DE69231499D1 - Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen - Google Patents

Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Info

Publication number
DE69231499D1
DE69231499D1 DE69231499T DE69231499T DE69231499D1 DE 69231499 D1 DE69231499 D1 DE 69231499D1 DE 69231499 T DE69231499 T DE 69231499T DE 69231499 T DE69231499 T DE 69231499T DE 69231499 D1 DE69231499 D1 DE 69231499D1
Authority
DE
Germany
Prior art keywords
microcrystalline cellulose
composition
production
spherical particles
hydrocolloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231499T
Other languages
English (en)
Other versions
DE69231499T2 (de
Inventor
David Frank Erkoboni
Scott Allan Fiore
Thomas Albert Wheatley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FMC Corp
Original Assignee
FMC Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FMC Corp filed Critical FMC Corp
Application granted granted Critical
Publication of DE69231499D1 publication Critical patent/DE69231499D1/de
Publication of DE69231499T2 publication Critical patent/DE69231499T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/005—Processes for mixing polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/02—Cellulose; Modified cellulose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2300/00—Characterised by the use of unspecified polymers
    • C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
DE69231499T 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen Expired - Fee Related DE69231499T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81602791A 1991-12-30 1991-12-30
PCT/US1992/009983 WO1993012768A1 (en) 1991-12-30 1992-11-18 Microcrystalline cellulose spheronization composition

Publications (2)

Publication Number Publication Date
DE69231499D1 true DE69231499D1 (de) 2000-11-09
DE69231499T2 DE69231499T2 (de) 2001-05-03

Family

ID=25219497

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231499T Expired - Fee Related DE69231499T2 (de) 1991-12-30 1992-11-18 Zusammensetzung auf der basis von mikrokristalliner zellulose für die herstellung von kugelförmigen teilchen

Country Status (16)

Country Link
US (1) US5725886A (de)
EP (1) EP0619731B1 (de)
JP (1) JP2628230B2 (de)
CN (1) CN1074228A (de)
AT (1) ATE196733T1 (de)
AU (1) AU663146B2 (de)
BR (1) BR9206996A (de)
CA (1) CA2126441C (de)
DE (1) DE69231499T2 (de)
ES (1) ES2150438T3 (de)
FI (1) FI943121A (de)
IL (1) IL104087A (de)
MX (1) MX9207438A (de)
NO (1) NO942457L (de)
WO (1) WO1993012768A1 (de)
ZA (1) ZA929161B (de)

