DE69230885D1 - Gasförmige ultraschallkontrastmittel - Google Patents

Gasförmige ultraschallkontrastmittel

Info

Publication number
DE69230885D1
DE69230885D1 DE69230885T DE69230885T DE69230885D1 DE 69230885 D1 DE69230885 D1 DE 69230885D1 DE 69230885 T DE69230885 T DE 69230885T DE 69230885 T DE69230885 T DE 69230885T DE 69230885 D1 DE69230885 D1 DE 69230885D1
Authority
DE
Germany
Prior art keywords
agents
microbubbles
gases
comprised
produced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230885T
Other languages
English (en)
Other versions
DE69230885T3 (de
DE69230885T2 (de
Inventor
Steven C Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Sonus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27116965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69230885(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/893,657 external-priority patent/US5409688A/en
Application filed by Sonus Pharmaceuticals Inc filed Critical Sonus Pharmaceuticals Inc
Publication of DE69230885D1 publication Critical patent/DE69230885D1/de
Application granted granted Critical
Publication of DE69230885T2 publication Critical patent/DE69230885T2/de
Publication of DE69230885T3 publication Critical patent/DE69230885T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
DE69230885T 1991-09-17 1992-09-02 Gasförmige ultraschallkontrastmittel Expired - Lifetime DE69230885T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US76131191A 1991-09-17 1991-09-17
US893657 1992-06-05
US07/893,657 US5409688A (en) 1991-09-17 1992-06-05 Gaseous ultrasound contrast media
PCT/US1992/007250 WO1993005819A1 (en) 1991-09-17 1992-09-02 Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
US761311 2001-01-17

Publications (3)

Publication Number Publication Date
DE69230885D1 true DE69230885D1 (de) 2000-05-11
DE69230885T2 DE69230885T2 (de) 2001-06-07
DE69230885T3 DE69230885T3 (de) 2008-01-24

Family

ID=27116965

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0605477T Pending DE605477T1 (de) 1991-09-17 1992-09-02 Gasförmige ultraschallkontrastmittel und verfahren zur auswahl von gasen für die verwendung als ultraschallkontrastmittel.
DE69230885T Expired - Lifetime DE69230885T3 (de) 1991-09-17 1992-09-02 Gasförmige ultraschallkontrastmittel

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0605477T Pending DE605477T1 (de) 1991-09-17 1992-09-02 Gasförmige ultraschallkontrastmittel und verfahren zur auswahl von gasen für die verwendung als ultraschallkontrastmittel.

Country Status (19)

Country Link
US (1) US5558094B1 (de)
EP (1) EP0605477B2 (de)
JP (2) JP3231768B2 (de)
KR (1) KR100191303B1 (de)
AT (1) ATE191346T1 (de)
AU (2) AU679428C (de)
CA (1) CA2119129C (de)
CZ (1) CZ286149B6 (de)
DE (2) DE605477T1 (de)
DK (1) DK0605477T4 (de)
ES (1) ES2145011T5 (de)
FI (1) FI119466B (de)
GR (1) GR3033908T3 (de)
HK (1) HK1012564A1 (de)
HU (1) HU218018B (de)
NO (1) NO313577B1 (de)
RU (1) RU2114637C1 (de)
SG (1) SG54121A1 (de)
WO (1) WO1993005819A1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580575A (en) 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US5733572A (en) 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US5656211A (en) 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5149319A (en) * 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6001335A (en) 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US6875420B1 (en) 1991-09-17 2005-04-05 Amersham Health As Method of ultrasound imaging
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
HUT72323A (en) * 1993-01-25 1996-04-29 Sonus Pharma Inc Phase shift colloids as ultrasound contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
GB9305349D0 (en) * 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
US5695740A (en) * 1993-05-12 1997-12-09 The Board Of Regents Of The University Of Nebraska Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide
US5701899A (en) * 1993-05-12 1997-12-30 The Board Of Regents Of The University Of Nebraska Perfluorobutane ultrasound contrast agent and methods for its manufacture and use
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US5855865A (en) * 1993-07-02 1999-01-05 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
AU683485B2 (en) * 1993-07-02 1997-11-13 Molecular Biosystems, Inc. Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
DE69434119T3 (de) * 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego Stabilisierte mikrogasbläschen-zusammensetzungen für echographie
AU679295B2 (en) * 1993-12-15 1997-06-26 Bracco Suisse S.A. Gas mixtures useful as ultrasound contrast media
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent
US5736121A (en) 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5730955A (en) * 1994-08-02 1998-03-24 Molecular Biosystems, Inc. Process for making gas-filled microspheres containing a liquid hydrophobic barrier
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
WO1998053855A1 (en) 1997-05-30 1998-12-03 Alliance Pharmaceutical Corp. Methods and apparatus for monitoring and quantifying the movement of fluid
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
IL116328A (en) † 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5674469A (en) * 1995-06-07 1997-10-07 Molecular Biosystems, Inc. Gas-exchange method of making gas-filled microspheres
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
US5840276A (en) * 1996-01-11 1998-11-24 Apfel Enterprises, Inc. Activatable infusable dispersions containing drops of a superheated liquid for methods of therapy and diagnosis
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
PT904113E (pt) * 1996-03-05 2004-09-30 Acusphere Inc Gases fluorados microencapsulados para utilizacao como agentes de aquisicao de imagem
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
US5728315A (en) * 1996-05-01 1998-03-17 Alliedsignal Inc. Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane and hexafluoroethane
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5849727A (en) 1996-06-28 1998-12-15 Board Of Regents Of The University Of Nebraska Compositions and methods for altering the biodistribution of biological agents
AU3665297A (en) * 1996-07-19 1998-02-10 Sonus Pharmaceuticals, Inc. Enhanced ultrasound contrast imaging using inhaled gases
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
CA2263568C (en) 1996-09-11 2008-12-02 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6439236B1 (en) 1999-10-25 2002-08-27 The Board Of Regents Of The University Of Nebraska Methods for inducing atrial and ventricular rhythms using ultrasound and microbubbles
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US7358226B2 (en) * 2003-08-27 2008-04-15 The Regents Of The University Of California Ultrasonic concentration of drug delivery capsules
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
ES2339117T5 (es) 2003-11-17 2019-04-10 Btg Int Ltd Procedimientos de preparación de una espuma que comprende un agente esclerosante
US8708909B2 (en) 2004-01-20 2014-04-29 Fujifilm Visualsonics, Inc. High frequency ultrasound imaging using contrast agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
EP2200652B1 (de) 2007-09-27 2018-03-21 Children's Medical Center Corporation Mikrobläschen und sauerstoffabgabe-verfahren
CN101951839B (zh) * 2008-01-23 2013-11-06 M·阿韦基乌 利用超声造影剂的呼吸门控治疗评估
US8846063B2 (en) 2008-12-16 2014-09-30 Kimberly-Clark Worldwide, Inc. Personal care composition containing a volatile and a terpene alcohol
WO2013151682A1 (en) 2012-04-06 2013-10-10 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
EP2858554A4 (de) * 2012-06-11 2016-02-24 Univ California Verfahren und system für in-vivo-wasserstoffperoxidnachweis mit ultraschall
AU2013283409B2 (en) 2012-06-26 2017-06-08 Ge Healthcare As Preparation of composition comprising gas microbubbles
WO2014144364A1 (en) 2013-03-15 2014-09-18 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
EA201791437A1 (ru) 2014-12-31 2017-12-29 Лантеус Медикал Имэджинг, Инк. Композиции микросфер c инкапсулированным в липиде газом и соответствующие способы
JP2019515936A (ja) 2016-05-04 2019-06-13 ランセウス メディカル イメージング， インコーポレイテッド 超音波造影剤を調製するための方法およびデバイス
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use
TW202313536A (zh) * 2019-02-08 2023-04-01 日商大金工業股份有限公司 含有含氟烯烴之組成物

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
JPS57150542A (en) * 1981-03-13 1982-09-17 Katashi Aoki Injection, stretching, and blow molding machine
US4361979A (en) * 1981-04-07 1982-12-07 Brio Toy Ab Connection element for making assemblies of toy units
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
DE3141641A1 (de) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
JPS5967229A (ja) * 1982-10-08 1984-04-16 Green Cross Corp:The 超音波診断造影剤
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
JPS6073621A (ja) * 1983-09-30 1985-04-25 Fuji Photo Film Co Ltd 折畳み式カメラ
US4767610A (en) * 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
GB8504916D0 (en) * 1985-02-26 1985-03-27 Isc Chemicals Ltd Emulsions of perfluorocarbons in aqueous media
DE3529195A1 (de) * 1985-08-14 1987-02-26 Max Planck Gesellschaft Kontrastmittel fuer ultraschalluntersuchungen und verfahren zu seiner herstellung
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
ATE90879T1 (de) * 1985-11-18 1993-07-15 Access Pharma Inc Polychelierende stoffe fuer abbildung- und spektralerhoehung (und spektrale verschiebung).
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
EP0231091B1 (de) * 1986-01-24 1993-03-31 Children's Hospital Medical Center Stabile Emulsionen von stark fluorierten, organischen Verbindungen
EP0245019A3 (de) * 1986-04-30 1989-05-10 Michael A. Davis Kontrastmedium mit niedriger Dichte zur Diagnose von pathologischen Bedingungen
JPS6360943A (ja) * 1986-09-01 1988-03-17 Green Cross Corp:The 超音波診断造影剤
US5219538A (en) * 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US4895876A (en) * 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US5354549A (en) * 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
CN1013830B (zh) * 1987-08-26 1991-09-11 宋振才 B超胃肠造影剂的制造工艺
IE61591B1 (en) * 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE66912B1 (en) * 1988-02-05 1996-02-07 Schering Ag Ultrasonic contrast agents process for their preparation and their use as diagnostic and therapeutic agents
US5171755A (en) * 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
ES2045944T3 (es) * 1989-08-30 1994-01-16 Kali Chemie Ag Procedimiento para la separacion de mezclas de compuestos hidrocarbonados parcialmente fluorados o perfluorados.
JPH062134B2 (ja) * 1989-09-08 1994-01-12 株式会社東芝 超音波診断装置
JPH02196730A (ja) * 1989-12-15 1990-08-03 Green Cross Corp:The 超音波診断造影剤
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) * 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5209720A (en) * 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
IN172208B (de) * 1990-04-02 1993-05-01 Sint Sa
DK0454044T3 (da) * 1990-04-25 1996-04-22 Hoechst Ag Farmakologisk præparat indeholdende polyelektrolytkomplekser på mikropartikelform og mindst et virksomt stof
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
EP0728486A3 (de) * 1990-06-01 1997-12-03 Imarx Pharmaceutical Corp. Kontrastmittel für Ultraschallabbildung
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
FR2665705B1 (fr) * 1990-08-09 1993-07-30 Atta Nouveaux derives fluores amphiphiles a structure telomere, leur procede de preparation et leur utilisation dans des preparations a usage biomedical.
EP0504340B1 (de) * 1990-10-05 1995-06-21 BRACCO International B.V. Verfahren zur herstellung von stabilen suspensionen von hohlen mit gasgefüllten mikrosphären zur verwendung in ultraschallechographie
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US5107842A (en) * 1991-02-22 1992-04-28 Molecular Biosystems, Inc. Method of ultrasound imaging of the gastrointestinal tract
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5496535A (en) * 1991-04-12 1996-03-05 Alliance Pharmaceutical Corp. Fluorocarbon contrast media for use with MRI and radiographic imaging
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (en) * 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
WO1992022298A1 (en) * 1991-06-18 1992-12-23 Unger Evan C Novel liposomal drug delivery systems
DK0593624T3 (da) * 1991-07-05 1997-05-20 Nycomed Imaging As Forbedringer af eller i relation til kontrastmidler
EP0593627A1 (de) * 1991-07-05 1994-04-27 The University Of Rochester Ultrakleine nicht-aggregierten porösen partikeln für einkapseln von gasblasen
FR2679150A1 (fr) * 1991-07-17 1993-01-22 Atta Preparations comprenant un fluorocarbure ou compose hautement fluore et un compose organique lipophile-fluorophile, et leurs utilisations.
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
ES2145011T5 (es) * 1991-09-17 2008-02-01 Ge Healthcare As Medios de contraste gaseoso para ecografias.
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
AU2789192A (en) * 1991-10-04 1993-05-03 Mallinckrodt Medical, Inc. Gaseous ultrasound contrast agents
US5344640A (en) * 1991-10-22 1994-09-06 Mallinckrodt Medical, Inc. Preparation of apatite particles for medical diagnostic imaging
CA2121681A1 (en) * 1991-11-19 1993-05-27 Evan C. Unger Gel particle contrast media for improved diagnostic imaging
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5344393A (en) * 1992-02-28 1994-09-06 Alliance Pharmaceutical Corp. Use of synthetic oxygen carriers to facilitate oxygen delivery
US5406950A (en) * 1993-12-23 1995-04-18 Mallinckrodt Medical, Inc. Inhalable contrast agent

Also Published As

Publication number Publication date
KR100191303B1 (ko) 1999-06-15
JP2001026554A (ja) 2001-01-30
ES2145011T3 (es) 2000-07-01
AU2550392A (en) 1993-04-27
SG54121A1 (en) 1998-11-16
FI941242A0 (fi) 1994-03-16
NO940956D0 (no) 1994-03-16
NO940956L (no) 1994-03-16
CA2119129C (en) 1999-11-09
EP0605477B1 (de) 2000-04-05
JPH07501319A (ja) 1995-02-09
DE605477T1 (de) 1998-09-24
FI119466B (fi) 2008-11-28
NO313577B1 (no) 2002-10-28
HUT68083A (en) 1995-05-29
HU218018B (hu) 2000-05-28
ATE191346T1 (de) 2000-04-15
AU679428C (en) 2006-07-13
DK0605477T3 (da) 2000-08-14
AU3995997A (en) 1998-02-05
US5558094A (en) 1996-09-24
WO1993005819A1 (en) 1993-04-01
CZ286149B6 (cs) 2000-01-12
EP0605477B2 (de) 2007-06-20
FI941242A (fi) 1994-05-16
DE69230885T3 (de) 2008-01-24
HK1012564A1 (en) 1999-08-06
CZ61294A3 (en) 1994-10-19
RU2114637C1 (ru) 1998-07-10
CA2119129A1 (en) 1993-04-01
EP0605477A4 (en) 1994-09-07
DK0605477T4 (da) 2007-10-01
HU9400786D0 (en) 1994-08-29
EP0605477A1 (de) 1994-07-13
AU679428B2 (en) 1997-07-03
GR3033908T3 (en) 2000-11-30
DE69230885T2 (de) 2001-06-07
ES2145011T5 (es) 2008-02-01
JP3231768B2 (ja) 2001-11-26
US5558094B1 (en) 1999-01-19

Similar Documents

Publication Publication Date Title
DE69230885T2 (de) Gasförmige ultraschallkontrastmittel
CA2273140A1 (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
PT100867A (pt) Meios de contraste gasoso para ultrsons e metodo para seleccionar gases para utilizacao como meios de contraste para ultrasons
RU94030382A (ru) Биосовместимая контрастная среда и способ получения ультразвукового изображения
NO305385B1 (no) Kontrastmidler for ultralyd-ekkografi, fremgangsmÕte for fremstilling av disse, kontrastmiddelforl°pere og anvendelse derav
DK0788348T3 (da) Beholder med multifasesammensætning til brug i diagnostiske og terapeutiske anvendelser
ITRM920590A1 (it) Sistema per la realizzazione distrutture in fibra di carbonio, e procedimento per detto, particolarmente idoneo per applicazioni aeronautiche.
FI934226A0 (fi) Foerbaettringar i eller relaterande till kontrastmedel
NO981044L (no) Sirkulært DNA-molekyl med kondisjonell replikasjonsopprinnelse, dets fremstilling og anvendelse derav i genterapi
DK0531421T3 (da) Kontrastmedier til ultralydsimagografi
HUP0104176A2 (hu) Párologtató- és öntözőberendezés
MY111060A (en) Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media
DE69426912D1 (de) Gerät zur lokale Hydromassage
FR2710544B1 (fr) Rétro tuba.
DE69421665D1 (de) Anomere Fluorribosylamine
ITSA930012A0 (it) Sistema, per strumenti musicali e simili, in grado di interagire con l'utente segnalandogli, mediante illuminazioni, la corretta procedura di esecuzione di un brano.
ITRM920224A0 (it) Sistema ottico per la combinazione di due cammini ottici, in particolare i cammini ottici di uno strumento di diagnostica oculare e di un altro strumento.
ATE97314T1 (de) Ausbildung des mundstuecks eines mit ultraschall arbeitenden absaug-endoskops und dazugehoeriger vibrator.
JPS57123475A (en) Recognizer of hand-written information
KR870006272A (ko) 확대안내면을 갖는 초음파 세척기용 진동자기구
KR950005709U (ko) 유희용 훌라후프(Hula-Hoop)에 설치된 음발생장치의 결착구조
JPS6091299U (ja) 汚濁水の清澄化装置
ITPN910075A1 (it) Procedimento di costruzione di telai in fibra di carbonio.
RO113500B1 (ro) Suport contrabărbie pentru vioară şi violă

Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: AMERSHAM HEALTH A/B, OSLO, NO

8327 Change in the person/name/address of the patent owner

Owner name: GE HEALTHCARE AS, OSLO, NO

8366 Restricted maintained after opposition proceedings
8328 Change in the person/name/address of the agent

Representative=s name: HAMMONDS LLP, LONDON, GB

R071 Expiry of right

Ref document number: 605477

Country of ref document: EP