DE69222535T2 - Nachweis von molekularen veränderungen der augenlinse - Google Patents

Nachweis von molekularen veränderungen der augenlinse

Info

Publication number
DE69222535T2
DE69222535T2 DE69222535T DE69222535T DE69222535T2 DE 69222535 T2 DE69222535 T2 DE 69222535T2 DE 69222535 T DE69222535 T DE 69222535T DE 69222535 T DE69222535 T DE 69222535T DE 69222535 T2 DE69222535 T2 DE 69222535T2
Authority
DE
Germany
Prior art keywords
detection
eye lens
molecular changes
molecular
changes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69222535T
Other languages
English (en)
Other versions
DE69222535D1 (de
Inventor
Mark Samuels
Scott Patterson
Jonathan A Eppstein
Nai Teug Yu
Sven-Erik Bursell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Institute
Georgia Tech Research Corp
Original Assignee
Georgia Tech Research Institute
Georgia Tech Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Research Institute, Georgia Tech Research Corp filed Critical Georgia Tech Research Institute
Application granted granted Critical
Publication of DE69222535D1 publication Critical patent/DE69222535D1/de
Publication of DE69222535T2 publication Critical patent/DE69222535T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • A61B3/1173Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Eye Examination Apparatus (AREA)
  • Optical Filters (AREA)
  • Prostheses (AREA)
  • Glass Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69222535T 1991-07-17 1992-07-16 Nachweis von molekularen veränderungen der augenlinse Expired - Lifetime DE69222535T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/731,533 US5203328A (en) 1991-07-17 1991-07-17 Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
PCT/US1992/005941 WO1993001745A1 (en) 1991-07-17 1992-07-16 Measuring molecular change in the ocular lens

Publications (2)

Publication Number Publication Date
DE69222535D1 DE69222535D1 (de) 1997-11-06
DE69222535T2 true DE69222535T2 (de) 1998-03-26

Family

ID=24939928

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222535T Expired - Lifetime DE69222535T2 (de) 1991-07-17 1992-07-16 Nachweis von molekularen veränderungen der augenlinse

Country Status (9)

Country Link
US (2) US5203328A (de)
EP (1) EP0597932B1 (de)
JP (1) JPH07500030A (de)
AT (1) ATE158704T1 (de)
AU (1) AU661026B2 (de)
CA (1) CA2113268C (de)
DE (1) DE69222535T2 (de)
ES (1) ES2110007T3 (de)
WO (1) WO1993001745A1 (de)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
DE4243142A1 (de) * 1992-12-19 1994-06-23 Boehringer Mannheim Gmbh Vorrichtung zur in-vivo-Bestimmung einer optischen Eigenschaft des Kammerwassers des Auges
US5341805A (en) * 1993-04-06 1994-08-30 Cedars-Sinai Medical Center Glucose fluorescence monitor and method
US5427094A (en) * 1993-11-08 1995-06-27 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5427095A (en) * 1993-11-09 1995-06-27 Massachusetts Institute of Technology Oculon Corporation Method and apparatus for detecting cataractogenesis
US5560356A (en) * 1994-02-23 1996-10-01 Vitrophage, Inc. Diagnostic system and method using an implanted reflective device
US5685313A (en) * 1994-05-31 1997-11-11 Brain Monitor Ltd. Tissue monitor
US5701902A (en) * 1994-09-14 1997-12-30 Cedars-Sinai Medical Center Spectroscopic burn injury evaluation apparatus and method
EP0785747A1 (de) * 1995-03-23 1997-07-30 Koninklijke Philips Electronics N.V. Vorrichtung zur optischen messung in zähflüssigen medien
US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
DE19538372A1 (de) * 1995-10-14 1997-04-17 Laser & Med Tech Gmbh Nicht invasive Glukosemessung
US6002954A (en) * 1995-11-22 1999-12-14 The Regents Of The University Of California Detection of biological molecules using boronate-based chemical amplification and optical sensors
WO1997019188A1 (en) 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
US6766183B2 (en) 1995-11-22 2004-07-20 Medtronic Minimed, Inc. Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers
US6232609B1 (en) * 1995-12-01 2001-05-15 Cedars-Sinai Medical Center Glucose monitoring apparatus and method using laser-induced emission spectroscopy
US5882301A (en) 1995-12-13 1999-03-16 Yoshida; Akitoshi Measuring apparatus for intraocular substance employing light from eyeball
KR19990076724A (ko) * 1996-01-26 1999-10-15 로셰 디아그노스틱스 게엠베하 산란 매트릭스내에 함유된 분석물을 측정하는 방법 및 장치
US6544193B2 (en) 1996-09-04 2003-04-08 Marcio Marc Abreu Noninvasive measurement of chemical substances
WO1998022820A1 (en) 1996-11-21 1998-05-28 Lawrence Livermore National Laboratory Detection of biological molecules using boronate-based chemical amplification and optical sensors
CA2192036A1 (en) * 1996-12-04 1998-06-04 Harvey Lui Fluorescence scope system for dermatologic diagnosis
US6826422B1 (en) 1997-01-13 2004-11-30 Medispectra, Inc. Spectral volume microprobe arrays
US6847490B1 (en) 1997-01-13 2005-01-25 Medispectra, Inc. Optical probe accessory device for use in vivo diagnostic procedures
US7865230B1 (en) 1997-02-07 2011-01-04 Texas A&M University System Method and system for detecting sentinel lymph nodes
US5880812A (en) * 1997-03-13 1999-03-09 Ramot-University Authority For Applied Research And Industrial Development, Ltd. Method and apparatus for evaluating and mapping visual field
JP4383545B2 (ja) 1997-03-19 2009-12-16 ルーシド インコーポレーテッド 共焦点顕微鏡使用法を利用する細胞手術
US6091984A (en) * 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
ATE352252T1 (de) 1997-11-12 2007-02-15 Lightouch Medical Inc Verfahren zur nicht invasiven analytenmessung
US6070093A (en) 1997-12-02 2000-05-30 Abbott Laboratories Multiplex sensor and method of use
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
DE19808779C1 (de) * 1998-03-03 1999-10-28 Paul Dobrinski Meßvorrichtung zur objektiven Beurteilung des Zustandes eines grauen Stars (einer Katarakt) durch den Augenarzt
US6174291B1 (en) 1998-03-09 2001-01-16 Spectrascience, Inc. Optical biopsy system and methods for tissue diagnosis
US6560478B1 (en) * 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US5919132A (en) * 1998-03-26 1999-07-06 Universite De Montreal On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye
US6149589A (en) * 1998-03-26 2000-11-21 Universite De Montreal On-line and real-time spectroreflectometry measurement of oxygenation in a patient's eye
ATE225142T1 (de) 1998-07-07 2002-10-15 Lightouch Medical Inc Verfahren zur gewebemodulation für die quantitative nichtinvasive in vivo spektroskopische analyse von gewebe
EP1112022A4 (de) * 1998-09-11 2004-08-04 Spectrx Inc Multi-modale optische gewebediagnosevorrichtung
US6708060B1 (en) * 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6721583B1 (en) * 1998-11-19 2004-04-13 The United States Of America Method for non-invasive identification of individuals at risk for diabetes
WO2000037917A2 (en) 1998-12-23 2000-06-29 Medispectra, Inc. Systems and methods for optical examination of samples
CA2356195A1 (en) * 1998-12-23 2000-06-29 Medispectra, Inc. Optical methods and systems for cervical screening
US6404497B1 (en) 1999-01-25 2002-06-11 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
US6665556B1 (en) * 1999-01-29 2003-12-16 Robert R. Alfano Method and apparatus for examining a tissue using the spectral wing emission therefrom induced by visible to infrared photoexcitation
US6088606A (en) * 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
US6219566B1 (en) * 1999-07-13 2001-04-17 Photonics Research Ontario Method of measuring concentration of luminescent materials in turbid media
CA2381520C (en) 1999-08-26 2009-05-26 Novartis Ag Ocular analyte sensor
US6673625B2 (en) 1999-09-15 2004-01-06 The Regents Of The University Of California Saccharide sensing molecules having enhanced fluorescent properties
US6682938B1 (en) 1999-09-15 2004-01-27 The Regents Of The University Of California Glucose sensing molecules having selected fluorescent properties
US6494576B1 (en) 1999-09-30 2002-12-17 L'esperance, Jr. Francis A. Method and apparatus for spectrophotometry of the eye
US7054002B1 (en) 1999-10-08 2006-05-30 The Texas A&M University System Characterization of luminescence in a scattering medium
AU1572401A (en) * 1999-11-05 2001-06-06 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US7187810B2 (en) * 1999-12-15 2007-03-06 Medispectra, Inc. Methods and systems for correcting image misalignment
US7260248B2 (en) * 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US6902935B2 (en) * 1999-12-15 2005-06-07 Medispectra, Inc. Methods of monitoring effects of chemical agents on a sample
US6377841B1 (en) * 2000-03-31 2002-04-23 Vanderbilt University Tumor demarcation using optical spectroscopy
US20040044287A1 (en) * 2000-03-31 2004-03-04 Wei-Chiang Lin Identification of human tissue using optical spectroscopy
ATE417543T1 (de) * 2000-07-13 2009-01-15 Univ Virginia Commonwealth Verwendung von ultraviolett, nahultraviolett und nahinfrarot-resonanzrmanspektroskopie und fluoresenzspektoskopie zur gewebeuntersuchung auf schockzustand, kritische krankheiten oder andere krankheitszustände
US6549861B1 (en) 2000-08-10 2003-04-15 Euro-Celtique, S.A. Automated system and method for spectroscopic analysis
WO2002016905A2 (en) 2000-08-21 2002-02-28 Euro-Celtique, S.A. Near infrared blood glucose monitoring system
IL155837A0 (en) 2000-11-16 2004-06-01 Chameleon Medical Innovation L A diagnostic system for the ear
US6839661B2 (en) * 2000-12-15 2005-01-04 Medispectra, Inc. System for normalizing spectra
US6697652B2 (en) 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
AU2002251944A1 (en) * 2001-02-15 2002-09-04 Medtronic Minimed, Inc. Polymers functionalized with fluorescent boronate motifs
US7139598B2 (en) * 2002-04-04 2006-11-21 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence
US7043288B2 (en) * 2002-04-04 2006-05-09 Inlight Solutions, Inc. Apparatus and method for spectroscopic analysis of tissue to detect diabetes in an individual
US20070276199A1 (en) * 2002-04-04 2007-11-29 Ediger Marwood N Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence
CA2441787C (en) * 2001-04-27 2011-08-09 Novartis Ag Apparatus for measuring blood glucose concentrations
US7904176B2 (en) * 2006-09-07 2011-03-08 Bio Control Medical (B.C.M.) Ltd. Techniques for reducing pain associated with nerve stimulation
US7045361B2 (en) 2001-09-12 2006-05-16 Medtronic Minimed, Inc. Analyte sensing via acridine-based boronate biosensors
US6650915B2 (en) 2001-09-13 2003-11-18 Fovioptics, Inc. Non-invasive measurement of blood analytes using photodynamics
US8308797B2 (en) * 2002-01-04 2012-11-13 Colibri Heart Valve, LLC Percutaneously implantable replacement heart valve device and method of making same
US8140147B2 (en) * 2002-04-04 2012-03-20 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using a flexible probe to determine tissue fluorescence of various sites
US8131332B2 (en) * 2002-04-04 2012-03-06 Veralight, Inc. Determination of a measure of a glycation end-product or disease state using tissue fluorescence of various sites
