DE69133452D1 - Bestimmungsverfahren und zusammensetzungen zum nachweis und zur auswertung der intrazellulären umwandlung eines extrazellulären signals - Google Patents

Bestimmungsverfahren und zusammensetzungen zum nachweis und zur auswertung der intrazellulären umwandlung eines extrazellulären signals

Info

Publication number
DE69133452D1
DE69133452D1 DE69133452T DE69133452T DE69133452D1 DE 69133452 D1 DE69133452 D1 DE 69133452D1 DE 69133452 T DE69133452 T DE 69133452T DE 69133452 T DE69133452 T DE 69133452T DE 69133452 D1 DE69133452 D1 DE 69133452D1
Authority
DE
Germany
Prior art keywords
cell surface
reporter gene
intra
evaluating
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133452T
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English (en)
Other versions
DE69133452T3 (de
DE69133452T2 (de
Inventor
Miller Harpold
Paul Brust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69133452D1 publication Critical patent/DE69133452D1/de
Application granted granted Critical
Publication of DE69133452T2 publication Critical patent/DE69133452T2/de
Anticipated expiration legal-status Critical
Publication of DE69133452T3 publication Critical patent/DE69133452T3/de
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
DE69133452.8T 1990-08-07 1991-08-07 Bestimmungsverfahren und zusammensetzungen zum nachweis und zur auswertung der intrazellulären umwandlung eines extrazellulären signals Expired - Lifetime DE69133452T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/563,751 US5401629A (en) 1990-08-07 1990-08-07 Assay methods and compositions useful for measuring the transduction of an intracellular signal
US563751 1990-08-07
EP91914376.8A EP0542830B2 (de) 1990-08-07 1991-08-07 Bestimmungsverfahren und zusammensetzungen zum nachweis und zur auswertung der intrazellulären umwandlung eines extrazellulären signals
PCT/US1991/005625 WO1992002639A1 (en) 1990-08-07 1991-08-07 Assay methods and compositions for detecting and evaluating the intracellular transduction of an extracellular signal

Publications (3)

Publication Number Publication Date
DE69133452D1 true DE69133452D1 (de) 2005-05-04
DE69133452T2 DE69133452T2 (de) 2005-12-15
DE69133452T3 DE69133452T3 (de) 2014-06-18

Family

ID=24251750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133452.8T Expired - Lifetime DE69133452T3 (de) 1990-08-07 1991-08-07 Bestimmungsverfahren und zusammensetzungen zum nachweis und zur auswertung der intrazellulären umwandlung eines extrazellulären signals

Country Status (9)

Country Link
US (2) US5401629A (de)
EP (2) EP1586658A3 (de)
JP (1) JPH06502527A (de)
AT (1) ATE292190T1 (de)
CA (1) CA2087532C (de)
DE (1) DE69133452T3 (de)
DK (1) DK0542830T4 (de)
ES (1) ES2240957T5 (de)
WO (1) WO1992002639A1 (de)

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