DE69302721T2 - Herstellungsverfahren für biologisch aktives Material enthaltende Polymere Mikrokapseln - Google Patents

Herstellungsverfahren für biologisch aktives Material enthaltende Polymere Mikrokapseln

Info

Publication number
DE69302721T2
DE69302721T2 DE69302721T DE69302721T DE69302721T2 DE 69302721 T2 DE69302721 T2 DE 69302721T2 DE 69302721 T DE69302721 T DE 69302721T DE 69302721 T DE69302721 T DE 69302721T DE 69302721 T2 DE69302721 T2 DE 69302721T2
Authority
DE
Germany
Prior art keywords
manufacturing process
polymers containing
bioactive material
containing bioactive
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69302721T
Other languages
English (en)
Other versions
DE69302721D1 (de
Inventor
Cardina Anna Maria Chris Dirix
Hendrikus Johannes Maria Kamp
Anthonius Paulus Sam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69302721D1 publication Critical patent/DE69302721D1/de
Publication of DE69302721T2 publication Critical patent/DE69302721T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
DE69302721T 1992-02-18 1993-02-16 Herstellungsverfahren für biologisch aktives Material enthaltende Polymere Mikrokapseln Expired - Fee Related DE69302721T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92200466 1992-02-18

Publications (2)

Publication Number Publication Date
DE69302721D1 DE69302721D1 (de) 1996-06-27
DE69302721T2 true DE69302721T2 (de) 1996-09-19

Family

ID=8210436

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69302721T Expired - Fee Related DE69302721T2 (de) 1992-02-18 1993-02-16 Herstellungsverfahren für biologisch aktives Material enthaltende Polymere Mikrokapseln

Country Status (16)

Country Link
US (1) US5389379A (de)
EP (1) EP0556917B1 (de)
JP (1) JPH05337360A (de)
KR (1) KR930017574A (de)
AT (1) ATE138263T1 (de)
AU (1) AU658715B2 (de)
CA (1) CA2089354A1 (de)
DE (1) DE69302721T2 (de)
DK (1) DK0556917T3 (de)
ES (1) ES2090836T3 (de)
FI (1) FI930672A (de)
GR (1) GR3020417T3 (de)
MX (1) MX9300851A (de)
NO (1) NO930557L (de)
NZ (1) NZ245914A (de)
ZA (1) ZA93929B (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023767A1 (en) 1993-04-22 1994-10-27 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US6383470B1 (en) 1992-09-26 2002-05-07 Thomas Fritzsch Microparticle preparations made of biodegradable copolymers
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6461643B2 (en) * 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US20010003001A1 (en) 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
CN1151836C (zh) 1995-03-31 2004-06-02 艾米斯菲尔技术有限公司 用作传送活性剂的化合物和组合物
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5824345A (en) 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
CN1055417C (zh) * 1995-09-05 2000-08-16 中国科学院成都有机化学研究所 一种核-壳结构的蛋白高分子微球及其制法
DE19681560T1 (de) 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
AU2595697A (en) * 1996-03-29 1997-10-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
IE960308A1 (en) * 1996-04-23 1997-11-05 Kinerton Ltd Sustained release ionic conjugate
JP2000512671A (ja) 1996-06-14 2000-09-26 エミスフェアー テクノロジーズ インク マイクロカプセル化香料及び調製方法
EP0886471A4 (de) 1996-11-18 2002-07-17 Emisphere Tech Inc Verfahren und zusammensetzungen zur induzierung oraler toleranz in saugetieren
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) * 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US5989463A (en) * 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
US6498153B1 (en) 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
ES2254164T3 (es) * 1999-10-29 2006-06-16 Nektar Therapeutics Composiciones de polvo seco con dispersabilidad mejorada.
US6767637B2 (en) * 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
WO2007070957A1 (en) * 2005-12-21 2007-06-28 Monash University Process and apparatus for generating particles
TWI318894B (en) * 2006-08-07 2010-01-01 Ind Tech Res Inst System for fabricating nano particles
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US10149826B2 (en) * 2015-01-20 2018-12-11 Hyalo Technologies, LLC Method of preparing microspheres

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
FR2618674B1 (fr) * 1987-07-30 1990-06-15 Ire Celltarg Sa Microparticules comportant un polymere biodegradable controlant la liberation d'un principe actif antimalarique, compositions pharmaceutiques en comprenant et procede de preparation
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
DE69024953T3 (de) * 1989-05-04 2005-01-27 Southern Research Institute, Birmingham Einkapselungsverfahren
US5091187A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs

Also Published As

Publication number Publication date
EP0556917A1 (de) 1993-08-25
US5389379A (en) 1995-02-14
DE69302721D1 (de) 1996-06-27
NO930557D0 (no) 1993-02-17
JPH05337360A (ja) 1993-12-21
ES2090836T3 (es) 1996-10-16
NO930557L (no) 1993-08-19
FI930672A (fi) 1993-08-19
FI930672A0 (fi) 1993-02-16
AU3313493A (en) 1993-08-19
EP0556917B1 (de) 1996-05-22
MX9300851A (es) 1994-08-31
AU658715B2 (en) 1995-04-27
CA2089354A1 (en) 1993-08-19
ZA93929B (en) 1993-09-10
ATE138263T1 (de) 1996-06-15
KR930017574A (ko) 1993-09-20
NZ245914A (en) 1995-02-24
DK0556917T3 (da) 1996-09-16
GR3020417T3 (en) 1996-10-31

Similar Documents

Publication Publication Date Title
DE69302721D1 (de) Herstellungsverfahren für biologisch aktives Material enthaltende Polymere Mikrokapseln
EP0193725A3 (en) Process for spinning hollow fiber membranes
DE69006472T2 (de) Zahnärztliche Zusammensetzungen, Verfahren zur Herstellung von geformten, zahnärztlichen Artikeln via "photoiniferte Polymerisation" von zahnärztlichen Zusammensetzungen und dadurch erzeugte geformte, zahnärztliche Artikel.
DE69526787D1 (de) Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln
DE69629795D1 (de) Verfahren zur Herstellung von Gegenständen aus einem regenerierte Chitin-Chitosan enthaltenden Material und erhaltene Gegenstände
GR3015885T3 (en) A process for preparing a microporous membrane and such a membrane.
ATE329955T1 (de) Superabsorbierende polymere mit einer kern-schale-struktur und verfahren zu deren herstellung
ATE87540T1 (de) Verfahren und vorrichtung zur herstellung von polymermaterial.
FR2619385B1 (fr) Poudre de polyamide constituee de particules a structure " rose des sables ". procede d'obtention de la poudre de polyamide
DE69531957D1 (de) Granulat-präparate mit kontinuierlicher freisetzung und verfahren zur herstellung
DE69608199T2 (de) Hydrophiler Vliesstoff auf Basis von Polylactiden
ATE173770T1 (de) Verfahren zur herstellung von cellulose- formkörpern
PT97976A (pt) Processo de tratamento farmaco-tecnico de uma substancia activa, injectavel, com uma substancia suporte, nomeadamente coprosterol, acido glicocolico, colesterol ou esteres de colesterol, e de formulacoes parentericas
DE69412948T2 (de) Vliesstoff bestehend aus Polymeren von Milchsäurederivaten und Herstellverfahren und Anwendung eines solchen Vliesstoffes
ATE198341T1 (de) Verfahren zur herstellung von sphärischen mikropartikeln auf celluloseacetat-basis
ATE197823T1 (de) Elektrisch beheizbarer, in teilbereiche unterteilter wabenkorper mit verbindungsstegen
BR9810778A (pt) Partìculas termoplásticas expansiveis e processo de atomização para fabricação das mesmas
Buck et al. Process for Spinning Hollow Fiber Membranes
ATE139793T1 (de) Verfahren zur herstellung von orientierten geformten gegenständen aus mischungen von lyotropen polysacchariden und thermisch verdichtbaren polymeren
ATE16194T1 (de) Verfahren zur herstellung von blockcopolymeren auf der basis von ethylenpolymerisaten und anderen polymeren.
JPH0347265A (ja) 生体吸収性医療用具の製造法

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee