DE69128530D1 - Zusammengesetztes äquivalent der lebenden haut - Google Patents

Zusammengesetztes äquivalent der lebenden haut

Info

Publication number
DE69128530D1
DE69128530D1 DE69128530T DE69128530T DE69128530D1 DE 69128530 D1 DE69128530 D1 DE 69128530D1 DE 69128530 T DE69128530 T DE 69128530T DE 69128530 T DE69128530 T DE 69128530T DE 69128530 D1 DE69128530 D1 DE 69128530D1
Authority
DE
Germany
Prior art keywords
pct
skin
skin equivalent
collagen
equivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69128530T
Other languages
English (en)
Other versions
DE69128530T2 (de
Inventor
Mark Eisenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25643857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69128530(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of DE69128530D1 publication Critical patent/DE69128530D1/de
Application granted granted Critical
Publication of DE69128530T2 publication Critical patent/DE69128530T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/10—Hair or skin implants
    • A61F2/105—Skin implants, e.g. artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A61L27/3891—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types as distinct cell layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C12N5/0698—Skin equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
    • C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C12N2503/06—Screening or testing on artificial skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/08—Collagen
DE69128530T 1990-04-24 1991-04-24 Zusammengesetztes äquivalent der lebenden haut Expired - Fee Related DE69128530T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPJ981990 1990-04-24
AUPK430291 1991-01-22
PCT/AU1991/000160 WO1991016010A1 (en) 1990-04-24 1991-04-24 Composite living skin equivalents

Publications (2)

Publication Number Publication Date
DE69128530D1 true DE69128530D1 (de) 1998-02-05
DE69128530T2 DE69128530T2 (de) 1998-08-20

Family

ID=25643857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128530T Expired - Fee Related DE69128530T2 (de) 1990-04-24 1991-04-24 Zusammengesetztes äquivalent der lebenden haut

Country Status (15)

Country Link
US (3) US5282859A (de)
EP (1) EP0526550B1 (de)
JP (1) JPH0747043B2 (de)
AT (1) ATE161408T1 (de)
BR (1) BR9106354A (de)
CA (1) CA2080693C (de)
DE (1) DE69128530T2 (de)
DK (1) DK0526550T3 (de)
ES (1) ES2111566T3 (de)
FI (1) FI924773A0 (de)
GR (1) GR3026463T3 (de)
HU (1) HUT63319A (de)
RU (1) RU2135191C1 (de)
TW (1) TW225986B (de)
WO (1) WO1991016010A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976878A (en) * 1987-04-28 1999-11-02 The Regents Of The University Of California Method and apparatus for preparing composite skin replacement
ATE161408T1 (de) * 1990-04-24 1998-01-15 Mark Eisenberg Zusammengesetztes äquivalent der lebenden haut
US6399380B1 (en) * 1991-02-28 2002-06-04 Anti-Cancer, Inc. Native-state histoculturing skin extracellular support
US5888720A (en) * 1992-10-27 1999-03-30 Yissum Research And Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs
US5610007A (en) * 1993-01-21 1997-03-11 Universite Laval Chimeric sheets of epithelial cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
CH687153A5 (de) * 1993-12-22 1996-09-30 Jiri E Dr Prenosil Verfahren und Vorrichtung zur Herstellung einer Zellstruktur auf einer semipermeablen Membran.
US5489304A (en) * 1994-04-19 1996-02-06 Brigham & Women's Hospital Method of skin regeneration using a collagen-glycosaminoglycan matrix and cultured epithelial autograft
DE4414755C2 (de) * 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
JP2858087B2 (ja) * 1994-09-19 1999-02-17 グンゼ株式会社 組織培養用基材及び組織培養法
US20030152909A1 (en) * 1994-11-16 2003-08-14 Mitrani Eduardo N. In vitro micro-organs, and uses related thereto
US6080194A (en) * 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
IT1281870B1 (it) * 1995-04-27 1998-03-03 Fidia Advanced Biopolymers Srl Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico
US20040002772A1 (en) * 1995-04-28 2004-01-01 Organogenesis, Inc. Tissue equivalents with perforations for improved integration to host tissues and methods for producing perforated tissue equivalents
AU7274696A (en) 1995-11-06 1997-05-29 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US20020111695A1 (en) * 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
ES2117573B1 (es) * 1996-07-19 1999-02-16 Comunitario De Transfusion Del Base dermica especialmente diseñada para el cultivo de queratinocitos.
AU4264597A (en) * 1996-09-24 1998-04-17 Brigham And Women's Hospital Cultured cell-seeded fibrous lattice for tissue replacement
FR2757635B1 (fr) * 1996-12-24 1999-02-05 Oreal Procede d'evaluation des dommages induits dans la peau par les uv-a
CA2207882A1 (en) * 1997-06-17 1998-12-17 Joel Claveau Assessment of human skin damage following exposure to harmful agents
ES2132027B1 (es) * 1997-07-04 2000-04-01 Comunitario De Transfusion Del Desarrollo de una piel artificial mediante cultivo de queratinocitos sobre una base de fibrina y fibroblastos humanos y metodo de preparacion de esta piel para trasplante.
US7687057B2 (en) * 1998-01-09 2010-03-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
WO1999046285A2 (en) 1998-03-11 1999-09-16 University Of Southern California Method of promoting production of living tissue equivalents
US6432710B1 (en) * 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
US6177514B1 (en) * 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
FR2792650B1 (fr) 1999-04-20 2003-02-28 Oreal Equivalent de peau agee, son procede de preparation et son utilisation
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
DE19922078A1 (de) * 1999-05-15 2000-11-23 Weitzel Kage Doris Gewebekonstrukt für die Transplantationschirurgie
FR2801313A1 (fr) 1999-05-19 2001-05-25 Coletica Produit collagenique contenant du collagene d'origine marine a faible odeur et de preference a proprietes mecaniques ameliorees, ainsi que son utilisation sous forme de compositions ou de produits cosmetiques ou pharmaceutiques
FR2798735B1 (fr) * 1999-09-17 2001-11-23 Serobiologiques Lab Sa Procede d'evaluation et de suivi du vieillissement tissulaire
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
WO2001091821A1 (fr) * 2000-05-26 2001-12-06 Coletica Supports a base de collagene pour l'ingenierie tissulaire et la preparation de biomateriaux
FR2809412A1 (fr) 2000-05-26 2001-11-30 Coletica Utilisation de collagene d'origine aquatique pour la realisation de supports destines a l'ingenierie tissulaire, et supports et biomateriaux obtenus
US6974679B2 (en) * 2000-05-26 2005-12-13 Coletica Support with collagen base for tissue engineering and manufacture of biomaterials
KR100520944B1 (ko) * 2000-05-26 2005-10-17 꼴레띠까 인공조직 및 생체재료 제조용 콜라겐 지지체
FR2809313B1 (fr) * 2000-05-26 2005-11-18 Coletica Procedes de preparation de nouveaux supports a base de collagene pour l'ingenieurie tissulaire et biomateriaux obtenus
US6790454B1 (en) * 2000-05-26 2004-09-14 Coletica Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
WO2001092476A2 (de) * 2000-05-31 2001-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. In vitro-gewebetestsystem
DE10026789B4 (de) * 2000-05-31 2004-09-02 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Knorpelersatz und Verfahren zu dessen Herstellung
ES2252259T3 (es) * 2000-05-31 2006-05-16 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Modelo de piel tridiminsional.
WO2002058588A2 (en) * 2000-12-27 2002-08-01 Ortec International, Inc. Processes for making cryopreserved composite living constructs and products resulting therefrom
US6500464B2 (en) * 2000-12-28 2002-12-31 Ortec International, Inc. Bilayered collagen construct
NZ549526A (en) * 2001-03-02 2009-06-26 Stratatech Corp Human skin equivalents comprising near diploid immortalized keratinocyte cells (NIKS)
US6974697B2 (en) * 2001-03-02 2005-12-13 Stratech Corporation Skin substitutes with improved barrier function
EP1273913A1 (de) * 2001-07-02 2003-01-08 Cognis France S.A. Verfahren zur Bestimmung der Interaktionen zwischen Keratinocyten und Neuronen
US8088568B2 (en) * 2001-11-05 2012-01-03 Medgentics, Inc. Dermal micro-organs, methods and apparatuses for producing and using the same
US8501396B2 (en) 2001-11-05 2013-08-06 Medgenics Medical Israel Ltd. Dermal micro-organs, methods and apparatuses for producing and using the same
US7468242B2 (en) 2001-11-05 2008-12-23 Medgenics, Inc. Dermal micro organs, methods and apparatuses for producing and using the same
US8394371B2 (en) 2002-02-11 2013-03-12 Neocutis Sa Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
AU2003219830A1 (en) * 2002-02-22 2003-09-09 Ebi, L.P. Methods and compositions for treating bone or cartilage defects
US7741116B2 (en) * 2002-03-06 2010-06-22 University Of Cincinnati Surgical device for skin therapy or testing
KR100874543B1 (ko) * 2002-04-22 2008-12-16 동아제약주식회사 인공피부 배양물 및 그 제조방법
IL164817A0 (en) * 2002-04-30 2005-12-18 Stratatech Corp Keratinocytes expressing exogenous angiogenic growth factors
US7229820B2 (en) * 2002-06-13 2007-06-12 Wilson Wolf Manufacturing Corporation Apparatus and method for culturing and preserving tissue constructs
US20030235580A1 (en) * 2002-06-24 2003-12-25 Fen Zhang Amniotic membrane mediated delivery of bioactive molecules
JP2005533102A (ja) * 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
US7462448B2 (en) * 2002-08-02 2008-12-09 Stratatech Corporation Species specific DNA detection
US7666134B2 (en) * 2002-09-28 2010-02-23 Kci Licensing, Inc. System and method for transplantation of dermal tissue
US20050107876A1 (en) * 2002-09-30 2005-05-19 Kim Ki-Ho Dermal substitute consisting of amnion and biodegradable polymer, the preparation method and the use thereof
US7177705B2 (en) * 2003-02-19 2007-02-13 Stimu-Heal Inc. Surface electrode for electrical stimulation of tissue
JP4097544B2 (ja) * 2003-02-27 2008-06-11 独立行政法人理化学研究所 人工リンパ節
CA2748659A1 (en) * 2003-05-01 2004-11-18 Medgenics Inc. Dermal micro organs, methods and apparatuses for producing and using the same
AU2004262002B2 (en) * 2003-08-01 2010-03-25 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
US7375077B2 (en) * 2003-09-19 2008-05-20 The Board Of Trustees Of The University Of Illinois In vivo synthesis of connective tissues
DE102004039537A1 (de) * 2004-08-13 2006-02-23 Phenion Gmbh & Co. Kg Vernetzte Kollagenmatrix zur Herstellung eines Hautäquivalentes
US20060058238A1 (en) 2004-09-15 2006-03-16 Lee Laurent-Applegate Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
US9163076B2 (en) 2005-03-01 2015-10-20 Stratatech Corporation Human skin equivalents expressing exogenous polypeptides
JP2008532550A (ja) 2005-03-17 2008-08-21 ストラタテック コーポレーション 純度が改良された代用皮膚
JP5138580B2 (ja) * 2005-04-06 2013-02-06 フジフィルム マニュファクチャリング ユーロプ ビー．ブイ． 細胞培養用非孔質フィルム
WO2006107188A1 (en) 2005-04-06 2006-10-12 Fujifilm Manufacturing Europe B.V. A non-porous film for culturing cells
FR2889808B1 (fr) 2005-08-17 2011-07-22 Oreal Utilisation de l'acide 8-hexadecene-1,16-dicarboxylique comme agent de soin destine a favoriser la cohesion de la couche cornee
WO2007029676A1 (ja) * 2005-09-07 2007-03-15 Arblast Co., Ltd. 生体組織シート及びその作製方法
EP1998787A4 (de) * 2006-03-03 2010-04-21 Organogenesis Inc Wiederherstellung und reparatur von oralem gewebe
US9155749B2 (en) * 2006-09-14 2015-10-13 Medgenics Medical Israel Ltd. Long lasting drug formulations
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
US8105380B2 (en) * 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
US8709081B2 (en) 2006-10-23 2014-04-29 Stemedica Cell Technologies, Inc. Cellular scaffold
US20080260794A1 (en) * 2007-02-12 2008-10-23 Lauritzen Nels J Collagen products and methods for producing collagen products
US9056151B2 (en) * 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
DE102007026639A1 (de) 2007-06-06 2008-12-11 Stefan-Andreas Ulrich Industrielle Fertigung tierischer Lederhautsubstitute für die Lederproduktion aus etablierten Epithelzelllinien und/oder primären Epithelzellkulturen, wie vorzugsweise Fibroplasten, Melanozyten, Keratiozyten sowie deren Verfahren und Vorrichtungen
US20090145087A1 (en) 2007-11-14 2009-06-11 Stratatech Corporation Cold storage of organotypically cultured skin equivalents for clinical applications
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
WO2009155334A1 (en) 2008-06-20 2009-12-23 Escape Therapeutics, Inc. Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
WO2010053948A1 (en) 2008-11-04 2010-05-14 Stratatech Corporation Dried and irradiated skin equivalents for ready use
DE102009022349B4 (de) * 2009-05-15 2011-02-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Automatisches Trennen von Gewebeschichten
DE102009022351A1 (de) * 2009-05-15 2010-11-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Modulares Produktionssystem zur automatischen Herstellung von dreidimensionalen Gewebestrukturen
WO2010135655A2 (en) 2009-05-21 2010-11-25 Stratatech Corporation Human skin substitutes expressing il-12
FR2949688B1 (fr) 2009-09-04 2012-08-24 Sofradim Production Tissu avec picots revetu d'une couche microporeuse bioresorbable
AU2011219882A1 (en) 2010-02-23 2012-07-12 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for preparing human melanocytes from human pluripotent stem cells
GB201003656D0 (en) * 2010-03-05 2010-04-21 Tigenix Ltd Fabrication process
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
ES2761307T3 (es) * 2010-05-21 2020-05-19 Soto Pareja Rodrigo Focion Proceso para la producción de parches o apósitos de piel autóloga mediante cultivo de queratinocitos y fibroblastos autólogos con suero autólogo para generación de piel
WO2011159758A2 (en) 2010-06-15 2011-12-22 Medgenics Medical Israel Ltd. Long lasting drug formulations
CA2802880C (en) * 2010-06-18 2019-09-24 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Hair follicle neogenesis
FR2967163A1 (fr) 2010-11-05 2012-05-11 Centre Nat Rech Scient Procede in vitro ou ex vivo pour la maintenance en survie et la generation ou reconstruction d'un epiderme
JP6031221B2 (ja) * 2011-03-02 2016-11-24 花王株式会社 皮膚感作性物質の評価方法
FR2972626B1 (fr) 2011-03-16 2014-04-11 Sofradim Production Prothese comprenant un tricot tridimensionnel et ajoure
JP5868601B2 (ja) * 2011-03-23 2016-02-24 フタムラ化学株式会社 液体培地用足場部材
JP2012205516A (ja) * 2011-03-29 2012-10-25 Osaka Univ 人工皮膚モデルの製造方法、及び人工皮膚モデル
RU2464987C1 (ru) * 2011-04-07 2012-10-27 Российская Федерация, от имени которой выступает Министерство образования и науки РФ Способ получения резорбируемой полилактидной матрицы для культивирования и имплантации клеток, предназначенных для заживления ран
FR2976001B1 (fr) 2011-05-30 2014-10-31 Oreal Modele de cuir chevelu reconstruit et procede de screening de molecules actives
FR2977789B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
FR2977790B1 (fr) 2011-07-13 2013-07-19 Sofradim Production Prothese pour hernie ombilicale
GB201112922D0 (en) 2011-07-27 2011-09-14 Univ Durham Micro-organ
WO2013046058A2 (en) 2011-09-30 2013-04-04 Sofradim Production Reversible stiffening of light weight mesh
FR2985271B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Tricot a picots
FR2985170B1 (fr) 2011-12-29 2014-01-24 Sofradim Production Prothese pour hernie inguinale
FR2994185B1 (fr) 2012-08-02 2015-07-31 Sofradim Production Procede de preparation d’une couche poreuse a base de chitosane
FR2995778B1 (fr) 2012-09-25 2015-06-26 Sofradim Production Prothese de renfort de la paroi abdominale et procede de fabrication
FR2995788B1 (fr) 2012-09-25 2014-09-26 Sofradim Production Patch hemostatique et procede de preparation
FR2995779B1 (fr) 2012-09-25 2015-09-25 Sofradim Production Prothese comprenant un treillis et un moyen de consolidation
EP2900174B1 (de) 2012-09-28 2017-04-12 Sofradim Production Verpackung für eine bruchoperationsvorrichtung
DK3470018T3 (da) 2013-03-13 2021-10-04 Stratatech Corp Kryokonservering af levedygtige menneskehudssubstitutter
US10478526B2 (en) 2013-05-03 2019-11-19 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Skin substitutes and methods for hair follicle neogenesis
FR3006581B1 (fr) 2013-06-07 2016-07-22 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
FR3006578B1 (fr) 2013-06-07 2015-05-29 Sofradim Production Prothese a base d’un textile pour voie laparoscopique
EP3000433B1 (de) 2014-09-29 2022-09-21 Sofradim Production Vorrichtung zur Einführung einer Prothese zur Hernie-Behandlung in einen Einschnitt und flexible textile Prothese
EP3000432B1 (de) 2014-09-29 2022-05-04 Sofradim Production Textilbasierte Prothese für die Behandlung von Leistenbruch
WO2016080732A1 (ko) * 2014-11-17 2016-05-26 주식회사 바이오코즈글로벌코리아 세포 배양 배지， 표피성장인자 및 소혈청알부민을 포함하는 피부 상태 개선용 화장료 조성물
EP3029189B1 (de) 2014-12-05 2021-08-11 Sofradim Production Prothetisches poröses Netz, sein Herstellungsverfahren und Hernienprothese
EP3059255B1 (de) 2015-02-17 2020-05-13 Sofradim Production Verfahren zur Herstellung einer Matrix auf Chitosanbasis mit faseroptischem Verstärkungselement
EP3085337B1 (de) 2015-04-24 2022-09-14 Sofradim Production Prothese zur unterstützung einer bruststruktur
ES2676072T3 (es) 2015-06-19 2018-07-16 Sofradim Production Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla
EP3195830B1 (de) 2016-01-25 2020-11-18 Sofradim Production Prothese zur hernienreparatur
CN109415692A (zh) * 2016-06-24 2019-03-01 株式会社资生堂 三维培养皮肤片、用于其制造的细胞培养容器和该三维培养皮肤片的制造方法
FR3054449B1 (fr) 2016-07-29 2018-08-31 L'oreal Equivalent de peau a compartiments dermiques juxtaposes distincts
EP3312325B1 (de) 2016-10-21 2021-09-22 Sofradim Production Verfahren zur herstellung eines netzes mit einem daran befestigten nahtmaterial mit widerhaken und dadurch erhaltenes netz
EP3398554A1 (de) 2017-05-02 2018-11-07 Sofradim Production Prothese zur leistenbruch-reparatur
FR3071512B1 (fr) 2017-09-28 2022-02-25 Oreal Signatures moleculaires de trois sous-populations de fibroblastes dermiques et equivalent de derme comprenant une de ces sous-populations
EP3653171A1 (de) 2018-11-16 2020-05-20 Sofradim Production Implantate zur weichgewebereparatur
IT201800010390A1 (it) * 2018-11-16 2020-05-16 Diego Furlan Dispositivo medico monouso per la medicazione di lesioni della pelle di un paziente e relativi procedimenti di preparazione e utilizzazione
FR3108505A1 (fr) * 2020-03-30 2021-10-01 Universite Grenoble Alpes Biomatériau comprenant une matrice poreuse résorbable et procédé de fabrication associé
FR3111904B1 (fr) 2020-06-30 2022-10-21 Oreal Bioencre pour bioimpression d’un modèle de jonction dermo-épidermique invaginée
WO2022056131A2 (en) * 2020-09-11 2022-03-17 The Trustees Of Columbia University In The City Of New York Wearable engineered human skin and systems and methods for making the same

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144126A (en) * 1975-05-21 1979-03-13 Beecham Group Limited Cell culture method
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4016036A (en) * 1975-11-14 1977-04-05 Massachusetts Institute Of Technology Process for serially culturing keratinocytes
US4024020A (en) * 1975-12-15 1977-05-17 Monsanto Company Method of cell culture on polyacrylonitrile surface
DE2557870A1 (de) * 1975-12-22 1977-06-23 Linde Ag Verfahren und vorrichtung zum tiefgefrieren von biologischen substanzen
US4117881A (en) * 1977-06-14 1978-10-03 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration System for and method of freezing biological tissue
US4135975A (en) * 1977-12-14 1979-01-23 Lichtman Marshall A Obtaining human cell lines that elaborate colony stimulating activity for marrow cells of man and other species and methods of preparing same
US4228243A (en) * 1978-07-13 1980-10-14 Toray Industries, Inc. Cell culture propagation apparatus
US4299819A (en) * 1979-01-02 1981-11-10 Sloan-Kettering Institute For Cancer Research Process for treating burn victims
FR2461002A1 (fr) * 1979-07-13 1981-01-30 Inst Nat Sante Rech Med Procede pour stimuler la croissance des cellules d'epiderme humain et produits faisant application dudit procede
US4342828A (en) * 1979-07-20 1982-08-03 Morinaga Milk Industry Co., Ltd. Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
US4254226A (en) * 1979-09-13 1981-03-03 Sloan Kettering Institute For Cancer Research Process for growing human epidermal cells in tissue culture
US4352887A (en) * 1979-10-29 1982-10-05 Albert Einstein College Of Medicine Of Yeshiva University Method and article for culturing differentiated cells
US4642292A (en) * 1979-10-29 1987-02-10 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Method for isolation of connective tissue biomatrix
US4304866A (en) * 1979-11-14 1981-12-08 Massachusetts Institute Of Technology Transplantable sheets of living keratinous tissue
US4522753A (en) * 1980-07-17 1985-06-11 Massachusetts Institute Of Technology Method for preserving porosity in porous materials
US4486188A (en) * 1980-08-14 1984-12-04 Applied Medical Devices, Inc. Bone marrow transplant method and apparatus
US4481946A (en) * 1980-08-14 1984-11-13 Altshuler John H Bone marrow transplant method and apparatus
US4314380A (en) * 1980-09-26 1982-02-09 Koken Co., Ltd. Artificial bone
US4565784A (en) * 1981-01-26 1986-01-21 Trustees Of Boston University Hydrogels capable of supporting cell growth
US4553272A (en) * 1981-02-26 1985-11-19 University Of Pittsburgh Regeneration of living tissues by growth of isolated cells in porous implant and product thereof
US4546500A (en) * 1981-05-08 1985-10-15 Massachusetts Institute Of Technology Fabrication of living blood vessels and glandular tissues
US4489710A (en) * 1981-06-23 1984-12-25 Xoma Corporation Composition and method for transplantation therapy
US4350629A (en) * 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4621100A (en) * 1981-09-25 1986-11-04 The Upjohn Company Treatment of osteoporosis with prostaglandins
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4418691A (en) * 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
FR2517315B1 (fr) * 1981-11-30 1985-12-20 Tech Cuir Centre Procede de preparation de formes nouvelles de collagene, natif ou dereticule, a structure helicoidale preservee, associees a des mucopolysaccharides et leurs applications notamment dans les domaines cosmetologiques, pharmaceutiques, analytiques et autres
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
US4520821A (en) * 1982-04-30 1985-06-04 The Regents Of The University Of California Growing of long-term biological tissue correction structures in vivo
US4485097A (en) * 1982-05-26 1984-11-27 Massachusetts Institute Of Technology Bone-equivalent and method for preparation thereof
JPS5928472A (ja) * 1982-08-09 1984-02-15 Koken:Kk 細胞培養用基質およびこの基質を用いた細胞培養・分離法
US4645669A (en) * 1982-10-04 1987-02-24 Albert Einstein College Of Medicine Of Yeshiva University Culturing and emplacement of differentiated cells in vivo
US4960423A (en) * 1982-11-17 1990-10-02 Smith Donald W Method of enhancing the attachment of endothelial cells on a matrix and vascular prosthesis with enhanced anti-thrombogenic characteristics
US5000963A (en) * 1983-06-14 1991-03-19 Hefton John M Method of treating the skin using human epidermal sheets
US4769317A (en) * 1983-06-14 1988-09-06 Hefton John M Process for growing human epidermis, product thereof
US4940666A (en) * 1983-07-15 1990-07-10 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
US4673649A (en) * 1983-07-15 1987-06-16 University Patents, Inc. Process and defined medium for growth of human epidermal keratinocyte cells
US4448718A (en) * 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
US4609551A (en) * 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4925924A (en) * 1984-03-27 1990-05-15 University Of Medicine And Dentistry Of New Jersey Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof
MX163953B (es) * 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
JPS60261460A (ja) * 1984-06-11 1985-12-24 株式会社　高研 コラ−ゲンとポリ―α―アミノ酸膜から成る人工皮膚
US4604346A (en) * 1984-10-09 1986-08-05 Massachusetts Institute Of Technology Skin-equivalent prepared by the use of punch biopsy
JPS61253065A (ja) * 1985-05-02 1986-11-10 片倉チツカリン株式会社 キトサン誘導体およびコラ−ゲンの複合材の医用材料およびその製造法
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
JPS62246371A (ja) * 1986-04-19 1987-10-27 株式会社　高研 人工皮膚及びその製造方法
FR2612938B1 (fr) * 1987-03-26 1989-06-23 Cird Procede d'obtention d'un equivalent de peau et equivalent de peau correspondant
FR2612939B1 (fr) * 1987-03-26 1989-06-23 Cird Equivalent de peau
US4835102A (en) * 1987-03-31 1989-05-30 Eugene Bell Tissue equivalent test systems
JP3050879B2 (ja) * 1987-04-28 2000-06-12 ザ・リージエント・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア 複合皮膚代用品の調製方法及び装置
US5273900A (en) * 1987-04-28 1993-12-28 The Regents Of The University Of California Method and apparatus for preparing composite skin replacement
US4975377A (en) * 1987-05-14 1990-12-04 Key Marc E Cell growth chambers and method of use thereof
US4888291A (en) * 1987-06-19 1989-12-19 President And Fellows Of Harvard College Human epithelium originating from cell cultures
GB8721018D0 (en) * 1987-09-07 1987-10-14 Alcan Int Ltd Porous inorganic membrane support
US5015584A (en) * 1987-10-14 1991-05-14 Board Of Regents, The University Of Texas System Epidermal graft system
US4837379A (en) * 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
JPH0271749A (ja) * 1988-09-07 1990-03-12 Terumo Corp 人工皮膚
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue
NL8902237A (nl) * 1989-09-06 1991-04-02 Hc Implants Bv Kunsthuid.
ATE161408T1 (de) * 1990-04-24 1998-01-15 Mark Eisenberg Zusammengesetztes äquivalent der lebenden haut

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