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US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
IL139728A (en) * 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US5733578A (en) * 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
ATE262318T1 (de) * 1996-08-14 2004-04-15 Yamanouchi Europ Bv Eine wasserlösliche verbindung und cellulose enhaltende granulate
CN1086189C (zh) * 1997-06-12 2002-06-12 食品机械和化工公司 超细微晶纤维素组合物及其制备方法
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
US7122207B2 (en) * 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
US6596312B1 (en) 1999-09-29 2003-07-22 R.P. Scherer Technologies, Inc. Hydrolyzed cellulose granulations of salts of drugs
MXPA02009534A (es) 2000-03-30 2003-05-14 Squibb Bristol Myers Co Granulos de liberacion sostenida que contienen estavudina.
AU2002242084B2 (en) * 2001-02-05 2006-11-16 R.P. Scherer Technologies, Inc. Methods and compositions for reducing the taste of pharmaceutically active agents
WO2002088664A2 (en) * 2001-04-26 2002-11-07 Bristol-Myers Squibb Company Control of compactability through crystallization
EP1575487B1 (de) 2002-05-14 2019-08-14 DuPont Nutrition USA, Inc. Coattrittierte mikrokristalline zellulose hydrokolloid-zusammensetzungen und verfahren zur herstellung
JP5393032B2 (ja) * 2005-02-04 2014-01-22 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム シガレット及びセルロースのフレーバーが加えられたフィルタ
US20070000505A1 (en) * 2005-02-24 2007-01-04 Philip Morris Usa Inc. Smoking article with tobacco beads
US7879382B2 (en) * 2005-09-30 2011-02-01 Fmc Corporation Stabilizers and compositions and products comprising same
ZA200807571B (en) * 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
US20090324717A1 (en) * 2006-07-28 2009-12-31 Farmaprojects, S. A. Extended release pharmaceutical formulation of metoprolol and process for its preparation
DE602007011792D1 (de) * 2006-10-27 2011-02-17 Fmc Corp Gemeinsam aufbereitete mikrokristalline cellulose und zuckeralkohol als hilfsstoff für tablettenformulierungen
EP2144599B1 (de) * 2007-03-02 2010-08-04 Farnam Companies, Inc. Wachsähnliches material enthaltende tabletten mit verzögerter freisetzung
US9888712B2 (en) 2007-06-08 2018-02-13 Philip Morris Usa Inc. Oral pouch products including a liner and tobacco beads
BRPI0818317A8 (pt) * 2007-10-10 2018-12-18 Mallinckrodt Baker Inc composição, métodos de fabricação de excipiente, comprimido farmacêutico e método de fabricação do mesmo
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
KR20110089180A (ko) * 2008-11-19 2011-08-04 아반토르 퍼포먼스 머티리얼스, 인크. 직접 압축가능한 과립상 미세결정질 셀룰로스 기재 부형제, 그의 제조 방법 및 용도
US9221963B2 (en) 2008-11-27 2015-12-29 Speciality Fibres And Materials Ltd. Absorbent material
US9144625B2 (en) 2008-11-27 2015-09-29 Speciality Fibres And Materials Ltd. Cellulose ethylsulfonate-based absorbent material
US8377215B2 (en) 2008-12-18 2013-02-19 Philip Morris Usa Inc. Moist botanical pouch processing
US8863755B2 (en) * 2009-02-27 2014-10-21 Philip Morris Usa Inc. Controlled flavor release tobacco pouch products and methods of making
US20110277781A1 (en) 2010-03-26 2011-11-17 Philip Morris Usa Inc. Methods for improving quality of mainstream smoke and multicomponent filters and smoking articles therefor
US10051884B2 (en) 2010-03-26 2018-08-21 Philip Morris Usa Inc. Controlled release mentholated tobacco beads
CN103857739B (zh) 2011-10-05 2017-04-19 Fmc有限公司 共磨碎微晶纤维素和羧甲基纤维素的稳定剂组合物、制备方法和应用
EP2764046B1 (de) 2011-10-05 2021-04-21 DuPont Nutrition USA, Inc. Stabilisatorzusammensetzung aus mikrokristalliner cellulose und carboxymethylcellulose, verfahren zu ihrer herstellung und deren anwendungen
EP2787837B1 (de) 2011-12-09 2017-03-15 FMC Corporation Gemeinsam zersetzte stabilisatorzusammensetzung
CN105085992B (zh) * 2015-09-16 2017-12-29 珠海市东辰医药科技有限公司 一种改性微晶纤维素的制备工艺
CN105193738B (zh) * 2015-09-21 2018-09-04 珠海市东辰制药有限公司 一种微晶纤维素丸芯的制备工艺
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions

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Publication number Priority date Publication date Assignee Title
GB1010477A (en) * 1962-05-15 1965-11-17 Fmc Corp Method of making cellulose crystallite aggregates in particulate form and product of such method
GB1561204A (en) * 1977-06-01 1980-02-13 Ici Ltd Sustained release pharmaceutical composition
US4421778A (en) * 1982-11-04 1983-12-20 Rich Products Corporation Freezer stable whipped ice cream and milk shake food products
US4744987A (en) * 1985-03-08 1988-05-17 Fmc Corporation Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
GB8705083D0 (en) * 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
CA1323833C (en) * 1987-04-28 1993-11-02 Yatindra M. Joshi Pharmaceutical compositions in the form of beadlets and method
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds

Also Published As

Publication number Publication date
BR9206996A (pt) 1995-12-05
CN1074228A (zh) 1993-07-14
FI943121A0 (fi) 1994-06-29
DE69231499T2 (de) 2001-05-03
ES2150438T3 (es) 2000-12-01
JPH06511255A (ja) 1994-12-15
EP0619731A4 (de) 1995-05-03
CA2126441C (en) 1999-12-21
WO1993012768A1 (en) 1993-07-08
JP2628230B2 (ja) 1997-07-09
EP0619731B1 (de) 2000-10-04
IL104087A0 (en) 1993-05-13
AU663146B2 (en) 1995-09-28
NO942457D0 (no) 1994-06-29
ZA929161B (en) 1993-05-25
CA2126441A1 (en) 1993-07-08
US5725886A (en) 1998-03-10
ATE196733T1 (de) 2000-10-15
EP0619731A1 (de) 1994-10-19
NO942457L (no) 1994-06-29
AU3179393A (en) 1993-07-28
IL104087A (en) 1998-10-30
MX9207438A (es) 1993-06-01
FI943121A (fi) 1994-06-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee