DE69230254T2 - Herstellung von Mikropartikeln - Google Patents

Herstellung von Mikropartikeln

Info

Publication number
DE69230254T2
DE69230254T2 DE69230254T DE69230254T DE69230254T2 DE 69230254 T2 DE69230254 T2 DE 69230254T2 DE 69230254 T DE69230254 T DE 69230254T DE 69230254 T DE69230254 T DE 69230254T DE 69230254 T2 DE69230254 T2 DE 69230254T2
Authority
DE
Germany
Prior art keywords
microcapsules
pct
volatile oil
sec
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230254T
Other languages
English (en)
Other versions
DE69230254D1 (de
Inventor
Lisbeth Illum
Olufunmiloyo Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Publication of DE69230254D1 publication Critical patent/DE69230254D1/de
Application granted granted Critical
Publication of DE69230254T2 publication Critical patent/DE69230254T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
DE69230254T 1991-08-01 1992-08-03 Herstellung von Mikropartikeln Expired - Fee Related DE69230254T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919116610A GB9116610D0 (en) 1991-08-01 1991-08-01 Preparation of microparticles
PCT/GB1992/001421 WO1993002712A1 (en) 1991-08-01 1992-08-03 Preparation of microparticles

Publications (2)

Publication Number Publication Date
DE69230254D1 DE69230254D1 (de) 1999-12-09
DE69230254T2 true DE69230254T2 (de) 2000-03-16

Family

ID=10699347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230254T Expired - Fee Related DE69230254T2 (de) 1991-08-01 1992-08-03 Herstellung von Mikropartikeln

Country Status (14)

Country Link
US (1) US5648095A (de)
EP (1) EP0596984B1 (de)
JP (1) JP3604381B2 (de)
AT (1) ATE186221T1 (de)
AU (1) AU665206B2 (de)
CA (1) CA2113901C (de)
DE (1) DE69230254T2 (de)
DK (1) DK0596984T3 (de)
ES (1) ES2140415T3 (de)
FI (1) FI107993B (de)
GB (2) GB9116610D0 (de)
GR (1) GR3032234T3 (de)
NO (1) NO308448B1 (de)
WO (1) WO1993002712A1 (de)

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GB2273657B (en) 1995-03-15
DE69230254D1 (de) 1999-12-09
AU2376892A (en) 1993-03-02
NO940319L (no) 1994-01-31
CA2113901A1 (en) 1993-02-18
AU665206B2 (en) 1995-12-21
EP0596984A1 (de) 1994-05-18
ATE186221T1 (de) 1999-11-15
CA2113901C (en) 2003-12-02
FI107993B (fi) 2001-11-15
US5648095A (en) 1997-07-15
ES2140415T3 (es) 2000-03-01
FI940456A (fi) 1994-01-31
WO1993002712A1 (en) 1993-02-18
GB9116610D0 (en) 1991-09-18
GR3032234T3 (en) 2000-04-27
JP3604381B2 (ja) 2004-12-22
DK0596984T3 (da) 2000-01-03
GB2273657A (en) 1994-06-29
NO940319D0 (no) 1994-01-31
JPH06511423A (ja) 1994-12-22
FI940456A0 (fi) 1994-01-31
GB9400981D0 (en) 1994-04-13
EP0596984B1 (de) 1999-11-03

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