DE69222532D1 - Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung - Google Patents
Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellungInfo
- Publication number
- DE69222532D1 DE69222532D1 DE69222532T DE69222532T DE69222532D1 DE 69222532 D1 DE69222532 D1 DE 69222532D1 DE 69222532 T DE69222532 T DE 69222532T DE 69222532 T DE69222532 T DE 69222532T DE 69222532 D1 DE69222532 D1 DE 69222532D1
- Authority
- DE
- Germany
- Prior art keywords
- alkenylene
- optionally substituted
- sum
- phenyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrrole Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73442691A | 1991-07-23 | 1991-07-23 | |
US73465291A | 1991-07-23 | 1991-07-23 | |
PCT/US1992/005972 WO1993002048A1 (en) | 1991-07-23 | 1992-07-21 | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69222532D1 true DE69222532D1 (de) | 1997-11-06 |
DE69222532T2 DE69222532T2 (de) | 1998-02-26 |
Family
ID=27112730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69222532T Expired - Lifetime DE69222532T2 (de) | 1991-07-23 | 1992-07-21 | Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung |
Country Status (24)
Country | Link |
---|---|
US (2) | US5306817A (de) |
EP (2) | EP0596015B1 (de) |
JP (1) | JP2525125B2 (de) |
CN (1) | CN1069024A (de) |
AT (1) | ATE158789T1 (de) |
AU (1) | AU658441B2 (de) |
BG (1) | BG61118B2 (de) |
CZ (1) | CZ14294A3 (de) |
DE (1) | DE69222532T2 (de) |
EE (1) | EE9400342A (de) |
ES (1) | ES2107548T3 (de) |
FI (1) | FI940296A0 (de) |
HU (1) | HUT67341A (de) |
IE (1) | IE922374A1 (de) |
IL (1) | IL102582A0 (de) |
MX (1) | MX9204327A (de) |
MY (1) | MY131273A (de) |
NO (1) | NO940221L (de) |
NZ (1) | NZ243669A (de) |
OA (1) | OA09878A (de) |
SK (1) | SK7994A3 (de) |
TW (1) | TW223059B (de) |
WO (1) | WO1993002048A1 (de) |
YU (1) | YU72092A (de) |
Families Citing this family (92)
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US5688787A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
SK158394A3 (en) * | 1992-06-26 | 1995-05-10 | Pfizer | Steroidal glycosides |
CA2106840A1 (en) * | 1992-09-25 | 1994-03-26 | Marco Baroni | Heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them |
LT3300B (en) * | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
LT3595B (en) | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
SK3796A3 (en) * | 1993-07-09 | 1997-02-05 | Schering Corp | Process for the synthesis of azetidinones |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
JPH10501811A (ja) * | 1994-06-20 | 1998-02-17 | シェーリング コーポレイション | 低コレステロール化剤として有用な置換アゼチジノン化合物 |
US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
MX9802377A (es) * | 1995-09-27 | 1998-08-30 | Schering Corp | Proceso de reduccion microbiana estero selectiva. |
AU7472896A (en) * | 1995-11-02 | 1997-05-22 | Schering Corporation | Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon |
DE69636783T2 (de) | 1995-11-02 | 2007-10-18 | Warner-Lambert Co. Llc | Verfahren und pharmazeutische zusammensetzung zur regelung der lipidkonzentration |
PL329530A1 (en) * | 1996-04-26 | 1999-03-29 | Smithkline Beecham Plc | Derivatives of azetidinone for use in treatment of arterial atheromatosis |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
AU4343500A (en) | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
DE10042447A1 (de) * | 2000-08-29 | 2002-03-28 | Aventis Pharma Gmbh | Protein aus dem Darm von Wirbeltieren, welches Cholesterin absorbiert, sowie Verwendung dieses Proteins zur Identifizierung von Inhibitoren des intestinalen Cholesterintransports |
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US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
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EP1911462A3 (de) | 2001-01-26 | 2011-11-30 | Schering Corporation | Zusammensetzungen enthaltend einen Sterolabsorptionshemmer |
AU2005246926B2 (en) * | 2001-01-26 | 2008-02-28 | Merck Sharp & Dohme Corp. | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
TW200840563A (en) * | 2001-01-26 | 2008-10-16 | Schering Corp | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications |
RS51449B (sr) * | 2001-01-26 | 2011-04-30 | Schering Corporation | Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija |
TWI291957B (en) | 2001-02-23 | 2008-01-01 | Kotobuki Pharmaceutical Co Ltd | Beta-lactam compounds, process for repoducing the same and serum cholesterol-lowering agents containing the same |
BRPI0208384B1 (pt) | 2001-03-28 | 2016-05-31 | Merck Sharp & Dohme | síntese enantiosseletiva de compostos intermediários de azetidinona |
MXPA04000411A (es) | 2001-07-16 | 2004-03-18 | Euro Celtique Sa | Tiazolidinonas arilo sustituidas y uso de las mismas. |
DE60216300T2 (de) | 2001-09-21 | 2007-06-28 | Schering Corp. | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
CN1556700A (zh) * | 2001-09-21 | 2004-12-22 | ���鹫˾ | 使用甾醇吸收抑制剂治疗或预防脉管炎的方法 |
US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
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TW201427658A (zh) | 2012-12-10 | 2014-07-16 | Merck Sharp & Dohme | 藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法 |
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IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
-
1992
- 1992-07-21 ES ES92916790T patent/ES2107548T3/es not_active Expired - Lifetime
- 1992-07-21 JP JP5502964A patent/JP2525125B2/ja not_active Expired - Fee Related
- 1992-07-21 SK SK79-94A patent/SK7994A3/sk unknown
- 1992-07-21 IL IL102582A patent/IL102582A0/xx unknown
- 1992-07-21 WO PCT/US1992/005972 patent/WO1993002048A1/en active IP Right Grant
- 1992-07-21 EP EP92916790A patent/EP0596015B1/de not_active Expired - Lifetime
- 1992-07-21 DE DE69222532T patent/DE69222532T2/de not_active Expired - Lifetime
- 1992-07-21 MY MYPI92001303A patent/MY131273A/en unknown
- 1992-07-21 HU HU9400185A patent/HUT67341A/hu unknown
- 1992-07-21 TW TW081105745A patent/TW223059B/zh active
- 1992-07-21 EP EP19920112425 patent/EP0524595A1/de active Pending
- 1992-07-21 AU AU23980/92A patent/AU658441B2/en not_active Ceased
- 1992-07-21 AT AT92916790T patent/ATE158789T1/de not_active IP Right Cessation
- 1992-07-21 CZ CS94142A patent/CZ14294A3/cs unknown
- 1992-07-22 NZ NZ243669A patent/NZ243669A/en unknown
- 1992-07-22 CN CN92108760A patent/CN1069024A/zh active Pending
- 1992-07-22 IE IE237492A patent/IE922374A1/en not_active Application Discontinuation
- 1992-07-22 YU YU72092A patent/YU72092A/sh unknown
- 1992-07-23 MX MX9204327A patent/MX9204327A/es not_active IP Right Cessation
- 1992-10-19 US US07/962,768 patent/US5306817A/en not_active Expired - Fee Related
-
1994
- 1994-01-07 US US08/179,008 patent/US6093812A/en not_active Expired - Fee Related
- 1994-01-21 OA OA60459A patent/OA09878A/en unknown
- 1994-01-21 FI FI940296A patent/FI940296A0/fi not_active Application Discontinuation
- 1994-01-21 NO NO940221A patent/NO940221L/no unknown
- 1994-02-24 BG BG98565A patent/BG61118B2/bg unknown
- 1994-11-23 EE EE9400342A patent/EE9400342A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0596015B1 (de) | 1997-10-01 |
NO940221D0 (no) | 1994-01-21 |
NO940221L (no) | 1994-01-21 |
HUT67341A (en) | 1995-03-28 |
US6093812A (en) | 2000-07-25 |
YU72092A (sh) | 1995-12-04 |
AU2398092A (en) | 1993-02-23 |
MY131273A (en) | 2007-07-31 |
CN1069024A (zh) | 1993-02-17 |
EP0596015A1 (de) | 1994-05-11 |
CZ14294A3 (en) | 1994-07-13 |
IE922374A1 (en) | 1993-01-27 |
AU658441B2 (en) | 1995-04-13 |
FI940296A (fi) | 1994-01-21 |
ES2107548T3 (es) | 1997-12-01 |
EE9400342A (et) | 1996-04-15 |
JPH06508637A (ja) | 1994-09-29 |
HU9400185D0 (en) | 1994-05-30 |
US5306817A (en) | 1994-04-26 |
TW223059B (de) | 1994-05-01 |
BG61118B2 (bg) | 1996-11-29 |
OA09878A (en) | 1994-09-15 |
FI940296A0 (fi) | 1994-01-21 |
NZ243669A (en) | 1994-12-22 |
IL102582A0 (en) | 1993-01-14 |
SK7994A3 (en) | 1994-07-06 |
DE69222532T2 (de) | 1998-02-26 |
WO1993002048A1 (en) | 1993-02-04 |
MX9204327A (es) | 1994-07-29 |
ATE158789T1 (de) | 1997-10-15 |
JP2525125B2 (ja) | 1996-08-14 |
EP0524595A1 (de) | 1993-01-27 |
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