en) * 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
EP2224808A4 (de) * 2007-12-17 2013-11-27 Alpharma Pharmaceuticals Llc Pharmazeutische zusammensetzung
KR101598138B1 (ko) * 2008-04-24 2016-02-29 얀센 파마슈티카 엔.브이. 날메펜 디에스테르 프로드럭
ATE523512T1 (de) * 2008-04-24 2011-09-15 Janssen Pharmaceutica Nv Nalmefen-prodrugs
US20110177133A1 (en) * 2008-07-07 2011-07-21 Michael Hopp Use of opioid antagonists for treating urinary retention
WO2010103039A1 (en) 2009-03-10 2010-09-16 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
US20140005217A1 (en) * 2012-06-27 2014-01-02 H. Lundbeck A/S Nalmefene for reduction of alcohol consumption in specific target populations
WO2014170353A1 (en) * 2013-04-17 2014-10-23 H. Lundbeck A/S Nalmefene for treatment of patients with sleep disorder
CA2918004C (en) 2013-07-23 2018-11-20 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
US20170042887A1 (en) * 2014-04-22 2017-02-16 Otsuka Pharmaceutical. Co., Ltd. Combination of Brexpiprazole and Nalmefene and Use Thereof for Treating Substance-Related Disorders
ES2787223T3 (es) 2014-11-07 2020-10-15 Univ Minnesota Sales y composiciones útiles para tratar enfermedades
JP2019514872A (ja) * 2016-04-22 2019-06-06 タイワンジェ ファーマシューティカルズ カンパニー リミテッドＴａｉｗａｎｊ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ． （非）アルコ−ル性脂肪肝炎又は非アルコ−ル性脂肪性肝疾患の治療のためのナルメフェン（ＮＡＬＭＥＦＥＮＥ）、ナルトレキソン（ｎａｌｔｒｅｘｏｎｅ）及びその関連誘導体の応用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases
US4863928A (en) * 1989-01-04 1989-09-05 Baker Cummins Pharmaceuticals, Inc. Method of treatment for arthritic and inflammatory diseases
US5096715A (en) * 1989-11-20 1992-03-17 Alko Ltd. Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist

Also Published As

Publication number Publication date
LTIP1486A (en) 1995-09-25
FI925513A0 (fi) 1992-12-04
FI925513A (fi) 1992-12-04
US5086058A (en) 1992-02-04
IE77333B1 (en) 1997-12-03
CA2084519A1 (en) 1991-12-05
NZ238391A (en) 1997-06-24
EP0531415A1 (de) 1993-03-17
ES2097209T3 (es) 1997-04-01
AU642748B2 (en) 1993-10-28
WO1991018605A1 (en) 1991-12-12
DK0531415T3 (da) 1996-12-09
EP0531415B1 (de) 1996-11-20
LV10190A (lv) 1994-10-20
LT3893B (en) 1996-04-25
CA2084519C (en) 1999-02-09
IE911888A1 (en) 1991-12-04
AU7974091A (en) 1991-12-31
JPH06506665A (ja) 1994-07-28
DE69123247T2 (de) 1998-01-15
HUT65523A (en) 1994-06-28
JP3059213B2 (ja) 2000-07-04
HU210637B (en) 1995-06-28
ATE145329T1 (de) 1996-12-15
ZA914185B (en) 1992-07-29
GR3022289T3 (en) 1997-04-30
HU9203835D0 (en) 1993-03-29
LV10190B (en) 1995-06-20
RU2090190C1 (ru) 1997-09-20

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CONTRAL CLINICS OY, ESPOO, FI

8364 No opposition during term of opposition