DE69227347D1 - Auf rezeptorgrundlage arbeitende screening-verfahren für amylin-agonisten und- antagonisten - Google Patents

Auf rezeptorgrundlage arbeitende screening-verfahren für amylin-agonisten und- antagonisten

Info

Publication number
DE69227347D1
DE69227347D1 DE69227347T DE69227347T DE69227347D1 DE 69227347 D1 DE69227347 D1 DE 69227347D1 DE 69227347 T DE69227347 T DE 69227347T DE 69227347 T DE69227347 T DE 69227347T DE 69227347 D1 DE69227347 D1 DE 69227347D1
Authority
DE
Germany
Prior art keywords
antagonists
amylin
screening procedures
amylin agonists
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69227347T
Other languages
English (en)
Other versions
DE69227347T2 (de
Inventor
Kevin Beaumont
Timothy Rink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amylin Pharmaceuticals LLC
Original Assignee
Amylin Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amylin Pharmaceuticals LLC filed Critical Amylin Pharmaceuticals LLC
Publication of DE69227347D1 publication Critical patent/DE69227347D1/de
Application granted granted Critical
Publication of DE69227347T2 publication Critical patent/DE69227347T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
DE69227347T 1991-03-15 1992-03-13 Auf rezeptorgrundlage arbeitende screening-verfahren für amylin-agonisten und- antagonisten Expired - Fee Related DE69227347T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/670,231 US5264372A (en) 1991-03-15 1991-03-15 Receptor-based screening methods for amylin agonists and antagonists
PCT/US1992/002125 WO1992016845A1 (en) 1991-03-15 1992-03-13 Receptor-based screening methods for amylin agonists and antagonists

Publications (2)

Publication Number Publication Date
DE69227347D1 true DE69227347D1 (de) 1998-11-26
DE69227347T2 DE69227347T2 (de) 1999-03-18

Family

ID=24689539

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227347T Expired - Fee Related DE69227347T2 (de) 1991-03-15 1992-03-13 Auf rezeptorgrundlage arbeitende screening-verfahren für amylin-agonisten und- antagonisten

Country Status (13)

Country Link
US (1) US5264372A (de)
EP (1) EP0529065B1 (de)
JP (1) JPH05508226A (de)
AT (1) ATE172540T1 (de)
AU (1) AU1663092A (de)
CA (1) CA2082929A1 (de)
DE (1) DE69227347T2 (de)
DK (1) DK0529065T3 (de)
IL (5) IL101233A (de)
MX (1) MX9201113A (de)
TW (1) TW324064B (de)
WO (1) WO1992016845A1 (de)
ZA (1) ZA921884B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580953A (en) * 1991-08-14 1996-12-03 Amylin Pharmaceuticals, Inc. Amylin antagonist peptides and uses therefor
JP2820797B2 (ja) * 1992-05-15 1998-11-05 アミリン・ファーマシューティカルズ，インコーポレイテッド アミリンの抗体アッセイ法
WO1994018571A1 (en) * 1993-02-12 1994-08-18 Amylin Pharmaceuticals, Inc. Mcf-7 binding site assays
WO1994021665A1 (en) * 1993-03-24 1994-09-29 Amylin Pharmaceuticals, Inc. Cloned receptors and methods for screening
GB9317193D0 (en) * 1993-08-18 1993-10-06 Zeneca Ltd Method
AU7685894A (en) * 1993-09-07 1995-03-27 Amylin Pharmaceuticals, Inc. Methods for regulating gastrointestinal motility
US7115728B1 (en) * 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
AU5539596A (en) * 1995-04-06 1996-10-23 Amylin Pharmaceuticals, Inc. Anti-obesity agents
US6143718A (en) * 1995-06-07 2000-11-07 Amylin Pharmaceuticals, Inc. Treatment of Type II diabetes mellutis with amylin agonists
US5739106A (en) * 1995-06-07 1998-04-14 Rink; Timothy J. Appetite regulating compositions
AU4063697A (en) * 1996-08-08 1998-02-25 Amylin Pharmaceuticals, Inc. Methods for regulating gastrointestinal motility
US5677279A (en) * 1996-12-16 1997-10-14 Amylin Pharmaceuticals, Inc. Methods and compositions for treating pain with amylin or agonists thereof
CA2277112C (en) 1997-01-07 2008-08-26 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the reduction of food intake
US7101853B2 (en) 1997-05-06 2006-09-05 Amylin Pharmaceuticals, Inc. Method for treating or preventing gastritis using amylin or amylin agonists
US7910548B2 (en) 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
WO1999005161A1 (en) 1997-07-25 1999-02-04 Ligand Pharmaceuticals Incorporated HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA (PPARη) GENE REGULATORY SEQUENCES AND USES THEREFOR
US6936584B1 (en) 1998-02-13 2005-08-30 Amylin Pharmaceuticals, Inc. Mixed amylin activity compounds
WO1999061605A2 (en) * 1998-05-26 1999-12-02 University Of Medicine And Dentistry Of New Jersey System for reproducing and modulating stability and turnover of rna molecules
US20030087820A1 (en) * 1999-01-14 2003-05-08 Young Andrew A. Novel exendin agonist formulations and methods of administration thereof
US7399489B2 (en) * 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
EP1143989B1 (de) * 1999-01-14 2006-12-13 Amylin Pharmaceuticals, Inc. Exendine zur glucagon suppression
US6924264B1 (en) * 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
NZ514916A (en) 1999-04-30 2004-06-25 Amylin Pharmaceuticals Inc Exendins and exendin agonists linked to polyethylene glycol polymers
WO2001033220A2 (en) * 1999-07-13 2001-05-10 Amylin Pharmaceuticals, Inc. The use of the area postreama to identify therapeutic compounds
CA2425293A1 (en) * 2000-10-10 2002-04-18 Institut Fur Virologie Teilrechtsfahiges Institut An Der Veterinarmedizi Nischen Universitat Wien A novel system for the evaluation of the activity and/or specificity of a viral component
US20040005997A1 (en) * 2002-06-27 2004-01-08 The Procter & Gamble Company Methods for identifying compounds for regulating muscle mass of function using amylin receptors
DE60319093T2 (de) * 2002-08-06 2009-02-05 Sanofi-Aventis Deutschland Gmbh Verfahren zur isolierung eines intestilanen cholesterin bindenproteins
WO2004037168A2 (en) * 2002-10-18 2004-05-06 Amylin Pharmaceuticals, Inc. Treatment of pancreatitis with amylin
US20040214180A1 (en) * 2003-04-28 2004-10-28 Hironori Kobayashi Method and kit for determining quantity of protein
WO2005021026A2 (en) * 2003-08-29 2005-03-10 Amylin Pharmaceuticals, Inc. Methods for treating or ameliorating ghrelin-associated diseases and disorders
EP2233497A3 (de) 2004-02-11 2011-01-12 Amylin Pharmaceuticals, Inc. Peptide der amylin Familie, Verfahren zu deren Herstellung und Verwendung
US7399744B2 (en) * 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
AU2005295043A1 (en) 2004-10-08 2006-04-20 Amylin Pharmaceuticals, Inc. Amylin family polypeptide-6 (AFP-6) analogs and methods of making and using them
DE102004051014A1 (de) * 2004-10-20 2006-04-27 Rwth Aachen Chemisch modifizierte Peptidanaloga
CA2584806C (en) 2004-11-01 2014-06-17 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
US8394765B2 (en) * 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
WO2006055167A1 (en) * 2004-11-12 2006-05-26 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Regulation of f1-atpase beta subunit cellular location
ES2330671T3 (es) 2005-03-31 2009-12-14 Amylin Pharmaceuticals, Inc. Amilina y agonistas de amilina para el tratamiento de enfermedades y trastornos psiquiatricos.
WO2007014051A2 (en) * 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
WO2009064298A1 (en) * 2007-11-14 2009-05-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity and obesity related diseases and disorders
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
US9850302B2 (en) 2013-07-12 2017-12-26 Prothena Biosciences Limited Antibodies that recognize IAPP

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434236A (en) * 1982-10-20 1984-02-28 E. I. Du Pont De Nemours & Co. Immunoassay wherein labeled antibody is displaced from immobilized analyte-analogue
ATE128359T1 (de) * 1988-01-11 1995-10-15 Amylin Pharmaceuticals Inc Behandlung von diabetes mellitus typ 2.
CA2020786A1 (en) * 1989-07-10 1991-01-11 Amylin Pharmaceuticals, Inc. Treatment of obesity and essential hypertension and related disorders

Also Published As

Publication number Publication date
EP0529065B1 (de) 1998-10-21
IL101233A (en) 1997-04-15
US5264372A (en) 1993-11-23
EP0529065A1 (de) 1993-03-03
IL120081A (en) 1998-12-27
WO1992016845A1 (en) 1992-10-01
DK0529065T3 (da) 1999-06-28
IL120082A (en) 1998-12-27
ZA921884B (en) 1993-08-03
IL120082A0 (en) 1997-04-15
IL101233A0 (en) 1992-11-15
ATE172540T1 (de) 1998-11-15
CA2082929A1 (en) 1992-09-16
EP0529065A4 (en) 1993-10-20
MX9201113A (es) 1992-10-01
AU1663092A (en) 1992-10-21
TW324064B (en) 1998-01-01
IL120081A0 (en) 1997-04-15
DE69227347T2 (de) 1999-03-18
JPH05508226A (ja) 1993-11-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee