DE69206876T2 - Nukleosidanalogen enthaltende Antiviren-Zubereitungen - Google Patents
Nukleosidanalogen enthaltende Antiviren-ZubereitungenInfo
- Publication number
- DE69206876T2 DE69206876T2 DE69206876T DE69206876T DE69206876T2 DE 69206876 T2 DE69206876 T2 DE 69206876T2 DE 69206876 T DE69206876 T DE 69206876T DE 69206876 T DE69206876 T DE 69206876T DE 69206876 T2 DE69206876 T2 DE 69206876T2
- Authority
- DE
- Germany
- Prior art keywords
- antivirus
- preparations containing
- nucleoside analogs
- containing nucleoside
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002155 anti-virotic effect Effects 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919110624A GB9110624D0 (en) | 1991-05-16 | 1991-05-16 | Combinations |
GB9110624 | 1991-05-16 | ||
GB919121381A GB9121381D0 (en) | 1991-10-08 | 1991-10-08 | Combinations |
GB9121381 | 1991-10-08 | ||
GB919123581A GB9123581D0 (en) | 1991-11-06 | 1991-11-06 | Combinations |
GB9123581 | 1991-11-06 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69206876D1 DE69206876D1 (de) | 1996-02-01 |
DE69206876T2 true DE69206876T2 (de) | 1996-05-23 |
DE69206876T3 DE69206876T3 (de) | 2004-08-12 |
Family
ID=27265656
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1998175016 Active DE19875016I2 (de) | 1991-05-16 | 1992-05-11 | Nukleosidanalogen enthaltende Antiviren-Zubereitungen. |
DE69206876T Expired - Lifetime DE69206876T3 (de) | 1991-05-16 | 1992-05-11 | Nukleosidanalogen enthaltende Antiviren-Zubereitungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1998175016 Active DE19875016I2 (de) | 1991-05-16 | 1992-05-11 | Nukleosidanalogen enthaltende Antiviren-Zubereitungen. |
Country Status (25)
Country | Link |
---|---|
US (2) | US5627186A (de) |
EP (1) | EP0513917B2 (de) |
JP (1) | JP2868671B2 (de) |
KR (1) | KR100246687B1 (de) |
CN (1) | CN1045961C (de) |
AT (1) | ATE131730T1 (de) |
AU (2) | AU1787492A (de) |
CA (1) | CA2068790C (de) |
CZ (1) | CZ285232B6 (de) |
DE (2) | DE19875016I2 (de) |
DK (1) | DK0513917T4 (de) |
ES (1) | ES2083668T5 (de) |
GR (1) | GR3018915T3 (de) |
HK (1) | HK78897A (de) |
IE (1) | IE73261B1 (de) |
IL (1) | IL101883A (de) |
LU (1) | LU90234I2 (de) |
MX (1) | MX9202279A (de) |
NL (1) | NL980018I2 (de) |
NO (2) | NO301690B1 (de) |
NZ (2) | NZ242754A (de) |
OA (1) | OA10058A (de) |
SK (1) | SK279262B6 (de) |
TW (1) | TW273550B (de) |
WO (1) | WO1992020344A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
US6812233B1 (en) | 1991-03-06 | 2004-11-02 | Emory University | Therapeutic nucleosides |
ES2138624T3 (es) * | 1992-05-13 | 2000-01-16 | Wellcome Found | Combinaciones terapeuticas. |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
GB9215178D0 (en) * | 1992-07-16 | 1992-08-26 | Glaxo Group Ltd | Antiviral combinations |
IL113432A (en) | 1994-04-23 | 2000-11-21 | Glaxo Group Ltd | Process for the diastereoselective synthesis of nucleoside analogues |
FR2720397B1 (fr) * | 1994-05-24 | 1996-08-23 | Laphal Laboratoires Sa | Nouveaux oxathiolanes, leur procédé de préparation et les compositions pharmaceutiques qui en renferment. |
TW401303B (en) * | 1994-07-01 | 2000-08-11 | Janssen Pharmaceutica Nv | Anti-HIV triple combination |
GB9503850D0 (en) * | 1995-02-25 | 1995-04-19 | Glaxo Group Ltd | Medicaments |
MY115461A (en) * | 1995-03-30 | 2003-06-30 | Wellcome Found | Synergistic combinations of zidovudine, 1592u89 and 3tc |
TR199802704T2 (xx) | 1996-06-25 | 1999-03-22 | Glaxo Group Limited | H�V tedavisinde Vx478, Zidov�din, FTC ve/veya 3TC i�eren kombinasyonlar�n kullan�m�. |
GB9622681D0 (en) * | 1996-10-31 | 1997-01-08 | Glaxo Group Ltd | Pharmaceutical compositions |
US6113920A (en) * | 1996-10-31 | 2000-09-05 | Glaxo Wellcome Inc. | Pharmaceutical compositions |
TW536403B (en) * | 1997-03-24 | 2003-06-11 | Glaxo Group Ltd | An ethanol and ethylenediaminetetraacetic acid free pharmaceutical composition comprising lamivudine and exhibiting antimicrobial preservative efficacy |
WO1999008110A1 (en) | 1997-08-08 | 1999-02-18 | Newbiotics, Inc. | Methods and compositions for overcoming resistance to biologic and chemotherapy |
US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
EP1167972B1 (de) | 1998-01-23 | 2017-03-08 | Kiadis Pharma Intellectual Property B.V. | Enzymkatalisierte therapeutische Agenzien |
WO1999066936A1 (en) * | 1998-06-24 | 1999-12-29 | Emory University | Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv |
JP2003525866A (ja) | 1999-07-22 | 2003-09-02 | ニューバイオティックス インコーポレイテッド | 治療抵抗性腫瘍を処置するための方法 |
US6432966B2 (en) | 1999-10-29 | 2002-08-13 | Smithkline Beecham Corporation | Antiviral combinations |
AP2220A (en) * | 2001-05-11 | 2011-03-24 | Cipla Medpro Pty Ltd | Pharmaceutical composition. |
ATE361059T1 (de) * | 2002-11-08 | 2007-05-15 | Glaxo Group Ltd | Antivirale zusammensetzungen |
KR20090053867A (ko) * | 2003-01-14 | 2009-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 복합 항바이러스 치료를 위한 조성물 및 방법 |
JP4482883B2 (ja) | 2003-05-22 | 2010-06-16 | リードケミカル株式会社 | 抗ウイルス作用を有する化合物およびその配合剤 |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
EP1975923B1 (de) * | 2007-03-28 | 2016-04-27 | Nuance Communications, Inc. | Mehrsprachige nicht-muttersprachliche Spracherkennung |
EP2435052B1 (de) | 2009-05-27 | 2015-07-15 | Hetero Research Foundation | Feste orale lamivudin-darreichgungsformen mit isomalt |
US20130115237A1 (en) | 2010-06-09 | 2013-05-09 | Vaccine Technologies, Incorporated | Therapeutic immunization in hiv infected subjects to augment antiretroviral treatment |
WO2013132208A1 (en) | 2012-03-05 | 2013-09-12 | Cipla Limited | Pharmaceutical antiretroviral combinations comprising lamivudine, festinavir and nevirapine |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1214611B (it) * | 1985-05-22 | 1990-01-18 | Schiena Ricerche | Composti per uso cosmetico dermatologico e relative composizioni. |
GB8717955D0 (en) * | 1987-07-29 | 1987-09-03 | Fujisawa Pharmaceutical Co | Prevention & treatment of aids |
US5270464A (en) * | 1989-03-14 | 1993-12-14 | Janssen Pharmaceutica N.V. | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones |
AU3423989A (en) * | 1988-03-23 | 1989-10-16 | New York University | Antiviral composition containing aromatic polycyclic diones and nucleoside analogs and method for treating retrovirus infections |
JPH02504283A (ja) * | 1988-03-23 | 1990-12-06 | ニューヨーク ユニバーシィティ | 芳香族多環式ジオン化合物とヌクレオシド類似化合物とを含む抗ウイルス性組成物及びレトロウイルス感染を治療するための方法 |
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
DE68900926D1 (de) * | 1988-09-28 | 1992-04-09 | Sigma Tau Ind Farmaceuti | Pharmazeutische zubereitung, die zidovudin und inosiplex oder bestandteile davon enthaelt, fuer die behandlung von aids-verwandten syndromen. |
EP0374096B1 (de) * | 1988-12-14 | 1992-12-02 | Ciba-Geigy Ag | 2',3'-Dideoxypurinnucleosid/Purinnucleosid-Phosphorylase-Inhibitor Kombinationstherapie und Zusammensetzungen dafür |
US5132291A (en) * | 1989-01-24 | 1992-07-21 | Gensia Pharmaceuticals, Inc. | Antivirals and methods for increasing the antiviral activity of azt |
IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them |
NZ232912A (en) * | 1989-03-17 | 1992-06-25 | Oncogen Ltd Lp | Synergistic composition of nucleoside derivatives for inhibiting hiv |
US5011829A (en) * | 1989-06-02 | 1991-04-30 | G. D. Searle & Co. | Pharmaceutical composition and method of inhibiting virus |
SE464168B (sv) † | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
US5116823A (en) * | 1990-02-27 | 1992-05-26 | Roger Williams General Hospital | Drug combinations containing AZT |
GB9009861D0 (en) * | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
GB9104740D0 (en) * | 1991-03-06 | 1991-04-17 | Wellcome Found | Antiviral nucleoside combination |
-
1992
- 1992-05-11 CZ CZ932428A patent/CZ285232B6/cs not_active IP Right Cessation
- 1992-05-11 SK SK1199-93A patent/SK279262B6/sk not_active IP Right Cessation
- 1992-05-11 DE DE1998175016 patent/DE19875016I2/de active Active
- 1992-05-11 WO PCT/EP1992/001106 patent/WO1992020344A1/en active IP Right Grant
- 1992-05-11 EP EP92201328A patent/EP0513917B2/de not_active Expired - Lifetime
- 1992-05-11 ES ES92201328T patent/ES2083668T5/es not_active Expired - Lifetime
- 1992-05-11 DE DE69206876T patent/DE69206876T3/de not_active Expired - Lifetime
- 1992-05-11 DK DK92201328T patent/DK0513917T4/da active
- 1992-05-11 AT AT92201328T patent/ATE131730T1/de active
- 1992-05-11 AU AU17874/92A patent/AU1787492A/en not_active Abandoned
- 1992-05-15 CN CN92104553A patent/CN1045961C/zh not_active Expired - Lifetime
- 1992-05-15 CA CA002068790A patent/CA2068790C/en not_active Expired - Lifetime
- 1992-05-15 IL IL10188392A patent/IL101883A/en not_active IP Right Cessation
- 1992-05-15 NZ NZ242754A patent/NZ242754A/en not_active IP Right Cessation
- 1992-05-15 NO NO921947A patent/NO301690B1/no not_active IP Right Cessation
- 1992-05-15 NZ NZ299240A patent/NZ299240A/en not_active IP Right Cessation
- 1992-05-15 MX MX9202279A patent/MX9202279A/es not_active IP Right Cessation
- 1992-05-15 KR KR1019920008239A patent/KR100246687B1/ko not_active IP Right Cessation
- 1992-05-15 JP JP4148384A patent/JP2868671B2/ja not_active Expired - Lifetime
- 1992-05-15 TW TW081103780A patent/TW273550B/zh not_active IP Right Cessation
- 1992-05-15 AU AU16279/92A patent/AU661307B2/en not_active Expired
- 1992-07-01 IE IE921566A patent/IE73261B1/en not_active IP Right Cessation
-
1993
- 1993-10-22 OA OA60427A patent/OA10058A/en unknown
-
1994
- 1994-03-28 US US08/219,176 patent/US5627186A/en not_active Expired - Lifetime
-
1996
- 1996-02-07 GR GR960400321T patent/GR3018915T3/el unknown
- 1996-02-22 US US08/605,610 patent/US5859021A/en not_active Expired - Lifetime
-
1997
- 1997-06-12 HK HK78897A patent/HK78897A/xx not_active IP Right Cessation
-
1998
- 1998-04-24 LU LU90234C patent/LU90234I2/fr unknown
- 1998-04-28 NL NL980018C patent/NL980018I2/nl unknown
-
1999
- 1999-07-22 NO NO1999018C patent/NO1999018I1/no unknown
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