US7725144B2 (en) * 2002-04-04 2010-05-25 Veralight, Inc. Determination of disease state using raman spectroscopy of tissue
US20120078075A1 (en) * 2002-04-04 2012-03-29 Maynard John D Determination of a measure of a glycation end-product or disease state using tissue fluorescence in combination with one or more other tests
AU2003226605A1 (en) * 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US7187960B2 (en) 2002-04-22 2007-03-06 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US10123732B2 (en) 2002-04-22 2018-11-13 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US6933154B2 (en) * 2002-07-09 2005-08-23 Medispectra, Inc. Optimal windows for obtaining optical data for characterization of tissue samples
US7459696B2 (en) 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US7469160B2 (en) * 2003-04-18 2008-12-23 Banks Perry S Methods and apparatus for evaluating image focus
US20040208385A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for visually enhancing images
US7136518B2 (en) * 2003-04-18 2006-11-14 Medispectra, Inc. Methods and apparatus for displaying diagnostic data
US6818903B2 (en) * 2002-07-09 2004-11-16 Medispectra, Inc. Method and apparatus for identifying spectral artifacts
US20040209237A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US7282723B2 (en) * 2002-07-09 2007-10-16 Medispectra, Inc. Methods and apparatus for processing spectral data for use in tissue characterization
US7309867B2 (en) 2003-04-18 2007-12-18 Medispectra, Inc. Methods and apparatus for characterization of tissue samples
US20040208390A1 (en) * 2003-04-18 2004-10-21 Medispectra, Inc. Methods and apparatus for processing image data for use in tissue characterization
US6768918B2 (en) * 2002-07-10 2004-07-27 Medispectra, Inc. Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
US7103401B2 (en) 2002-07-10 2006-09-05 Medispectra, Inc. Colonic polyp discrimination by tissue fluorescence and fiberoptic probe
US6895264B2 (en) 2002-08-26 2005-05-17 Fovioptics Inc. Non-invasive psychophysical measurement of glucose using photodynamics
WO2004060154A1 (en) * 2003-01-07 2004-07-22 Intelligent Photonics Control Corp. Non-invasive blood monitor
WO2004113889A1 (en) * 2003-06-20 2004-12-29 The Texas A & M University System Method and system for near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection
US7356365B2 (en) * 2003-07-09 2008-04-08 Glucolight Corporation Method and apparatus for tissue oximetry
US20050090723A1 (en) * 2003-10-23 2005-04-28 Nassar Saeed Method and apparatus for non-invasive measuring of physiological glucose concentration in bodies of humans or animals
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
CN100998499B (zh) * 2003-10-28 2013-07-24 薇拉莱特公司 使用组织荧光确定某一糖化终产物或疾病状态
WO2005050156A2 (en) * 2003-11-18 2005-06-02 Chameleon Medical Innovation Ltd. Measurement system and method for use in determining the patient's condition
GB2409033C (en) * 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
US7510849B2 (en) * 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US8036727B2 (en) 2004-08-11 2011-10-11 Glt Acquisition Corp. Methods for noninvasively measuring analyte levels in a subject
US7822452B2 (en) 2004-08-11 2010-10-26 Glt Acquisition Corp. Method for data reduction and calibration of an OCT-based blood glucose monitor
US7330746B2 (en) * 2005-06-07 2008-02-12 Chem Image Corporation Non-invasive biochemical analysis
US7330747B2 (en) * 2005-06-07 2008-02-12 Chemimage Corporation Invasive chemometry
CA2616376A1 (en) * 2005-07-25 2007-02-01 Duke University Methods, systems, and computer program products for optimization of probes for spectroscopic measurement in turbid media
US20070167835A1 (en) * 2005-07-25 2007-07-19 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
US20070173736A1 (en) * 2005-10-07 2007-07-26 Femspec Llc Apparatus and methods for endometrial biopsies
KR101370985B1 (ko) 2005-10-24 2014-03-10 마시오 마크 아우렐리오 마틴스 애브리우 생물학적 파라미터들을 측정하기 위한 장치 및 방법
JP2009520547A (ja) * 2005-12-22 2009-05-28 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 化学的な分子の制御された解放のためのデバイス
EP2001352A4 (de) * 2006-03-17 2010-04-07 Univ Duke Auf monte-carlo-simulation basierendes modell für fluoreszenz in trüben medien sowie verfahren und systeme zu seiner verwendung zur bestimmung der intrinsischen fluoreszenz trüber medien
US7751039B2 (en) * 2006-03-30 2010-07-06 Duke University Optical assay system for intraoperative assessment of tumor margins
WO2008052221A2 (en) * 2006-10-27 2008-05-02 Aretais, Inc. Use of coherent raman techniques for medical diagnostic and therapeutic purposes, and calibration techniques for same
US8498695B2 (en) 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
JP2008197088A (ja) * 2007-01-19 2008-08-28 Shimadzu Corp 蛍光検出器
WO2008103486A1 (en) * 2007-02-23 2008-08-28 Duke University Scaling method for fast monte carlo simulation of diffuse reflectance spectra
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
GB2451443B (en) 2007-07-30 2012-12-26 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
WO2009043050A2 (en) * 2007-09-27 2009-04-02 Duke University Optical assay system with a multi-probe imaging array
WO2009043045A1 (en) * 2007-09-28 2009-04-02 Duke University Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a monte carlo or a diffusion algorithm
EP2057941A1 (de) * 2007-11-07 2009-05-13 Koninklijke Philips Electronics N.V. Verfahren und Vorrichtung zur Abbildung des Inneren eines optisch trüben Mediums
DE102007061987A1 (de) * 2007-12-21 2009-06-25 Carl Zeiss Meditec Ag Vorrichtung und Verfahren zum Nachweisen von Molekülen im Auge
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
GB2457302B (en) 2008-02-11 2013-04-10 Lein Applied Diagnostics Ltd Measurement apparatus and method therefor
US8768423B2 (en) 2008-03-04 2014-07-01 Glt Acquisition Corp. Multispot monitoring for use in optical coherence tomography
JP5094484B2 (ja) * 2008-03-11 2012-12-12 富士フイルム株式会社 蛍光検出方法および蛍光検出装置
JP5097590B2 (ja) * 2008-03-26 2012-12-12 富士フイルム株式会社 ラマン信号測定方法およびラマン信号測定装置
US20110105865A1 (en) * 2008-04-24 2011-05-05 Duke University Diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US20100249607A1 (en) * 2008-09-26 2010-09-30 Massachusetts Institute Of Technology Quantitative spectroscopic imaging
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
GB0903274D0 (en) 2009-02-26 2009-04-08 Edinburgh Instr Fluoreence method and system
US7896498B2 (en) * 2009-03-30 2011-03-01 Ottawa Hospital Research Institute Apparatus and method for optical measurements
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
EP2467805B1 (de) 2009-08-20 2020-08-05 Koninklijke Philips N.V. Bildanalyseverfahren und -system
BR112012007924A2 (pt) * 2009-10-06 2020-08-18 Koninklijke Philips Electronics N. V método de fotopletismografia remota e sistema para a realização de fotopletismografia remota
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
SG10201501500TA (en) 2010-03-01 2015-04-29 Colibri Heart Valve Llc Percutaneously deliverable heart valve and methods associated therewith
CA2806544C (en) 2010-06-28 2016-08-23 Colibri Heart Valve Llc Method and apparatus for the endoluminal delivery of intravascular devices
AU2015202762B2 (en) * 2010-11-05 2017-04-20 Sinocare Meditech, Inc. Improved algorithm for detection of diabetes
AU2011323110B2 (en) 2010-11-05 2015-07-30 Sinocare Meditech, Inc. Apparatus and method for non-invasively detecting diseases that affect structural properties in biological tissues
JP2014507179A (ja) 2010-12-14 2014-03-27 コリブリ ハート バルブ エルエルシー 統合された弁尖を伴う折り畳まれた膜の心臓弁膜尖を含む経皮的にデリバリー可能な心臓弁
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
WO2015054681A1 (en) 2013-10-11 2015-04-16 Marcio Marc Abreu Method and apparatus for biological evaluation
CA2936235A1 (en) 2014-01-10 2015-07-16 Marcio Marc Abreu Devices to monitor and provide treatment at an abreu brain tunnel
AU2015204638A1 (en) 2014-01-10 2016-07-21 Marcio Marc Abreu Device for measuring the infrared output of the Abreu brain thermal tunnel
US10238847B2 (en) 2014-01-22 2019-03-26 Geelux Holdings, Ltd. Devices and methods for transdermal drug delivery
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
WO2016145215A1 (en) 2015-03-10 2016-09-15 Marcio Marc Abreu Devices, apparatuses, systems, and methods for measuring temperature of an abtt terminus
WO2017079844A1 (en) * 2015-11-13 2017-05-18 Novadaq Technologies Inc. Systems and methods for illumination and imaging of a target
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US10869645B2 (en) 2016-06-14 2020-12-22 Stryker European Operations Limited Methods and systems for adaptive imaging for low light signal enhancement in medical visualization
WO2018003906A1 (ja) * 2016-06-30 2018-01-04 興和株式会社 眼科測定装置
US11395726B2 (en) 2017-09-11 2022-07-26 Incubar Llc Conduit vascular implant sealing device for reducing endoleaks

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1531145A (fr) * 1966-07-13 1968-06-28 Ici Ltd Polyamides
US3948248A (en) * 1974-09-05 1976-04-06 Zuckerman Joel L Method of measuring ocular pulse
US3958560A (en) * 1974-11-25 1976-05-25 Wayne Front March Non-invasive automatic glucose sensor system
US4014321A (en) * 1974-11-25 1977-03-29 March Wayne F Non-invasive glucose sensor system
DE2619571A1 (de) * 1976-05-04 1977-11-17 Dynamit Nobel Ag Verfahren zum fixieren loeslicher acylasen an anorganisches traegermaterial
US4350163A (en) * 1980-05-29 1982-09-21 Ford Jr Norman C Method and apparatus for analyzing contaminants in aqueous humor
US4412543A (en) * 1981-04-09 1983-11-01 Xanar, Inc. Apparatus for determining the concentration of a fluorescent material in an eye
SE8102772L (sv) * 1981-05-04 1982-11-05 Sven Staffan Folestad Forfarande for laserinducerad fluoriscensdetektering och anordning for genomforande av forfarandet
US4592361A (en) * 1982-06-28 1986-06-03 The Johns Hopkins University Electro-optical device and method for monitoring instantaneous singlet oxygen concentration produced during photoradiation using pulsed excitation and time domain signal processing
US4883351A (en) * 1982-09-10 1989-11-28 Weiss Jeffrey N Apparatus for the detection of diabetes and other abnormalities affecting the lens of the eye
US4895159A (en) * 1982-09-10 1990-01-23 Weiss Jeffrey N Diabetes detection method
US5025785A (en) * 1982-09-10 1991-06-25 Weiss Jeffrey N Diabetes detection method
US4573778A (en) * 1983-03-16 1986-03-04 Boston University Aqueous fluorophotometer
DE3331586A1 (de) * 1983-09-01 1985-03-28 Fa. Carl Zeiss, 7920 Heidenheim Ophthalmologisches kombinationsgeraet fuer diagnose und therapie
DE3346338A1 (de) * 1983-12-22 1985-07-11 Pka Pyrolyse Kraftanlagen Gmbh, 7080 Aalen Rotierende schweltrommel zum verschwelen von abfallstoffen
US4711540A (en) * 1984-01-04 1987-12-08 Tokyo Kogaku Kikai Kabushiki Kaisha Eye disease inspecting instrument
JPS60148537A (ja) * 1984-01-12 1985-08-05 興和株式会社 レ−ザ−光を利用した眼科測定装置
US4711541A (en) * 1984-02-02 1987-12-08 Tokyo Kogaku Kikai Kabushiki Kaisha Slit lamp and accessory device thereof
JPS61243827A (ja) * 1985-04-22 1986-10-30 Toray Ind Inc 高速製糸用ナイロン66ポリマの製造方法
JPS61268230A (ja) * 1985-05-22 1986-11-27 興和株式会社 眼科測定装置
JPS61268229A (ja) * 1985-05-22 1986-11-27 興和株式会社 眼科測定装置
US4758081A (en) * 1985-07-18 1988-07-19 Bausch & Lomb Incorporated Control of laser photocoagulation using Raman radiation
US4675300A (en) * 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US4702576A (en) * 1985-09-27 1987-10-27 Cambridge Instruments Inc. Ocular scattering analyzer
US5042494A (en) * 1985-11-13 1991-08-27 Alfano Robert R Method and apparatus for detecting cancerous tissue using luminescence excitation spectra
DE3542167A1 (de) * 1985-11-29 1987-06-04 Wolfgang Prof Dr Lohmann Verfahren zur messung der augen-linsen-truebung und anordnung zur durchfuehrung des verfahrens
CH671329A5 (de) * 1986-01-21 1989-08-31 Interzeag Ag
JPS62266032A (ja) * 1986-05-12 1987-11-18 興和株式会社 眼底検査装置
JPS6399836A (ja) * 1986-05-19 1988-05-02 興和株式会社 眼科測定装置
JPS63135128A (ja) * 1986-11-27 1988-06-07 興和株式会社 眼科測定装置
JPH06100B2 (ja) * 1987-03-31 1994-01-05 興和株式会社 眼科診断装置
JP2520418B2 (ja) * 1987-04-09 1996-07-31 興和株式会社 眼科測定装置
US4877322A (en) * 1987-04-30 1989-10-31 Eyedentify, Inc. Method and apparatus for measuring blood oxygen levels in selected areas of the eye fundus
EP0292216B1 (de) * 1987-05-20 1993-11-03 Kowa Co. Ltd. Gerät zur Diagnostik von Augenleiden
