DE69131539D1 - Polypeptide mit fibrinbindungsdomäne, verwendungen und verfahren zu deren herstellung - Google Patents

Polypeptide mit fibrinbindungsdomäne, verwendungen und verfahren zu deren herstellung

Info

Publication number
DE69131539D1
DE69131539D1 DE69131539T DE69131539T DE69131539D1 DE 69131539 D1 DE69131539 D1 DE 69131539D1 DE 69131539 T DE69131539 T DE 69131539T DE 69131539 T DE69131539 T DE 69131539T DE 69131539 D1 DE69131539 D1 DE 69131539D1
Authority
DE
Germany
Prior art keywords
polypeptides
fibrin
binding domain
binding
naturally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69131539T
Other languages
English (en)
Other versions
DE69131539T2 (de
Inventor
Tikva Vogel
Avigdor Levanon
Moshe Werber
Rachel Guy
Amos Panet
Jacob Hartman
Hadassa Shaked
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SAVIENT PHARMACEUTICALS INC.(N.D.GES.D.STAATES DEL
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69131539D1 publication Critical patent/DE69131539D1/de
Publication of DE69131539T2 publication Critical patent/DE69131539T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
DE69131539T 1990-05-21 1991-05-21 Polypeptide mit fibrinbindungsdomäne, verwendungen und verfahren zu deren herstellung Expired - Lifetime DE69131539T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/526,397 US5270030A (en) 1988-12-29 1990-05-21 Fibrin binding domain polypeptide and method of producing
PCT/US1991/003584 WO1991017765A1 (en) 1990-05-21 1991-05-21 Fibrin binding domain polypeptides and uses and methods of producing same

Publications (2)

Publication Number Publication Date
DE69131539D1 true DE69131539D1 (de) 1999-09-23
DE69131539T2 DE69131539T2 (de) 2000-05-04

Family

ID=24097174

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131539T Expired - Lifetime DE69131539T2 (de) 1990-05-21 1991-05-21 Polypeptide mit fibrinbindungsdomäne, verwendungen und verfahren zu deren herstellung

Country Status (18)

Country Link
US (4) US5270030A (de)
EP (1) EP0651799B1 (de)
JP (1) JP3419772B2 (de)
AT (1) ATE183545T1 (de)
AU (1) AU660618B2 (de)
CA (1) CA2083271C (de)
DE (1) DE69131539T2 (de)
DK (1) DK0651799T3 (de)
ES (1) ES2137928T3 (de)
FI (1) FI108298B (de)
GR (1) GR3031708T3 (de)
HK (1) HK1013255A1 (de)
HU (1) HU216302B (de)
IL (1) IL98197A0 (de)
NO (1) NO310559B1 (de)
NZ (1) NZ238208A (de)
RU (1) RU2109750C1 (de)
WO (1) WO1991017765A1 (de)

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AU8076091A (en) 1991-12-10
DE69131539T2 (de) 2000-05-04
EP0651799A4 (de) 1993-10-05
US6121426A (en) 2000-09-19
FI925296A0 (fi) 1992-11-20
GR3031708T3 (en) 2000-02-29
JPH05508766A (ja) 1993-12-09
ATE183545T1 (de) 1999-09-15
US5965383A (en) 1999-10-12
NO924405L (no) 1993-01-13
AU660618B2 (en) 1995-07-06
RU2109750C1 (ru) 1998-04-27
EP0651799B1 (de) 1999-08-18
US5455158A (en) 1995-10-03
WO1991017765A1 (en) 1991-11-28
HUT66189A (en) 1994-10-28
IL98197A0 (en) 1992-06-21
CA2083271A1 (en) 1991-11-22
NZ238208A (en) 1993-01-27
US5270030A (en) 1993-12-14
HK1013255A1 (en) 1999-08-20
HU216302B (hu) 1999-06-28
DK0651799T3 (da) 2000-03-06
CA2083271C (en) 2002-04-09
JP3419772B2 (ja) 2003-06-23
ES2137928T3 (es) 2000-01-01
FI925296A (fi) 1992-11-20
NO310559B1 (no) 2001-07-23
EP0651799A1 (de) 1995-05-10
NO924405D0 (no) 1992-11-13
FI108298B (fi) 2001-12-31
HU9203516D0 (en) 1993-04-28

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