DE69123632D1 - Verfahren zur Einführung von Lithium in ortho-Stellung zur Synthese von 2-substituierten 1-(Tetrazol-5-yl) benzolen - Google Patents

Verfahren zur Einführung von Lithium in ortho-Stellung zur Synthese von 2-substituierten 1-(Tetrazol-5-yl) benzolen

Info

Publication number
DE69123632D1
DE69123632D1 DE69123632T DE69123632T DE69123632D1 DE 69123632 D1 DE69123632 D1 DE 69123632D1 DE 69123632 T DE69123632 T DE 69123632T DE 69123632 T DE69123632 T DE 69123632T DE 69123632 D1 DE69123632 D1 DE 69123632D1
Authority
DE
Germany
Prior art keywords
tetrazol
synthesis
substituted
ortho position
benzenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69123632T
Other languages
English (en)
Other versions
DE69123632T2 (de
Inventor
Richard F Shuman
Anthony O King
Robert K Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24061644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69123632(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69123632D1 publication Critical patent/DE69123632D1/de
Application granted granted Critical
Publication of DE69123632T2 publication Critical patent/DE69123632T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69123632T 1990-05-02 1991-04-25 Verfahren zur Einführung von Lithium in ortho-Stellung zur Synthese von 2-substituierten 1-(Tetrazol-5-yl) benzolen Expired - Lifetime DE69123632T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/517,889 US5039814A (en) 1990-05-02 1990-05-02 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

Publications (2)

Publication Number Publication Date
DE69123632D1 true DE69123632D1 (de) 1997-01-30
DE69123632T2 DE69123632T2 (de) 1997-05-15

Family

ID=24061644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69123632T Expired - Lifetime DE69123632T2 (de) 1990-05-02 1991-04-25 Verfahren zur Einführung von Lithium in ortho-Stellung zur Synthese von 2-substituierten 1-(Tetrazol-5-yl) benzolen

Country Status (15)

Country Link
US (1) US5039814A (de)
EP (1) EP0455423B1 (de)
JP (1) JPH0717619B2 (de)
AT (1) ATE146461T1 (de)
CA (1) CA2041620C (de)
CY (1) CY1998A (de)
DE (1) DE69123632T2 (de)
DK (1) DK0455423T3 (de)
ES (1) ES2095907T3 (de)
GR (1) GR3022107T3 (de)
HK (1) HK59497A (de)
IE (1) IE911455A1 (de)
LV (1) LV11893B (de)
PT (1) PT97528B (de)
RO (1) RO110339B1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5256654A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
DE69233734D1 (de) * 1991-11-18 2008-06-26 Du Pont 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)phenylborsäure als Zwischenprodukt zur Synthese von A II Receptorenantagonisten
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
EP0550313A1 (de) * 1991-12-30 1993-07-07 Synthelabo 2-(Tetranol-5-yl)-(1,1'-Biphenyl)derivate, ihre Herstellung und Anwendung als Zwischenverbindungen
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2696745B1 (fr) * 1992-10-12 1995-05-12 Synthelabo Procédé de préparation de dérivés de phényltétrazole.
CZ283315B6 (cs) * 1992-12-17 1998-02-18 Sankyo Company Limited Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují
US5567815A (en) * 1994-07-18 1996-10-22 Bridgestone Corporation Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof
ES2129850T3 (es) * 1994-09-20 1999-06-16 Wakunaga Seiyaku Kk Procedimiento de produccion de un derivado de n-bifenilmetiltiadiazolina o una sal de este y su producto intermediario de produccion.
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
ATE240325T1 (de) * 1995-06-07 2003-05-15 Wyeth Corp Verfahren zur herstellung von biphenylderivaten
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
WO2008058402A1 (en) 2006-11-17 2008-05-22 Queen's University At Kingston Compounds and methods for treating protein folding disorders
ES2630407T3 (es) 2007-12-17 2017-08-21 United Therapeutics Corporation Procedimiento mejorado para preparar treprostinil, el principio activo en Remodulin®
KR101868166B1 (ko) 2010-06-03 2018-06-15 유나이티드 세러퓨틱스 코오포레이션 트레프로스티닐의 제조
US20130345471A1 (en) * 2011-03-02 2013-12-26 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
CA2964804C (en) 2014-10-20 2019-04-02 United Therapeutics Corporation Synthesis of intermediate for producing prostacyclin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534113A (en) * 1968-02-08 1970-10-13 Lithium Corp Preparation of aryllithium compounds by metalation
CH531511A (de) * 1969-03-05 1972-12-15 Sandoz Ag Verfahren zur Herstellung des N,o-Dilithium-Derivats von 2-Phenyl-2-imidazolin
US4620025A (en) * 1984-08-01 1986-10-28 Merck & Co., Inc. Process for the preparation of biphenyl intermediates
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
EP0455423B1 (de) 1996-12-18
EP0455423A2 (de) 1991-11-06
CA2041620A1 (en) 1991-11-03
GR3022107T3 (en) 1997-03-31
PT97528A (pt) 1992-01-31
ATE146461T1 (de) 1997-01-15
JPH0717619B2 (ja) 1995-03-01
CA2041620C (en) 2003-03-11
RO110339B1 (ro) 1995-12-29
US5039814A (en) 1991-08-13
LV11893A (en) 1997-12-20
LV11893B (en) 1998-03-20
DK0455423T3 (da) 1997-06-09
HK59497A (en) 1997-05-16
IE911455A1 (en) 1991-11-06
PT97528B (pt) 1998-08-31
ES2095907T3 (es) 1997-03-01
DE69123632T2 (de) 1997-05-15
CY1998A (en) 1997-12-05
EP0455423A3 (en) 1992-12-09
JPH04225966A (ja) 1992-08-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US