DE69216621D1 - Makrozyklische Seltener-Erden-Komplexe und deren Verwendung für die Reduzierung von Interferenzen in Fluoreszenzbestimmungsverfahren - Google Patents
Makrozyklische Seltener-Erden-Komplexe und deren Verwendung für die Reduzierung von Interferenzen in FluoreszenzbestimmungsverfahrenInfo
- Publication number
- DE69216621D1 DE69216621D1 DE69216621T DE69216621T DE69216621D1 DE 69216621 D1 DE69216621 D1 DE 69216621D1 DE 69216621 T DE69216621 T DE 69216621T DE 69216621 T DE69216621 T DE 69216621T DE 69216621 D1 DE69216621 D1 DE 69216621D1
- Authority
- DE
- Germany
- Prior art keywords
- crc
- radicals
- rare earth
- pct
- macrocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/40—Rare earth chelates
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9110809A FR2680787B1 (fr) | 1991-08-30 | 1991-08-30 | Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence. |
PCT/FR1992/000832 WO1993005049A1 (fr) | 1991-08-30 | 1992-08-28 | Complexes macrocycliques de terres rares et leur utilisation pour reduire les interferences dans un dosage par fluorescence |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69216621D1 true DE69216621D1 (de) | 1997-02-20 |
DE69216621T2 DE69216621T2 (de) | 1997-07-24 |
Family
ID=9416529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69216621T Expired - Fee Related DE69216621T2 (de) | 1991-08-30 | 1992-08-28 | Makrozyklische Seltener-Erden-Komplexe und deren Verwendung für die Reduzierung von Interferenzen in Fluoreszenzbestimmungsverfahren |
Country Status (9)
Country | Link |
---|---|
US (1) | US5457184A (de) |
EP (1) | EP0601113B1 (de) |
JP (1) | JP3345417B2 (de) |
AT (1) | ATE147391T1 (de) |
AU (1) | AU2568092A (de) |
DE (1) | DE69216621T2 (de) |
ES (1) | ES2099280T3 (de) |
FR (1) | FR2680787B1 (de) |
WO (1) | WO1993005049A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
US6331273B1 (en) | 1995-04-25 | 2001-12-18 | Discovery Partners International | Remotely programmable matrices with memories |
US5874214A (en) | 1995-04-25 | 1999-02-23 | Irori | Remotely programmable matrices with memories |
US6416714B1 (en) | 1995-04-25 | 2002-07-09 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
US5751629A (en) | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
US6017496A (en) | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
FR2735238B1 (fr) * | 1995-06-09 | 1997-09-05 | Cis Bio Int | Utilisation d'un complexe phycobiliproteine-peptide de liaison en tant que traceur fluorescent |
WO1997006830A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
US5859215A (en) * | 1995-10-25 | 1999-01-12 | Wallac Oy | Biospecific binding reactants labelled with luminescent lanthanide chelates and their use |
FR2768817B1 (fr) | 1997-09-19 | 1999-12-10 | Cis Bio Int | Methode homogene pour la detection et/ou la determination de l'activite phosphorylante d'un materiel biologique |
FR2809817B1 (fr) | 2000-06-02 | 2003-08-15 | Cis Bio Int | Procede de detection de presence d'un liquide dans un melange |
US7018851B2 (en) | 2003-02-13 | 2006-03-28 | Innotrac Diagnostics Oy | Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use |
WO2006014645A1 (en) * | 2004-07-23 | 2006-02-09 | Amgen Inc. | Generic probes for the detection of phosphorylated sequences |
FR2878850B1 (fr) | 2004-12-02 | 2008-10-31 | Cis Bio Internat Sa | Derives de l'inositol-1-phosphate |
FR2890174B1 (fr) | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
FR2890446B1 (fr) | 2005-09-05 | 2008-04-18 | Cis Bio Internat Sa | Methode de detection d'interaction intracellulaire entre bio-molecules |
US7482444B2 (en) | 2006-03-13 | 2009-01-27 | Wallac Oy | Terminating substrates for DNA polymerases |
WO2008020113A1 (en) | 2006-08-18 | 2008-02-21 | Abacus Diagnostica Oy | Luminescent lanthanide labelling reagents and their use |
KR20090094303A (ko) * | 2006-11-27 | 2009-09-04 | 스미또모 가가꾸 가부시키가이샤 | 다핵 착체 |
WO2010006605A2 (en) | 2008-07-16 | 2010-01-21 | Radiometer Medical Aps | Thrombin substrate and assay for determining the level of bioactive thrombin in a sample |
FR2934684B1 (fr) | 2008-07-31 | 2012-11-16 | Cis Bio Int | Methode de detection de l'internalisation de proteines membranaires. |
FR2936245B1 (fr) | 2008-09-23 | 2012-07-06 | Cis Bio Int | Nouveaux substrats d'o6-alkylguanine-adn alkyltransferase et ses mutants. |
FR2940286B1 (fr) | 2008-12-19 | 2011-04-08 | Cis Bio Int | Nouveaux cryptates de terres rares comportant un motif tetraazatriphenylene |
CA2759885A1 (fr) | 2009-04-30 | 2010-11-04 | Etienne Doumazane | Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft |
FR2949156B1 (fr) | 2009-08-13 | 2016-04-15 | Cis-Bio Int | Methode de determination de la liaison d'un compose donne a un recepteur membranaire |
US8153442B2 (en) * | 2009-10-21 | 2012-04-10 | Siemens Healthcare Diagnostics Inc. | Stabilization of signal generation in particles used in assays |
FR2977674B1 (fr) | 2011-07-06 | 2015-08-14 | Cisbio Bioassays | Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule |
FR2978149B1 (fr) | 2011-07-18 | 2014-01-10 | Cisbio Bioassays | Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents |
FR2980271B1 (fr) | 2011-09-16 | 2013-10-11 | Cisbio Bioassays | Procede de determination de la glycosylation d'un anticorps |
EP2817614A1 (de) | 2012-02-22 | 2014-12-31 | Cisbio Bioassays | Verfahren zur normalisierung der von einem messmedium emittierten lumineszenz |
FR2988174B1 (fr) | 2012-03-19 | 2014-04-25 | Cisbio Bioassays | Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre |
FR3000960B1 (fr) | 2013-01-16 | 2015-03-06 | Cisbio Bioassays | Nouveaux agents complexants hydrosolubles et complexes de lanthanide correspondants |
FR3004189B1 (fr) | 2013-04-04 | 2015-09-04 | Ecole Norm Superieure Lyon | Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents |
FR3032797B1 (fr) | 2015-02-13 | 2017-03-03 | Cisbio Bioassays | Procede de quantification d'une proteine d'interet presente dans un echantillon biologique |
FR3045053B1 (fr) | 2015-12-09 | 2018-01-05 | Cisbio Bioassays | Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants |
FR3067349B1 (fr) | 2017-06-12 | 2020-12-04 | Cisbio Bioassays | Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants |
FR3067712B1 (fr) | 2017-06-14 | 2019-08-02 | Cisbio Bioassays | Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants |
FR3069644A1 (fr) | 2017-07-28 | 2019-02-01 | Cisbio Bioassays | Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g |
FR3084365B1 (fr) | 2018-07-27 | 2020-10-23 | Cisbio Bioassays | Anticorps a domaine unique qui se lient a la proteine g alpha |
FR3092172B1 (fr) | 2019-01-30 | 2021-02-12 | Cisbio Bioassays | Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP |
CN113801148B (zh) * | 2020-06-15 | 2022-11-22 | 北京大学 | 亚铕大环配合物及其作为电致发光材料的应用 |
CN112521937B (zh) * | 2020-12-10 | 2022-07-19 | 四川师范大学 | 一种可用于尿酸检测的稀土荧光复合材料的制备及应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2570703B1 (fr) * | 1984-09-26 | 1988-07-08 | Commissariat Energie Atomique | Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents |
US5220012A (en) * | 1984-09-26 | 1993-06-15 | Compagnie Oris Industrie Sa | Macropolycyclic rare earth complexes and application as fluorescent tracers |
US4761481A (en) * | 1985-03-18 | 1988-08-02 | Baxter Travenol Laboratories, Inc. | Substituted pyridine derivatives |
SE8800613D0 (sv) * | 1988-02-23 | 1988-02-23 | Wallac Oy | A novel spectrofluorometric method and compounds that are of value for the method |
DE69132750T2 (de) * | 1990-05-15 | 2002-06-20 | Hyperion Inc | Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden |
-
1991
- 1991-08-30 FR FR9110809A patent/FR2680787B1/fr not_active Expired - Fee Related
-
1992
- 1992-08-28 AT AT92919653T patent/ATE147391T1/de not_active IP Right Cessation
- 1992-08-28 AU AU25680/92A patent/AU2568092A/en not_active Abandoned
- 1992-08-28 US US08/199,135 patent/US5457184A/en not_active Expired - Lifetime
- 1992-08-28 DE DE69216621T patent/DE69216621T2/de not_active Expired - Fee Related
- 1992-08-28 EP EP92919653A patent/EP0601113B1/de not_active Expired - Lifetime
- 1992-08-28 WO PCT/FR1992/000832 patent/WO1993005049A1/fr active IP Right Grant
- 1992-08-28 ES ES92919653T patent/ES2099280T3/es not_active Expired - Lifetime
- 1992-08-28 JP JP50499693A patent/JP3345417B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2099280T3 (es) | 1997-05-16 |
FR2680787B1 (fr) | 1994-11-04 |
DE69216621T2 (de) | 1997-07-24 |
FR2680787A1 (fr) | 1993-03-05 |
WO1993005049A1 (fr) | 1993-03-18 |
JP3345417B2 (ja) | 2002-11-18 |
EP0601113A1 (de) | 1994-06-15 |
AU2568092A (en) | 1993-04-05 |
ATE147391T1 (de) | 1997-01-15 |
US5457184A (en) | 1995-10-10 |
EP0601113B1 (de) | 1997-01-08 |
JPH06510296A (ja) | 1994-11-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |