DE69229779D1 - Konvertierbare mikroemulsionsverbindungen - Google Patents

Konvertierbare mikroemulsionsverbindungen

Info

Publication number
DE69229779D1
DE69229779D1 DE69229779T DE69229779T DE69229779D1 DE 69229779 D1 DE69229779 D1 DE 69229779D1 DE 69229779 T DE69229779 T DE 69229779T DE 69229779 T DE69229779 T DE 69229779T DE 69229779 D1 DE69229779 D1 DE 69229779D1
Authority
DE
Germany
Prior art keywords
microemulsion
water
connections
emulsion
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69229779T
Other languages
English (en)
Other versions
DE69229779T2 (de
Inventor
Albert Owen
Seang Yiv
Ani Sarkahian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LDS Technologies Inc
Original Assignee
LDS Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LDS Technologies Inc filed Critical LDS Technologies Inc
Publication of DE69229779D1 publication Critical patent/DE69229779D1/de
Application granted granted Critical
Publication of DE69229779T2 publication Critical patent/DE69229779T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/23Calcitonins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/25Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH] (Somatotropin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/363Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
DE69229779T 1991-04-19 1992-04-15 Konvertierbare mikroemulsionsverbindungen Expired - Lifetime DE69229779T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68769191A 1991-04-19 1991-04-19
US83734792A 1992-02-14 1992-02-14
US84193192A 1992-02-25 1992-02-25
PCT/US1992/003086 WO1992018147A1 (en) 1991-04-19 1992-04-15 Convertible microemulsion formulations

Publications (2)

Publication Number Publication Date
DE69229779D1 true DE69229779D1 (de) 1999-09-16
DE69229779T2 DE69229779T2 (de) 1999-12-23

Family

ID=27418494

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229779T Expired - Lifetime DE69229779T2 (de) 1991-04-19 1992-04-15 Konvertierbare mikroemulsionsverbindungen

Country Status (16)

Country Link
US (3) US5444041A (de)
EP (1) EP0580778B1 (de)
JP (1) JPH06507172A (de)
CN (1) CN1066183A (de)
AT (1) ATE183099T1 (de)
AU (1) AU668509B2 (de)
CA (1) CA2108266C (de)
DE (1) DE69229779T2 (de)
DK (1) DK0580778T3 (de)
ES (1) ES2136620T3 (de)
GR (1) GR3031718T3 (de)
IE (1) IE921212A1 (de)
IL (1) IL101613A (de)
MX (1) MX9201816A (de)
PT (1) PT100400B (de)
WO (1) WO1992018147A1 (de)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06507172A (ja) * 1991-04-19 1994-08-11 アフィニティー バイオテック,インコーポレイテッド 転換可能なミクロエマルジョン処方剤
US5688761A (en) * 1991-04-19 1997-11-18 Lds Technologies, Inc. Convertible microemulsion formulations
WO1994008603A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
JPH08505367A (ja) * 1992-10-16 1996-06-11 スミスクライン・ビーチャム・コーポレイション 医薬用エマルジョン組成物
AU679013B2 (en) * 1992-10-16 1997-06-19 Ibah, Inc. Convertible microemulsion formulations
EP0666752A4 (de) * 1992-10-16 1996-09-11 Smithkline Beecham Corp Therapeutische mikroemulsionen.
DK17093D0 (da) * 1993-02-15 1993-02-15 Lyfjathroun H F Farmaceutisk praeparat til topisk administrering af antigener og/eller vacciner til pattedyr via slimhinder
JPH06279228A (ja) * 1993-03-30 1994-10-04 Kao Corp 発泡性組成物
US5948825A (en) * 1993-04-19 1999-09-07 Institute For Advanced Skin Research Inc. Microemulsion preparation containing a slightly absorbable substance
US6191105B1 (en) * 1993-05-10 2001-02-20 Protein Delivery, Inc. Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5744155A (en) * 1993-08-13 1998-04-28 Friedman; Doron Bioadhesive emulsion preparations for enhanced drug delivery
JPH09512037A (ja) * 1993-09-29 1997-12-02 コンソルツイオ・テクノバイオチツプ・ソチエタ・コンソルテイレ・エイ・アール・エル タンパク質薄フィルム及びその製造で用いるための組成物
DE4335045A1 (de) * 1993-10-14 1995-04-20 Henkel Kgaa Fließfähiges Emulsionskonzentrat
DE69434626D1 (de) * 1993-11-17 2006-04-20 Athena Neurosciences Inc Transparente flüssigkeit zur verabreichung von verkapselten medikamenten
CA2185803C (en) * 1994-03-18 2006-07-11 Edward M. Rudnic Emulsified drug delivery systems
US5672358A (en) * 1994-06-21 1997-09-30 Ascent Pharmaceuticals, Inc. Controlled release aqueous emulsion
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
JPH0827018A (ja) * 1994-07-22 1996-01-30 Sanwa Kagaku Kenkyusho Co Ltd 生理活性ペプチド又は蛋白質を含有する薬剤組成物
US5707641A (en) * 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
AU698317B2 (en) 1995-02-25 1998-10-29 Cancer Research Technology Limited Transgenic animals as model of psoriasis
DE19509079A1 (de) * 1995-03-15 1996-09-19 Beiersdorf Ag Kosmetische oder dermatologische Mikroemulsionen
US6689370B1 (en) 1995-04-20 2004-02-10 Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
US6117432A (en) * 1995-04-20 2000-09-12 Societe D'exploitation De Produits Pour Les Industries Chimiques (S.E.P.P.I.C.) Therapeutic composition comprising an antigen or an in vivo generator of a compound comprising an amino acid sequence
FR2733151B1 (fr) * 1995-04-20 1997-05-23 Seppic Sa Composition therapeutique comprenant un antigene ou un generateur in vivo d'un compose comprenant une sequence d'acides amines
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US5766636A (en) * 1995-09-06 1998-06-16 Natura, Inc. Edible, low calorie compositions of a carrier and an active ingredient and methods for preparation thereof
SE9503143D0 (sv) 1995-09-12 1995-09-12 Astra Ab New preparation
ES2277339T3 (es) * 1995-11-30 2007-07-01 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Vacuna con adyuvante de aceite y metodo para su preparacion.
US5858401A (en) * 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
WO1997029773A1 (fr) * 1996-02-13 1997-08-21 The Nisshin Oil Mills, Ltd. Emulsion et poudre renfermant un vaccin et destinees a une administration orale, et procede de production associe
US6245349B1 (en) 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
EP0914094A4 (de) 1996-03-28 2000-03-01 Univ Illinois Materialen und verfahren zur herstellung verbesserter liposomaler mittel
US5726154A (en) * 1996-06-28 1998-03-10 University Of Utah Research Foundation Stabilization and oral delivery of calcitonin
DE69723375T3 (de) * 1996-08-30 2012-12-20 Ajinomoto Co., Inc. Waschmittelzusammensetzung
WO1998013032A1 (en) * 1996-09-27 1998-04-02 Trega Biosciences, Inc. Compositions of therapeutic agents suitable for oral administration
SE511313C2 (sv) 1997-01-13 1999-09-06 Gs Dev Ab Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US7585645B2 (en) * 1997-05-27 2009-09-08 Sembiosys Genetics Inc. Thioredoxin and thioredoxin reductase containing oil body based products
IS4518A (is) * 1997-07-09 1999-01-10 Lyfjathroun Hf, The Icelandic Bio Pharmaceutical Group Nýtt lyfjaform fyrir bóluefni
US6217886B1 (en) 1997-07-14 2001-04-17 The Board Of Trustees Of The University Of Illinois Materials and methods for making improved micelle compositions
FR2767064B1 (fr) * 1997-08-07 1999-11-12 Centre Nat Rech Scient Procede de liberation d'un principe actif contenu dans une emulsion multiple
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6024786A (en) * 1997-10-30 2000-02-15 Hewlett-Packard Company Stable compositions of nano-particulate unmodified pigments and insoluble colorants in aqueous microemulsions, and principle of stability and methods of formation thereof
US20020031513A1 (en) * 1997-11-24 2002-03-14 Shamir Leibovitz Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
DE19806889A1 (de) * 1998-02-19 1999-08-26 Beiersdorf Ag Verwendung von Acyl-Carnitin
US20030180368A1 (en) * 1998-03-14 2003-09-25 Cenes Drug Delivery Limited Production of microparticles
TWI241915B (en) 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6241969B1 (en) 1998-06-26 2001-06-05 Elan Corporation Plc Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
US8466134B1 (en) 1998-06-26 2013-06-18 Athena Neurosciences, Inc. Aqueous compositions containing corticosteroids for nasal and pulmonary delivery
FR2780644B1 (fr) * 1998-07-03 2001-07-20 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse et d'une phase aqueuse, stabilisee a l'aide de particules de gel cubique
EP0976394A1 (de) * 1998-07-30 2000-02-02 Biosearch Italia S.p.A. Neue injizierbare Formulierungen
EP1104290B1 (de) 1998-08-13 2010-03-31 Cima Labs Inc. Microemulsionen als feste dosisformen zur oralen verabreichung
US6174547B1 (en) * 1999-07-14 2001-01-16 Alza Corporation Dosage form comprising liquid formulation
DE19859427A1 (de) * 1998-12-22 2000-06-29 Beiersdorf Ag Kosmetische oder pharmazeutische lecithinhaltige Gele oder niedrigviskose, lecithinhaltige O/W-Mikroemulsionen
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
EP1064934A1 (de) 1999-06-30 2001-01-03 Applied Research Systems ARS Holding N.V. Gefriergetrocknete GRF-enthaltende Arzneimittel
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
GB0005736D0 (en) * 2000-03-09 2000-05-03 G C Hahn Co Ltd Low fat edible emulsions
DE10015463B4 (de) * 2000-03-29 2008-01-10 Heide, Peter Edgar, Dr. Creme in Form einer überwässerten Wasser-in-Öl-Emulsion
WO2001097837A1 (en) * 2000-06-21 2001-12-27 Ferring Bv Solubilised protein vaccines
AU8436401A (en) 2000-07-31 2002-02-13 Univ Bar Ilan Methods and pharmaceutical compositions for healing wounds
US20060258562A1 (en) * 2000-07-31 2006-11-16 Healor Ltd. Methods and pharmaceutical compositions for healing wounds
US20100129332A1 (en) * 2000-07-31 2010-05-27 Tamar Tennenbaum Methods and pharmaceutical compositions for healing wounds
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US20030148924A1 (en) * 2002-07-09 2003-08-07 Tamar Tennenbaum Methods and pharmaceutical compositions of healing wounds
US6582682B2 (en) * 2000-10-30 2003-06-24 Noville, Inc. Oral care compositions comprising stabilized chlorine dioxide
CN1406131A (zh) * 2000-12-25 2003-03-26 株式会社资生堂 活化交感神经的香料组合物
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6692771B2 (en) 2001-02-23 2004-02-17 Cima Labs Inc. Emulsions as solid dosage forms for oral administration
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
EP1528937B1 (de) * 2001-06-05 2016-08-10 The Regents Of The University Of Michigan Nanoemulsionsvakzine
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
WO2003047494A2 (en) * 2001-12-03 2003-06-12 Dor Biopharma Inc. Reverse micelle compositions and uses thereof
US8535650B2 (en) * 2001-12-03 2013-09-17 Soligenix, Inc. Stabilized reverse micelle compositions and uses thereof
BR0307913A (pt) * 2002-02-25 2005-01-11 Lyfjathroun Hf Uso de uma composição, composição farmacêutica para administração nasal, e, métodos para eliciar um efeito terapêutico, profilático e/ou diagnóstico em um mamìfero, para obter um inìcio rápido de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero e para melhorar a biodisponibilidade de um efeito terapêutico, profilático e/ou diagnóstico de uma substância ativa em um mamìfero
US20050124705A1 (en) * 2002-03-28 2005-06-09 Beiersdorf Ag Cosmetic or pharmaceutical, low-viscosity oil-in-water emulsions containing phospholipids
AU2003223005A1 (en) * 2002-05-06 2003-11-17 Vectura Limited Application device for topical administration of pharmaceutical agents
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10226990A1 (de) * 2002-06-18 2004-03-18 Sanguibiotech Ag Topisch applizierbare Mikro-Emulsionen mit binärer Phasen- und Wirkstoffdifferenzierbarkeit, deren Herstellung und deren Verwendung, insbesondere zur Versorgung der Haut mit bioverfügbarem Sauerstoff
CA2430889A1 (en) * 2002-06-19 2003-12-19 Bayer Corporation Stabilization of brain natriuretic peptide (bnp) in blood samples, methods and compositions related thereto
US6855332B2 (en) 2002-07-03 2005-02-15 Lyfjathroun Hf. Absorption promoting agent
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
US20050196370A1 (en) * 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
KR100515752B1 (ko) * 2003-05-16 2005-09-20 주식회사 엘지화학 초임계 유체를 이용한 스티렌과 말레이미드 공중합체의제조 방법
US7445933B2 (en) * 2003-07-16 2008-11-04 Abbott Laboratories, Inc. Stable calibrators or controls for measuring human natriuretic peptides
US7291501B2 (en) 2003-07-16 2007-11-06 Abbott Laboratories Stable compositions for measuring human natriuretic peptides
US7004340B2 (en) * 2003-07-25 2006-02-28 Alpha Security Products, Inc. Bottle security device
AU2004263009B2 (en) 2003-08-07 2009-12-24 Healor Ltd. Pharmaceutical compositions and methods for accelerating wound healing
US9259390B2 (en) * 2003-08-13 2016-02-16 The University Of Houston System Parenteral and oral formulations of benzimidazoles
CN1893931B (zh) * 2003-10-27 2011-07-20 陶氏康宁公司 局部用制剂及将活性剂传递给基底的方法
WO2005053612A2 (en) * 2003-11-26 2005-06-16 Shire Laboratories, Inc. Micellar systems useful for delivery of lipophilic or hydrophobic compounds
PE20050596A1 (es) * 2003-12-19 2005-10-18 Novartis Ag Microemulsion que comprende un inhibidor renina
US20050232974A1 (en) * 2004-04-19 2005-10-20 Gore Makarand P System and a method for pharmaceutical dosage preparation using jettable microemulsions
US20050238675A1 (en) * 2004-04-26 2005-10-27 Wenjie Li Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US7357957B2 (en) * 2004-05-07 2008-04-15 Fractec Research & Development Inc. Spreadable food product
US20070093610A1 (en) * 2004-05-12 2007-04-26 Kim Dong R Method for preparing styrene and maleimide copolymer using super critical fluid
ES2618028T3 (es) 2004-07-19 2017-06-20 Biocon Limited Conjugados insulina-oligómero, formulaciones y usos de éstos.
US20060078623A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
US20080262084A1 (en) * 2004-09-13 2008-10-23 Gautam Vinod Daftary Stable Emulsion Compositions for Intravenous Administration Having Preservatie Efficacy
DE102004049574A1 (de) 2004-10-12 2006-04-20 Doris Dr. Barnikol-Keuten Arzneimittel und System zur perkutanen Arzneistoffverabreichung
WO2006078059A1 (ja) * 2005-01-19 2006-07-27 Dainippon Sumitomo Pharma Co., Ltd. 希釈用乳化組成物および癌ワクチン組成物
US20060205904A1 (en) * 2005-03-11 2006-09-14 St Clair David J Oil gels of controlled distribution block copolymers and ester oils
EP2985026B1 (de) 2005-04-15 2022-08-03 Clarus Therapeutics, Inc. Systeme zur pharmazeutischen verabreichung hydrophober wirkstoffe und zusammensetzungen damit
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
EP1906974A4 (de) * 2005-07-22 2010-06-23 Univ California Heparinzusammensetzungen und selectin-hemmung
US20070042007A1 (en) * 2005-08-19 2007-02-22 Joseph Schwarz Topical composition for delivery of salicylate esters
EP1940440A4 (de) * 2005-08-29 2009-11-11 Healor Ltd Verfahren und zusammensetzungen zur prävention und behandlung von diabetischer und gealterter haut
DOP2006000267A (es) * 2005-11-30 2009-06-30 Colgate Palmalive Company Composiciones y métodos de limpieza
US20070243132A1 (en) * 2005-12-22 2007-10-18 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
CN101437522A (zh) * 2006-04-07 2009-05-20 默里昂研究Ⅲ有限公司 包含增强剂的固体口服剂型
GB0623838D0 (en) * 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
US9918934B2 (en) * 2006-12-12 2018-03-20 Edgar Joel Acosta-Zara Linker-based lecithin microemulsion delivery vehicles
US7968635B2 (en) * 2006-12-28 2011-06-28 Continental Ag Tire compositions and components containing free-flowing filler compositions
FR2915101B1 (fr) * 2007-04-23 2011-07-29 Fabre Pierre Dermo Cosmetique Composition dermatologique pour la prevention et/ou le traitement de la rosacee, de la couperose ou des peaux qui presentent des rougeurs diffuses ou des petits vaisseaux dilates
CN101835486B (zh) * 2007-07-30 2012-12-12 希尔洛有限公司 用于治疗创伤的药物组合物以及相关方法
JP5156458B2 (ja) * 2008-03-31 2013-03-06 理研ビタミン株式会社 ソフトカプセル充填用液状組成物
CN101772352B (zh) * 2007-09-27 2012-05-23 理研维他命株式会社 软胶囊填充用液态组合物
AU2008313248B2 (en) 2007-10-16 2012-04-26 Biocon Limited An orally administerable solid pharmaceutical composition and a process thereof
CA2711114A1 (en) * 2008-01-02 2009-07-16 Kringle Pharma Inc. Topical compositions for the controlled delivery of proteins and peptides
BRPI0912384A2 (pt) * 2008-05-07 2015-10-13 Merrion Res Iii Ltd composição, e, método para preparar uma composição
US20100004196A1 (en) * 2008-06-17 2010-01-07 Hopitaux Universitaires De Geneve Heparan sulfate proteoglycan composition and use thereof
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
AU2010217213B2 (en) * 2009-02-24 2013-05-23 Healor Ltd. Visfatin therapeutic agents for the treatment of acne and other conditions
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
ES2600929T3 (es) * 2009-09-10 2017-02-13 Merial, Inc. Nuevas formulaciones de vacuna que comprenden adyuvantes que contienen saponina
SG181487A1 (en) * 2009-12-10 2012-07-30 Merck Patent Gmbh Pharmaceutical composition comprising oligopeptides, preferably cilengitide
EP2536421A4 (de) 2010-01-11 2013-10-09 Healor Ltd Verfahren zur behandlung von schuppenflechte
MX2012007806A (es) 2010-01-12 2012-08-01 Novo Nordisk As Composiciones farmaceuticas para administracion oral de peptidos de insulina.
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
FR2964332A1 (fr) * 2010-09-06 2012-03-09 Capsum Nanodispersions inverses stables
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9168309B2 (en) 2010-12-01 2015-10-27 Omnis Biotechnology Inc. Thixotropic compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
KR20140026354A (ko) 2011-01-07 2014-03-05 메리온 리서치 Ⅲ 리미티드 경구 투여용 철의 제약 조성물
GB201107630D0 (en) * 2011-05-06 2011-06-22 Proxima Concepts Ltd Microemulsions
KR102276161B1 (ko) 2011-10-25 2021-07-14 프로테나 바이오사이언시즈 리미티드 항체 제형 및 방법
EP3129002A4 (de) * 2014-04-09 2017-11-08 Nanoceutica Laboratories Pvt. Ltd Zusammensetzung und verfahren zur herstellung einer nanoformulierung aus wasserunlöslichen bioaktiven stoffen in wässriger base
EP2946788A1 (de) 2014-05-23 2015-11-25 Immundiagnostik AG Verfahren und Zusammensetzung zur Behandlung von Herzversagen mit erhaltener Austreibungsfraktion
US20170246187A1 (en) 2014-08-28 2017-08-31 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
US9872832B2 (en) * 2015-10-23 2018-01-23 LG Bionano, LLC Nanoemulsions having reversible continuous and dispersed phases
US20180077951A1 (en) * 2016-09-16 2018-03-22 Kemin Industries, Inc. Animal feed supplement
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
KR101786914B1 (ko) * 2017-01-31 2017-11-15 주식회사 삼양사 피부 리프팅 또는 탄력 개선을 위한 점착성 탄력 밴드
CN112915916B (zh) * 2021-01-29 2022-05-24 江南大学 一种pH刺激响应型胆汁盐Pickering复合乳化剂

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US962957A (en) * 1909-03-26 1910-06-28 Albert G Hermanson Mole-plow.
US962956A (en) * 1909-10-02 1910-06-28 Almon E Hall Coin-mailing device.
US3083142A (en) * 1958-02-27 1963-03-26 Glaxo Group Ltd Improved swine erysipelas vaccine
US3100178A (en) * 1961-08-31 1963-08-06 Parke Davis & Co Vaccine products and method of preparing same
US3149036A (en) * 1961-10-16 1964-09-15 Merck & Co Inc Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent
US3438782A (en) * 1965-01-18 1969-04-15 Vitamins Inc Edible oil supplement for feed ration
US3492399A (en) * 1965-09-27 1970-01-27 Samuel J Prigal Emulsion compositions and methods
GB1171125A (en) * 1966-06-08 1969-11-19 Glaxo Lab Ltd Improvements in or relating to Injectable Preparations
US3776857A (en) * 1971-09-24 1973-12-04 Witco Chemical Corp Water-in-oil emulsions
US3983228A (en) * 1973-08-28 1976-09-28 Merck & Co., Inc. Water-in-oil adjuvant composition
DE2514873C2 (de) * 1975-04-05 1983-12-29 Merck Patent Gmbh, 6100 Darmstadt Salbengrundlage
FR2321896A1 (fr) * 1975-08-29 1977-03-25 Anvar Agents adjuvants immunologiques actifs en solution aqueuse
US4122158A (en) * 1976-09-23 1978-10-24 Alza Corporation Topical therapeutic preparations
JPS5940137B2 (ja) * 1976-10-14 1984-09-28 武田薬品工業株式会社 経口投与用医薬組成物
US4104403A (en) * 1976-12-21 1978-08-01 Witco Chemical Corporation Water-oil emulsions and method of preparing same
US4183918A (en) * 1977-03-08 1980-01-15 Exxon Research & Engineering Co. Detoxifying-medicinal emulsions
US4241051A (en) * 1977-11-04 1980-12-23 Christie Robert B Calcitonin
US4395394A (en) * 1979-10-26 1983-07-26 Pfizer Inc. Use of lipid amines formulated with fat or lipid emulsions as vaccine adjuvants
IT1139177B (it) * 1980-09-19 1986-09-24 Elf Aquitaine Microemulsione di sostanze nutritive
FR2502951B1 (fr) * 1981-04-06 1985-12-06 Sandoz Sa Compositions pharmaceutiques topiques sous forme d'une micro-emulsion
EP0073856A1 (de) * 1981-08-28 1983-03-16 Gist-Brocades N.V. Impfstoff gegen ansteckende Bronchitis bei Geflügel, kombinierte Impfstoffe gegen ansteckende Bronchitis, Verfahren zu deren Herstellung, Verfahren zur Vorbeugung der ansteckenden Bronchitis und Virenstamm der ansteckenden Bronchitis
NL8301996A (nl) * 1983-06-06 1985-01-02 Duphar Int Res Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins.
US4731384A (en) * 1983-07-01 1988-03-15 Troponwerke Gmbh & Co, Kg Etofenamate formulation
JPS6061535A (ja) * 1983-08-24 1985-04-09 エフ・ホフマン・ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 製薬学的組成物
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
DE3339236A1 (de) * 1983-10-28 1985-05-09 Bayer Ag Arzneimittelzubereitung
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用w/o/w型複合エマルジヨンの製造法
US4963367A (en) * 1984-04-27 1990-10-16 Medaphore, Inc. Drug delivery compositions and methods
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
CH662944A5 (it) * 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
GB8426467D0 (en) * 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
JPS61185332A (ja) * 1985-02-12 1986-08-19 Morinaga Milk Ind Co Ltd 安定な油中水型乳化物およびその製造法
US4690774A (en) * 1985-09-11 1987-09-01 Chesebrough Pond's Inc. Novel translucent water in oil emulsions
US4980084A (en) * 1985-09-11 1990-12-25 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Water rinsable petroleum jelly compositions
US5036045A (en) * 1985-09-12 1991-07-30 The University Of Virginia Alumni Patents Foundation Method for increasing growth hormone secretion
US4797272A (en) * 1985-11-15 1989-01-10 Eli Lilly And Company Water-in-oil microemulsions for cosmetic uses
US4781914A (en) * 1985-12-04 1988-11-01 Charles Of The Ritz Group Ltd. Sunscreen and moisturizer
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806350A (en) * 1986-04-18 1989-02-21 Norden Laboratories, Inc. Vaccine formulation
JPS62270521A (ja) * 1986-05-16 1987-11-24 Green Cross Corp:The フルルビプロフエン眼投与製剤
US5371109A (en) * 1986-07-01 1994-12-06 Drilletten Ab Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase
SE457693B (sv) * 1986-07-01 1989-01-23 Drilletten Ab Komposition med reglerad frigoering vari ett biologiskt material aer loest eller dispergerat i en l2-fas
ATE74009T1 (de) * 1986-08-11 1992-04-15 American Cyanamid Co Zusammensetzungen zur parenteralen verabreichung und deren verwendung.
GB8630273D0 (en) * 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
IE60024B1 (en) * 1987-02-03 1994-05-18 Stiefel Laboratories Ltd Microemulsions
CA1301642C (en) * 1987-03-30 1992-05-26 Howard Bernard Dawson Chemical formulations
US4720353A (en) * 1987-04-14 1988-01-19 Richardson-Vicks Inc. Stable pharmaceutical w/o emulsion composition
US5064653A (en) * 1988-03-29 1991-11-12 Ferris Mfg. Co. Hydrophilic foam compositions
US5026825A (en) * 1988-09-08 1991-06-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Intranasal calcitonin formulations
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US5036108A (en) * 1988-12-14 1991-07-30 Kao Corporation Water-in-oil emulsion cosmetic
KR910004884B1 (ko) * 1989-02-01 1991-07-15 한국식품개발연구원 유지류의 산화억제방법
US5002771A (en) * 1989-02-06 1991-03-26 Rorer Pharmaceutical Corp. Calcitonin suppository formulations
DE3919982A1 (de) * 1989-06-19 1990-12-20 Liedtke Pharmed Gmbh Orale lipidarzneiform
JP2785981B2 (ja) * 1989-11-20 1998-08-13 株式会社資生堂 乳化組成物
US5045337A (en) * 1990-04-19 1991-09-03 The Procter & Gamble Company Food microemulsion
US5162378A (en) * 1990-04-20 1992-11-10 Revlon Consumer Products Corporation Silicone containing water-in-oil microemulsions having increased salt content
US5110606A (en) * 1990-11-13 1992-05-05 Affinity Biotech, Inc. Non-aqueous microemulsions for drug delivery
JPH06507172A (ja) * 1991-04-19 1994-08-11 アフィニティー バイオテック,インコーポレイテッド 転換可能なミクロエマルジョン処方剤
AU667483B2 (en) * 1991-07-26 1996-03-28 Smithkline Beecham Corporation W/O microemulsions
IL102633A0 (en) * 1991-07-26 1993-01-14 Smithkline Beecham Corp Compositions
WO1993006921A1 (en) * 1991-10-04 1993-04-15 Gs Biochem Ab Particles, method of preparing said particles and uses thereof
US5206219A (en) * 1991-11-25 1993-04-27 Applied Analytical Industries, Inc. Oral compositions of proteinaceous medicaments
EP0666752A4 (de) * 1992-10-16 1996-09-11 Smithkline Beecham Corp Therapeutische mikroemulsionen.
WO1994008603A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Corporation Compositions
JPH08505367A (ja) * 1992-10-16 1996-06-11 スミスクライン・ビーチャム・コーポレイション 医薬用エマルジョン組成物

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ES2136620T3 (es) 1999-12-01
CA2108266A1 (en) 1992-10-20
IL101613A (en) 1998-02-22
JPH06507172A (ja) 1994-08-11
DK0580778T3 (da) 2000-01-31
ATE183099T1 (de) 1999-08-15
EP0580778A4 (en) 1996-01-31
PT100400A (pt) 1993-08-31
US5444041A (en) 1995-08-22
GR3031718T3 (en) 2000-02-29
US5633226A (en) 1997-05-27
DE69229779T2 (de) 1999-12-23
CA2108266C (en) 2003-06-03
CN1066183A (zh) 1992-11-18
IE921212A1 (en) 1992-10-21
EP0580778B1 (de) 1999-08-11
AU668509B2 (en) 1996-05-09
WO1992018147A1 (en) 1992-10-29
AU1896692A (en) 1992-11-17
US5646109A (en) 1997-07-08
PT100400B (pt) 1999-08-31
EP0580778A1 (de) 1994-02-02

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