DE69212870D1 - 4-Aryl-thiazole oder imidazolederivate - Google Patents

4-Aryl-thiazole oder imidazolederivate

Info

Publication number
DE69212870D1
DE69212870D1 DE69212870T DE69212870T DE69212870D1 DE 69212870 D1 DE69212870 D1 DE 69212870D1 DE 69212870 T DE69212870 T DE 69212870T DE 69212870 T DE69212870 T DE 69212870T DE 69212870 D1 DE69212870 D1 DE 69212870D1
Authority
DE
Germany
Prior art keywords
lower alkyl
hydrogen
aryl
alk
thiazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69212870T
Other languages
English (en)
Other versions
DE69212870T2 (de
Inventor
John Henry Pick
Robert Thomas Logan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE69212870D1 publication Critical patent/DE69212870D1/de
Application granted granted Critical
Publication of DE69212870T2 publication Critical patent/DE69212870T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
DE69212870T 1991-03-25 1992-03-23 4-Aryl-thiazole oder imidazolederivate Expired - Fee Related DE69212870T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91302573 1991-03-25

Publications (2)

Publication Number Publication Date
DE69212870D1 true DE69212870D1 (de) 1996-09-26
DE69212870T2 DE69212870T2 (de) 1997-01-16

Family

ID=8208225

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69212870T Expired - Fee Related DE69212870T2 (de) 1991-03-25 1992-03-23 4-Aryl-thiazole oder imidazolederivate

Country Status (17)

Country Link
US (2) US5254575A (de)
EP (1) EP0506194B1 (de)
JP (1) JPH0597816A (de)
KR (1) KR920018037A (de)
AT (1) ATE141597T1 (de)
AU (1) AU648394B2 (de)
CA (1) CA2063172A1 (de)
DE (1) DE69212870T2 (de)
DK (1) DK0506194T3 (de)
ES (1) ES2093765T3 (de)
FI (1) FI921262A (de)
GR (1) GR3021260T3 (de)
IE (1) IE73235B1 (de)
MX (1) MX9203810A (de)
NO (1) NO301929B1 (de)
NZ (1) NZ242095A (de)
ZA (1) ZA921781B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
JP2001504457A (ja) * 1996-11-01 2001-04-03 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化ホスホジエステラーゼ阻害剤化合物、組成物及びその使用法
USRE37234E1 (en) 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
US5874437A (en) * 1996-11-01 1999-02-23 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
WO1998031380A1 (en) * 1997-01-16 1998-07-23 Washington State University Research Foundation Phalloidin derivatives and analogs to treat congestive heart failure
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
EA200501548A1 (ru) 2003-04-01 2006-02-24 Апплайд Резеч Системз Арс Холдинг Н.В. Ингибиторы фосфодиэстераз при бесплодии
WO2004094395A2 (en) * 2003-04-18 2004-11-04 Merck & Co., Inc. Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers
TWI336697B (en) * 2003-09-19 2011-02-01 Solvay Pharm Bv Thiazole derivatives as cannabinoid receptor modulators
PE20070530A1 (es) * 2005-10-26 2007-05-31 Smithkline Beecham Corp Compuestos derivados de tiazoles sustituidos como agentes de apertura de canales de potasio activados por calcio de alta conductancia
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (en) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
EP3718557A3 (de) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylat-cyclase-rezeptoragonist sp-333 zur verwendung in der darmreinigung
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2913737A1 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
CA2920856A1 (en) 2013-08-09 2015-02-12 Ardelyx, Inc. Ph modulating compounds for inhibiting gastrointestinal phosphate uptake
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168036B (de) * 1973-11-09 1976-02-28
FR2261756A1 (en) * 1974-02-27 1975-09-19 Roussel Uclaf 2-Thiazole-N-(Piperazino or piperidino) alkyl carboxamides - as hypotensive and anti-hypertensive agents of low toxicity
EP0199968B1 (de) * 1985-03-27 1990-02-28 Zenyaku Kogyo Kabushiki Kaisha Thiazolderivate
JPH02262562A (ja) * 1988-10-20 1990-10-25 Ishihara Sangyo Kaisha Ltd イミダゾール系化合物

Also Published As

Publication number Publication date
US5254575A (en) 1993-10-19
IE73235B1 (en) 1997-05-21
FI921262A (fi) 1992-09-26
DK0506194T3 (da) 1996-12-23
GR3021260T3 (en) 1997-01-31
ZA921781B (en) 1992-11-25
NZ242095A (en) 1994-04-27
JPH0597816A (ja) 1993-04-20
NO921156D0 (no) 1992-03-24
KR920018037A (ko) 1992-10-21
NO921156L (no) 1992-09-28
CA2063172A1 (en) 1992-09-26
ATE141597T1 (de) 1996-09-15
ES2093765T3 (es) 1997-01-01
US5462959A (en) 1995-10-31
EP0506194B1 (de) 1996-08-21
AU648394B2 (en) 1994-04-21
DE69212870T2 (de) 1997-01-16
NO301929B1 (no) 1997-12-29
AU1291592A (en) 1992-10-01
EP0506194A1 (de) 1992-09-30
MX9203810A (es) 1992-07-31
IE920734A1 (en) 1992-10-07
FI921262A0 (fi) 1992-03-24

Similar Documents

Publication Publication Date Title
DE69212870D1 (de) 4-Aryl-thiazole oder imidazolederivate
RU2403251C2 (ru) Производные 2, 4-ди(гетеро)ариламинопиримидина в качестве ингибиторов zap-70
NO20004485D0 (no) Sykloalkenderivater, deres fremstilling og anvendelse
DE69109631T2 (de) 2-Substituierte Adenosinderivate und pharmazeutische Zusammensetzungen zur Verwendung gegen Infektionskrankheiten.
DK1533292T3 (da) Dibenzylaminforbindelse og medicinsk anvendelse deraf
NO170084C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive dihydropyridinderivater
EA200300265A1 (ru) Производные хиназолина в качестве ингибиторов киназы
ATE169914T1 (de) Piperazin-derivate und ihre verwendung als calmodulin-inhibitoren
DE3781080D1 (de) 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
ATE117295T1 (de) 4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
ATE123771T1 (de) Stickstoff enthaltende heterozyklische verbindungen, ihre herstellung und verwendung.
WO2004004730A3 (en) 2-aminopyrazine derivatives as inhibitors of cyclin dependent kinases for the treatment of proliferative disorders
DE69316067D1 (de) Arzneimittel zur Verwendung bei der Behandlung von Parkinsonismus
DK275483D0 (da) 1,2,4-triazolderivater eller deres farmaceutisk acceptable salte, fremgangsmade til fremstilling deraf og landbrugsfungicider indeholdende disse forbindelser
ES528984A0 (es) Procedimiento para la preparacion de nuevos derivados de triazol dotado de actividad antifungica.
DE69116392D1 (de) Benzosoxazolderivate
EP0373591A3 (de) Polyhydroxybenzyloxypropanolamine
ATE19881T1 (de) Tropyl- und pseudotropylalkylbenzoate und ihre verwendung in der behandlung von migraene.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee