DE69124769D1 - Verfahren zur Herstellung von (1'R,3S)-3-(1'-hydroxy-ethyl)-Azetidin-2-on und deren Derivaten - Google Patents
Verfahren zur Herstellung von (1'R,3S)-3-(1'-hydroxy-ethyl)-Azetidin-2-on und deren DerivatenInfo
- Publication number
- DE69124769D1 DE69124769D1 DE69124769T DE69124769T DE69124769D1 DE 69124769 D1 DE69124769 D1 DE 69124769D1 DE 69124769 T DE69124769 T DE 69124769T DE 69124769 T DE69124769 T DE 69124769T DE 69124769 D1 DE69124769 D1 DE 69124769D1
- Authority
- DE
- Germany
- Prior art keywords
- azetidin
- hydroxy
- derivatives
- ethyl
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2301016A JP2640986B2 (ja) | 1990-11-08 | 1990-11-08 | (1′r,3s)―3―(1′―ヒドロキシエチル)―アゼチジン―2―オン又はその誘導体の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69124769D1 true DE69124769D1 (de) | 1997-04-03 |
DE69124769T2 DE69124769T2 (de) | 1997-09-11 |
Family
ID=17891828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69124769T Expired - Fee Related DE69124769T2 (de) | 1990-11-08 | 1991-11-07 | Verfahren zur Herstellung von (1'R,3S)-3-(1'-hydroxy-ethyl)-Azetidin-2-on und deren Derivaten |
Country Status (4)
Country | Link |
---|---|
US (1) | US5204461A (de) |
EP (1) | EP0485218B1 (de) |
JP (1) | JP2640986B2 (de) |
DE (1) | DE69124769T2 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2948504B2 (ja) * | 1995-05-11 | 1999-09-13 | 高砂香料工業株式会社 | 光学活性アゼチジン−2−オン誘導体の製造方法 |
JPH09143156A (ja) | 1995-11-17 | 1997-06-03 | Tanabe Seiyaku Co Ltd | アセトキシアゼチジノン誘導体の製法及びその合成中間体 |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
CA2434033A1 (en) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
CA2434488A1 (en) * | 2001-01-26 | 2002-08-01 | Harry R. Davis | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
AR035533A1 (es) * | 2001-01-26 | 2004-06-02 | Schering Corp | Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la |
US20020151536A1 (en) * | 2001-01-26 | 2002-10-17 | Schering Corporation | Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
EP1385548B1 (de) * | 2001-01-26 | 2007-05-23 | Schering Corporation | Kombinationen eines hemmers der sterolabsorption und eines kardiovaskulären wirkstoffes zur behandlung von kardiovaskulären indikationen |
SK9502003A3 (en) * | 2001-01-26 | 2003-12-02 | Schering Corp | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
AR038956A1 (es) * | 2001-05-25 | 2005-02-02 | Schering Corp | Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto |
JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
DK1427409T3 (da) * | 2001-09-21 | 2009-01-12 | Schering Corp | Fremgangsmåde til behandling eller forhindring af vaskulær inflammation under brug af en eller flere sterolabssorptionsinhibitorer |
US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
MXPA05004811A (es) * | 2002-11-06 | 2005-07-22 | Schering Corp | Inhibidores de absorcion de colesterol para el tratamiento de trastornos autoinmunes. |
US7208486B2 (en) * | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
MXPA05009503A (es) * | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
CA2544309A1 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5777670A (en) * | 1980-10-31 | 1982-05-15 | Microbial Chem Res Found | Preparation of 2-azetidinone derivative |
EP0290385B1 (de) * | 1987-05-04 | 1992-10-21 | Ciba-Geigy Ag | Neues Verfahren zur Herstellung von 4-Acyloxy-3-hydroxyethyl-azetidinonen |
US5037974A (en) * | 1988-05-23 | 1991-08-06 | Merck & Co., Inc. | Cyclization process for synthesis of a beta-lactam carbapenem intermediate |
JPH0623150B2 (ja) * | 1988-11-15 | 1994-03-30 | 高砂香料工業株式会社 | 光学活性3−ヒドロキシブタン酸類の製造方法 |
-
1990
- 1990-11-08 JP JP2301016A patent/JP2640986B2/ja not_active Expired - Fee Related
-
1991
- 1991-11-07 EP EP91310321A patent/EP0485218B1/de not_active Expired - Lifetime
- 1991-11-07 DE DE69124769T patent/DE69124769T2/de not_active Expired - Fee Related
- 1991-11-08 US US07/789,604 patent/US5204461A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2640986B2 (ja) | 1997-08-13 |
JPH04173776A (ja) | 1992-06-22 |
EP0485218A2 (de) | 1992-05-13 |
US5204461A (en) | 1993-04-20 |
DE69124769T2 (de) | 1997-09-11 |
EP0485218A3 (en) | 1992-10-28 |
EP0485218B1 (de) | 1997-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |