DE69231345D1 - Oberflächenmodifizierte Arzneimittel-Nanopartikel - Google Patents

Oberflächenmodifizierte Arzneimittel-Nanopartikel

Info

Publication number
DE69231345D1
DE69231345D1 DE69231345T DE69231345T DE69231345D1 DE 69231345 D1 DE69231345 D1 DE 69231345D1 DE 69231345 T DE69231345 T DE 69231345T DE 69231345 T DE69231345 T DE 69231345T DE 69231345 D1 DE69231345 D1 DE 69231345D1
Authority
DE
Germany
Prior art keywords
particles
surface modified
methods
modified drug
drug nanoparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69231345T
Other languages
English (en)
Other versions
DE69231345T2 (de
Inventor
Gary Liversidge
Kenneth Cundy
John Bishop
David Czekai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosystems LLC
Original Assignee
Nanosystems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24595721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69231345(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nanosystems LLC filed Critical Nanosystems LLC
Application granted granted Critical
Publication of DE69231345D1 publication Critical patent/DE69231345D1/de
Publication of DE69231345T2 publication Critical patent/DE69231345T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0423—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/0428—Surface-modified nanoparticles, e.g. immuno-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
DE69231345T 1991-01-25 1992-01-20 Oberflächenmodifizierte Arzneimittel-Nanopartikel Revoked DE69231345T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/647,105 US5145684A (en) 1991-01-25 1991-01-25 Surface modified drug nanoparticles

Publications (2)

Publication Number Publication Date
DE69231345D1 true DE69231345D1 (de) 2000-09-21
DE69231345T2 DE69231345T2 (de) 2001-04-26

Family

ID=24595721

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231345T Revoked DE69231345T2 (de) 1991-01-25 1992-01-20 Oberflächenmodifizierte Arzneimittel-Nanopartikel

Country Status (22)

Country Link
US (1) US5145684A (de)
EP (1) EP0499299B1 (de)
JP (1) JP3602546B2 (de)
KR (1) KR100200061B1 (de)
AT (1) ATE195416T1 (de)
CA (1) CA2059432C (de)
DE (1) DE69231345T2 (de)
DK (1) DK0499299T3 (de)
ES (1) ES2149164T3 (de)
FI (1) FI108333B (de)
GR (1) GR3034759T3 (de)
HU (1) HU221586B (de)
IE (1) IE920217A1 (de)
IL (1) IL100754A (de)
MX (1) MX9200291A (de)
MY (1) MY108134A (de)
NO (1) NO303668B1 (de)
NZ (1) NZ241362A (de)
PT (1) PT499299E (de)
RU (1) RU2066553C1 (de)
SG (1) SG55104A1 (de)
TW (1) TW247275B (de)

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US5145684A (en) 1992-09-08
IL100754A (en) 1996-10-16
NO920334L (no) 1992-07-27
DE69231345T2 (de) 2001-04-26
DK0499299T3 (da) 2001-01-02
FI920321A0 (fi) 1992-01-24
ATE195416T1 (de) 2000-09-15
EP0499299B1 (de) 2000-08-16
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AU1014792A (en) 1992-07-30
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KR920014468A (ko) 1992-08-25
HU9200226D0 (en) 1992-04-28
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JP3602546B2 (ja) 2004-12-15
PT499299E (pt) 2001-01-31
RU2066553C1 (ru) 1996-09-20
TW247275B (de) 1995-05-11
FI108333B (fi) 2002-01-15
NZ241362A (en) 1993-06-25
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HU221586B (hu) 2002-11-28

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