DE69233076D1 - Aerosolpräparate - Google Patents

Aerosolpräparate

Info

Publication number
DE69233076D1
DE69233076D1 DE69233076T DE69233076T DE69233076D1 DE 69233076 D1 DE69233076 D1 DE 69233076D1 DE 69233076 T DE69233076 T DE 69233076T DE 69233076 T DE69233076 T DE 69233076T DE 69233076 D1 DE69233076 D1 DE 69233076D1
Authority
DE
Germany
Prior art keywords
aerosol preparations
aerosol
preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233076T
Other languages
English (en)
Other versions
DE69233076T3 (de
DE69233076T2 (de
Inventor
Rachel Ann Marriott
Anthony James Taylor
David Andrew Wyatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69233076(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919126405A external-priority patent/GB9126405D0/en
Priority claimed from GB919126378A external-priority patent/GB9126378D0/en
Priority claimed from GB929202522A external-priority patent/GB9202522D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE69233076D1 publication Critical patent/DE69233076D1/de
Application granted granted Critical
Publication of DE69233076T2 publication Critical patent/DE69233076T2/de
Publication of DE69233076T3 publication Critical patent/DE69233076T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
DE69233076T 1991-12-12 1992-12-04 Aerosolpräparate Expired - Lifetime DE69233076T3 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB919126405A GB9126405D0 (en) 1991-12-12 1991-12-12 Medicaments
GB9126378 1991-12-12
GB919126378A GB9126378D0 (en) 1991-12-12 1991-12-12 Medicaments
GB9126405 1991-12-12
GB929202522A GB9202522D0 (en) 1992-02-06 1992-02-06 Medicaments
GB9202522 1992-02-06

Publications (3)

Publication Number Publication Date
DE69233076D1 true DE69233076D1 (de) 2003-06-26
DE69233076T2 DE69233076T2 (de) 2004-03-18
DE69233076T3 DE69233076T3 (de) 2007-07-12

Family

ID=27265965

Family Applications (8)

Application Number Title Priority Date Filing Date
DE69233755T Expired - Lifetime DE69233755D1 (de) 1991-12-12 1992-12-04 Aerosolzubereitungen
DE200612000020 Pending DE122006000020I1 (de) 1991-12-12 1992-12-04 Aerosolpraparate.
DE69232856T Expired - Lifetime DE69232856T3 (de) 1991-12-12 1992-12-04 Aerosolpräparate
DE69233712T Expired - Lifetime DE69233712T2 (de) 1991-12-12 1992-12-04 Aerosolzubereitungen
DE69233519T Expired - Lifetime DE69233519T2 (de) 1991-12-12 1992-12-04 Verfahren zur Herstellung von Aerosolzusammensetzungen
DE69224656T Expired - Lifetime DE69224656T2 (de) 1991-12-12 1992-12-04 Arzneimittel
DE69231857T Expired - Lifetime DE69231857T2 (de) 1991-12-12 1992-12-04 Aerosolzusammensetzungen
DE69233076T Expired - Lifetime DE69233076T3 (de) 1991-12-12 1992-12-04 Aerosolpräparate

Family Applications Before (7)

Application Number Title Priority Date Filing Date
DE69233755T Expired - Lifetime DE69233755D1 (de) 1991-12-12 1992-12-04 Aerosolzubereitungen
DE200612000020 Pending DE122006000020I1 (de) 1991-12-12 1992-12-04 Aerosolpraparate.
DE69232856T Expired - Lifetime DE69232856T3 (de) 1991-12-12 1992-12-04 Aerosolpräparate
DE69233712T Expired - Lifetime DE69233712T2 (de) 1991-12-12 1992-12-04 Aerosolzubereitungen
DE69233519T Expired - Lifetime DE69233519T2 (de) 1991-12-12 1992-12-04 Verfahren zur Herstellung von Aerosolzusammensetzungen
DE69224656T Expired - Lifetime DE69224656T2 (de) 1991-12-12 1992-12-04 Arzneimittel
DE69231857T Expired - Lifetime DE69231857T2 (de) 1991-12-12 1992-12-04 Aerosolzusammensetzungen

Country Status (30)

Country Link
US (10) US5674472A (de)
EP (8) EP1275375B1 (de)
JP (2) JP3026840B2 (de)
KR (1) KR100278339B1 (de)
AP (1) AP402A (de)
AT (7) ATE201587T1 (de)
AU (1) AU663904C (de)
BG (3) BG62119B1 (de)
CA (7) CA2654849A1 (de)
CY (6) CY2134B1 (de)
CZ (1) CZ287039B6 (de)
DE (8) DE69233755D1 (de)
DK (7) DK0756868T3 (de)
ES (7) ES2294386T3 (de)
GE (1) GEP20002253B (de)
GR (1) GR3036476T3 (de)
HK (3) HK1012988A1 (de)
HU (3) HU227383B1 (de)
IL (1) IL104068A (de)
IS (1) IS1709B (de)
MX (1) MX9207205A (de)
MY (1) MY109758A (de)
NO (3) NO307864B1 (de)
NZ (1) NZ246044A (de)
OA (1) OA09926A (de)
PT (6) PT1287820E (de)
RU (2) RU2179037C2 (de)
SK (1) SK279920B6 (de)
TW (1) TW232654B (de)
WO (1) WO1993011743A1 (de)

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BG62119B1 (bg) 1999-03-31
DE69231857T2 (de) 2001-11-29
AP402A (en) 1995-08-22
ES2158988T3 (es) 2001-09-16
ATE227975T1 (de) 2002-12-15
PT1287820E (pt) 2009-03-11
HK1054500A1 (en) 2003-12-05
SK67494A3 (en) 1995-03-08
US6238647B1 (en) 2001-05-29
IL104068A0 (en) 1993-05-13
NO942185L (de) 1994-06-10
HU227383B1 (en) 2011-05-30
US20030143163A1 (en) 2003-07-31
KR100278339B1 (ko) 2001-01-15
EP1275375B1 (de) 2005-06-01
NO20001227L (no) 1994-06-10
PT1066828E (pt) 2003-10-31
CA2303685C (en) 2002-02-12
EP1287820A1 (de) 2003-03-05
NO20065102L (no) 1994-06-10
DE69233076T3 (de) 2007-07-12
HU227681B1 (en) 2011-11-28
DE69233712D1 (de) 2007-10-31
MY109758A (en) 1997-06-30
CA2362539A1 (en) 1993-06-24
EP1066828B9 (de) 2008-03-26
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AU3085092A (en) 1993-07-19
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CA2586146A1 (en) 1993-06-24
DE69224656T2 (de) 1998-07-23
NZ246044A (en) 1996-01-26
CA2402300C (en) 2005-06-28
PT1440686E (pt) 2007-12-19
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ES2319873T3 (es) 2009-05-14
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US20090188491A1 (en) 2009-07-30
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CA2447510C (en) 2007-07-03
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US5676929A (en) 1997-10-14
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BG102689A (en) 1999-02-26
DE122006000020I1 (de) 2011-12-01
PT1275375E (pt) 2005-09-30
NO325422B1 (no) 2008-04-21
ATE201587T1 (de) 2001-06-15
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EP1066828B2 (de) 2006-12-06
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US7498020B2 (en) 2009-03-03
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US6251368B1 (en) 2001-06-26
WO1993011743A1 (en) 1993-06-24
US6303103B1 (en) 2001-10-16
DE69232856T2 (de) 2003-07-31
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EP0990437B2 (de) 2008-10-22
DK1440686T3 (da) 2008-01-21
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HUT67534A (en) 1995-04-28
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CY2566B1 (en) 2008-07-02
CY2134B1 (en) 2002-06-21
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US5674472A (en) 1997-10-07
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US20020028183A1 (en) 2002-03-07
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HU211671A9 (en) 1995-12-28
ATE296617T1 (de) 2005-06-15
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HK1054500B (zh) 2005-12-30

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Free format text: PRODUCT NAME: KOMBINATION AUS SALMETEROL ODER PHYSIOLOGISCH ANNEHMBAREN SALZEN ODER SOLVATEN DAVON,WIE XINAFOAT, UND 1,1,1,2-TERTRAFLUORETHAN; NAT. REGISTRATION NO/DATE: 25243.00.00 20051008; FIRST REGISTRATION: CH 57169 01 20050125

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Free format text: PRODUCT NAME: KOMBINATION AUS SALMETEROL ODER PHYSIOLOGISCH ANNEHMBAREN SALZEN ODER SOLVATEN DAVON,WIE XINAFOAT, UND 1,1,1,2-TETRAFLUORETHAN; NAT. REGISTRATION NO/DATE: 25243.00.00 20051008; FIRST REGISTRATION: CH 57169 01 20050125

Spc suppl protection certif: 122006000020

Filing date: 20060407

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