DE69302938D1 - Erythromycinderivate, Herstellung und Verwendung davon - Google Patents

Erythromycinderivate, Herstellung und Verwendung davon

Info

Publication number
DE69302938D1
DE69302938D1 DE69302938T DE69302938T DE69302938D1 DE 69302938 D1 DE69302938 D1 DE 69302938D1 DE 69302938 T DE69302938 T DE 69302938T DE 69302938 T DE69302938 T DE 69302938T DE 69302938 D1 DE69302938 D1 DE 69302938D1
Authority
DE
Germany
Prior art keywords
hemiacetal
salt
erythromycin derivative
positions
hydroxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69302938T
Other languages
English (en)
Other versions
DE69302938T2 (de
Inventor
Setsuo Harada
Yasunori Funabashi
Nobuhiro Inatomi
Shigeharu Tanayama
Seiichi Tanida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KITASATO KENKYUSHO TOKIO/TOKYO JP
Takeda Pharmaceutical Co Ltd
Original Assignee
KITASATO KENKYUSHO TOKIO/TOKYO JP
Kitasato Institute
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KITASATO KENKYUSHO TOKIO/TOKYO JP, Kitasato Institute, Takeda Chemical Industries Ltd filed Critical KITASATO KENKYUSHO TOKIO/TOKYO JP
Publication of DE69302938D1 publication Critical patent/DE69302938D1/de
Application granted granted Critical
Publication of DE69302938T2 publication Critical patent/DE69302938T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
DE69302938T 1992-03-19 1993-03-19 Erythromycinderivate, Herstellung und Verwendung davon Expired - Fee Related DE69302938T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6424392 1992-03-19
JP15246792 1992-06-11

Publications (2)

Publication Number Publication Date
DE69302938D1 true DE69302938D1 (de) 1996-07-11
DE69302938T2 DE69302938T2 (de) 1996-10-17

Family

ID=26405362

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69302938T Expired - Fee Related DE69302938T2 (de) 1992-03-19 1993-03-19 Erythromycinderivate, Herstellung und Verwendung davon

Country Status (5)

Country Link
US (2) US5470961A (de)
EP (1) EP0561413B1 (de)
AT (1) ATE138925T1 (de)
CA (1) CA2092045C (de)
DE (1) DE69302938T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE138925T1 (de) * 1992-03-19 1996-06-15 Takeda Chemical Industries Ltd Erythromycinderivate, herstellung und verwendung davon
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
CA2399198A1 (en) 2000-02-18 2001-08-23 Christopher Carreras Motilide compounds
CA2437576A1 (en) 2001-02-15 2002-08-22 Kosan Biosciences, Inc. Method for evaluating therapeutic efficacy
WO2004111077A1 (en) 2003-06-18 2004-12-23 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US7211568B2 (en) * 2003-12-18 2007-05-01 Kosan Biosciences Incorporated 9-Desoxoerythromycin compounds as prokinetic agents
US7582611B2 (en) 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP1960414A4 (de) * 2005-12-08 2008-12-17 Pfizer VERFAHREN ZUR DEMETHYLIERUNG DER 3ý-DIMETHYLAMINOGRUPPE VON ERYTHROMYCINVERBINDUNGEN
JP5684474B2 (ja) 2006-09-11 2015-03-11 オセラ セラピューティクス， インコーポレイテッド 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト
ES2401467T3 (es) 2006-12-05 2013-04-19 Bristol-Myers Squibb Company Polimorfos de motilida
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2926959A1 (de) * 1979-07-04 1981-01-22 Hoechst Ag Vorrichtung zur fluessig-fluessig- extraktion
US5008249A (en) * 1985-08-31 1991-04-16 Kitasato Kenkyusho Therapeutic method of stimulating digestive tract contractile motion in mammals
DE3689758T2 (de) * 1985-08-31 1994-08-18 Kitasato Inst Erythromycinderivat und Verfahren zu dessen Herstellung.
US4672056A (en) * 1985-11-12 1987-06-09 Abbott Laboratories Erythromycin A derivatives and method of use
JPH0633312B2 (ja) * 1986-05-02 1994-05-02 大正製薬株式会社 １４−ハイドロキシエリスロマイシン誘導体およびその製造方法
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives
US4920102A (en) * 1988-04-18 1990-04-24 Eli Lilly And Company Method for treating gastrointestinal disorders
ATE138925T1 (de) * 1992-03-19 1996-06-15 Takeda Chemical Industries Ltd Erythromycinderivate, herstellung und verwendung davon

Also Published As

Publication number Publication date
CA2092045C (en) 2004-08-10
CA2092045A1 (en) 1993-09-20
DE69302938T2 (de) 1996-10-17
EP0561413B1 (de) 1996-06-05
EP0561413A1 (de) 1993-09-22
US5470961A (en) 1995-11-28
US5854407A (en) 1998-12-29
ATE138925T1 (de) 1996-06-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

Owner name: KITASATO KENKYUSHO, TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee