DE69131204T2 - Prothrombinzeitreagenz basierend auf gewebefaktor - Google Patents

Prothrombinzeitreagenz basierend auf gewebefaktor

Info

Publication number
DE69131204T2
DE69131204T2 DE69131204T DE69131204T DE69131204T2 DE 69131204 T2 DE69131204 T2 DE 69131204T2 DE 69131204 T DE69131204 T DE 69131204T DE 69131204 T DE69131204 T DE 69131204T DE 69131204 T2 DE69131204 T2 DE 69131204T2
Authority
DE
Germany
Prior art keywords
tissue factor
prothrome
bin
reagent based
liposome compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131204T
Other languages
English (en)
Other versions
DE69131204T3 (de
DE69131204D1 (de
Inventor
Scott Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendreon Pharmaceuticals LLC
Original Assignee
Corvas International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69131204(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corvas International Inc filed Critical Corvas International Inc
Application granted granted Critical
Publication of DE69131204D1 publication Critical patent/DE69131204D1/de
Publication of DE69131204T2 publication Critical patent/DE69131204T2/de
Publication of DE69131204T3 publication Critical patent/DE69131204T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
DE69131204T 1990-11-13 1991-11-04 Prothrombinzeitreagenz basierend auf gewebefaktor Expired - Lifetime DE69131204T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61211890A 1990-11-13 1990-11-13
US612118 1990-11-13
US07/784,326 US5314695A (en) 1990-11-13 1991-10-29 Tissue factor based prothrombin time reagent
US784326 1991-10-29
PCT/US1991/008174 WO1992008479A1 (en) 1990-11-13 1991-11-04 Tissue factor based prothrombin time reagent

Publications (3)

Publication Number Publication Date
DE69131204D1 DE69131204D1 (de) 1999-06-10
DE69131204T2 true DE69131204T2 (de) 1999-12-23
DE69131204T3 DE69131204T3 (de) 2007-05-24

Family

ID=27086686

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131204T Expired - Lifetime DE69131204T3 (de) 1990-11-13 1991-11-04 Prothrombinzeitreagenz basierend auf gewebefaktor

Country Status (18)

Country Link
US (1) US5314695A (de)
EP (1) EP0564495B2 (de)
JP (1) JP3441456B2 (de)
KR (1) KR100196107B1 (de)
AT (1) ATE179608T1 (de)
AU (2) AU9090791A (de)
CA (1) CA2096109C (de)
DE (1) DE69131204T3 (de)
DK (1) DK0564495T4 (de)
ES (1) ES2133310T5 (de)
FI (1) FI109764B (de)
GR (1) GR3030906T3 (de)
IE (1) IE913955A1 (de)
MX (1) MX9102042A (de)
NO (1) NO314617B1 (de)
NZ (2) NZ264556A (de)
PT (1) PT99499B (de)
WO (1) WO1992008479A1 (de)

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US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
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AU674139B2 (en) * 1992-04-13 1996-12-12 Ortho Diagnostic Systems Inc. Synthetic phospholipid reagent
DE59309374D1 (de) * 1992-05-15 1999-03-25 Immuno Ag Reagens zur Bestimmung der aktivierten partiellen Thromboplastinzeit (aPTT)
DE4243729A1 (de) * 1992-12-23 1994-06-30 Behringwerke Ag Verfahren zur Reaktivierung von gereinigten Membranproteinen
US7169572B1 (en) * 1993-01-29 2007-01-30 T.A.C. Thrombosis And Coagulation Ab Assays for determining anticoagulant cofactor activity
US7393682B1 (en) 1993-03-19 2008-07-01 The Johns Hopkins University School Of Medicine Polynucleotides encoding promyostatin polypeptides
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AT403437B (de) * 1995-02-15 1998-02-25 Immuno Ag Physiologisch aktive gewebefaktor-präparation
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
CA2278106C (en) * 1997-01-22 2005-04-12 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
US6100072A (en) * 1997-04-23 2000-08-08 Instrumentation Laboratory S.P.A. Recombinant rabbit tissue factor based prothrombin time reagent
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6245573B1 (en) 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
US6699718B1 (en) * 1999-09-03 2004-03-02 Roche Diagnostics Corporation Method, reagent and test cartridge for determining clotting time
US6576610B1 (en) 1999-10-04 2003-06-10 Nuvas, Llc Use of a context-dependent functional entity to enhance the efficacy of an agent
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
WO2001041738A2 (en) * 1999-12-10 2001-06-14 Celator Technologies Inc. Lipid carrier compositions with protected surface reactive functions
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6596543B2 (en) 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
EP2272946B9 (de) 2002-02-25 2015-06-24 Vaxiion Therapeutics, LLC Minizell-Zusammensetzungen und Verfahren
US7601489B2 (en) * 2002-03-12 2009-10-13 The Johns Hopkins University Manganese ion regulation of reverse transcriptase activity and methods of modulating same
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
US7049087B2 (en) * 2002-11-05 2006-05-23 Lifescan, Inc. Method for manufacturing a tissue factor-based prothrombin time reagent
AU2004263538B2 (en) * 2003-08-08 2009-09-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
EP1562047B1 (de) * 2004-02-06 2008-05-14 Sysmex Corporation Reagenziensatz zum Nachweis von Lupus-Antikoagulant.
JP4617458B2 (ja) * 2004-02-10 2011-01-26 財団法人ヒューマンサイエンス振興財団 中空糸透析カラムを利用したリポソームの製造方法
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US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US7635754B2 (en) * 2004-09-22 2009-12-22 Aerovance, Inc. Interleukin-9 and interleukin-4 chimeric antagonist muteins and methods of using same
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
AT501650A1 (de) * 2005-02-22 2006-10-15 Technoclone Ges M B H Verfahren zur bestimmung der gerinnungsaktivierung sowie gerät zur durchführung des verfahrens
EP3332808B1 (de) 2005-03-03 2020-09-09 Immunomedics Inc. Humanisierte l243-antikörper
EP1869082B1 (de) * 2005-03-04 2011-04-13 The Board Of Trustees Of The University Of Illinois Modulator von coagulationskaskaden und fibrinolytischen kaskaden
JP2007091625A (ja) * 2005-09-28 2007-04-12 Shino Test Corp 血液凝固反応促進剤
JP5017622B2 (ja) * 2005-11-30 2012-09-05 株式会社シノテスト 血液凝固反応抑制剤
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DK2758074T3 (da) 2011-09-23 2020-07-27 Univ Loma Linda Bakteriestammer der udtrykker methylasegener og anvendelser deraf
CN102565427A (zh) * 2011-12-28 2012-07-11 苏州良辰生物医药科技有限公司 一种凝血酶原时间测定试剂的制备方法
EP2893017A4 (de) 2012-09-07 2016-05-25 Childrens Medical Center Für hämatopoetische stammzellen spezifische reportermaus und verwendungen davon
CN113577260A (zh) 2012-10-02 2021-11-02 瓦克星治疗有限责任公司 免疫调节性小细胞及使用方法
JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
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JP6626761B2 (ja) * 2016-03-30 2019-12-25 シスメックス株式会社 プロトロンビン時間測定用試薬およびその製造方法
JP6652873B2 (ja) * 2016-03-30 2020-02-26 シスメックス株式会社 プロトロンビン時間測定用試薬、その製造方法およびプロトロンビン時間の測定方法
WO2018098163A1 (en) 2016-11-23 2018-05-31 Vaxiion Therapeutics, Llc Immunomodulatory & oncolytic minicells and methods of use
CN106680339A (zh) * 2016-12-28 2017-05-17 北京乐普医疗科技有限责任公司 一种基于电化学方法的凝血酶原时间测试卡及其制备方法
CN109239373A (zh) * 2018-08-15 2019-01-18 迪瑞医疗科技股份有限公司 一种组织因子酯化物试剂及其制备方法与应用
CN109613279A (zh) * 2018-12-06 2019-04-12 太原博奥特生物技术有限公司 一种新型鞣花酸化合物及利用鞣花酸化合物制备活化部分凝血活酶时间测定试剂
CN110244066A (zh) * 2019-07-01 2019-09-17 北京乐普医疗科技有限责任公司 一种干式电化学法凝血酶原时间检测卡及制备方法

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Also Published As

Publication number Publication date
NZ240577A (en) 1996-07-26
DK0564495T4 (da) 2007-04-30
NO931708L (no) 1993-07-08
EP0564495B2 (de) 2006-12-27
EP0564495B1 (de) 1999-05-06
DK0564495T3 (da) 1999-11-15
ES2133310T5 (es) 2007-08-16
US5314695A (en) 1994-05-24
AU4448996A (en) 1996-05-09
FI932148A (fi) 1993-06-03
GR3030906T3 (en) 1999-11-30
JPH06502649A (ja) 1994-03-24
EP0564495A4 (de) 1994-12-21
CA2096109A1 (en) 1992-05-14
CA2096109C (en) 2004-01-06
EP0564495A1 (de) 1993-10-13
PT99499A (pt) 1992-11-30
NZ264556A (en) 1996-07-26
JP3441456B2 (ja) 2003-09-02
MX9102042A (es) 1994-01-31
IE913955A1 (en) 1992-05-20
ATE179608T1 (de) 1999-05-15
ES2133310T3 (es) 1999-09-16
AU9090791A (en) 1992-06-11
DE69131204T3 (de) 2007-05-24
WO1992008479A1 (en) 1992-05-29
PT99499B (pt) 1999-04-30
FI109764B (fi) 2002-10-15
FI932148A0 (fi) 1993-05-12
NO314617B1 (no) 2003-04-22
NO931708D0 (no) 1993-05-11
DE69131204D1 (de) 1999-06-10
KR100196107B1 (ko) 1999-06-15

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