US4842401A (en) * 1987-06-15 1989-06-27 The Board Of Trustees Of The Leland Stanford Jr. University Eye diagnosis process
JP2516631B2 (ja) * 1987-06-18 1996-07-24 興和株式会社 眼科測定装置
DE3851183D1 (de) * 1987-06-25 1994-09-29 Kowa Co Verfahren und Gerät zur Diagnostik von Augenleiden.
DD261957A1 (de) * 1987-07-13 1988-11-16 Friedrich Schiller Uni Jena Bf Anordnung zur kataraktfruehdiagnostik
JPS6417623A (en) * 1987-07-14 1989-01-20 Kowa Co Alignment apparatus in opthalmic apparatus
JP2520426B2 (ja) * 1987-07-15 1996-07-31 興和株式会社 眼科測定装置
US5072731A (en) * 1987-09-01 1991-12-17 Massachusetts Institute Of Technology Apparatus for detecting cataractogenesis using quasielastic light scattering
US4993827A (en) * 1987-09-01 1991-02-19 Massachusetts Institute Of Technology Method for detecting cataractogenesis
US4957113A (en) * 1987-09-01 1990-09-18 Massachusetts Institute Of Technology Method for detecting cataractogenesis using quasi-elastic light scattering
US4832483A (en) * 1987-09-03 1989-05-23 New England Medical Center Hospitals, Inc. Method of using resonance raman spectroscopy for detection of malignancy disease
US4836207A (en) * 1987-09-09 1989-06-06 The Beth Israel Hospital Association Method and apparatus to monitor cholesterol levels with photon correlation spectroscopy
JPS6469925A (en) * 1987-09-11 1989-03-15 Hitachi Cable Optical fiber type temperature distribution measuring apparatus
US4882492A (en) * 1988-01-19 1989-11-21 Biotronics Associates, Inc. Non-invasive near infrared measurement of blood analyte concentrations
US5137355A (en) * 1988-06-08 1992-08-11 The Research Foundation Of State University Of New York Method of imaging a random medium
JPH02119837A (ja) * 1988-10-28 1990-05-07 Kowa Co 眼科測定方法および装置
DD298677A5 (de) * 1989-11-16 1992-03-05 ��������`������������@�������@�������@M�������]k�� Verfahren zur bestimmung des volumenflusses
JP2994703B2 (ja) * 1990-07-23 1999-12-27 興和株式会社 眼科測定装置
US5186173A (en) * 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5139022A (en) * 1990-10-26 1992-08-18 Philip Lempert Method and apparatus for imaging and analysis of ocular tissue
US5243983A (en) * 1990-12-14 1993-09-14 Georgia Tech Research Corporation Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
US5279296A (en) * 1991-01-04 1994-01-18 Oculon Corporation Method and apparatus for detecting cataractogenesis
US5219400A (en) * 1991-06-11 1993-06-15 The United States Of America As Represented By The Secretary Of The Army Noninvasive method for quantitation of oxyhemoglobin saturation by near-infrared reflectance spectrophotometry
US5203328A (en) * 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
JPH07508426A (ja) * 1991-10-17 1995-09-21 サイエンティフィック ジェネリクス リミテッド 血液検体測定装置及びその方法
US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy
US5284149A (en) * 1992-01-23 1994-02-08 Dhadwal Harbans S Method and apparatus for determining the physical characteristics of ocular tissue
US5340991A (en) * 1993-05-21 1994-08-23 The Board Of Regents Of The University Of Oklahoma Fluorokinetic analysis of diffusion from a vessel

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EP0597932A1 (de) 1994-05-25
ES2110007T3 (es) 1998-02-01
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EP0597932A4 (de) 1994-12-07
JPH07500030A (ja) 1995-01-05
AU661026B2 (en) 1995-07-13
US5582168A (en) 1996-12-10
CA2113268C (en) 1999-01-12
DE69222535D1 (de) 1997-11-06
CA2113268A1 (en) 1993-02-04
AU2373392A (en) 1993-02-23
WO1993001745A1 (en) 1993-02-04

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